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The map label for this gene is creC [H]

Identifier: 21243581

GI number: 21243581

Start: 3346147

End: 3347595

Strand: Reverse

Name: creC [H]

Synonym: XAC2854

Alternate gene names: 21243581

Gene position: 3347595-3346147 (Counterclockwise)

Preceding gene: 21243582

Following gene: 21243579

Centisome position: 64.68

GC content: 66.8

Gene sequence:

>1449_bases
ATGCGGCTTGGTCTCAAGCTGTTTCTGGGCTTCTTCCTGATCGTGGGCCTGGCCGCGTTCTTCGTGATGCGCGTGTTCGT
CAACGAGGTCAAGCCGGGGGTGCGCCAGGCGATGGAATCCACGCTGGTGGATGCGGCCAATGTGCTGGCAGAAGTCGCCA
GTAGCGAGTTGGCTGCCGGCACGCTTGCCGATGGCCGCTTCGCGCGCAACGTGGCCAGGGCCCAGCAGCGCGACCCCAAG
GCATGGGTATGGCGCTTTCGCAAGAACACGGTGGATTACCGCGTGACCGTCACCGATGCGCGCGGCGTGGTGGTGTTCGA
TTCGCTTGGCCGCGACGTGGGCCGCGACAACTCGCGCTGGAACGATGTCTACCGCACGTTGCGCGGCGAATATGGCGCGC
GTTCCAGCCCGGAGATCGATGGCGACCCCGCCGCCACGGTGATGCATGTGGCCGCGCCGATCTACGCACCGGATGACCCC
GGGCAACTGATCGGCGTGCTGACCCTGGCACAGCCCAATCGCAGCATCGACCCGTTTATCGAGGCCAGCCAGCGCAACAT
CCTGCAGCGCGGCGCCTGGTTGATCGGCATTTCAGCGTTGATCGGCATCTTGATGACCTGGTGGTTGATGCGTGGCATCG
GCCGGCTCAATCGCTATGCGCAGGCGGTGAGCGCCGGCATCCCGGTACCGCCGCCCGAACCGCGTGGCGACGAGATCGGC
GATCTGGGCCAGGCGCTGGAGAGCATGCGCCGCAAGCTGGAAGGCAAGGCGTATGTAGAGCAGTACGTGCAGTCGCTGAC
GCACGAGATGAAAAGCCCGCTGGCGGCGATTCGCGGTGCCTCGGAGTTGTTGGCCGAGCCACTGCCGGAGGCCGACCGCC
AGCATTTCGTTGCCACCATCCGCGCGCAGGAGCGCCGGCTCACCGAAACCATCGACAAGCTGCTGGCACTGGCCGAGGTG
GAGCAGCACGGCTGGCTGCAGAAGCGCGAGCGCGTCGGTATTGACGGGCTGCTGCAGGCTGCAGCGGACGCAGTGGCGCT
GCGTGCCGCGGCGGCGGGCGTCACCGTGGAGGTGGATGCGGGGCCTGGCGCGTCAGGCGGTCACCACGTACTTGGCGATG
GTTTTCTGCTGCGACAGGCACTGATCAATCTGCTCGAAAACGCCATCGCGTTTTCGCCGCAAAACAGCCATGTGCGCCTG
CGGGCGCGGCTGCACGATGGACGCTGGGAGTTGGTGGTCGAAGACCGTGGCAGCGGCGTGCCCGATTACGCGCTCGAGCG
CGTCTTCGAGCGGTTCTATTCGTTGGCACGTCCGCAGACCGGCCAGCGCAGCTCCGGGCTTGGCTTGCCGTTCGTGCGCG
AGGTCGCGCGCCTGCATGGCGGGGACGTGACGCTGGGCAATCGCCACGGTGGCGGTGCGCGTGCGGTGTTGCGCCTGCCG
ATCGGCTGA

Upstream 100 bases:

>100_bases
GGTCGACCCGATCCGCACCCACCGTGGCCTTGGCTACGCGCTGGAAGTGTAGGCATGCGCCGGCACTTCCTTGGTGAACT
GAGCGAGGCCGCGGGCTGAC

Downstream 100 bases:

>100_bases
GTTGCCGCGGTGGCTGGCGCCTGTGGCAGCCGTGCGTTCAAGGCTGCGGCATGCGCCAGAGCACATGCCGCGCCTGCGTC
ACGCAGCGTACGGCGCGTGG

Product: sensory histidine kinase CreC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 482; Mature: 482

Protein sequence:

>482_residues
MRLGLKLFLGFFLIVGLAAFFVMRVFVNEVKPGVRQAMESTLVDAANVLAEVASSELAAGTLADGRFARNVARAQQRDPK
AWVWRFRKNTVDYRVTVTDARGVVVFDSLGRDVGRDNSRWNDVYRTLRGEYGARSSPEIDGDPAATVMHVAAPIYAPDDP
GQLIGVLTLAQPNRSIDPFIEASQRNILQRGAWLIGISALIGILMTWWLMRGIGRLNRYAQAVSAGIPVPPPEPRGDEIG
DLGQALESMRRKLEGKAYVEQYVQSLTHEMKSPLAAIRGASELLAEPLPEADRQHFVATIRAQERRLTETIDKLLALAEV
EQHGWLQKRERVGIDGLLQAAADAVALRAAAAGVTVEVDAGPGASGGHHVLGDGFLLRQALINLLENAIAFSPQNSHVRL
RARLHDGRWELVVEDRGSGVPDYALERVFERFYSLARPQTGQRSSGLGLPFVREVARLHGGDVTLGNRHGGGARAVLRLP
IG

Sequences:

>Translated_482_residues
MRLGLKLFLGFFLIVGLAAFFVMRVFVNEVKPGVRQAMESTLVDAANVLAEVASSELAAGTLADGRFARNVARAQQRDPK
AWVWRFRKNTVDYRVTVTDARGVVVFDSLGRDVGRDNSRWNDVYRTLRGEYGARSSPEIDGDPAATVMHVAAPIYAPDDP
GQLIGVLTLAQPNRSIDPFIEASQRNILQRGAWLIGISALIGILMTWWLMRGIGRLNRYAQAVSAGIPVPPPEPRGDEIG
DLGQALESMRRKLEGKAYVEQYVQSLTHEMKSPLAAIRGASELLAEPLPEADRQHFVATIRAQERRLTETIDKLLALAEV
EQHGWLQKRERVGIDGLLQAAADAVALRAAAAGVTVEVDAGPGASGGHHVLGDGFLLRQALINLLENAIAFSPQNSHVRL
RARLHDGRWELVVEDRGSGVPDYALERVFERFYSLARPQTGQRSSGLGLPFVREVARLHGGDVTLGNRHGGGARAVLRLP
IG
>Mature_482_residues
MRLGLKLFLGFFLIVGLAAFFVMRVFVNEVKPGVRQAMESTLVDAANVLAEVASSELAAGTLADGRFARNVARAQQRDPK
AWVWRFRKNTVDYRVTVTDARGVVVFDSLGRDVGRDNSRWNDVYRTLRGEYGARSSPEIDGDPAATVMHVAAPIYAPDDP
GQLIGVLTLAQPNRSIDPFIEASQRNILQRGAWLIGISALIGILMTWWLMRGIGRLNRYAQAVSAGIPVPPPEPRGDEIG
DLGQALESMRRKLEGKAYVEQYVQSLTHEMKSPLAAIRGASELLAEPLPEADRQHFVATIRAQERRLTETIDKLLALAEV
EQHGWLQKRERVGIDGLLQAAADAVALRAAAAGVTVEVDAGPGASGGHHVLGDGFLLRQALINLLENAIAFSPQNSHVRL
RARLHDGRWELVVEDRGSGVPDYALERVFERFYSLARPQTGQRSSGLGLPFVREVARLHGGDVTLGNRHGGGARAVLRLP
IG

Specific function: Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. CreC may function as a membrane- associated protein kinase that phosphorylates CreB in response to environmental signals. CreC can also phosphorylate PhoB [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790861, Length=481, Percent_Identity=46.985446985447, Blast_Score=393, Evalue=1e-110,
Organism=Escherichia coli, GI48994928, Length=224, Percent_Identity=27.6785714285714, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1786600, Length=223, Percent_Identity=28.2511210762332, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87082128, Length=315, Percent_Identity=27.3015873015873, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788393, Length=254, Percent_Identity=27.5590551181102, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1789403, Length=294, Percent_Identity=29.9319727891156, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788279, Length=274, Percent_Identity=28.1021897810219, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786912, Length=237, Percent_Identity=26.5822784810127, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1788549, Length=247, Percent_Identity=24.2914979757085, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788713, Length=253, Percent_Identity=25.6916996047431, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1786783, Length=301, Percent_Identity=21.9269102990033, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1790551, Length=294, Percent_Identity=26.530612244898, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1790436, Length=243, Percent_Identity=26.7489711934156, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87081816, Length=293, Percent_Identity=25.5972696245734, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1787374, Length=237, Percent_Identity=26.5822784810127, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52662; Mature: 52662

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLGLKLFLGFFLIVGLAAFFVMRVFVNEVKPGVRQAMESTLVDAANVLAEVASSELAAG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TLADGRFARNVARAQQRDPKAWVWRFRKNTVDYRVTVTDARGVVVFDSLGRDVGRDNSRW
CCCCHHHHHHHHHHHHCCCHHHHHHHHCCCEEEEEEEECCCCEEEEHHHCCCCCCCCCHH
NDVYRTLRGEYGARSSPEIDGDPAATVMHVAAPIYAPDDPGQLIGVLTLAQPNRSIDPFI
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCHHH
EASQRNILQRGAWLIGISALIGILMTWWLMRGIGRLNRYAQAVSAGIPVPPPEPRGDEIG
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHH
DLGQALESMRRKLEGKAYVEQYVQSLTHEMKSPLAAIRGASELLAEPLPEADRQHFVATI
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHH
RAQERRLTETIDKLLALAEVEQHGWLQKRERVGIDGLLQAAADAVALRAAAAGVTVEVDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCEEEEEC
GPGASGGHHVLGDGFLLRQALINLLENAIAFSPQNSHVRLRARLHDGRWELVVEDRGSGV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEECCCCCC
PDYALERVFERFYSLARPQTGQRSSGLGLPFVREVARLHGGDVTLGNRHGGGARAVLRLP
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCEEECCCCCCCCEEEEECC
IG
CC
>Mature Secondary Structure
MRLGLKLFLGFFLIVGLAAFFVMRVFVNEVKPGVRQAMESTLVDAANVLAEVASSELAAG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TLADGRFARNVARAQQRDPKAWVWRFRKNTVDYRVTVTDARGVVVFDSLGRDVGRDNSRW
CCCCHHHHHHHHHHHHCCCHHHHHHHHCCCEEEEEEEECCCCEEEEHHHCCCCCCCCCHH
NDVYRTLRGEYGARSSPEIDGDPAATVMHVAAPIYAPDDPGQLIGVLTLAQPNRSIDPFI
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCHHH
EASQRNILQRGAWLIGISALIGILMTWWLMRGIGRLNRYAQAVSAGIPVPPPEPRGDEIG
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHH
DLGQALESMRRKLEGKAYVEQYVQSLTHEMKSPLAAIRGASELLAEPLPEADRQHFVATI
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHH
RAQERRLTETIDKLLALAEVEQHGWLQKRERVGIDGLLQAAADAVALRAAAAGVTVEVDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCEEEEEC
GPGASGGHHVLGDGFLLRQALINLLENAIAFSPQNSHVRLRARLHDGRWELVVEDRGSGV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEECCCCCC
PDYALERVFERFYSLARPQTGQRSSGLGLPFVREVARLHGGDVTLGNRHGGGARAVLRLP
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCEEECCCCCCCCEEEEECC
IG
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3531171; 7610040; 9278503; 2835585; 2228961 [H]