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The map label for this gene is uvrD [H]

Identifier: 21244868

GI number: 21244868

Start: 4878411

End: 4880603

Strand: Reverse

Name: uvrD [H]

Synonym: XAC4151

Alternate gene names: 21244868

Gene position: 4880603-4878411 (Counterclockwise)

Preceding gene: 21244869

Following gene: 21244867

Centisome position: 94.3

GC content: 65.07

Gene sequence:

>2193_bases
GTGCCGGTGGATGTCTCTCATTTGCTCGATCATTTAAACCCCGCCCAGCGCGAGGCCGTTTCTGCGCCGCCGGGGCACTA
CCTCGTGCTGGCCGGCGCCGGCTCCGGCAAGACGCGCGTGCTGATCCATCGCATCGCCTGGCTCAATGAAGTCCAGGGCG
TGCCCAACCACGGCATCTTCGCGGTGACCTTCACCAACAAGGCCGCCGGCGAAATGCGTCACCGTACCGACCTGCAGCTG
CGCAATGGCAGCCGCGGGATGTGGATCGGTACATTTCACGGGCTGGCACATCGCCTGTTGCGTCTGCATTGGCAGGATGC
GCGGCTGCCGGAAGGCTTCCAGGTCATGGACAGCGACGACCAGTTGCGGCTCGTCAAGCGCGTGGTGCAGGCGCTGGAGC
TGGACGAGAGCAAGTATCCTCCCAAGCAGATGAGCTGGTGGATCAACGAGCAGAAGGATGAGGGCCGCCGTCCGCAGCAT
ATCCAGCCCGAGCCCAACGACGATTGGACCGAGGTGCGCCGGCAGGTGTATGCGGCCTACCAGGAACGCTGCGACCGCTC
CGGGCTGCTGGATTTCGCCGAGTTGCTGCTGCGCGCGCATGAGTTGCTGCGCGACACGCCGGCATTGCTGGCGCATTACC
GCGCGCGCTTCCGCGAGATTCTGGTGGACGAGTTCCAGGACACCAACGCCATCCAGTACGCCTTCGTGCGCGTGCTGGCC
GGCGAGTCGGGCAATGTGTTCGTGGTCGGCGACGACGACCAGGCCATCTATGGCTGGCGCGGCGCCAAGGTCGAAAACGT
CCAGCGCTTTCTGAAGGATTTCCCCGGTGCGCAGACCGTGCGGCTGGAGCAGAACTACCGTTCCAGCGCGAATATTCTGG
GCGCTGCCAATGCGGTGATTGCGCACAACCCGGACCGTATCGGCAAACAGCTGTGGACCGATTCAGGCAATGGCGACCCG
ATCGATCTGTACGCGGCCTACAACGAAGTGGACGAAGCGCGCTATGTGGTCGAGCGTGCACGGCAGTGGGTGCGCGACGG
CGGCAGTTATGGCGAAGTGGCGGTGCTCTACCGCAGCAACGCGCAATCGCGCGCGCTGGAAGAAGCGCTGATTTCCGAGC
AGTTGCCGTACCGCGTGTATGGCGGCATGCGTTTCTTCGAACGTGCCGAAATCAAGGACGCGTTGGCTTACTTGCGTCTG
CTGACCAATCGCAGCGACGACGCTGCGTTCGAACGCGCGGTCAACACGCCCACGCGCGGCATTGGCGATCGGACGCTGGA
TGAGGTGCGCCGGCTGGCACGTGCCAGTGCGCTGTCGTTGTGGGAAGCGGCGATGCTGTGCACGCAGCAGAACACGCTGG
CCGCGCGCGCACGCAATGCCCTGGCCACCTTCCTCAGCCTGATCGGCCAGCTGCATGCCGAAACCGGCGAGATGGAACTG
GCCGAACGCATCGACCATGTGCTGATGCGCTCGGGCCTGCGCGAGCATTGGGCCAAGGAAAGCCGCGGCGGGCTGGATTC
GGAATCGCGTACCGAGAACCTGGACGAACTGGTGTCGGTCGCCTCGCGCTTCACCCGCCCGGACGATGAAGACAGCCAGG
GCATGACCGAGCTGGTCGCCTTCCTGGCTTACGCCTCGCTGGAGGCCGGCGCAGGCCAGGCGCAGGCTGGCGAAGAAGGC
GTGCAGCTGATGACGCTGCATTCGGCCAAGGGCCTGGAATTTCCGATTGTGTTCCTGGTCGGCCTGGAAGACGGCCTGTT
TCCGAGTGCGCGCTCGCTGGAAGAGAGCGGGCGGCTGGAAGAAGAGCGTCGCCTGGCGTACGTGGGCATCACCCGCGCGC
GGCAGAAGCTGGTGCTGTGCTACGCCGAATCGCGCCGTATCCACGGCCAGGACAATTACAACGTGCCCTCGCGCTTCCTG
CGTGAGATTCCGCGCGACCTGCTCAACGAAGTGCGCCCGAAGGTGCAGGTTTCGCGCACCGCATCGCTGGGCGCGGCGCG
CGGCGGCCCGGTGCATGGCATCGTGGAAACGGCACCGATCAAGCTCGGCGCCAACGTCGAACACCCCAAGTTCGGCGGCG
GCGTGGTCGTCGATTACGAAGGCGCTGGCGCGCATGCGCGCGTGCAGGTGCAGTTCGACGAGGTCGGCGCCAAGTGGCTG
GTGATGGCCTACGCCAATCTGACTGTTGTCTAG

Upstream 100 bases:

>100_bases
CGCCCCGTACCCTCACTCCAACCCCTCTGCCGATGGGAGAGGGGCTTACCCAACCGCTTCATCGCAATCTCAGCCGCAAC
GACGCCACAACCGGTAAAAT

Downstream 100 bases:

>100_bases
TCAGGTTGCACTCGTCTGCGATTGCAGTTTCTTCAGCAGGCGAGGGCGTAGTGCGGTTGCACTGTGCGTGCAGCAAGCGG
AACCGACCCTGCTGCACCTC

Product: DNA-dependent helicase II

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 730; Mature: 729

Protein sequence:

>730_residues
MPVDVSHLLDHLNPAQREAVSAPPGHYLVLAGAGSGKTRVLIHRIAWLNEVQGVPNHGIFAVTFTNKAAGEMRHRTDLQL
RNGSRGMWIGTFHGLAHRLLRLHWQDARLPEGFQVMDSDDQLRLVKRVVQALELDESKYPPKQMSWWINEQKDEGRRPQH
IQPEPNDDWTEVRRQVYAAYQERCDRSGLLDFAELLLRAHELLRDTPALLAHYRARFREILVDEFQDTNAIQYAFVRVLA
GESGNVFVVGDDDQAIYGWRGAKVENVQRFLKDFPGAQTVRLEQNYRSSANILGAANAVIAHNPDRIGKQLWTDSGNGDP
IDLYAAYNEVDEARYVVERARQWVRDGGSYGEVAVLYRSNAQSRALEEALISEQLPYRVYGGMRFFERAEIKDALAYLRL
LTNRSDDAAFERAVNTPTRGIGDRTLDEVRRLARASALSLWEAAMLCTQQNTLAARARNALATFLSLIGQLHAETGEMEL
AERIDHVLMRSGLREHWAKESRGGLDSESRTENLDELVSVASRFTRPDDEDSQGMTELVAFLAYASLEAGAGQAQAGEEG
VQLMTLHSAKGLEFPIVFLVGLEDGLFPSARSLEESGRLEEERRLAYVGITRARQKLVLCYAESRRIHGQDNYNVPSRFL
REIPRDLLNEVRPKVQVSRTASLGAARGGPVHGIVETAPIKLGANVEHPKFGGGVVVDYEGAGAHARVQVQFDEVGAKWL
VMAYANLTVV

Sequences:

>Translated_730_residues
MPVDVSHLLDHLNPAQREAVSAPPGHYLVLAGAGSGKTRVLIHRIAWLNEVQGVPNHGIFAVTFTNKAAGEMRHRTDLQL
RNGSRGMWIGTFHGLAHRLLRLHWQDARLPEGFQVMDSDDQLRLVKRVVQALELDESKYPPKQMSWWINEQKDEGRRPQH
IQPEPNDDWTEVRRQVYAAYQERCDRSGLLDFAELLLRAHELLRDTPALLAHYRARFREILVDEFQDTNAIQYAFVRVLA
GESGNVFVVGDDDQAIYGWRGAKVENVQRFLKDFPGAQTVRLEQNYRSSANILGAANAVIAHNPDRIGKQLWTDSGNGDP
IDLYAAYNEVDEARYVVERARQWVRDGGSYGEVAVLYRSNAQSRALEEALISEQLPYRVYGGMRFFERAEIKDALAYLRL
LTNRSDDAAFERAVNTPTRGIGDRTLDEVRRLARASALSLWEAAMLCTQQNTLAARARNALATFLSLIGQLHAETGEMEL
AERIDHVLMRSGLREHWAKESRGGLDSESRTENLDELVSVASRFTRPDDEDSQGMTELVAFLAYASLEAGAGQAQAGEEG
VQLMTLHSAKGLEFPIVFLVGLEDGLFPSARSLEESGRLEEERRLAYVGITRARQKLVLCYAESRRIHGQDNYNVPSRFL
REIPRDLLNEVRPKVQVSRTASLGAARGGPVHGIVETAPIKLGANVEHPKFGGGVVVDYEGAGAHARVQVQFDEVGAKWL
VMAYANLTVV
>Mature_729_residues
PVDVSHLLDHLNPAQREAVSAPPGHYLVLAGAGSGKTRVLIHRIAWLNEVQGVPNHGIFAVTFTNKAAGEMRHRTDLQLR
NGSRGMWIGTFHGLAHRLLRLHWQDARLPEGFQVMDSDDQLRLVKRVVQALELDESKYPPKQMSWWINEQKDEGRRPQHI
QPEPNDDWTEVRRQVYAAYQERCDRSGLLDFAELLLRAHELLRDTPALLAHYRARFREILVDEFQDTNAIQYAFVRVLAG
ESGNVFVVGDDDQAIYGWRGAKVENVQRFLKDFPGAQTVRLEQNYRSSANILGAANAVIAHNPDRIGKQLWTDSGNGDPI
DLYAAYNEVDEARYVVERARQWVRDGGSYGEVAVLYRSNAQSRALEEALISEQLPYRVYGGMRFFERAEIKDALAYLRLL
TNRSDDAAFERAVNTPTRGIGDRTLDEVRRLARASALSLWEAAMLCTQQNTLAARARNALATFLSLIGQLHAETGEMELA
ERIDHVLMRSGLREHWAKESRGGLDSESRTENLDELVSVASRFTRPDDEDSQGMTELVAFLAYASLEAGAGQAQAGEEGV
QLMTLHSAKGLEFPIVFLVGLEDGLFPSARSLEESGRLEEERRLAYVGITRARQKLVLCYAESRRIHGQDNYNVPSRFLR
EIPRDLLNEVRPKVQVSRTASLGAARGGPVHGIVETAPIKLGANVEHPKFGGGVVVDYEGAGAHARVQVQFDEVGAKWLV
MAYANLTVV

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=728, Percent_Identity=59.0659340659341, Blast_Score=868, Evalue=0.0,
Organism=Escherichia coli, GI48994965, Length=646, Percent_Identity=38.0804953560372, Blast_Score=387, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6322369, Length=757, Percent_Identity=25.6274768824306, Blast_Score=171, Evalue=5e-43,
Organism=Saccharomyces cerevisiae, GI6324477, Length=680, Percent_Identity=21.6176470588235, Blast_Score=127, Evalue=8e-30,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005753
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 81752; Mature: 81621

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVDVSHLLDHLNPAQREAVSAPPGHYLVLAGAGSGKTRVLIHRIAWLNEVQGVPNHGIF
CCCCHHHHHHHCCHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEE
AVTFTNKAAGEMRHRTDLQLRNGSRGMWIGTFHGLAHRLLRLHWQDARLPEGFQVMDSDD
EEEECCCHHHHHHHHCCCEEECCCCCEEEEHHHHHHHHHHHHHCCCCCCCCCCEECCCCH
QLRLVKRVVQALELDESKYPPKQMSWWINEQKDEGRRPQHIQPEPNDDWTEVRRQVYAAY
HHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
QERCDRSGLLDFAELLLRAHELLRDTPALLAHYRARFREILVDEFQDTNAIQYAFVRVLA
HHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHC
GESGNVFVVGDDDQAIYGWRGAKVENVQRFLKDFPGAQTVRLEQNYRSSANILGAANAVI
CCCCCEEEEECCCCEEECCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCHHCCCCEEE
AHNPDRIGKQLWTDSGNGDPIDLYAAYNEVDEARYVVERARQWVRDGGSYGEVAVLYRSN
ECCHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECC
AQSRALEEALISEQLPYRVYGGMRFFERAEIKDALAYLRLLTNRSDDAAFERAVNTPTRG
CHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCC
IGDRTLDEVRRLARASALSLWEAAMLCTQQNTLAARARNALATFLSLIGQLHAETGEMEL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
AERIDHVLMRSGLREHWAKESRGGLDSESRTENLDELVSVASRFTRPDDEDSQGMTELVA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHCCCCCCCCCCCHHHHHH
FLAYASLEAGAGQAQAGEEGVQLMTLHSAKGLEFPIVFLVGLEDGLFPSARSLEESGRLE
HHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCEEEEEEEECCCCCCCCHHHHHHHCCCC
EERRLAYVGITRARQKLVLCYAESRRIHGQDNYNVPSRFLREIPRDLLNEVRPKVQVSRT
HHHHEEHEEHHHHHHHEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEHHH
ASLGAARGGPVHGIVETAPIKLGANVEHPKFGGGVVVDYEGAGAHARVQVQFDEVGAKWL
HHCCCCCCCCCCCEEECCCEEECCCCCCCCCCCCEEEEECCCCCEEEEEEEEHHCCCCEE
VMAYANLTVV
EEEEECEEEC
>Mature Secondary Structure 
PVDVSHLLDHLNPAQREAVSAPPGHYLVLAGAGSGKTRVLIHRIAWLNEVQGVPNHGIF
CCCHHHHHHHCCHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEE
AVTFTNKAAGEMRHRTDLQLRNGSRGMWIGTFHGLAHRLLRLHWQDARLPEGFQVMDSDD
EEEECCCHHHHHHHHCCCEEECCCCCEEEEHHHHHHHHHHHHHCCCCCCCCCCEECCCCH
QLRLVKRVVQALELDESKYPPKQMSWWINEQKDEGRRPQHIQPEPNDDWTEVRRQVYAAY
HHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
QERCDRSGLLDFAELLLRAHELLRDTPALLAHYRARFREILVDEFQDTNAIQYAFVRVLA
HHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHC
GESGNVFVVGDDDQAIYGWRGAKVENVQRFLKDFPGAQTVRLEQNYRSSANILGAANAVI
CCCCCEEEEECCCCEEECCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCHHCCCCEEE
AHNPDRIGKQLWTDSGNGDPIDLYAAYNEVDEARYVVERARQWVRDGGSYGEVAVLYRSN
ECCHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECC
AQSRALEEALISEQLPYRVYGGMRFFERAEIKDALAYLRLLTNRSDDAAFERAVNTPTRG
CHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCC
IGDRTLDEVRRLARASALSLWEAAMLCTQQNTLAARARNALATFLSLIGQLHAETGEMEL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
AERIDHVLMRSGLREHWAKESRGGLDSESRTENLDELVSVASRFTRPDDEDSQGMTELVA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHCCCCCCCCCCCHHHHHH
FLAYASLEAGAGQAQAGEEGVQLMTLHSAKGLEFPIVFLVGLEDGLFPSARSLEESGRLE
HHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCEEEEEEEECCCCCCCCHHHHHHHCCCC
EERRLAYVGITRARQKLVLCYAESRRIHGQDNYNVPSRFLREIPRDLLNEVRPKVQVSRT
HHHHEEHEEHHHHHHHEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEHHH
ASLGAARGGPVHGIVETAPIKLGANVEHPKFGGGVVVDYEGAGAHARVQVQFDEVGAKWL
HHCCCCCCCCCCCEEECCCEEECCCCCCCCCCCCEEEEECCCCCEEEEEEEEHHCCCCEE
VMAYANLTVV
EEEEECEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6379604; 2943729; 1379743; 9278503; 6324092; 2254268; 8419285 [H]