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The map label for this gene is gcvT

Identifier: 21243788

GI number: 21243788

Start: 3583364

End: 3584473

Strand: Reverse

Name: gcvT

Synonym: XAC3061

Alternate gene names: 21243788

Gene position: 3584473-3583364 (Counterclockwise)

Preceding gene: 21243789

Following gene: 21243787

Centisome position: 69.26

GC content: 65.32

Gene sequence:

>1110_bases
ATGACCCAGAAGACCATCCTCAACGACACCCATCGTGCGCTTGGCGCCAAGATGGTCGACTTCGGCGGCTGGGACATGCC
GATCCACTACGGCTCGCAACTGGACGAGCACCACCAGGTGCGTCGCGACGCCGGCATGTTCGACGTCAGCCACATGACGG
TGGTCGACCTGCACGGCGCGCGGGTGCGCGAGTTTCTGCGCTACCTGCTCGCCAACTCGGTGGACAAGCTCAAGGTCTCC
GGCAAGGCGCTGTACACCTGCATGCTCAATCCGCAGGGTGGGGTGATCGACGACCTCATCGTCTATTACATGACAGAAGA
CTTCTTCCGTCTGGTGGTCAACGCCGCCACCCGCGAAAAGGACCTGCAGTGGATCGGCGAGCAGGCCGCGCGCTTCGACG
TGCGCGTCGAAGAGCGCAGCGACTTCGCCATGATTGCCGTGCAAGGTCCCAGCGCGCGTACCAAGGTCATCGACCTGCTC
GACCCTGCCGACACTGCAGCGGCGAGCAAGCTCGGCCGGTTCGCCGCGCTGCAGACGCGTTCGCGCGATGGCATCGAGTT
GTTCCTTGCGCGCACCGGCTACACCGGCGAAGACGGTTTCGAAATCGTGTTGCCGCAGCAGGCCGCCGTCGCATTCTGGA
ATGCGTTGCTCGCGCAGGGCGTCAAACCGGCCGGCCTGGGCGCACGCGACACCCTGCGTCTGGAAGCGGGCATGAATCTT
TACGGGCAGGACATGGACGATGGCGTCACCCCTTACGAGGCAGGGCTGGCCTGGACGATCGCCCTGGACGAAGGACGCGA
CTTCATCGGTCGCAGCGTGCTCGAATCGCAAAAGGCGCAGGGCGCACCGCGTCAGCTGATCGGTGTGGTGATGGACGAGA
AGGGCGTGTTACGGCATGGCCAGACCGTGCTCACCGCCAACGGCGAAGGCGAGATCCTGTCCGGCACGTTCTCGCCGACG
CTGGGCAAGGCGATCGCCTTCGCGCGCGTGCCGGCCGGCAGCATCGAGCAGCTGCGCGTGGACATCCGCGGCAAACAGGT
GCCGTTGAGAGCGGTGAAGTTTCCGTTCGTGCGCGATGGCCAGGCACAGCCCGGCGTGCTCGGCGACTGA

Upstream 100 bases:

>100_bases
TTACTGCCCGCAGGCAGCGCAACCACACAGCGGCGTGTCTGCCGTTCCCCCAAGCGTGACAGGATGGCGATAATGGCCGT
CTTTCCTCGGAACGGCGCAC

Downstream 100 bases:

>100_bases
ATCGTGTAGCGCCATGTATGCCGCGCGCGGCGCTGCGCCCGCGTCCGGATCGCCATCGCCACACCGCCGTGCGTGCACCT
GTCTTGTCGCGCGGTCTAAA

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein

Number of amino acids: Translated: 369; Mature: 368

Protein sequence:

>369_residues
MTQKTILNDTHRALGAKMVDFGGWDMPIHYGSQLDEHHQVRRDAGMFDVSHMTVVDLHGARVREFLRYLLANSVDKLKVS
GKALYTCMLNPQGGVIDDLIVYYMTEDFFRLVVNAATREKDLQWIGEQAARFDVRVEERSDFAMIAVQGPSARTKVIDLL
DPADTAAASKLGRFAALQTRSRDGIELFLARTGYTGEDGFEIVLPQQAAVAFWNALLAQGVKPAGLGARDTLRLEAGMNL
YGQDMDDGVTPYEAGLAWTIALDEGRDFIGRSVLESQKAQGAPRQLIGVVMDEKGVLRHGQTVLTANGEGEILSGTFSPT
LGKAIAFARVPAGSIEQLRVDIRGKQVPLRAVKFPFVRDGQAQPGVLGD

Sequences:

>Translated_369_residues
MTQKTILNDTHRALGAKMVDFGGWDMPIHYGSQLDEHHQVRRDAGMFDVSHMTVVDLHGARVREFLRYLLANSVDKLKVS
GKALYTCMLNPQGGVIDDLIVYYMTEDFFRLVVNAATREKDLQWIGEQAARFDVRVEERSDFAMIAVQGPSARTKVIDLL
DPADTAAASKLGRFAALQTRSRDGIELFLARTGYTGEDGFEIVLPQQAAVAFWNALLAQGVKPAGLGARDTLRLEAGMNL
YGQDMDDGVTPYEAGLAWTIALDEGRDFIGRSVLESQKAQGAPRQLIGVVMDEKGVLRHGQTVLTANGEGEILSGTFSPT
LGKAIAFARVPAGSIEQLRVDIRGKQVPLRAVKFPFVRDGQAQPGVLGD
>Mature_368_residues
TQKTILNDTHRALGAKMVDFGGWDMPIHYGSQLDEHHQVRRDAGMFDVSHMTVVDLHGARVREFLRYLLANSVDKLKVSG
KALYTCMLNPQGGVIDDLIVYYMTEDFFRLVVNAATREKDLQWIGEQAARFDVRVEERSDFAMIAVQGPSARTKVIDLLD
PADTAAASKLGRFAALQTRSRDGIELFLARTGYTGEDGFEIVLPQQAAVAFWNALLAQGVKPAGLGARDTLRLEAGMNLY
GQDMDDGVTPYEAGLAWTIALDEGRDFIGRSVLESQKAQGAPRQLIGVVMDEKGVLRHGQTVLTANGEGEILSGTFSPTL
GKAIAFARVPAGSIEQLRVDIRGKQVPLRAVKFPFVRDGQAQPGVLGD

Specific function: The glycine cleavage system catalyzes the degradation of glycine

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family

Homologues:

Organism=Homo sapiens, GI44662838, Length=375, Percent_Identity=34.9333333333333, Blast_Score=174, Evalue=8e-44,
Organism=Homo sapiens, GI257796258, Length=345, Percent_Identity=35.0724637681159, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI257796254, Length=370, Percent_Identity=31.8918918918919, Blast_Score=138, Evalue=7e-33,
Organism=Homo sapiens, GI24797151, Length=337, Percent_Identity=30.2670623145401, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI257796256, Length=287, Percent_Identity=35.8885017421603, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI197927446, Length=344, Percent_Identity=28.1976744186047, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI21361378, Length=344, Percent_Identity=28.1976744186047, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI194306651, Length=316, Percent_Identity=24.0506329113924, Blast_Score=79, Evalue=9e-15,
Organism=Escherichia coli, GI1789272, Length=368, Percent_Identity=57.8804347826087, Blast_Score=412, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17560118, Length=375, Percent_Identity=36, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI71994045, Length=348, Percent_Identity=26.7241379310345, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71994052, Length=348, Percent_Identity=26.7241379310345, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI32563613, Length=338, Percent_Identity=24.2603550295858, Blast_Score=88, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6320222, Length=382, Percent_Identity=35.3403141361257, Blast_Score=193, Evalue=4e-50,
Organism=Drosophila melanogaster, GI20129441, Length=378, Percent_Identity=33.8624338624339, Blast_Score=171, Evalue=6e-43,
Organism=Drosophila melanogaster, GI28571104, Length=268, Percent_Identity=27.2388059701493, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI20130091, Length=386, Percent_Identity=25.1295336787565, Blast_Score=92, Evalue=7e-19,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GCST_XANAC (Q8PI37)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_643370.1
- ProteinModelPortal:   Q8PI37
- SMR:   Q8PI37
- GeneID:   1157132
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC3061
- NMPDR:   fig|190486.1.peg.3014
- HOGENOM:   HBG299834
- OMA:   KALYGGM
- ProtClustDB:   PRK00389
- BioCyc:   XAXO190486:XAC3061-MONOMER
- BRENDA:   2.1.2.10
- GO:   GO:0005737
- HAMAP:   MF_00259
- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903
- PIRSF:   PIRSF006487
- TIGRFAMs:   TIGR00528

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C

EC number: =2.1.2.10

Molecular weight: Translated: 40362; Mature: 40230

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQKTILNDTHRALGAKMVDFGGWDMPIHYGSQLDEHHQVRRDAGMFDVSHMTVVDLHGA
CCCCCCCCHHHHHHCCEEEECCCCCCCCCCCCCCHHHHHHHHHCCCEEECCEEEEECCCH
RVREFLRYLLANSVDKLKVSGKALYTCMLNPQGGVIDDLIVYYMTEDFFRLVVNAATREK
HHHHHHHHHHHCCCHHEEECCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DLQWIGEQAARFDVRVEERSDFAMIAVQGPSARTKVIDLLDPADTAAASKLGRFAALQTR
HHHHHHHHHHEEEEEEECCCCEEEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHCC
SRDGIELFLARTGYTGEDGFEIVLPQQAAVAFWNALLAQGVKPAGLGARDTLRLEAGMNL
CCCCEEEEEEECCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCC
YGQDMDDGVTPYEAGLAWTIALDEGRDFIGRSVLESQKAQGAPRQLIGVVMDEKGVLRHG
CCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCHHHHEEEECCCCHHHCC
QTVLTANGEGEILSGTFSPTLGKAIAFARVPAGSIEQLRVDIRGKQVPLRAVKFPFVRDG
CEEEEECCCCCEEECCCCCHHHHHHHHEECCCCCHHHEEEEECCCCCCHHEEECCCEECC
QAQPGVLGD
CCCCCCCCC
>Mature Secondary Structure 
TQKTILNDTHRALGAKMVDFGGWDMPIHYGSQLDEHHQVRRDAGMFDVSHMTVVDLHGA
CCCCCCCHHHHHHCCEEEECCCCCCCCCCCCCCHHHHHHHHHCCCEEECCEEEEECCCH
RVREFLRYLLANSVDKLKVSGKALYTCMLNPQGGVIDDLIVYYMTEDFFRLVVNAATREK
HHHHHHHHHHHCCCHHEEECCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DLQWIGEQAARFDVRVEERSDFAMIAVQGPSARTKVIDLLDPADTAAASKLGRFAALQTR
HHHHHHHHHHEEEEEEECCCCEEEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHCC
SRDGIELFLARTGYTGEDGFEIVLPQQAAVAFWNALLAQGVKPAGLGARDTLRLEAGMNL
CCCCEEEEEEECCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCC
YGQDMDDGVTPYEAGLAWTIALDEGRDFIGRSVLESQKAQGAPRQLIGVVMDEKGVLRHG
CCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCHHHHEEEECCCCHHHCC
QTVLTANGEGEILSGTFSPTLGKAIAFARVPAGSIEQLRVDIRGKQVPLRAVKFPFVRDG
CEEEEECCCCCEEECCCCCHHHHHHHHEECCCCCHHHEEEEECCCCCCHHEEECCCEECC
QAQPGVLGD
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217