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The map label for this gene is ispA [H]

Identifier: 21243489

GI number: 21243489

Start: 3234631

End: 3235506

Strand: Direct

Name: ispA [H]

Synonym: XAC2762

Alternate gene names: 21243489

Gene position: 3234631-3235506 (Clockwise)

Preceding gene: 21243488

Following gene: 21243490

Centisome position: 62.5

GC content: 68.84

Gene sequence:

>876_bases
GTGAGCTCGGCGTTGTTCGACCACTGGATCGCCCGCACCGAACGCAGCCTGGAGGCCGGCTTGCCGAGCGCCACGCATGC
GCCGCAGCGCCTGCATGCAGCGATGCGCCACGCCGTGCTGGGCGGGGGCAAGCGCATGCGGCCGCTGCTGGTCTACGCAA
GCGGCGCATTGTTCGGTGCCGCTGAGGATCAACTCGACACGCCCGCGGTGGCAGTAGAGCTGATTCACGCTTATTCGCTG
GTGCACGACGATTTGCCGGCGATGGACGACGACGCGCTGCGACGCGGCCAGCCCACCGTGCATATCGCCTTCGACGAGGC
CACCGCGATTCTGGCCGGCGATGCCTTGCAGACGCGCGCGTTCGAATTACTCGCCGCTGCCTCTGCCAGCGCCGAACTGC
GCGTGGGCTGGATGCAGAGCCTGGCCACCGCGGCGGGCGCGGCCGGCATGTGCGGCGGCCAGGCGCTGGACATCGATGCG
ACCGGGCAACTGCAATCGCTGCAGCACCTGCAGCGCATGCATGCGCTCAAGACCGGCGCGTTGATCCGCGCAGCGGTACG
GATGGGCGCACTGACCGGAGGCGCAGCGTTGGCCGACCAGCAGCGCCTGGACGAATTTGCCGACGCGCTGGGCCTGGCCT
TCCAGGTGCGCGACGACATCCTGGATGTGGAATCGAGCTCGGCGCAGCTGGGCAAGACCGCCGGCAAGGACGCGGCGCAA
TCCAAATCCACCTACCCCGCCCTGCTGGGGATGGACGGCGCCAAGGCGAAGCTGGCCGAACTGGCCGCGCGCATGCATGA
CGTCCTGCAGCCCTACGGGCAACCAGGCGAGACATTAGCCACCTTGGCCCGGTTTGCGGTGAACCGCGCGCACTAG

Upstream 100 bases:

>100_bases
CAGGCGCTGGAACAGGCCGAACTGCGCGTGCGCCTGTTGACCGACCCCGCCCGCCCCGAGCTTGCCGAAGCCTTCGAACC
GCCGTCGCTGGACGGCTGAG

Downstream 100 bases:

>100_bases
GCGCCGTTGCCAACGCCGCTACGCCGCAGCAAGCGGGGGCGGCCGATGCCCAATGGATCTGAAGTTCCTGCGTGCCGCGA
CGGCGCGCTGGTCGCTCGCG

Product: farnesyl-diphosphate synthase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MSSALFDHWIARTERSLEAGLPSATHAPQRLHAAMRHAVLGGGKRMRPLLVYASGALFGAAEDQLDTPAVAVELIHAYSL
VHDDLPAMDDDALRRGQPTVHIAFDEATAILAGDALQTRAFELLAAASASAELRVGWMQSLATAAGAAGMCGGQALDIDA
TGQLQSLQHLQRMHALKTGALIRAAVRMGALTGGAALADQQRLDEFADALGLAFQVRDDILDVESSSAQLGKTAGKDAAQ
SKSTYPALLGMDGAKAKLAELAARMHDVLQPYGQPGETLATLARFAVNRAH

Sequences:

>Translated_291_residues
MSSALFDHWIARTERSLEAGLPSATHAPQRLHAAMRHAVLGGGKRMRPLLVYASGALFGAAEDQLDTPAVAVELIHAYSL
VHDDLPAMDDDALRRGQPTVHIAFDEATAILAGDALQTRAFELLAAASASAELRVGWMQSLATAAGAAGMCGGQALDIDA
TGQLQSLQHLQRMHALKTGALIRAAVRMGALTGGAALADQQRLDEFADALGLAFQVRDDILDVESSSAQLGKTAGKDAAQ
SKSTYPALLGMDGAKAKLAELAARMHDVLQPYGQPGETLATLARFAVNRAH
>Mature_290_residues
SSALFDHWIARTERSLEAGLPSATHAPQRLHAAMRHAVLGGGKRMRPLLVYASGALFGAAEDQLDTPAVAVELIHAYSLV
HDDLPAMDDDALRRGQPTVHIAFDEATAILAGDALQTRAFELLAAASASAELRVGWMQSLATAAGAAGMCGGQALDIDAT
GQLQSLQHLQRMHALKTGALIRAAVRMGALTGGAALADQQRLDEFADALGLAFQVRDDILDVESSSAQLGKTAGKDAAQS
KSTYPALLGMDGAKAKLAELAARMHDVLQPYGQPGETLATLARFAVNRAH

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=251, Percent_Identity=27.4900398406374, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1786623, Length=266, Percent_Identity=53.3834586466165, Blast_Score=227, Evalue=6e-61,
Organism=Escherichia coli, GI1789578, Length=215, Percent_Identity=31.6279069767442, Blast_Score=103, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6325188, Length=229, Percent_Identity=28.3842794759825, Blast_Score=83, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24651612, Length=266, Percent_Identity=27.0676691729323, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 30517; Mature: 30386

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSALFDHWIARTERSLEAGLPSATHAPQRLHAAMRHAVLGGGKRMRPLLVYASGALFGA
CCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCEECC
AEDQLDTPAVAVELIHAYSLVHDDLPAMDDDALRRGQPTVHIAFDEATAILAGDALQTRA
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCEEEEEECCCHHHHCCCHHHHHH
FELLAAASASAELRVGWMQSLATAAGAAGMCGGQALDIDATGQLQSLQHLQRMHALKTGA
HHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHH
LIRAAVRMGALTGGAALADQQRLDEFADALGLAFQVRDDILDVESSSAQLGKTAGKDAAQ
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHH
SKSTYPALLGMDGAKAKLAELAARMHDVLQPYGQPGETLATLARFAVNRAH
CCCCCCHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SSALFDHWIARTERSLEAGLPSATHAPQRLHAAMRHAVLGGGKRMRPLLVYASGALFGA
CCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCEECC
AEDQLDTPAVAVELIHAYSLVHDDLPAMDDDALRRGQPTVHIAFDEATAILAGDALQTRA
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCEEEEEECCCHHHHCCCHHHHHH
FELLAAASASAELRVGWMQSLATAAGAAGMCGGQALDIDATGQLQSLQHLQRMHALKTGA
HHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHH
LIRAAVRMGALTGGAALADQQRLDEFADALGLAFQVRDDILDVESSSAQLGKTAGKDAAQ
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHH
SKSTYPALLGMDGAKAKLAELAARMHDVLQPYGQPGETLATLARFAVNRAH
CCCCCCHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]