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The map label for this gene is iciA [C]

Identifier: 21243861

GI number: 21243861

Start: 3686345

End: 3687247

Strand: Direct

Name: iciA [C]

Synonym: XAC3134

Alternate gene names: 21243861

Gene position: 3686345-3687247 (Clockwise)

Preceding gene: 77748700

Following gene: 21243864

Centisome position: 71.23

GC content: 66.11

Gene sequence:

>903_bases
ATGGATCTTCTGCACCCGCAATTGGCCGCCTTCGCAGCCGTTCTGAATGAGGGCAGCTTCGACGCGGCCGCGCAGCGTCT
TGCACTGACGCCCTCGGCAATCTCGCAACGCATCAAGGCGCTCGAAGACCGACTCGGGCAGGTACTGGTCATGCGCACGG
CGCCCTGCCGGCCCACGCCGGCCGGCGAACGGCTGCTGCGCCGGCTCAAACCCATGCAGGTCCTCGAGGCCGAAGCGGTC
GCCGACCTCCTGCCTGGCGATCGCATCGCCGGTCATCCACGCACTCTCGCCATCGCGGTCAATGACGACTCGTTACAGAC
CTGGTTCCTGCAGGCGCTGTCTTCGCTGCACCGGGCGCACGGCTTTTTGTTCGATGTACAGATGGACGACCAGGACCACA
CCCTGGAATTGCTGCGCGCTGGCAGCGTGCTGGGCGCGGTCACCTCGGAGCGCGCGCCACTGCAGGGTTGCAACGTCCAG
GCGTTGGGCGTGATGCGCTACCACGCGATCGCATCGGCAGCGTTCGTCGCCGCACATTTCCAGGACGGCTTTACCGCCGA
CGCGCTGGGGAAGGCGCCGATGCTGGTGTTCAATCGCAAAGACACCTTGCAGGCGCGTTTCGTCAGGCGGATCACGCGTG
CCCGGCTGACCCCGCCCACGCATTACCTGCCCACCTCCACCGGCTTTGTCGAAGCCGCTGCACGCGAGCTGGGCTGGTGC
CTGGCGCCCGAAGCGATGGTGCTGCCTGCGGTGCGCAACAGGCAGGTCGTCATCATCGACCCCACCCGCTGGCTCGATGT
TCCGCTGTACTGGCAATACACCGCTGTGCGCTCGAACGCCTTGCAACAACTCAGCCAGGCACTGCGCAAGGCGGCTGCCA
CCAGCTTGCGTGGCAGCAGATAG

Upstream 100 bases:

>100_bases
GTGTTGTCTCCGAGGCTGGAGTGAATCGTGCGTCCTCGCGTCGGATTAGGAAAACTAAATAATCTGTATGCTCATTAGAA
CTTCTAATGTCGGCAAAAGC

Downstream 100 bases:

>100_bases
ACACCACGCCCACCGATCTCACCGCCGGCCAATCGCCGGACTGCCATGCATCTGCGGCGCTCCGAGTTTACCGGCCCTAA
TCGCCGCGTTGGCTGCACCT

Product: chromosome replication initiation inhibitor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MDLLHPQLAAFAAVLNEGSFDAAAQRLALTPSAISQRIKALEDRLGQVLVMRTAPCRPTPAGERLLRRLKPMQVLEAEAV
ADLLPGDRIAGHPRTLAIAVNDDSLQTWFLQALSSLHRAHGFLFDVQMDDQDHTLELLRAGSVLGAVTSERAPLQGCNVQ
ALGVMRYHAIASAAFVAAHFQDGFTADALGKAPMLVFNRKDTLQARFVRRITRARLTPPTHYLPTSTGFVEAAARELGWC
LAPEAMVLPAVRNRQVVIIDPTRWLDVPLYWQYTAVRSNALQQLSQALRKAAATSLRGSR

Sequences:

>Translated_300_residues
MDLLHPQLAAFAAVLNEGSFDAAAQRLALTPSAISQRIKALEDRLGQVLVMRTAPCRPTPAGERLLRRLKPMQVLEAEAV
ADLLPGDRIAGHPRTLAIAVNDDSLQTWFLQALSSLHRAHGFLFDVQMDDQDHTLELLRAGSVLGAVTSERAPLQGCNVQ
ALGVMRYHAIASAAFVAAHFQDGFTADALGKAPMLVFNRKDTLQARFVRRITRARLTPPTHYLPTSTGFVEAAARELGWC
LAPEAMVLPAVRNRQVVIIDPTRWLDVPLYWQYTAVRSNALQQLSQALRKAAATSLRGSR
>Mature_300_residues
MDLLHPQLAAFAAVLNEGSFDAAAQRLALTPSAISQRIKALEDRLGQVLVMRTAPCRPTPAGERLLRRLKPMQVLEAEAV
ADLLPGDRIAGHPRTLAIAVNDDSLQTWFLQALSSLHRAHGFLFDVQMDDQDHTLELLRAGSVLGAVTSERAPLQGCNVQ
ALGVMRYHAIASAAFVAAHFQDGFTADALGKAPMLVFNRKDTLQARFVRRITRARLTPPTHYLPTSTGFVEAAARELGWC
LAPEAMVLPAVRNRQVVIIDPTRWLDVPLYWQYTAVRSNALQQLSQALRKAAATSLRGSR

Specific function: Specific Inhibitor Of Chromosomal Initiation Of Replication In VItro. Binds The Three 13-Mers In The Origin (Oric) To Block Initiation Of Replication. [C]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789283, Length=293, Percent_Identity=34.1296928327645, Blast_Score=160, Evalue=9e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR017685
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32909; Mature: 32909

Theoretical pI: Translated: 10.14; Mature: 10.14

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLLHPQLAAFAAVLNEGSFDAAAQRLALTPSAISQRIKALEDRLGQVLVMRTAPCRPTP
CCCCHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCEEEEECCCCCCCC
AGERLLRRLKPMQVLEAEAVADLLPGDRIAGHPRTLAIAVNDDSLQTWFLQALSSLHRAH
HHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHC
GFLFDVQMDDQDHTLELLRAGSVLGAVTSERAPLQGCNVQALGVMRYHAIASAAFVAAHF
CEEEEEEECCCHHHHHHHHHCHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHH
QDGFTADALGKAPMLVFNRKDTLQARFVRRITRARLTPPTHYLPTSTGFVEAAARELGWC
CCCCCHHHCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCC
LAPEAMVLPAVRNRQVVIIDPTRWLDVPLYWQYTAVRSNALQQLSQALRKAAATSLRGSR
CCCCHHCCCCCCCCEEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MDLLHPQLAAFAAVLNEGSFDAAAQRLALTPSAISQRIKALEDRLGQVLVMRTAPCRPTP
CCCCHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCEEEEECCCCCCCC
AGERLLRRLKPMQVLEAEAVADLLPGDRIAGHPRTLAIAVNDDSLQTWFLQALSSLHRAH
HHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHC
GFLFDVQMDDQDHTLELLRAGSVLGAVTSERAPLQGCNVQALGVMRYHAIASAAFVAAHF
CEEEEEEECCCHHHHHHHHHCHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHH
QDGFTADALGKAPMLVFNRKDTLQARFVRRITRARLTPPTHYLPTSTGFVEAAARELGWC
CCCCCHHHCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCC
LAPEAMVLPAVRNRQVVIIDPTRWLDVPLYWQYTAVRSNALQQLSQALRKAAATSLRGSR
CCCCHHCCCCCCCCEEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]