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The map label for this gene is coaE

Identifier: 21243970

GI number: 21243970

Start: 3822547

End: 3823155

Strand: Direct

Name: coaE

Synonym: XAC3244

Alternate gene names: 21243970

Gene position: 3822547-3823155 (Clockwise)

Preceding gene: 21243969

Following gene: 21243971

Centisome position: 73.86

GC content: 64.53

Gene sequence:

>609_bases
ATGAGCGACTTCATCGTCGGCCTTACGGGCGGCATCGCCTCCGGCAAGAGCGCGCTGGCCGCCGAGTTCGAGAAGCTGGG
TGTACCGGTTATCGATGCCGATGTGATTGCACGGCAGGTCGCGGAGCCGGGGCCGATCCTCGACGCCATTGCTGCGTACT
TCGGGGATAGCGTTTTGCTCCCCGACGGAACCTTGAACCGACAAGCGCTACGCTACCGCGTCTTTGCAGACACCGCGCAA
CGGCAAGCGCTCGAAGCCATCACCCACCCGGCCATCCGCAGAGAACTGCAGCGCGCAGCGCTGGCTGCACAGGGCCCCTA
TGCAATTGTCGCAATCCCCCTGCTCGCCGAAGCCGGTGGGCGCGCCACCTATCCATGGCTAGATCGCATCCTCGTCGTCG
ATGTGCCAGTCGCCTTACAACACGAACGCCTGATGCAGCGGGATGGAGCGACGGCCGAACTGGCCGATCGCATGATTACT
GCGCAGGCGACGCGGGAGAAGCGGCTGGCCATCGCCGATGAAGTCGTCTGCAATCACGGCGTCCTGAAGCAGTTGTCGCA
GGCGGCACGCCGACTGGACGCGGACTATCGGGCACGCGCCAACCCTTAG

Upstream 100 bases:

>100_bases
CCCTACCTGGCCATTGCTGGCTGGGTGGTGTTCTTTTGGGGCAACGACCTGGTGGACGGCTACCTGCACTTCGCAGGCCT
GCGTTGACCCTGGCACGACG

Downstream 100 bases:

>100_bases
GCCTTTGTGCATCGGCACTTGCTTATGCGCTATGCGTAATATATCGATCGCCTACCTGATCAGACATGGTTGTAGCCATC
GCTGCAGAGCGCCGAGAGTG

Product: dephospho-CoA kinase

Products: NA

Alternate protein names: Dephosphocoenzyme A kinase

Number of amino acids: Translated: 202; Mature: 201

Protein sequence:

>202_residues
MSDFIVGLTGGIASGKSALAAEFEKLGVPVIDADVIARQVAEPGPILDAIAAYFGDSVLLPDGTLNRQALRYRVFADTAQ
RQALEAITHPAIRRELQRAALAAQGPYAIVAIPLLAEAGGRATYPWLDRILVVDVPVALQHERLMQRDGATAELADRMIT
AQATREKRLAIADEVVCNHGVLKQLSQAARRLDADYRARANP

Sequences:

>Translated_202_residues
MSDFIVGLTGGIASGKSALAAEFEKLGVPVIDADVIARQVAEPGPILDAIAAYFGDSVLLPDGTLNRQALRYRVFADTAQ
RQALEAITHPAIRRELQRAALAAQGPYAIVAIPLLAEAGGRATYPWLDRILVVDVPVALQHERLMQRDGATAELADRMIT
AQATREKRLAIADEVVCNHGVLKQLSQAARRLDADYRARANP
>Mature_201_residues
SDFIVGLTGGIASGKSALAAEFEKLGVPVIDADVIARQVAEPGPILDAIAAYFGDSVLLPDGTLNRQALRYRVFADTAQR
QALEAITHPAIRRELQRAALAAQGPYAIVAIPLLAEAGGRATYPWLDRILVVDVPVALQHERLMQRDGATAELADRMITA
QATREKRLAIADEVVCNHGVLKQLSQAARRLDADYRARANP

Specific function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A

COG id: COG0237

COG function: function code H; Dephospho-CoA kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DPCK (dephospho-CoA kinase) domain

Homologues:

Organism=Homo sapiens, GI191252797, Length=181, Percent_Identity=39.7790055248619, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI191252795, Length=181, Percent_Identity=39.7790055248619, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI110227607, Length=167, Percent_Identity=30.5389221556886, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI110227605, Length=173, Percent_Identity=31.2138728323699, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI110227603, Length=173, Percent_Identity=31.2138728323699, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI110227601, Length=173, Percent_Identity=31.2138728323699, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI205277394, Length=173, Percent_Identity=31.2138728323699, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI1786292, Length=194, Percent_Identity=47.9381443298969, Blast_Score=164, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17554944, Length=204, Percent_Identity=33.3333333333333, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6320402, Length=201, Percent_Identity=39.8009950248756, Blast_Score=110, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24644728, Length=190, Percent_Identity=36.8421052631579, Blast_Score=117, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24658602, Length=96, Percent_Identity=42.7083333333333, Blast_Score=76, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAE_XANAC (Q8PHK7)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_643552.1
- ProteinModelPortal:   Q8PHK7
- SMR:   Q8PHK7
- GeneID:   1157315
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC3244
- NMPDR:   fig|190486.1.peg.3196
- HOGENOM:   HBG650290
- OMA:   IIAREVV
- ProtClustDB:   PRK00081
- BioCyc:   XAXO190486:XAC3244-MONOMER
- BRENDA:   2.7.1.24
- GO:   GO:0005737
- HAMAP:   MF_00376
- InterPro:   IPR001977
- TIGRFAMs:   TIGR00152

Pfam domain/function: PF01121 CoaE

EC number: =2.7.1.24

Molecular weight: Translated: 21757; Mature: 21626

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS51219 DPCK; PS01294 COAE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDFIVGLTGGIASGKSALAAEFEKLGVPVIDADVIARQVAEPGPILDAIAAYFGDSVLL
CCCEEEEECCCCCCCHHHHHHHHHHCCCCEECHHHHHHHHCCCCHHHHHHHHHHCCCEEC
PDGTLNRQALRYRVFADTAQRQALEAITHPAIRRELQRAALAAQGPYAIVAIPLLAEAGG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHCCC
RATYPWLDRILVVDVPVALQHERLMQRDGATAELADRMITAQATREKRLAIADEVVCNHG
CCCCHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHH
VLKQLSQAARRLDADYRARANP
HHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SDFIVGLTGGIASGKSALAAEFEKLGVPVIDADVIARQVAEPGPILDAIAAYFGDSVLL
CCEEEEECCCCCCCHHHHHHHHHHCCCCEECHHHHHHHHCCCCHHHHHHHHHHCCCEEC
PDGTLNRQALRYRVFADTAQRQALEAITHPAIRRELQRAALAAQGPYAIVAIPLLAEAGG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHCCC
RATYPWLDRILVVDVPVALQHERLMQRDGATAELADRMITAQATREKRLAIADEVVCNHG
CCCCHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHH
VLKQLSQAARRLDADYRARANP
HHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217