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The map label for this gene is holA [H]

Identifier: 21243506

GI number: 21243506

Start: 3257675

End: 3258703

Strand: Reverse

Name: holA [H]

Synonym: XAC2779

Alternate gene names: 21243506

Gene position: 3258703-3257675 (Counterclockwise)

Preceding gene: 21243507

Following gene: 21243505

Centisome position: 62.96

GC content: 69.1

Gene sequence:

>1029_bases
ATGGAACTTCGCCCAGAGCAGCTGGCCGGCCAGTCCAGCCAGCCATTGCAGCCGGTGTATCTGATCGCCGGCCCCGAGAC
CTTGCGTGTGCTTGAGGCCGCCGATGCGGTGCGCGCGCGCGCGCGCGCCGAAGGCATCGGCGAACGCGAAGTGTTCGATG
CCGATGGCCGCGAGTTCGACTGGAATCAGCTTGACGCCAGCTTCAATGCGCCCAGCCTGTTCAGTCCGCGCCGCCTGGTC
GAAGTGCGCCTGCCCAGCGGCAAGCCCGGCAAGGACGGGGCCGAGGTCATCAGCCGCTTCTGCGCCAACCCGCCGCCGGA
CGTGGTGCTGCTGATCACCGCCAACGACTGGAGCAAGGCGCATCACGGCAAGTGGGCGGAGGCGGTCGGCCGCATCGGTA
CCATCGCAGTGGCTTGGGCCATCAAACCGCACGAACTGTCCGACTGGATCGAGCGCCGCCTGCGCGCGCACGGCCTGCGC
GCCGACGCCGCTGCCGTGCAGCGCCTGAGCGAGCGGGTGGAAGGCAACCTGCTCGCCGCCGCGCAGGAAATCGACAAGCT
CGCCCTGTTGGCCGACGGCAAGACGCTGGATCTGGAGGCGATGGAATCGCTGGTGGCCGATGCCGCGCGCTACGACGTGT
TCCGGCTGGCCGAAACCACTTTTTCCGGGCAGCCGGCCGCGGTGATCCGCATGCTTGCCGGCCTGCGCGGCGAAGGCGAG
GCGGTCGCCGCGCTGATGCCGATCCTGATCAAGGAACTGCTACGCACCGCGTCATTGGCGAAGGTGCAGGCCAACGGCGG
CAACCTGGCTGCCGAAATGAAGGCACAGGGGCTGTGGGAGTCGCGCCAGGCGCCCTTCAAGCGCGCGCTGCAGCGTCACC
CCGAACCGCACCGCTGGGAACGCTTCGTCGCTGAAGCCGGGCTGGTCGATCGCATGGCCAAGGGCCGCGCCGACGGCGAT
GCCTGGGTTGGTCTGGAACGCCTGCTCGTGGCCGTGGCCGAAGCCCGCGCGGTGAGATTGTTGGCGTGA

Upstream 100 bases:

>100_bases
GCGCCAGCGCAGCCGACCACGACGCCCGAATCCAGCGTGCCGGCCTCGTTGCCGCCCGCGTCCACGTCGGGCAATTAAGC
CGCGCCCCGCGTTTCCGGTC

Downstream 100 bases:

>100_bases
AGGCTAGGGATGCCGGGACCCGGGACCCGGGACCGGGGAGCCGGGAAGGGCAGGGTGACCGGCAGCGAGCCCATTCCGAC
CAGCTTGCGCAGGCCAGCCC

Product: DNA polymerase III subunit delta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MELRPEQLAGQSSQPLQPVYLIAGPETLRVLEAADAVRARARAEGIGEREVFDADGREFDWNQLDASFNAPSLFSPRRLV
EVRLPSGKPGKDGAEVISRFCANPPPDVVLLITANDWSKAHHGKWAEAVGRIGTIAVAWAIKPHELSDWIERRLRAHGLR
ADAAAVQRLSERVEGNLLAAAQEIDKLALLADGKTLDLEAMESLVADAARYDVFRLAETTFSGQPAAVIRMLAGLRGEGE
AVAALMPILIKELLRTASLAKVQANGGNLAAEMKAQGLWESRQAPFKRALQRHPEPHRWERFVAEAGLVDRMAKGRADGD
AWVGLERLLVAVAEARAVRLLA

Sequences:

>Translated_342_residues
MELRPEQLAGQSSQPLQPVYLIAGPETLRVLEAADAVRARARAEGIGEREVFDADGREFDWNQLDASFNAPSLFSPRRLV
EVRLPSGKPGKDGAEVISRFCANPPPDVVLLITANDWSKAHHGKWAEAVGRIGTIAVAWAIKPHELSDWIERRLRAHGLR
ADAAAVQRLSERVEGNLLAAAQEIDKLALLADGKTLDLEAMESLVADAARYDVFRLAETTFSGQPAAVIRMLAGLRGEGE
AVAALMPILIKELLRTASLAKVQANGGNLAAEMKAQGLWESRQAPFKRALQRHPEPHRWERFVAEAGLVDRMAKGRADGD
AWVGLERLLVAVAEARAVRLLA
>Mature_342_residues
MELRPEQLAGQSSQPLQPVYLIAGPETLRVLEAADAVRARARAEGIGEREVFDADGREFDWNQLDASFNAPSLFSPRRLV
EVRLPSGKPGKDGAEVISRFCANPPPDVVLLITANDWSKAHHGKWAEAVGRIGTIAVAWAIKPHELSDWIERRLRAHGLR
ADAAAVQRLSERVEGNLLAAAQEIDKLALLADGKTLDLEAMESLVADAARYDVFRLAETTFSGQPAAVIRMLAGLRGEGE
AVAALMPILIKELLRTASLAKVQANGGNLAAEMKAQGLWESRQAPFKRALQRHPEPHRWERFVAEAGLVDRMAKGRADGD
AWVGLERLLVAVAEARAVRLLA

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the b

COG id: COG1466

COG function: function code L; DNA polymerase III, delta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786859, Length=294, Percent_Identity=31.9727891156463, Blast_Score=107, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008921
- InterPro:   IPR010372
- InterPro:   IPR005790 [H]

Pfam domain/function: PF06144 DNA_pol3_delta [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 37291; Mature: 37291

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELRPEQLAGQSSQPLQPVYLIAGPETLRVLEAADAVRARARAEGIGEREVFDADGREFD
CCCCCHHHCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCC
WNQLDASFNAPSLFSPRRLVEVRLPSGKPGKDGAEVISRFCANPPPDVVLLITANDWSKA
HHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCHH
HHGKWAEAVGRIGTIAVAWAIKPHELSDWIERRLRAHGLRADAAAVQRLSERVEGNLLAA
HCCHHHHHHCCHHHEEEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHH
AQEIDKLALLADGKTLDLEAMESLVADAARYDVFRLAETTFSGQPAAVIRMLAGLRGEGE
HHHHHHHHEEECCCEECHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCH
AVAALMPILIKELLRTASLAKVQANGGNLAAEMKAQGLWESRQAPFKRALQRHPEPHRWE
HHHHHHHHHHHHHHHHHHHHEEECCCCCEEHHHHHHCCHHHCCCHHHHHHHHCCCHHHHH
RFVAEAGLVDRMAKGRADGDAWVGLERLLVAVAEARAVRLLA
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MELRPEQLAGQSSQPLQPVYLIAGPETLRVLEAADAVRARARAEGIGEREVFDADGREFD
CCCCCHHHCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCC
WNQLDASFNAPSLFSPRRLVEVRLPSGKPGKDGAEVISRFCANPPPDVVLLITANDWSKA
HHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCHH
HHGKWAEAVGRIGTIAVAWAIKPHELSDWIERRLRAHGLRADAAAVQRLSERVEGNLLAA
HCCHHHHHHCCHHHEEEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHH
AQEIDKLALLADGKTLDLEAMESLVADAARYDVFRLAETTFSGQPAAVIRMLAGLRGEGE
HHHHHHHHEEECCCEECHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCH
AVAALMPILIKELLRTASLAKVQANGGNLAAEMKAQGLWESRQAPFKRALQRHPEPHRWE
HHHHHHHHHHHHHHHHHHHHEEECCCCCEEHHHHHHCCHHHCCCHHHHHHHHCCCHHHHH
RFVAEAGLVDRMAKGRADGDAWVGLERLLVAVAEARAVRLLA
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8505303; 1400251; 8905232; 9278503; 3316191; 8505304; 1575709 [H]