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The map label for this gene is yhfM [H]

Identifier: 21243806

GI number: 21243806

Start: 3612182

End: 3613549

Strand: Direct

Name: yhfM [H]

Synonym: XAC3079

Alternate gene names: 21243806

Gene position: 3612182-3613549 (Clockwise)

Preceding gene: 21243805

Following gene: 21243807

Centisome position: 69.79

GC content: 65.94

Gene sequence:

>1368_bases
ATGCTGAGTCCCTCGGTGGTGCCGCCATCGTCCACAGCTGCAGGCGCCCCGCCGCGCACGCTGGGTTTCTGGAGCGCGCT
GTCGGCCAATCTGCTCAACATGATCGGCATCGGCCCGTTCATCACCATTCCGCTGGCGTTGTCGGCGTTGGCTGGCCCAT
CGGTGTTGATCGGCTGGGTGGCCGGTGCGCTGCTGTGCCTGTGCGATGGGCTGGTGTGGGCCGAACTCGGCGCTGCGATT
CCGCGCTCGGGCGGACCGTACCACTATCTGCGCGAGGCATACGGGCGCGAACGCTGGGGGCGCCTGTTCGGGTTTTTGTA
TCTGTGGCAAACGCTGCTGACCGCACCGCTGTCGGTGGGCTCGGCGGCGGTGGGCTGCGTGCAATATCTGGCGTTCCTGC
TGCCCGGCCTGGGCCATGCCCGGCTCACCGCCATGGCGATGGCGCTGTGCGCCTTCAACACACTGCTGCTGTATCGCAAG
GTGCGTTCGGTGCAAGTGCTGTCGTTGCTGGTGAGCGCAGCGGTGATCGGTGCCTGCGTGTGGATCATTTGCAGCGGCGT
GCTGCATTTCGATCTGGGCATCGCCGAGGATTTTCTGCATGCGCGCCCGGCTTCGCCGCACGGCTTCTGGCTGGGCTTGG
GCGCAGTGGCATTGATCGCGGTGTACGACTACGGCGGCTACAACAACGTGTGCATGCTCGGTGGCGAAATCCGCAAGCCA
CGCCGCACCATTCCGCGGGCGGTGCTGGTCTCGATCCCGATCGTGGCGCTGCTCTATCTGGGCCTCAACGTCACCTTGCT
CGGCGTGCTGCCTTGGCAGCAGGCGGCGCAATCCAAGGCGGTGATGGCCGACTTCATGCAGGCCATCTACGGGCCGGCGG
GCAGCACCGTGGCAGTGGCGTTGATCGTGCTGGCCAGCTGGGGCTCGGCACTGGTGGTGTTGCTGGGATATTCGCGGGTG
CCATATGCCGCCGCCGCGGCCGGGCAATTCTTCGGCGTGTTTGCGCGGCTGCATCCACGTGGCGGCTTTCCCACCGTATC
GCTGCTGTTCGTCGGCGCAACGTCCGTGCTGGCCTGCCTGCTGTCGCTGGACGATCTGATCGCCACCTTGATGATCATCC
AGATCCTGTTCCAGTTTCTGGCGCAGTGCCTGGCCGTGGTGCTGTTGCGACGCAAGCGGCGGCGCCGTGCATTTTCGATG
CCGCTGTATCCGTGGCCGCTGCTGATCAGCGTGGCCGGTTGGCTGTATCTGCTGGCCGCCAGCCCCGGCCATCGCGTATT
GGCGGCAGTGCTGGCGCTGTGCGTGGGCAGTGCGCTGTATCTGATCCAGGCACGGAGGGAGCGCGCATGGCCGTTCCAGC
TGCAATGA

Upstream 100 bases:

>100_bases
TGCATCAAATGGAAGCCACCGCGATCCACTGCGCCGACAGCCTGCGCGCTGCCCATGACGCAGCCACCACAGCACGCAGC
ACGCATGCGGCGTACAGCGC

Downstream 100 bases:

>100_bases
GCGCCGCACAGATCATGGTGGTCGGCGAGGTGTATCTCGACCACATCTTCAGCGGTTTCGAGCGCTGGCCGGCACCCGGC
GAAGAAGCGCTTGCGCGTCA

Product: cationic amino acid transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MLSPSVVPPSSTAAGAPPRTLGFWSALSANLLNMIGIGPFITIPLALSALAGPSVLIGWVAGALLCLCDGLVWAELGAAI
PRSGGPYHYLREAYGRERWGRLFGFLYLWQTLLTAPLSVGSAAVGCVQYLAFLLPGLGHARLTAMAMALCAFNTLLLYRK
VRSVQVLSLLVSAAVIGACVWIICSGVLHFDLGIAEDFLHARPASPHGFWLGLGAVALIAVYDYGGYNNVCMLGGEIRKP
RRTIPRAVLVSIPIVALLYLGLNVTLLGVLPWQQAAQSKAVMADFMQAIYGPAGSTVAVALIVLASWGSALVVLLGYSRV
PYAAAAAGQFFGVFARLHPRGGFPTVSLLFVGATSVLACLLSLDDLIATLMIIQILFQFLAQCLAVVLLRRKRRRRAFSM
PLYPWPLLISVAGWLYLLAASPGHRVLAAVLALCVGSALYLIQARRERAWPFQLQ

Sequences:

>Translated_455_residues
MLSPSVVPPSSTAAGAPPRTLGFWSALSANLLNMIGIGPFITIPLALSALAGPSVLIGWVAGALLCLCDGLVWAELGAAI
PRSGGPYHYLREAYGRERWGRLFGFLYLWQTLLTAPLSVGSAAVGCVQYLAFLLPGLGHARLTAMAMALCAFNTLLLYRK
VRSVQVLSLLVSAAVIGACVWIICSGVLHFDLGIAEDFLHARPASPHGFWLGLGAVALIAVYDYGGYNNVCMLGGEIRKP
RRTIPRAVLVSIPIVALLYLGLNVTLLGVLPWQQAAQSKAVMADFMQAIYGPAGSTVAVALIVLASWGSALVVLLGYSRV
PYAAAAAGQFFGVFARLHPRGGFPTVSLLFVGATSVLACLLSLDDLIATLMIIQILFQFLAQCLAVVLLRRKRRRRAFSM
PLYPWPLLISVAGWLYLLAASPGHRVLAAVLALCVGSALYLIQARRERAWPFQLQ
>Mature_455_residues
MLSPSVVPPSSTAAGAPPRTLGFWSALSANLLNMIGIGPFITIPLALSALAGPSVLIGWVAGALLCLCDGLVWAELGAAI
PRSGGPYHYLREAYGRERWGRLFGFLYLWQTLLTAPLSVGSAAVGCVQYLAFLLPGLGHARLTAMAMALCAFNTLLLYRK
VRSVQVLSLLVSAAVIGACVWIICSGVLHFDLGIAEDFLHARPASPHGFWLGLGAVALIAVYDYGGYNNVCMLGGEIRKP
RRTIPRAVLVSIPIVALLYLGLNVTLLGVLPWQQAAQSKAVMADFMQAIYGPAGSTVAVALIVLASWGSALVVLLGYSRV
PYAAAAAGQFFGVFARLHPRGGFPTVSLLFVGATSVLACLLSLDDLIATLMIIQILFQFLAQCLAVVLLRRKRRRRAFSM
PLYPWPLLISVAGWLYLLAASPGHRVLAAVLALCVGSALYLIQARRERAWPFQLQ

Specific function: Exhibits an obligate exchange activity for serine, threonine and aromatic amino acids [H]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family [H]

Homologues:

Organism=Homo sapiens, GI187423910, Length=450, Percent_Identity=25.7777777777778, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI7657591, Length=450, Percent_Identity=25.7777777777778, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI71999149, Length=391, Percent_Identity=26.5984654731458, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI186910308, Length=388, Percent_Identity=26.5463917525773, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI186910306, Length=388, Percent_Identity=26.5463917525773, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI186910304, Length=388, Percent_Identity=26.5463917525773, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI9790235, Length=332, Percent_Identity=28.0120481927711, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI115648063, Length=417, Percent_Identity=25.6594724220624, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI115648022, Length=417, Percent_Identity=25.6594724220624, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI33286428, Length=405, Percent_Identity=26.4197530864197, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI71979932, Length=406, Percent_Identity=27.3399014778325, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI7657683, Length=361, Percent_Identity=24.3767313019391, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI114326544, Length=403, Percent_Identity=25.0620347394541, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI114326550, Length=403, Percent_Identity=25.0620347394541, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI258614005, Length=409, Percent_Identity=23.2273838630807, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI258614003, Length=400, Percent_Identity=23.5, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI110347453, Length=378, Percent_Identity=25.9259259259259, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI87082250, Length=449, Percent_Identity=26.9487750556793, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1786789, Length=417, Percent_Identity=25.6594724220624, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI32566699, Length=314, Percent_Identity=28.9808917197452, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71982612, Length=458, Percent_Identity=25.3275109170306, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71982608, Length=458, Percent_Identity=25.3275109170306, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71993915, Length=434, Percent_Identity=24.8847926267281, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71995382, Length=440, Percent_Identity=25, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71995388, Length=437, Percent_Identity=24.7139588100687, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17540018, Length=402, Percent_Identity=25.1243781094527, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17532491, Length=386, Percent_Identity=24.3523316062176, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17568033, Length=345, Percent_Identity=24.6376811594203, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193208714, Length=346, Percent_Identity=26.0115606936416, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI32566695, Length=346, Percent_Identity=26.0115606936416, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71982623, Length=285, Percent_Identity=25.6140350877193, Blast_Score=65, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6321492, Length=318, Percent_Identity=22.6415094339623, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21357367, Length=367, Percent_Identity=27.5204359673025, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24641995, Length=408, Percent_Identity=26.4705882352941, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24641993, Length=408, Percent_Identity=26.4705882352941, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI45550968, Length=352, Percent_Identity=27.2727272727273, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI19921172, Length=352, Percent_Identity=27.2727272727273, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24651635, Length=322, Percent_Identity=25.4658385093168, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24651633, Length=322, Percent_Identity=25.4658385093168, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI221331183, Length=339, Percent_Identity=27.4336283185841, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17647653, Length=339, Percent_Identity=27.4336283185841, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24664379, Length=339, Percent_Identity=27.4336283185841, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24667468, Length=387, Percent_Identity=23.5142118863049, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI221512776, Length=394, Percent_Identity=22.8426395939086, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24666159, Length=394, Percent_Identity=22.8426395939086, Blast_Score=73, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 48607; Mature: 48607

Theoretical pI: Translated: 9.97; Mature: 9.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSPSVVPPSSTAAGAPPRTLGFWSALSANLLNMIGIGPFITIPLALSALAGPSVLIGWV
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHH
AGALLCLCDGLVWAELGAAIPRSGGPYHYLREAYGRERWGRLFGFLYLWQTLLTAPLSVG
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCC
SAAVGCVQYLAFLLPGLGHARLTAMAMALCAFNTLLLYRKVRSVQVLSLLVSAAVIGACV
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WIICSGVLHFDLGIAEDFLHARPASPHGFWLGLGAVALIAVYDYGGYNNVCMLGGEIRKP
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCH
RRTIPRAVLVSIPIVALLYLGLNVTLLGVLPWQQAAQSKAVMADFMQAIYGPAGSTVAVA
HHHHHHHHHHHHHHHHHHHHCCCHHEEEECCHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LIVLASWGSALVVLLGYSRVPYAAAAAGQFFGVFARLHPRGGFPTVSLLFVGATSVLACL
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
LSLDDLIATLMIIQILFQFLAQCLAVVLLRRKRRRRAFSMPLYPWPLLISVAGWLYLLAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHC
SPGHRVLAAVLALCVGSALYLIQARRERAWPFQLQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MLSPSVVPPSSTAAGAPPRTLGFWSALSANLLNMIGIGPFITIPLALSALAGPSVLIGWV
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHH
AGALLCLCDGLVWAELGAAIPRSGGPYHYLREAYGRERWGRLFGFLYLWQTLLTAPLSVG
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCC
SAAVGCVQYLAFLLPGLGHARLTAMAMALCAFNTLLLYRKVRSVQVLSLLVSAAVIGACV
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WIICSGVLHFDLGIAEDFLHARPASPHGFWLGLGAVALIAVYDYGGYNNVCMLGGEIRKP
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCH
RRTIPRAVLVSIPIVALLYLGLNVTLLGVLPWQQAAQSKAVMADFMQAIYGPAGSTVAVA
HHHHHHHHHHHHHHHHHHHHCCCHHEEEECCHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LIVLASWGSALVVLLGYSRVPYAAAAAGQFFGVFARLHPRGGFPTVSLLFVGATSVLACL
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
LSLDDLIATLMIIQILFQFLAQCLAVVLLRRKRRRRAFSMPLYPWPLLISVAGWLYLLAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHC
SPGHRVLAAVLALCVGSALYLIQARRERAWPFQLQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]