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The map label for this gene is relA [H]

Identifier: 21243840

GI number: 21243840

Start: 3659326

End: 3661509

Strand: Reverse

Name: relA [H]

Synonym: XAC3113

Alternate gene names: 21243840

Gene position: 3661509-3659326 (Counterclockwise)

Preceding gene: 77748698

Following gene: 21243839

Centisome position: 70.75

GC content: 67.49

Gene sequence:

>2184_bases
TTGCCCGCCGCCGTGTCCACCGTTGTGACCAGTTCCTCATTTGATCGTCTGCAGGCGTTGCTGCAGCGTCCCGCCGTGGC
CTCGATCGCGCCCGCAGTGCGCGATGCGCTGGCGCAGGCCTGGCAGGACCTGTCGCCCGCGCAGACCGATAACGTGCCGT
GGGCATTGCTTGGCGACACCCTGGATGCATTGGCACTGCTGGCTGCCGATGAAGCCACCCTGATTGCGGCGTTGCTGTTC
GATTTGCCTGCCTTGCGTGGCGCGATCGCGGGCCTGCCGTGGCAACCGGCGGAGCGGCGGGTGGCGGTGGAAGGTCTGCT
AGACGGCCTGGACGCAGCCGATCAGGTCTGGGCGCTGCATGCCGGACGCGAGGCCGGGCGCAACAGCGAAGGGTTGCGAC
GTCTGCTGCTTTCCATCATCCACGACTTGCGCGTGGTGCCGATCCTGCTGGCACGGCAGCTGGCGCGCATGCGCGTGGCC
GATCGCCTGAGCGAAGATGAGCGCCGCGCGCTGGCCCAGCTCACGCGCGACATCCACGCGCCGCTGGCCAACCGGCTGGG
CATCTGGCAGGTGAAGTGGGAGCTGGAGGACCTGGCATTCCGGCATCTGGAGCCGGAGACCTATCGTCGCATCGCCCGTG
AAGTGGACGAAACCCGCGTGGCGCGCGAGCGCTACCTGGAAGCGGTCAAGCGCACCTTGTCGGCAGCGCTTGCCCAGCAG
GGCCTGCGCGCGGAGGTGAGCGGGCGGCCGAAGCACATCTACAGCATCTGGCGGAAGATGCAGAAAAAGCGTCTGTCGTT
CGATCAGCTGTATGACATCCGTGCGGTGCGGGTCATGGTCGATGACGTGGCCGCCTGCTACGCCGCGTTGGGTGCGGTGC
ATTCGCTGTGGGCGCCGGTGCCGAGCGAGTTCGACGATTACATCGCCCGGCCCAAGGCCAACGACTACCGTTCGTTGCAT
ACCGCGGTGGTCGGCCCGGAAGGGCGCACGATCGAAATCCAGATCCGTACCTTCGAAATGCACGCTCAGGCCGAACTCGG
CGTGGCCGCGCACTGGAAATACAAGGAAGGCGGCAAGGGCGGCGAAAAGGCCTTCGACCGCAAGATTCTGTGGATGCGCC
AGCTGCTGGAGCAGGTGCAGGAGGGCGAGCATGGCGAGCTGGCCGGCGCGCTGGATGCCGAGCTGATCGAAGACCGCGTG
TACGCGCTGACCCCCAAGGGCGAGGTGATCGATCTGCCGCAAGGTGCCACGCCGCTGGATTTTGCATATCACGTGCACAC
CATGGTCGGGCATCGCTGCCGTGGCGCGCGCGTCAACGACCGTATCGTGCCGCTGACCTACCGGCTGCGCAGCGGCGACC
GCGTGGAGATCATGACCGCCAAGGAAGCGGACCCGCGCCGCGATTGGCTGCTGGCCTCCAACGGCTTTCTGGCCAGCGGG
CGCTCGCGCGACAAGGTGCGCGCCTGGTTCCATAAGCTGGACCGCGCGCGCAACGTGCAGGCGGGCAAGGACTTGCTTGA
TCGCGAGCTCAAGCGCCTGGGCCTGCAGCATGCGGATCTGAGCGTGGCCGCGCGCAAATTCCACGCCGAAAACATCGACG
AGCTGTATATCCAGGTCGCCCTGGGCGATACCGGCCCGAACCAAGTCAGCCGTGCATTGCTGGAGGCCGAGCGCGCCGCG
TCCCAGCCGGCAGTACCGGCACCCCCGCGGCCGACCGCGCGGCGCGATGGGTTGGGGAAATCCAAATTCACCGTCGAGGG
AGTGGGAAATTTGCTGGTGCAGTTGGCGCGTTGCTGCCAGCCGGTGGCCGGCGAGCCGATTGCCGGCTACCTCACTCGCG
GCCGTGGCATCACCGTGCACCGCACCGACTGCGCGGCACTGGCGCGCCTGGCGGCCGCCCACCCGCAGCGCGTGTTGCCG
GTGGAGTGGGGCAAGGCCGGCAGCGGCTACGAGGTGGATGTGCAGGTGCGCGCGGTGGACCGCCGCTGGCTGCTCAAGGA
CATCACCAACCTGATCGCCCAGGAAGACGCGCACGTGCTGGAAATCAACAGCGACAACGTTCGCGATACCGGCAGGGCGC
AACTGCGGCTGCGCTTGAAGGTCAGCGATTACGGCCAGCTGTCCGGCCTGCTTGGCAAGCTGGATGCGCTGCCCGGGGTG
AGCGAGGTGCGGCGGCTGGGCTGA

Upstream 100 bases:

>100_bases
TGGCATAAGCGAGAGCGGCGTCTCGCATGGCGAGCGCCCCGGCAAAACGCGTTGTGGAGAAGGTGACGCGCACGTTACCG
TAGTCGTCAGCCCCCTGCTG

Downstream 100 bases:

>100_bases
GGACGCCGCTTACCTGGAAGGTGCGCCCCGGTGTGAAACACACAGCCCATGAGGGGCGAGAGCTGTGCTTGCCTGACGAT
TCCCGATTCCCGATTCCCGA

Product: ATP:GTP 3'-pyrophosphotranferase

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 727; Mature: 726

Protein sequence:

>727_residues
MPAAVSTVVTSSSFDRLQALLQRPAVASIAPAVRDALAQAWQDLSPAQTDNVPWALLGDTLDALALLAADEATLIAALLF
DLPALRGAIAGLPWQPAERRVAVEGLLDGLDAADQVWALHAGREAGRNSEGLRRLLLSIIHDLRVVPILLARQLARMRVA
DRLSEDERRALAQLTRDIHAPLANRLGIWQVKWELEDLAFRHLEPETYRRIAREVDETRVARERYLEAVKRTLSAALAQQ
GLRAEVSGRPKHIYSIWRKMQKKRLSFDQLYDIRAVRVMVDDVAACYAALGAVHSLWAPVPSEFDDYIARPKANDYRSLH
TAVVGPEGRTIEIQIRTFEMHAQAELGVAAHWKYKEGGKGGEKAFDRKILWMRQLLEQVQEGEHGELAGALDAELIEDRV
YALTPKGEVIDLPQGATPLDFAYHVHTMVGHRCRGARVNDRIVPLTYRLRSGDRVEIMTAKEADPRRDWLLASNGFLASG
RSRDKVRAWFHKLDRARNVQAGKDLLDRELKRLGLQHADLSVAARKFHAENIDELYIQVALGDTGPNQVSRALLEAERAA
SQPAVPAPPRPTARRDGLGKSKFTVEGVGNLLVQLARCCQPVAGEPIAGYLTRGRGITVHRTDCAALARLAAAHPQRVLP
VEWGKAGSGYEVDVQVRAVDRRWLLKDITNLIAQEDAHVLEINSDNVRDTGRAQLRLRLKVSDYGQLSGLLGKLDALPGV
SEVRRLG

Sequences:

>Translated_727_residues
MPAAVSTVVTSSSFDRLQALLQRPAVASIAPAVRDALAQAWQDLSPAQTDNVPWALLGDTLDALALLAADEATLIAALLF
DLPALRGAIAGLPWQPAERRVAVEGLLDGLDAADQVWALHAGREAGRNSEGLRRLLLSIIHDLRVVPILLARQLARMRVA
DRLSEDERRALAQLTRDIHAPLANRLGIWQVKWELEDLAFRHLEPETYRRIAREVDETRVARERYLEAVKRTLSAALAQQ
GLRAEVSGRPKHIYSIWRKMQKKRLSFDQLYDIRAVRVMVDDVAACYAALGAVHSLWAPVPSEFDDYIARPKANDYRSLH
TAVVGPEGRTIEIQIRTFEMHAQAELGVAAHWKYKEGGKGGEKAFDRKILWMRQLLEQVQEGEHGELAGALDAELIEDRV
YALTPKGEVIDLPQGATPLDFAYHVHTMVGHRCRGARVNDRIVPLTYRLRSGDRVEIMTAKEADPRRDWLLASNGFLASG
RSRDKVRAWFHKLDRARNVQAGKDLLDRELKRLGLQHADLSVAARKFHAENIDELYIQVALGDTGPNQVSRALLEAERAA
SQPAVPAPPRPTARRDGLGKSKFTVEGVGNLLVQLARCCQPVAGEPIAGYLTRGRGITVHRTDCAALARLAAAHPQRVLP
VEWGKAGSGYEVDVQVRAVDRRWLLKDITNLIAQEDAHVLEINSDNVRDTGRAQLRLRLKVSDYGQLSGLLGKLDALPGV
SEVRRLG
>Mature_726_residues
PAAVSTVVTSSSFDRLQALLQRPAVASIAPAVRDALAQAWQDLSPAQTDNVPWALLGDTLDALALLAADEATLIAALLFD
LPALRGAIAGLPWQPAERRVAVEGLLDGLDAADQVWALHAGREAGRNSEGLRRLLLSIIHDLRVVPILLARQLARMRVAD
RLSEDERRALAQLTRDIHAPLANRLGIWQVKWELEDLAFRHLEPETYRRIAREVDETRVARERYLEAVKRTLSAALAQQG
LRAEVSGRPKHIYSIWRKMQKKRLSFDQLYDIRAVRVMVDDVAACYAALGAVHSLWAPVPSEFDDYIARPKANDYRSLHT
AVVGPEGRTIEIQIRTFEMHAQAELGVAAHWKYKEGGKGGEKAFDRKILWMRQLLEQVQEGEHGELAGALDAELIEDRVY
ALTPKGEVIDLPQGATPLDFAYHVHTMVGHRCRGARVNDRIVPLTYRLRSGDRVEIMTAKEADPRRDWLLASNGFLASGR
SRDKVRAWFHKLDRARNVQAGKDLLDRELKRLGLQHADLSVAARKFHAENIDELYIQVALGDTGPNQVSRALLEAERAAS
QPAVPAPPRPTARRDGLGKSKFTVEGVGNLLVQLARCCQPVAGEPIAGYLTRGRGITVHRTDCAALARLAAAHPQRVLPV
EWGKAGSGYEVDVQVRAVDRRWLLKDITNLIAQEDAHVLEINSDNVRDTGRAQLRLRLKVSDYGQLSGLLGKLDALPGVS
EVRRLG

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1789147, Length=714, Percent_Identity=42.9971988795518, Blast_Score=555, Evalue=1e-159,
Organism=Escherichia coli, GI1790082, Length=672, Percent_Identity=34.375, Blast_Score=380, Evalue=1e-106,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 80625; Mature: 80494

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAAVSTVVTSSSFDRLQALLQRPAVASIAPAVRDALAQAWQDLSPAQTDNVPWALLGDT
CCCHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEHHHH
LDALALLAADEATLIAALLFDLPALRGAIAGLPWQPAERRVAVEGLLDGLDAADQVWALH
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHH
AGREAGRNSEGLRRLLLSIIHDLRVVPILLARQLARMRVADRLSEDERRALAQLTRDIHA
CCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
PLANRLGIWQVKWELEDLAFRHLEPETYRRIAREVDETRVARERYLEAVKRTLSAALAQQ
HHHHCCCEEEEEEEHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GLRAEVSGRPKHIYSIWRKMQKKRLSFDQLYDIRAVRVMVDDVAACYAALGAVHSLWAPV
CCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PSEFDDYIARPKANDYRSLHTAVVGPEGRTIEIQIRTFEMHAQAELGVAAHWKYKEGGKG
CCCHHHHHCCCCCCCHHHHHHEEECCCCCEEEEEEEEEEEEHHHCCCEEEEECCCCCCCC
GEKAFDRKILWMRQLLEQVQEGEHGELAGALDAELIEDRVYALTPKGEVIDLPQGATPLD
CHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEECCCCCEEECCCCCCCHH
FAYHVHTMVGHRCRGARVNDRIVPLTYRLRSGDRVEIMTAKEADPRRDWLLASNGFLASG
HHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCCCEEEECCCCEECC
RSRDKVRAWFHKLDRARNVQAGKDLLDRELKRLGLQHADLSVAARKFHAENIDELYIQVA
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEEEE
LGDTGPNQVSRALLEAERAASQPAVPAPPRPTARRDGLGKSKFTVEGVGNLLVQLARCCQ
ECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHCCCCCCCEEHHHHHHHHHHHHHHCC
PVAGEPIAGYLTRGRGITVHRTDCAALARLAAAHPQRVLPVEWGKAGSGYEVDVQVRAVD
CCCCCCHHHHHCCCCCEEEECCHHHHHHHHHHCCCCCCCEECCCCCCCCEEEEEEEEEHH
RRWLLKDITNLIAQEDAHVLEINSDNVRDTGRAQLRLRLKVSDYGQLSGLLGKLDALPGV
HHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCH
SEVRRLG
HHHHHCC
>Mature Secondary Structure 
PAAVSTVVTSSSFDRLQALLQRPAVASIAPAVRDALAQAWQDLSPAQTDNVPWALLGDT
CCHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEHHHH
LDALALLAADEATLIAALLFDLPALRGAIAGLPWQPAERRVAVEGLLDGLDAADQVWALH
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHH
AGREAGRNSEGLRRLLLSIIHDLRVVPILLARQLARMRVADRLSEDERRALAQLTRDIHA
CCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
PLANRLGIWQVKWELEDLAFRHLEPETYRRIAREVDETRVARERYLEAVKRTLSAALAQQ
HHHHCCCEEEEEEEHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GLRAEVSGRPKHIYSIWRKMQKKRLSFDQLYDIRAVRVMVDDVAACYAALGAVHSLWAPV
CCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PSEFDDYIARPKANDYRSLHTAVVGPEGRTIEIQIRTFEMHAQAELGVAAHWKYKEGGKG
CCCHHHHHCCCCCCCHHHHHHEEECCCCCEEEEEEEEEEEEHHHCCCEEEEECCCCCCCC
GEKAFDRKILWMRQLLEQVQEGEHGELAGALDAELIEDRVYALTPKGEVIDLPQGATPLD
CHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEECCCCCEEECCCCCCCHH
FAYHVHTMVGHRCRGARVNDRIVPLTYRLRSGDRVEIMTAKEADPRRDWLLASNGFLASG
HHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCCCEEEECCCCEECC
RSRDKVRAWFHKLDRARNVQAGKDLLDRELKRLGLQHADLSVAARKFHAENIDELYIQVA
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEEEE
LGDTGPNQVSRALLEAERAASQPAVPAPPRPTARRDGLGKSKFTVEGVGNLLVQLARCCQ
ECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHCCCCCCCEEHHHHHHHHHHHHHHCC
PVAGEPIAGYLTRGRGITVHRTDCAALARLAAAHPQRVLPVEWGKAGSGYEVDVQVRAVD
CCCCCCHHHHHCCCCCEEEECCHHHHHHHHHHCCCCCCCEECCCCCCCCEEEEEEEEEHH
RRWLLKDITNLIAQEDAHVLEINSDNVRDTGRAQLRLRLKVSDYGQLSGLLGKLDALPGV
HHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCH
SEVRRLG
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7928955 [H]