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The map label for this gene is emrA [H]

Identifier: 21243754

GI number: 21243754

Start: 3535226

End: 3536659

Strand: Direct

Name: emrA [H]

Synonym: XAC3027

Alternate gene names: 21243754

Gene position: 3535226-3536659 (Clockwise)

Preceding gene: 21243752

Following gene: 21243759

Centisome position: 68.31

GC content: 65.27

Gene sequence:

>1434_bases
ATGGCGATGCTCATGTCCCAGCCCGTGCCCACCCTGCGCGCCTACGCCACCATCAAGTCGCTGCTGTGGCTGGTATCGCT
GGCGATCTTCATGCAGATGCTGGATGCGACCATCGTCAATACGGCGTTGCCGTCGATGGCGCGCAGCCTGCACGAAAGCC
CTCTGCAGATGCAGTCGGTGGTCTTCAGCTATGCGTTGGCGGTGGCGATGTTCATCCCCGCCTCGGGCTGGATTGCCGAC
CGCTTCGGCACGCGGCGCACCTTCCTGGTGGCGATCATCGTGTTCACGCTGGGCTCGCTGCTGTGCGCGGCCGCGCAACA
GCTGCCACAACTGGTGGCCGCGCGCGTGGTGCAGGGCATCGGTGGGGCGATGCTGCTGCCGGTGGGCCGGCTGGCAGTGC
TCAAGACCGTGGCGCGCGCCGACTTCCTGCGCGCGATGAGTTTCATCGCGATTCCCGCATTGATCGGCCCACTCGTCGGC
CCCACGCTGGGCGGCTGGCTGGTGGAAGTCGCCTCGTGGCATTGGGTGTTCCTGATCAACCTGCCGATTGGCGTGATCGG
TTTCATTGCTGCGCTGAAGATCATGCCCGACCACTACGGCGATGCGCGCCAGCGCTTCGATCTGATCGGCTATCTGATGC
TGGCGTTCGGCATGGTGGCGTTGTCGTTGGCGTTGGACGGCATCTCCGAACTCGGCCTGCGCCACGCCTTCGTCATGCTG
CTGGCAATCGGCGGGCTGGCCGCGTTGGCCGGCTACTGGCTGCATGCGGTCAGCACGCCGGCGGCGTTGTTTCCGCTGGC
CTTGTTCAAGGTAGCCAGCTACCGCATCGGCATTCTGTGCAACTTGTTCGCACGCGTGGGCAGCGGCTCGATGCCGTTCT
TGATTCCGTTGCTGTTGCAGGTGGGCCTGGGCATGAGCCCGATGAATGCCGGGCTGATGATGGTGCCGGTGGCGCTGGCC
GGCATGGCGGCCAAACGTGCTGCGGTGAAGCTGGTCGGTCGCTTCGGCTATCGCCGCGTATTGATGCTCAATACCGTGCT
GGTGGGCCTGGCGATGGCGAGCTTCGCGCTGGTCGATGTCGGCCAGCCGCTATGGCTGCGGCTGGTGCAGCTGGCCTGCT
TCGGCGCGGTGAACTCGCTGCAGTTCACCGTCATGAACACCGTGACCTTGCGCGACCTGGATCGTGAGCAGGCCAGCCCC
GGCAACAGCCTGCTATCGATGGTGATGATGTTGGCCACCGGGTTCGGCGCGGCGGCAGCGGGCAGTCTGCTGGCCGCCTT
CAACACGCACCTGGGCGACAGCCACGGCGCCACTGCCGCATTGCATGCGACCTTCCTGTGCGTCGGTGGCATCACCTTGT
CGTCGACGCTGATCTTCTGGCAGTTGGCCGAGACGCGGCCACATCCCAGGCAGGTGGAAGAAGTCGCCGAATGA

Upstream 100 bases:

>100_bases
GCTGCGGCGATGTGACGCTACGACGGGCTCAAGCAATGGCGTCGTATATAGTGTTGCGACGTTCTGCACGCGCGCGCAGG
GATAATGCGCTGTCTTCCCG

Downstream 100 bases:

>100_bases
CGCGGCCGCTGCGCCATCGACCAGCGCCGCGCGCCAGCGCCGCGCCGTGTGCGATTTCAACTGCGGTGCACGGCTCTAGA
TCTGCTCGCGCGGGCGTTCG

Product: MFS transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 477; Mature: 476

Protein sequence:

>477_residues
MAMLMSQPVPTLRAYATIKSLLWLVSLAIFMQMLDATIVNTALPSMARSLHESPLQMQSVVFSYALAVAMFIPASGWIAD
RFGTRRTFLVAIIVFTLGSLLCAAAQQLPQLVAARVVQGIGGAMLLPVGRLAVLKTVARADFLRAMSFIAIPALIGPLVG
PTLGGWLVEVASWHWVFLINLPIGVIGFIAALKIMPDHYGDARQRFDLIGYLMLAFGMVALSLALDGISELGLRHAFVML
LAIGGLAALAGYWLHAVSTPAALFPLALFKVASYRIGILCNLFARVGSGSMPFLIPLLLQVGLGMSPMNAGLMMVPVALA
GMAAKRAAVKLVGRFGYRRVLMLNTVLVGLAMASFALVDVGQPLWLRLVQLACFGAVNSLQFTVMNTVTLRDLDREQASP
GNSLLSMVMMLATGFGAAAAGSLLAAFNTHLGDSHGATAALHATFLCVGGITLSSTLIFWQLAETRPHPRQVEEVAE

Sequences:

>Translated_477_residues
MAMLMSQPVPTLRAYATIKSLLWLVSLAIFMQMLDATIVNTALPSMARSLHESPLQMQSVVFSYALAVAMFIPASGWIAD
RFGTRRTFLVAIIVFTLGSLLCAAAQQLPQLVAARVVQGIGGAMLLPVGRLAVLKTVARADFLRAMSFIAIPALIGPLVG
PTLGGWLVEVASWHWVFLINLPIGVIGFIAALKIMPDHYGDARQRFDLIGYLMLAFGMVALSLALDGISELGLRHAFVML
LAIGGLAALAGYWLHAVSTPAALFPLALFKVASYRIGILCNLFARVGSGSMPFLIPLLLQVGLGMSPMNAGLMMVPVALA
GMAAKRAAVKLVGRFGYRRVLMLNTVLVGLAMASFALVDVGQPLWLRLVQLACFGAVNSLQFTVMNTVTLRDLDREQASP
GNSLLSMVMMLATGFGAAAAGSLLAAFNTHLGDSHGATAALHATFLCVGGITLSSTLIFWQLAETRPHPRQVEEVAE
>Mature_476_residues
AMLMSQPVPTLRAYATIKSLLWLVSLAIFMQMLDATIVNTALPSMARSLHESPLQMQSVVFSYALAVAMFIPASGWIADR
FGTRRTFLVAIIVFTLGSLLCAAAQQLPQLVAARVVQGIGGAMLLPVGRLAVLKTVARADFLRAMSFIAIPALIGPLVGP
TLGGWLVEVASWHWVFLINLPIGVIGFIAALKIMPDHYGDARQRFDLIGYLMLAFGMVALSLALDGISELGLRHAFVMLL
AIGGLAALAGYWLHAVSTPAALFPLALFKVASYRIGILCNLFARVGSGSMPFLIPLLLQVGLGMSPMNAGLMMVPVALAG
MAAKRAAVKLVGRFGYRRVLMLNTVLVGLAMASFALVDVGQPLWLRLVQLACFGAVNSLQFTVMNTVTLRDLDREQASPG
NSLLSMVMMLATGFGAAAAGSLLAAFNTHLGDSHGATAALHATFLCVGGITLSSTLIFWQLAETRPHPRQVEEVAE

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=475, Percent_Identity=42.7368421052632, Blast_Score=378, Evalue=1e-106,
Organism=Escherichia coli, GI1788392, Length=420, Percent_Identity=49.7619047619048, Blast_Score=364, Evalue=1e-102,
Organism=Escherichia coli, GI1789042, Length=408, Percent_Identity=29.1666666666667, Blast_Score=148, Evalue=8e-37,
Organism=Escherichia coli, GI87081983, Length=440, Percent_Identity=27.5, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1788710, Length=344, Percent_Identity=29.9418604651163, Blast_Score=133, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6325455, Length=156, Percent_Identity=33.974358974359, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6322958, Length=189, Percent_Identity=29.1005291005291, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321663, Length=150, Percent_Identity=30, Blast_Score=68, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6323735, Length=211, Percent_Identity=27.9620853080569, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6319770, Length=328, Percent_Identity=25, Blast_Score=63, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 50773; Mature: 50641

Theoretical pI: Translated: 10.18; Mature: 10.18

Prosite motif: PS00213 LIPOCALIN ; PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMLMSQPVPTLRAYATIKSLLWLVSLAIFMQMLDATIVNTALPSMARSLHESPLQMQSV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
VFSYALAVAMFIPASGWIADRFGTRRTFLVAIIVFTLGSLLCAAAQQLPQLVAARVVQGI
HHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GGAMLLPVGRLAVLKTVARADFLRAMSFIAIPALIGPLVGPTLGGWLVEVASWHWVFLIN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEEE
LPIGVIGFIAALKIMPDHYGDARQRFDLIGYLMLAFGMVALSLALDGISELGLRHAFVML
CHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAIGGLAALAGYWLHAVSTPAALFPLALFKVASYRIGILCNLFARVGSGSMPFLIPLLLQ
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
VGLGMSPMNAGLMMVPVALAGMAAKRAAVKLVGRFGYRRVLMLNTVLVGLAMASFALVDV
HCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHC
GQPLWLRLVQLACFGAVNSLQFTVMNTVTLRDLDREQASPGNSLLSMVMMLATGFGAAAA
CCHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHCCCHHHH
GSLLAAFNTHLGDSHGATAALHATFLCVGGITLSSTLIFWQLAETRPHPRQVEEVAE
HHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHCC
>Mature Secondary Structure 
AMLMSQPVPTLRAYATIKSLLWLVSLAIFMQMLDATIVNTALPSMARSLHESPLQMQSV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH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HHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA