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The map label for this gene is gpmA

Identifier: 21243601

GI number: 21243601

Start: 3373708

End: 3374457

Strand: Reverse

Name: gpmA

Synonym: XAC2874

Alternate gene names: 21243601

Gene position: 3374457-3373708 (Counterclockwise)

Preceding gene: 21243603

Following gene: 21243600

Centisome position: 65.2

GC content: 65.33

Gene sequence:

>750_bases
GTGACCCGCAAACTCGTACTGCTGCGCCATGGCCAGAGCCAATGGAATCTGGACAACCGTTTCACCGGCTGGGTGGATGT
GGAACTCACCGACCAGGGCCGCCAGGAAGCTGTGGCGGCCGGCAGGCTGATGAAGGACGAAGGGCTGCAGTTCGATGTCG
CCCACACCTCGGTGCTCAAGCGCGCCATCCACACGCTGCAGGGCGCGTTGAAGGAACTCGACCAGGACTGGTTGCCGGTG
TCCAAGAGCTGGCGCCTCAACGAGCGCCACTACGGTGGCCTGCAAGGCCTGGACAAGGCCGAAACCGCGGCAAAGCACGG
CGAGGAGCAGGTCAAGATCTGGCGCCGTTCCTACGACATCCCGCCGCCGGCGATGGACGTCAACGACCCGGGCCACCCGT
GCCACGACCGTCGCTACGCCACGCTGGACCGCAATGCATTGCCAGGCACCGAGTCGCTGGCGACCACGCTGGTGCGCGTG
TTGCCGTATTGGCACGACGCGATTGCGCCGCAGTTGAAGGCCGGGCAGACCGTGCTGGTGACCGCGCACGGCAATTCGCT
GCGCGCGCTCTACAAGTACCTCAACGATGTCTCCAATGAGCAGATCCTGGAGCTCAACATCCCCACCGGCATCCCGTTGC
TGTTCGAGCTGGACGACAGCCTGCAGGTGCGCAGCTTCCGTTACCTGGGCGACCCGGAGGCGGCCAAGCGCGCGGCCGAA
GCGGTGGCCAATCAGGGCAAGGCGAAGTAA

Upstream 100 bases:

>100_bases
CCAAAGCATCGCGCGCTGCATGTGGCGATCTCGTGCACGCCTGCGATGCACGCGCTGCCGCTACAATCGCACGCTGATCG
GCCCCAATCGGAGAACCGTA

Downstream 100 bases:

>100_bases
TCGCCGCTGGCGCTTGCAGCGCTGCGTGCGGTGCGCGCAGCGCGAGTTCTTGCGCGGCACGCAGCTGCAAGCGGCTGCGT
GCGGTGGTGAATGGAAGCGG

Product: phosphoglyceromutase

Products: NA

Alternate protein names: BPG-dependent PGAM; PGAM; Phosphoglyceromutase; dPGM

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MTRKLVLLRHGQSQWNLDNRFTGWVDVELTDQGRQEAVAAGRLMKDEGLQFDVAHTSVLKRAIHTLQGALKELDQDWLPV
SKSWRLNERHYGGLQGLDKAETAAKHGEEQVKIWRRSYDIPPPAMDVNDPGHPCHDRRYATLDRNALPGTESLATTLVRV
LPYWHDAIAPQLKAGQTVLVTAHGNSLRALYKYLNDVSNEQILELNIPTGIPLLFELDDSLQVRSFRYLGDPEAAKRAAE
AVANQGKAK

Sequences:

>Translated_249_residues
MTRKLVLLRHGQSQWNLDNRFTGWVDVELTDQGRQEAVAAGRLMKDEGLQFDVAHTSVLKRAIHTLQGALKELDQDWLPV
SKSWRLNERHYGGLQGLDKAETAAKHGEEQVKIWRRSYDIPPPAMDVNDPGHPCHDRRYATLDRNALPGTESLATTLVRV
LPYWHDAIAPQLKAGQTVLVTAHGNSLRALYKYLNDVSNEQILELNIPTGIPLLFELDDSLQVRSFRYLGDPEAAKRAAE
AVANQGKAK
>Mature_248_residues
TRKLVLLRHGQSQWNLDNRFTGWVDVELTDQGRQEAVAAGRLMKDEGLQFDVAHTSVLKRAIHTLQGALKELDQDWLPVS
KSWRLNERHYGGLQGLDKAETAAKHGEEQVKIWRRSYDIPPPAMDVNDPGHPCHDRRYATLDRNALPGTESLATTLVRVL
PYWHDAIAPQLKAGQTVLVTAHGNSLRALYKYLNDVSNEQILELNIPTGIPLLFELDDSLQVRSFRYLGDPEAAKRAAEA
VANQGKAK

Specific function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate

COG id: COG0588

COG function: function code G; Phosphoglycerate mutase 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily

Homologues:

Organism=Homo sapiens, GI50593010, Length=251, Percent_Identity=55.7768924302789, Blast_Score=298, Evalue=3e-81,
Organism=Homo sapiens, GI4505753, Length=249, Percent_Identity=56.6265060240964, Blast_Score=283, Evalue=8e-77,
Organism=Homo sapiens, GI71274132, Length=249, Percent_Identity=54.6184738955823, Blast_Score=270, Evalue=9e-73,
Organism=Homo sapiens, GI4502445, Length=251, Percent_Identity=48.207171314741, Blast_Score=251, Evalue=4e-67,
Organism=Homo sapiens, GI40353764, Length=251, Percent_Identity=48.207171314741, Blast_Score=251, Evalue=4e-67,
Organism=Homo sapiens, GI310129614, Length=161, Percent_Identity=59.0062111801242, Blast_Score=185, Evalue=4e-47,
Organism=Escherichia coli, GI1786970, Length=246, Percent_Identity=60.5691056910569, Blast_Score=311, Evalue=4e-86,
Organism=Saccharomyces cerevisiae, GI6322697, Length=244, Percent_Identity=56.5573770491803, Blast_Score=270, Evalue=2e-73,
Organism=Saccharomyces cerevisiae, GI6324516, Length=302, Percent_Identity=33.112582781457, Blast_Score=144, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6320183, Length=299, Percent_Identity=31.438127090301, Blast_Score=136, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6324857, Length=108, Percent_Identity=32.4074074074074, Blast_Score=62, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24646216, Length=250, Percent_Identity=54, Blast_Score=289, Evalue=1e-78,
Organism=Drosophila melanogaster, GI85725270, Length=250, Percent_Identity=54, Blast_Score=264, Evalue=4e-71,
Organism=Drosophila melanogaster, GI85725272, Length=250, Percent_Identity=54, Blast_Score=264, Evalue=4e-71,
Organism=Drosophila melanogaster, GI24650981, Length=250, Percent_Identity=54, Blast_Score=264, Evalue=4e-71,
Organism=Drosophila melanogaster, GI28571815, Length=251, Percent_Identity=38.6454183266932, Blast_Score=170, Evalue=9e-43,
Organism=Drosophila melanogaster, GI28571817, Length=251, Percent_Identity=38.6454183266932, Blast_Score=170, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24648979, Length=251, Percent_Identity=38.6454183266932, Blast_Score=169, Evalue=1e-42,

Paralogues:

None

Copy number: 960 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GPMA_XANAC (Q8PIM1)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_643183.1
- ProteinModelPortal:   Q8PIM1
- SMR:   Q8PIM1
- GeneID:   1156945
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC2874
- NMPDR:   fig|190486.1.peg.2827
- HOGENOM:   HBG658938
- OMA:   TGWKDPD
- ProtClustDB:   PRK14115
- BioCyc:   XAXO190486:XAC2874-MONOMER
- BRENDA:   5.4.2.1
- GO:   GO:0006096
- HAMAP:   MF_01039
- InterPro:   IPR013078
- InterPro:   IPR001345
- InterPro:   IPR005952
- PANTHER:   PTHR11931
- SMART:   SM00855
- TIGRFAMs:   TIGR01258

Pfam domain/function: PF00300 PGAM

EC number: =5.4.2.1

Molecular weight: Translated: 27986; Mature: 27855

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: PS00175 PG_MUTASE

Important sites: ACT_SITE 10-10 ACT_SITE 183-183

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRKLVLLRHGQSQWNLDNRFTGWVDVELTDQGRQEAVAAGRLMKDEGLQFDVAHTSVLK
CCCEEEEEECCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCEEEHHHHHHHH
RAIHTLQGALKELDQDWLPVSKSWRLNERHYGGLQGLDKAETAAKHGEEQVKIWRRSYDI
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHCCC
PPPAMDVNDPGHPCHDRRYATLDRNALPGTESLATTLVRVLPYWHDAIAPQLKAGQTVLV
CCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHCCCCEEEE
TAHGNSLRALYKYLNDVSNEQILELNIPTGIPLLFELDDSLQVRSFRYLGDPEAAKRAAE
EECCCHHHHHHHHHHCCCCCEEEEEECCCCCEEEEECCCCCEEHHEECCCCHHHHHHHHH
AVANQGKAK
HHHHCCCCC
>Mature Secondary Structure 
TRKLVLLRHGQSQWNLDNRFTGWVDVELTDQGRQEAVAAGRLMKDEGLQFDVAHTSVLK
CCEEEEEECCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCEEEHHHHHHHH
RAIHTLQGALKELDQDWLPVSKSWRLNERHYGGLQGLDKAETAAKHGEEQVKIWRRSYDI
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHCCC
PPPAMDVNDPGHPCHDRRYATLDRNALPGTESLATTLVRVLPYWHDAIAPQLKAGQTVLV
CCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHCCCCEEEE
TAHGNSLRALYKYLNDVSNEQILELNIPTGIPLLFELDDSLQVRSFRYLGDPEAAKRAAE
EECCCHHHHHHHHHHCCCCCEEEEEECCCCCEEEEECCCCCEEHHEECCCCHHHHHHHHH
AVANQGKAK
HHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217