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The map label for this gene is dfp [H]

Identifier: 21244633

GI number: 21244633

Start: 4599510

End: 4600784

Strand: Reverse

Name: dfp [H]

Synonym: XAC3914

Alternate gene names: 21244633

Gene position: 4600784-4599510 (Counterclockwise)

Preceding gene: 21244639

Following gene: 21244632

Centisome position: 88.89

GC content: 69.57

Gene sequence:

>1275_bases
GTGATCGGCTCCACTCAGGCCCGCCCCCTGGACGGACAGCGTTTGCTGCTGTGCGTCGGCGGAGGCATCGCCGCTTACAA
ATCGCTCGAACTGGTCCGTCGCCTGCGCGACGCCGGTGCGCAGGTGCAGGTCGCCATGACCGGCGGTGCGCAGCAATTCA
TCACCCCGCTCAGCTTCCAGGCATTGTCCGGGCAGCCCACCCGCACCACGCTGTGGGACAGCGCCGCCGAGCAGGCGATG
GGCCACATCGAACTGGCGCGCTGGGCCGATCGGGTGATCGTCGCCCCGGCGACCGCCGACCTGCTGGCGCGGCTGGCGCA
TGGTCTGGCCGACGATCTGGTCACCACGCTGTGCCTGGCCACGACCGCGCCGCTGACCGTGGCGCCGGCCATGAACCACC
GCATGTGGCTGCATCCTGCCACCCAGGCCAACATCGCCACCCTGCGCGCGCGCGGGGTGACGGTGGTGGGCCCTGACGAC
GGCCCGCTGGCCGAGGGCGAATCCGGCCCCGGGCGGCTGGCCGAACCGGCGGCGATCATTGCTGCGCTGGCCGGTGGCGC
GGCGGCCGCCAGCACTGCCCCGGAGGGCGCCAGGAGCGTCGTCGCGCCCGTCTTCATCCCCAGCAGCGCGCAGTTGGAGG
GCCTGCGCATCGTGATCAGCGCCGGCCCCACCTTCGAAGACCTGGACCCGGTGCGCTACGTCGGCAACCGCAGCAGCGGC
AAGATGGGCTATGCCCTGGCCGCCGCAGCTGCCAGGCAAGGCGCTGATGTGGTGCTGGTCAGCGGGCCGGTGCATCAAAC
CACCCCGGATGGCGTGCAGCGCATCGACGTGCGCTCGGCCGCGCAGATGCGCGACGCGGTGCTGGGTGCATTCCCGGCCG
ACATCTACATCGGCGCTGCCGCCGTGGCCGACTACACCCCCAAGCGGGTGGTGTCGCAGAAGATCAAGAAGACCGGCGAA
ACGTTGACCCTGGAACTGGTGCGGACCCCGGACATCCTGTCCGAGGTCGCCGCGCAGACCGGCGCGCTGAAACTGGTGGT
CGGTTTTGCTGCCGAAACGCACGATGTGGAGCATTACGCCCGTGGCAAGCTGGCGGCCAAGCGCCTGGACCTGATCATCG
CCAACCAGGTAGGGATCGAAGGCGGCGGATTCGAAAGCGACAACAACGCAGCCACGGCCTATTGGCAGGGCGGCGAGCGC
GTGTTTCCCAGCAGCAGCAAGACCGAATTGGCCGACCAACTGCTGGCCCTGATCGCGGAGAGATTGCAGGCATGA

Upstream 100 bases:

>100_bases
GCATATGGCGAGATTGCCGGTGCTCATCGCCGACGCCCATCAGGCCAAGCAGAGGCATCGGCTAATCTAGTTGTCCTTGT
AACCGTAGGACGACCCCGAC

Downstream 100 bases:

>100_bases
GCCCCCCAACCCAGTCCTTGCAGGTGAAGTTGCTCGACCCGCGCTTCGGCGATCTGTGGCCGCTGCCGGCCTATGCCACC
GAATCCAGTGCAGGCATGGA

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MIGSTQARPLDGQRLLLCVGGGIAAYKSLELVRRLRDAGAQVQVAMTGGAQQFITPLSFQALSGQPTRTTLWDSAAEQAM
GHIELARWADRVIVAPATADLLARLAHGLADDLVTTLCLATTAPLTVAPAMNHRMWLHPATQANIATLRARGVTVVGPDD
GPLAEGESGPGRLAEPAAIIAALAGGAAAASTAPEGARSVVAPVFIPSSAQLEGLRIVISAGPTFEDLDPVRYVGNRSSG
KMGYALAAAAARQGADVVLVSGPVHQTTPDGVQRIDVRSAAQMRDAVLGAFPADIYIGAAAVADYTPKRVVSQKIKKTGE
TLTLELVRTPDILSEVAAQTGALKLVVGFAAETHDVEHYARGKLAAKRLDLIIANQVGIEGGGFESDNNAATAYWQGGER
VFPSSSKTELADQLLALIAERLQA

Sequences:

>Translated_424_residues
MIGSTQARPLDGQRLLLCVGGGIAAYKSLELVRRLRDAGAQVQVAMTGGAQQFITPLSFQALSGQPTRTTLWDSAAEQAM
GHIELARWADRVIVAPATADLLARLAHGLADDLVTTLCLATTAPLTVAPAMNHRMWLHPATQANIATLRARGVTVVGPDD
GPLAEGESGPGRLAEPAAIIAALAGGAAAASTAPEGARSVVAPVFIPSSAQLEGLRIVISAGPTFEDLDPVRYVGNRSSG
KMGYALAAAAARQGADVVLVSGPVHQTTPDGVQRIDVRSAAQMRDAVLGAFPADIYIGAAAVADYTPKRVVSQKIKKTGE
TLTLELVRTPDILSEVAAQTGALKLVVGFAAETHDVEHYARGKLAAKRLDLIIANQVGIEGGGFESDNNAATAYWQGGER
VFPSSSKTELADQLLALIAERLQA
>Mature_424_residues
MIGSTQARPLDGQRLLLCVGGGIAAYKSLELVRRLRDAGAQVQVAMTGGAQQFITPLSFQALSGQPTRTTLWDSAAEQAM
GHIELARWADRVIVAPATADLLARLAHGLADDLVTTLCLATTAPLTVAPAMNHRMWLHPATQANIATLRARGVTVVGPDD
GPLAEGESGPGRLAEPAAIIAALAGGAAAASTAPEGARSVVAPVFIPSSAQLEGLRIVISAGPTFEDLDPVRYVGNRSSG
KMGYALAAAAARQGADVVLVSGPVHQTTPDGVQRIDVRSAAQMRDAVLGAFPADIYIGAAAVADYTPKRVVSQKIKKTGE
TLTLELVRTPDILSEVAAQTGALKLVVGFAAETHDVEHYARGKLAAKRLDLIIANQVGIEGGGFESDNNAATAYWQGGER
VFPSSSKTELADQLLALIAERLQA

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=180, Percent_Identity=34.4444444444444, Blast_Score=87, Evalue=4e-17,
Organism=Escherichia coli, GI87082301, Length=416, Percent_Identity=52.1634615384615, Blast_Score=369, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17560194, Length=183, Percent_Identity=30.0546448087432, Blast_Score=81, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24657262, Length=181, Percent_Identity=28.7292817679558, Blast_Score=79, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 44049; Mature: 44049

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGSTQARPLDGQRLLLCVGGGIAAYKSLELVRRLRDAGAQVQVAMTGGAQQFITPLSFQ
CCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHCCCHHH
ALSGQPTRTTLWDSAAEQAMGHIELARWADRVIVAPATADLLARLAHGLADDLVTTLCLA
HCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHH
TTAPLTVAPAMNHRMWLHPATQANIATLRARGVTVVGPDDGPLAEGESGPGRLAEPAAII
HCCCEEEECCCCCEEEECCCCCCCCEEEEECCEEEECCCCCCCCCCCCCCCCCCCHHHHH
AALAGGAAAASTAPEGARSVVAPVFIPSSAQLEGLRIVISAGPTFEDLDPVRYVGNRSSG
HHHHCCCHHCCCCCCCHHHEEEEEEECCCCCCCCEEEEEECCCCCCCCCHHHHHCCCCCC
KMGYALAAAAARQGADVVLVSGPVHQTTPDGVQRIDVRSAAQMRDAVLGAFPADIYIGAA
CCHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCHH
AVADYTPKRVVSQKIKKTGETLTLELVRTPDILSEVAAQTGALKLVVGFAAETHDVEHYA
HHHCCCHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHCCCCEEEEEEECCCHHHHHHHH
RGKLAAKRLDLIIANQVGIEGGGFESDNNAATAYWQGGERVFPSSSKTELADQLLALIAE
HHHHHHHHHCEEEECCCCCCCCCCCCCCCEEEEEECCCCEECCCCCHHHHHHHHHHHHHH
RLQA
HHCC
>Mature Secondary Structure
MIGSTQARPLDGQRLLLCVGGGIAAYKSLELVRRLRDAGAQVQVAMTGGAQQFITPLSFQ
CCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHCCCHHH
ALSGQPTRTTLWDSAAEQAMGHIELARWADRVIVAPATADLLARLAHGLADDLVTTLCLA
HCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHH
TTAPLTVAPAMNHRMWLHPATQANIATLRARGVTVVGPDDGPLAEGESGPGRLAEPAAII
HCCCEEEECCCCCEEEECCCCCCCCEEEEECCEEEECCCCCCCCCCCCCCCCCCCHHHHH
AALAGGAAAASTAPEGARSVVAPVFIPSSAQLEGLRIVISAGPTFEDLDPVRYVGNRSSG
HHHHCCCHHCCCCCCCHHHEEEEEEECCCCCCCCEEEEEECCCCCCCCCHHHHHCCCCCC
KMGYALAAAAARQGADVVLVSGPVHQTTPDGVQRIDVRSAAQMRDAVLGAFPADIYIGAA
CCHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCHH
AVADYTPKRVVSQKIKKTGETLTLELVRTPDILSEVAAQTGALKLVVGFAAETHDVEHYA
HHHCCCHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHCCCCEEEEEEECCCHHHHHHHH
RGKLAAKRLDLIIANQVGIEGGGFESDNNAATAYWQGGERVFPSSSKTELADQLLALIAE
HHHHHHHHHCEEEECCCCCCCCCCCCCCCEEEEEECCCCEECCCCCHHHHHHHHHHHHHH
RLQA
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]