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The map label for this gene is phoQ [H]

Identifier: 21244739

GI number: 21244739

Start: 4713459

End: 4714874

Strand: Reverse

Name: phoQ [H]

Synonym: XAC4022

Alternate gene names: 21244739

Gene position: 4714874-4713459 (Counterclockwise)

Preceding gene: 21244740

Following gene: 21244738

Centisome position: 91.1

GC content: 64.12

Gene sequence:

>1416_bases
GTGCCGGGCCGCTCCAAGTGGTATAGACGCTGGCGGCCGCGCTCATTGCAGGCCCGCCAGCTGCTGGCCGCCAGCCTCAG
TCTGGTGGCCTTCCTGGCGCTGGCGGGTTACGCGCTGGATGTGGCGTTTGCCGACACCGCCGAGAAGAACCTGCGCGAGC
GGTTGAAGAACTACGCCTCCGCGTATGCGGCCAATATCGATTTCGTGCGCGACGGGTCGCTGTATATCGGCGGGCAACCG
CCCGACCCGCGTTTCGATGTGCCTGGTGGCGGCCTGTATGTGGAAGTGGTGCGTCCGGACGAAAGCTGGACCTCGATGTC
GGCCGAAGGCCCGAACATTCCGCATGGCCGCATGCTGGAGCCGCGCCAGGAAGAATTCATCGGCCCGCTGGAAATGACCC
AGATCGACGGCAGCCTGGGCCAGCTGTATCGCTACGGGCTGGGCGTGAGCTATGTCGAACGCGAACACGGCGGCGAGATT
CCGTACACCATCTACGTGATGGAGGACGCGCGCTCGATGGGCGCGCAACTGCGCGTGTTCCGTGGTGCGGTGTGGTTCTA
CCTTGGCAGCGCCGGTGTGGTGTTGCTGGTATTGCAAGCCTTCATTCTGCAATGGAGCCTGCGTCCGCTGCGGCGGGTCA
TCAACGAGTTGACGAAGGTGCAGCGCGGCGAGATCCAGCGCATGAGCGAGCAGCATCCGCGCGAACTGGAGCCGCTGACC
GACAGCATCAATGCCTTCATCGAGAGCGAACGCGACAACCTGGAGCGTCAGCGCAATACGCTGGCCGATCTTGCGCATAG
CCTCAAGACGCCCATCGCCGTCTTGCGCACACAACTCGATAGCGGTGCGTCCGAGCGCGATCTGCACGAAGAAATGGATG
TGCAGCTGCGCCGCATGAACGACCTGGTGTCGTATCAGCTGGCACGTGCGGCTTCCAGTGGGCACAAATTGTTCGCGGCA
CCATTGCCGATCGAGTCGACCGCCGAAGAAATCGTGCGTGGTCTTGAGAAGGTGTATTCGGTCAAAGGCGTCTTGTGCGA
ATTCGATATTTCCCCCGAGGCCCGCTTTCATGGCGAGCCGGGCGATTTGCAGGAACTGCTCGGCAACCTGCTGGAAAACG
GCTTCAAGTGGGCGCGCAGCCGCGTGCTGCTGACCGCGAAACCGGGGCCCACCACCGGTAGCCGTCGTGCCGGCCTGATT
CTGTCGGTGGAAGACGACGGCCCCGGCATCGCGCCGGAAGACGTGGCCAAGATCCTGCAGCGCGGCGTGCGTGGCGACGA
GCGCGTGCAAGGGCACGGCATCGGCATGTCGATCGTGCAGGACCTGATCAAGGGCTATCGCGGCGAGCTGCAGGTGGTGC
GCTCGCAGGAACTGGGCGGCGCCCGCTTCGATGTGACCCTGCCGCCGGGACTGTGA

Upstream 100 bases:

>100_bases
GTGAACTCAAGCCGATCGAAACCGTGCGTGGCCGCGGTTATCGCTTCGCCATTCCGCGTACCGAAGGCTGAGTCAGCGCG
TCAACGAGCAGGAAGACCAA

Downstream 100 bases:

>100_bases
CCGCCGCAGGGCCGATGAACCCGTGGCCAATGTGCGCTGGCGTTCCGACAACCGTTTAACGCCTCACGCGTTGGCTTACC
CATACTGGGTGGCAAGCCGT

Product: two-component system sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MPGRSKWYRRWRPRSLQARQLLAASLSLVAFLALAGYALDVAFADTAEKNLRERLKNYASAYAANIDFVRDGSLYIGGQP
PDPRFDVPGGGLYVEVVRPDESWTSMSAEGPNIPHGRMLEPRQEEFIGPLEMTQIDGSLGQLYRYGLGVSYVEREHGGEI
PYTIYVMEDARSMGAQLRVFRGAVWFYLGSAGVVLLVLQAFILQWSLRPLRRVINELTKVQRGEIQRMSEQHPRELEPLT
DSINAFIESERDNLERQRNTLADLAHSLKTPIAVLRTQLDSGASERDLHEEMDVQLRRMNDLVSYQLARAASSGHKLFAA
PLPIESTAEEIVRGLEKVYSVKGVLCEFDISPEARFHGEPGDLQELLGNLLENGFKWARSRVLLTAKPGPTTGSRRAGLI
LSVEDDGPGIAPEDVAKILQRGVRGDERVQGHGIGMSIVQDLIKGYRGELQVVRSQELGGARFDVTLPPGL

Sequences:

>Translated_471_residues
MPGRSKWYRRWRPRSLQARQLLAASLSLVAFLALAGYALDVAFADTAEKNLRERLKNYASAYAANIDFVRDGSLYIGGQP
PDPRFDVPGGGLYVEVVRPDESWTSMSAEGPNIPHGRMLEPRQEEFIGPLEMTQIDGSLGQLYRYGLGVSYVEREHGGEI
PYTIYVMEDARSMGAQLRVFRGAVWFYLGSAGVVLLVLQAFILQWSLRPLRRVINELTKVQRGEIQRMSEQHPRELEPLT
DSINAFIESERDNLERQRNTLADLAHSLKTPIAVLRTQLDSGASERDLHEEMDVQLRRMNDLVSYQLARAASSGHKLFAA
PLPIESTAEEIVRGLEKVYSVKGVLCEFDISPEARFHGEPGDLQELLGNLLENGFKWARSRVLLTAKPGPTTGSRRAGLI
LSVEDDGPGIAPEDVAKILQRGVRGDERVQGHGIGMSIVQDLIKGYRGELQVVRSQELGGARFDVTLPPGL
>Mature_470_residues
PGRSKWYRRWRPRSLQARQLLAASLSLVAFLALAGYALDVAFADTAEKNLRERLKNYASAYAANIDFVRDGSLYIGGQPP
DPRFDVPGGGLYVEVVRPDESWTSMSAEGPNIPHGRMLEPRQEEFIGPLEMTQIDGSLGQLYRYGLGVSYVEREHGGEIP
YTIYVMEDARSMGAQLRVFRGAVWFYLGSAGVVLLVLQAFILQWSLRPLRRVINELTKVQRGEIQRMSEQHPRELEPLTD
SINAFIESERDNLERQRNTLADLAHSLKTPIAVLRTQLDSGASERDLHEEMDVQLRRMNDLVSYQLARAASSGHKLFAAP
LPIESTAEEIVRGLEKVYSVKGVLCEFDISPEARFHGEPGDLQELLGNLLENGFKWARSRVLLTAKPGPTTGSRRAGLIL
SVEDDGPGIAPEDVAKILQRGVRGDERVQGHGIGMSIVQDLIKGYRGELQVVRSQELGGARFDVTLPPGL

Specific function: Member of the two-component regulatory system phoQ/phoP involved in virulence, adaptation to low Mg(2+) environments and the control of acid resistance genes. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane- associated p

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=288, Percent_Identity=34.7222222222222, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1786783, Length=330, Percent_Identity=27.8787878787879, Blast_Score=92, Evalue=9e-20,
Organism=Escherichia coli, GI1788393, Length=276, Percent_Identity=23.1884057971014, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1790346, Length=275, Percent_Identity=23.6363636363636, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1787894, Length=243, Percent_Identity=28.8065843621399, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1790551, Length=288, Percent_Identity=26.7361111111111, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1786600, Length=230, Percent_Identity=26.9565217391304, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1786912, Length=243, Percent_Identity=29.6296296296296, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1789808, Length=266, Percent_Identity=24.812030075188, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52428; Mature: 52297

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGRSKWYRRWRPRSLQARQLLAASLSLVAFLALAGYALDVAFADTAEKNLRERLKNYAS
CCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYAANIDFVRDGSLYIGGQPPDPRFDVPGGGLYVEVVRPDESWTSMSAEGPNIPHGRMLE
HHHCCCCEEECCCEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCC
PRQEEFIGPLEMTQIDGSLGQLYRYGLGVSYVEREHGGEIPYTIYVMEDARSMGAQLRVF
CHHHHCCCCHHHHHCCCHHHHHHHHCCCHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHH
RGAVWFYLGSAGVVLLVLQAFILQWSLRPLRRVINELTKVQRGEIQRMSEQHPRELEPLT
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
DSINAFIESERDNLERQRNTLADLAHSLKTPIAVLRTQLDSGASERDLHEEMDVQLRRMN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
DLVSYQLARAASSGHKLFAAPLPIESTAEEIVRGLEKVYSVKGVLCEFDISPEARFHGEP
HHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCC
GDLQELLGNLLENGFKWARSRVLLTAKPGPTTGSRRAGLILSVEDDGPGIAPEDVAKILQ
CHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHH
RGVRGDERVQGHGIGMSIVQDLIKGYRGELQVVRSQELGGARFDVTLPPGL
HCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEHHCCCCCEEEEECCCCC
>Mature Secondary Structure 
PGRSKWYRRWRPRSLQARQLLAASLSLVAFLALAGYALDVAFADTAEKNLRERLKNYAS
CCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYAANIDFVRDGSLYIGGQPPDPRFDVPGGGLYVEVVRPDESWTSMSAEGPNIPHGRMLE
HHHCCCCEEECCCEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCC
PRQEEFIGPLEMTQIDGSLGQLYRYGLGVSYVEREHGGEIPYTIYVMEDARSMGAQLRVF
CHHHHCCCCHHHHHCCCHHHHHHHHCCCHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHH
RGAVWFYLGSAGVVLLVLQAFILQWSLRPLRRVINELTKVQRGEIQRMSEQHPRELEPLT
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
DSINAFIESERDNLERQRNTLADLAHSLKTPIAVLRTQLDSGASERDLHEEMDVQLRRMN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
DLVSYQLARAASSGHKLFAAPLPIESTAEEIVRGLEKVYSVKGVLCEFDISPEARFHGEP
HHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCC
GDLQELLGNLLENGFKWARSRVLLTAKPGPTTGSRRAGLILSVEDDGPGIAPEDVAKILQ
CHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHH
RGVRGDERVQGHGIGMSIVQDLIKGYRGELQVVRSQELGGARFDVTLPPGL
HCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEHHCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]