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The map label for this gene is hemE

Identifier: 21243740

GI number: 21243740

Start: 3522754

End: 3523818

Strand: Direct

Name: hemE

Synonym: XAC3013

Alternate gene names: 21243740

Gene position: 3522754-3523818 (Clockwise)

Preceding gene: 21243739

Following gene: 21243741

Centisome position: 68.07

GC content: 67.14

Gene sequence:

>1065_bases
ATGCTCAAGAACGATCGCCTGCTGCGCGCGCTCAACCGTCAGCCCGTGGACCGCACCCCTGTGTGGTTGATGCGCCAGGC
CGGCCGCTATTTGCCGGAGTACCGCGCCACGCGGGCGCGCGCCGGCAGTTTTTTGGGCATGGCCAAGAATCCGGACATCG
CCTGCGAAGTGACCCTGCAGCCGCTGCAGCGCTTCCCGCTGGATGCGGCAATCCTGTTCTCCGACATCCTCACCATTCCC
GATGCGATGGGCCTGGAGCTGTATTTTGTCGAAGGCGAAGGTCCCAAGTTCCGCCACCCGGTGCGCGATGCCGCCGCAAT
CCACCGTCTGGGCGTGCCGGACATGGAAACCGAGCTGCGCTACGTGATGGATGCGGTGCGGGTGATCCGCCGCGAACTGG
ATGGTTCGGTGCCCTTGATCGGCTTCTCCGGCAGCCCGTGGACGCTAGCCTGTTACATGATCGAAGGCGGCGGCAGCAAG
GAATACGCACGCATCAAGGCGATGGCCTTCAACGCGCCGGAGCTGCTGCATCACCTGCTCAACACCGTCACCGACGCGGT
GATCGCCTACCTGGCCGCACAACGCGCCGCCGGTGCGCAGGCGCTGCAGGTGTTCGACACCTGGGGCGGCGTGCTCTCGC
CGGCGATGTACCGCGAATTCTCGCTGCCCTACCTCACTCGCATCGCGCGCGAGCTGGAACGCGGCGACGGCGCCGAGCGT
ACCCCGCTGGTGTTGTTCGGCAAGGGCAACGGCGCCTATGTGGCCGATCTGGCCGCCAGCGGTGCCGAAGCCGTGGGCGT
GGACTGGACCATCTCGCTGGCCGACGCGGCCCAGCGCGCCGGTGGCCGCGTCGCGCTGCAGGGCAACCTGGACCCGGCCA
CCCTGTACGGCTCGCCCGAAGCGATCCGCGCCGAAGTCGGCAAGACCCTGGACAGCTACGCCCAGGGCAATGGCGGCTCG
CGCGAAGGCCATGTCTTCAACCTCGGCCACGGCATGTCGCCAGACATGAATCCCGAACATGTGGGCGTGCTGGTGGAAGC
GGTGCAGACGCTGAGCAAGCGGTAA

Upstream 100 bases:

>100_bases
ACCGCGCCTTCGACAAGGCGCGCGACAGCCAACTCAAACGCGGTTTCCAACTCATCACCGGCGGCGCCGACGACGCGCCG
CGCTGAGGACACACTTCCCC

Downstream 100 bases:

>100_bases
TCCAAGGCACGGGTCGACAGCGCACCGGTGTGCTGTCGACCGCCGCTCAGCGCGCGACCGGGGAGTGCACGCTGAGCGTG
ATGACGGGCGGTGGCTGCAT

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MLKNDRLLRALNRQPVDRTPVWLMRQAGRYLPEYRATRARAGSFLGMAKNPDIACEVTLQPLQRFPLDAAILFSDILTIP
DAMGLELYFVEGEGPKFRHPVRDAAAIHRLGVPDMETELRYVMDAVRVIRRELDGSVPLIGFSGSPWTLACYMIEGGGSK
EYARIKAMAFNAPELLHHLLNTVTDAVIAYLAAQRAAGAQALQVFDTWGGVLSPAMYREFSLPYLTRIARELERGDGAER
TPLVLFGKGNGAYVADLAASGAEAVGVDWTISLADAAQRAGGRVALQGNLDPATLYGSPEAIRAEVGKTLDSYAQGNGGS
REGHVFNLGHGMSPDMNPEHVGVLVEAVQTLSKR

Sequences:

>Translated_354_residues
MLKNDRLLRALNRQPVDRTPVWLMRQAGRYLPEYRATRARAGSFLGMAKNPDIACEVTLQPLQRFPLDAAILFSDILTIP
DAMGLELYFVEGEGPKFRHPVRDAAAIHRLGVPDMETELRYVMDAVRVIRRELDGSVPLIGFSGSPWTLACYMIEGGGSK
EYARIKAMAFNAPELLHHLLNTVTDAVIAYLAAQRAAGAQALQVFDTWGGVLSPAMYREFSLPYLTRIARELERGDGAER
TPLVLFGKGNGAYVADLAASGAEAVGVDWTISLADAAQRAGGRVALQGNLDPATLYGSPEAIRAEVGKTLDSYAQGNGGS
REGHVFNLGHGMSPDMNPEHVGVLVEAVQTLSKR
>Mature_354_residues
MLKNDRLLRALNRQPVDRTPVWLMRQAGRYLPEYRATRARAGSFLGMAKNPDIACEVTLQPLQRFPLDAAILFSDILTIP
DAMGLELYFVEGEGPKFRHPVRDAAAIHRLGVPDMETELRYVMDAVRVIRRELDGSVPLIGFSGSPWTLACYMIEGGGSK
EYARIKAMAFNAPELLHHLLNTVTDAVIAYLAAQRAAGAQALQVFDTWGGVLSPAMYREFSLPYLTRIARELERGDGAER
TPLVLFGKGNGAYVADLAASGAEAVGVDWTISLADAAQRAGGRVALQGNLDPATLYGSPEAIRAEVGKTLDSYAQGNGGS
REGHVFNLGHGMSPDMNPEHVGVLVEAVQTLSKR

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=356, Percent_Identity=47.1910112359551, Blast_Score=328, Evalue=6e-90,
Organism=Escherichia coli, GI2367337, Length=353, Percent_Identity=58.9235127478753, Blast_Score=424, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6320252, Length=360, Percent_Identity=40.5555555555556, Blast_Score=285, Evalue=7e-78,
Organism=Drosophila melanogaster, GI221330099, Length=352, Percent_Identity=43.1818181818182, Blast_Score=280, Evalue=9e-76,
Organism=Drosophila melanogaster, GI19921920, Length=352, Percent_Identity=43.1818181818182, Blast_Score=280, Evalue=1e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_XANAC (Q8PI85)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_643322.1
- ProteinModelPortal:   Q8PI85
- SMR:   Q8PI85
- GeneID:   1157084
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC3013
- NMPDR:   fig|190486.1.peg.2966
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- ProtClustDB:   PRK00115
- BioCyc:   XAXO190486:XAC3013-MONOMER
- BRENDA:   4.1.1.37
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 38461; Mature: 38461

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 44-44 BINDING 75-75 BINDING 152-152 BINDING 207-207 BINDING 330-330

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKNDRLLRALNRQPVDRTPVWLMRQAGRYLPEYRATRARAGSFLGMAKNPDIACEVTLQ
CCCCHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCEECCCCCCCEEEEEEEH
PLQRFPLDAAILFSDILTIPDAMGLELYFVEGEGPKFRHPVRDAAAIHRLGVPDMETELR
HHHHCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHCCCCCHHHHHH
YVMDAVRVIRRELDGSVPLIGFSGSPWTLACYMIEGGGSKEYARIKAMAFNAPELLHHLL
HHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEEEECCCCCCHHEEEEEECCCHHHHHHHH
NTVTDAVIAYLAAQRAAGAQALQVFDTWGGVLSPAMYREFSLPYLTRIARELERGDGAER
HHHHHHHHHHHHHHHHCCHHHHHHHHHHCHHHCHHHHHHCCCHHHHHHHHHHHHCCCCCC
TPLVLFGKGNGAYVADLAASGAEAVGVDWTISLADAAQRAGGRVALQGNLDPATLYGSPE
CCEEEEECCCCCEEEEECCCCCCEECCEEEEEHHHHHHHCCCEEEEECCCCCEEECCCHH
AIRAEVGKTLDSYAQGNGGSREGHVFNLGHGMSPDMNPEHVGVLVEAVQTLSKR
HHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLKNDRLLRALNRQPVDRTPVWLMRQAGRYLPEYRATRARAGSFLGMAKNPDIACEVTLQ
CCCCHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCEECCCCCCCEEEEEEEH
PLQRFPLDAAILFSDILTIPDAMGLELYFVEGEGPKFRHPVRDAAAIHRLGVPDMETELR
HHHHCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHCCCCCHHHHHH
YVMDAVRVIRRELDGSVPLIGFSGSPWTLACYMIEGGGSKEYARIKAMAFNAPELLHHLL
HHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEEEECCCCCCHHEEEEEECCCHHHHHHHH
NTVTDAVIAYLAAQRAAGAQALQVFDTWGGVLSPAMYREFSLPYLTRIARELERGDGAER
HHHHHHHHHHHHHHHHCCHHHHHHHHHHCHHHCHHHHHHCCCHHHHHHHHHHHHCCCCCC
TPLVLFGKGNGAYVADLAASGAEAVGVDWTISLADAAQRAGGRVALQGNLDPATLYGSPE
CCEEEEECCCCCEEEEECCCCCCEECCEEEEEHHHHHHHCCCEEEEECCCCCEEECCCHH
AIRAEVGKTLDSYAQGNGGSREGHVFNLGHGMSPDMNPEHVGVLVEAVQTLSKR
HHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217