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The map label for this gene is rmlD [H]

Identifier: 21244307

GI number: 21244307

Start: 4248772

End: 4249671

Strand: Reverse

Name: rmlD [H]

Synonym: XAC3582

Alternate gene names: 21244307

Gene position: 4249671-4248772 (Counterclockwise)

Preceding gene: 21244308

Following gene: 21244306

Centisome position: 82.11

GC content: 68.44

Gene sequence:

>900_bases
ATGACCACGCTGGTACTGGGAGCCAATGGACAGGTCGGCACGGAATTGCTGCGGGCATTGGCAGCCAATGGCCCGATCCT
GGGTAGCACCCGCAGTGGTCGGTTGCCGGATGGTGCAGCGTGTGAGGTAGCCGACTTTGACGCACCGCATCGCCTGAGCG
AATTGCTGGATCGCTTGCAGCCAAGTTGCGTCGTCAACGCAGCCGCCTACACGGCCGTCGATCGTGCCGAGCAGGAGCGT
GATGCGGCCTTCCGCGCCAATGCCGAAGCGCCTGGCGTGATAGCGCAATGGTGCGCGCGCGCCGATGTGCCCCTGGTCCA
TTACTCGACCGACTATGTCTTCGATGGGCAGGGCACGCGCCCCTATCGGCCGGACGATGCCACCGCGCCGCTCGGCGTGT
ACGGGCAAAGCAAACTGGCGGGCGAGCAGGCAGTGCAGGCGGCCGGCGGCCGTCATCTGATCTTCCGCACTGCCTGGGTC
TACGCGGCGCATGGACACAATTTCCTGCGCACGATGCTGCGCGTGGGCGCCGAGCGCGATGTGCTGCGCGTGGTCGCCGA
CCAGATCGGCACGCCAACGCCAGCGGCGTTAATCGCCGACATCACGGCGCACGCGCTCCGCCAGCCGGGCGAACCCTCCG
GCTTGTGGCATCTGACTGCCGCCGGGCAGACCACCTGGCACGGTTTCGCCGAAGCCATCTTCGCGCAGGCGCGCGCGCGC
GGCCTGCTCGCCCGCACGCCGCGCGTGGAGGCGATCGGCACCGCCGACTATCCCACGCCGGCCACGCGCCCGGCCTATTC
GCGACTGGATACCCACAGCCTGCAGGACACCTTCGGCGTCCGCCTGCCGGACTGGCAGGATGGACTGAGCCAGGTGCTGG
ACACGCTCGCCCAACGGTGA

Upstream 100 bases:

>100_bases
GCATCGATTGGCCGATCAGCAACCCGTTGTTGTCTGCAAAGGACTCCGCCGCGCCGTTCCTGGGCGATGTGCCGGCCGAA
CGCCTGCCGGTGTATACGCC

Downstream 100 bases:

>100_bases
GCCTTGTCGGTGCTGCCATCGATCGGTGCGGCTTCAGCACCGACTCATAGCTTGCACTTCGCTTCGGCTACCATCAGGGC
TGATCCGCGCCGTACCGGCG

Product: dTDP-4-keto-L-rhamnose reductase

Products: NA

Alternate protein names: dTDP-4-keto-L-rhamnose reductase; dTDP-6-deoxy-L-lyxo-4-hexulose reductase; dTDP-6-deoxy-L-mannose dehydrogenase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MTTLVLGANGQVGTELLRALAANGPILGSTRSGRLPDGAACEVADFDAPHRLSELLDRLQPSCVVNAAAYTAVDRAEQER
DAAFRANAEAPGVIAQWCARADVPLVHYSTDYVFDGQGTRPYRPDDATAPLGVYGQSKLAGEQAVQAAGGRHLIFRTAWV
YAAHGHNFLRTMLRVGAERDVLRVVADQIGTPTPAALIADITAHALRQPGEPSGLWHLTAAGQTTWHGFAEAIFAQARAR
GLLARTPRVEAIGTADYPTPATRPAYSRLDTHSLQDTFGVRLPDWQDGLSQVLDTLAQR

Sequences:

>Translated_299_residues
MTTLVLGANGQVGTELLRALAANGPILGSTRSGRLPDGAACEVADFDAPHRLSELLDRLQPSCVVNAAAYTAVDRAEQER
DAAFRANAEAPGVIAQWCARADVPLVHYSTDYVFDGQGTRPYRPDDATAPLGVYGQSKLAGEQAVQAAGGRHLIFRTAWV
YAAHGHNFLRTMLRVGAERDVLRVVADQIGTPTPAALIADITAHALRQPGEPSGLWHLTAAGQTTWHGFAEAIFAQARAR
GLLARTPRVEAIGTADYPTPATRPAYSRLDTHSLQDTFGVRLPDWQDGLSQVLDTLAQR
>Mature_298_residues
TTLVLGANGQVGTELLRALAANGPILGSTRSGRLPDGAACEVADFDAPHRLSELLDRLQPSCVVNAAAYTAVDRAEQERD
AAFRANAEAPGVIAQWCARADVPLVHYSTDYVFDGQGTRPYRPDDATAPLGVYGQSKLAGEQAVQAAGGRHLIFRTAWVY
AAHGHNFLRTMLRVGAERDVLRVVADQIGTPTPAALIADITAHALRQPGEPSGLWHLTAAGQTTWHGFAEAIFAQARARG
LLARTPRVEAIGTADYPTPATRPAYSRLDTHSLQDTFGVRLPDWQDGLSQVLDTLAQR

Specific function: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose. RmlD uses NADH and NADPH nearly equally well [H]

COG id: COG1091

COG function: function code M; dTDP-4-dehydrorhamnose reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose reductase family [H]

Homologues:

Organism=Homo sapiens, GI11034825, Length=145, Percent_Identity=35.1724137931034, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI33519455, Length=145, Percent_Identity=35.1724137931034, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1788352, Length=299, Percent_Identity=45.819397993311, Blast_Score=256, Evalue=1e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005913
- InterPro:   IPR016040 [H]

Pfam domain/function: PF04321 RmlD_sub_bind [H]

EC number: =1.1.1.133 [H]

Molecular weight: Translated: 32034; Mature: 31903

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLVLGANGQVGTELLRALAANGPILGSTRSGRLPDGAACEVADFDAPHRLSELLDRLQ
CCEEEECCCCCHHHHHHHHHHCCCCEECCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHC
PSCVVNAAAYTAVDRAEQERDAAFRANAEAPGVIAQWCARADVPLVHYSTDYVFDGQGTR
CHHEEHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCEEEECCCEEECCCCCC
PYRPDDATAPLGVYGQSKLAGEQAVQAAGGRHLIFRTAWVYAAHGHNFLRTMLRVGAERD
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEEHHHHCCHHHHHHHHHCCCCHH
VLRVVADQIGTPTPAALIADITAHALRQPGEPSGLWHLTAAGQTTWHGFAEAIFAQARAR
HHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
GLLARTPRVEAIGTADYPTPATRPAYSRLDTHSLQDTFGVRLPDWQDGLSQVLDTLAQR
HHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TTLVLGANGQVGTELLRALAANGPILGSTRSGRLPDGAACEVADFDAPHRLSELLDRLQ
CEEEECCCCCHHHHHHHHHHCCCCEECCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHC
PSCVVNAAAYTAVDRAEQERDAAFRANAEAPGVIAQWCARADVPLVHYSTDYVFDGQGTR
CHHEEHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCEEEECCCEEECCCCCC
PYRPDDATAPLGVYGQSKLAGEQAVQAAGGRHLIFRTAWVYAAHGHNFLRTMLRVGAERD
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEEHHHHCCHHHHHHHHHCCCCHH
VLRVVADQIGTPTPAALIADITAHALRQPGEPSGLWHLTAAGQTTWHGFAEAIFAQARAR
HHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
GLLARTPRVEAIGTADYPTPATRPAYSRLDTHSLQDTFGVRLPDWQDGLSQVLDTLAQR
HHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1710759; 11677609 [H]