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The map label for this gene is gltT [H]

Identifier: 21243485

GI number: 21243485

Start: 3229477

End: 3230817

Strand: Reverse

Name: gltT [H]

Synonym: XAC2758

Alternate gene names: 21243485

Gene position: 3230817-3229477 (Counterclockwise)

Preceding gene: 21243491

Following gene: 21243484

Centisome position: 62.42

GC content: 63.61

Gene sequence:

>1341_bases
ATGAAACTGGTTGCGGCGTGGTTGCGCATTCCGTTCTGGCAGCGCGTGGTGGCCGGCTTCGTCCTCGGCGCGCTGGTCGG
CTGGGCCATGGGCCCGGCGGCCGATGTGTGGTTCGGTCCCCTGGGTGACCTGTACGTCACGCTGATCAAGATGATCGCCA
TCCCGCTGGTGTTCTTTGCGGTGATCAATGCGATCTCGTCGTTGCACGGGCAAAAGTCGGTTGCCGCACTCGGCGGGCGC
ACGTTCTTGTGGTTTGTGATCACCGCAGCATTGGCGGTGGCCGTGGGCCTGGCGGTCGGCACGATCATGCAGCCGGGTGC
CGGCCATTTCAGCTTGAGCGTGGATTCGGGCTGGAAACCGCGCGATGTGCCCAGCCCGGTCCAAGTGCTGCTGGATGTGG
TGCCGTCCAACCCGTTCTACGCATTGACCGGCATCGGCACCAAGACCAACGCGGCCGGCGAAACGGTGCTGGCGGCGGGG
CGTGGCTCGATCCTGCCGGTGATCTTCTTCGCCGCGTTGCTGGGCTTTGCGATGGTCAAGCTTGGCGAGCGTGTGGCCGA
GGCGCGCAAGCTCACCGGGCAGATGAGCGACATCATGATCCAGGTGACGCGCTTCGTGCTGGAGATGACTCCGCTCGGCA
CCTTTGGGCTGATCGCTGGCCTGGTCGGCAGCTACGGCTTTTCGAAGCTGCTGCCGTTCGGCAATTTCGTGCTGGCGCTG
TATGTGGCCTGCGCGATCCACATTGTGGTGGTCTACAGCAGCCTGTTGCTCGCACATGGGCTCAACCCGTGGAAGTTTTT
CCGCGGTGCCGCGCCTGGCATGCAGGTGGCGTTCGTCAGTTCGTCGAGCTTTGCGGCAATGCCGGTGGCGATGCGTTCGA
TTACCCACAACCTGGGGGTCAGCAAGGATTACGCTGCATTCGCGGTACCGCTGGGCGCCAGCATCAAGATGGATGGCTGC
GGCGCAATCTTTCCGGCGTTGTGCGCGGTGTTCATCGCGCAATACACCGGCGTCCCCCTGACCGCCAACCAGTATTTCGT
GGTGCTGATCGCCTCGGTGCTCGGCAGCTTCGGCACGGCCGGCGTACCGGGCACGGCGGTCATCATGGCCACGGTGGTGC
TGAGTGCGGCCAATCTGCCGTTGGAAGTGATCGGGTACCTGTATGCGATCGACCGCATCCTGGACATGATGCGCACCATG
ACCAACGTCACCGGGCAGATGCTGGTGCCGGTGCTGGTGGCCAAGCAAACCGGCCTGCTCGACAAGAGCATCTACGAATC
CGCCTCCACCAATGTGGGACTGGAAGAACCGCCGGCTGACAGCGCCAAACCACTGCGCTGA

Upstream 100 bases:

>100_bases
GGTGTCACACCGATGACACAGCGCTGTTCCAGCTGTGGTCTCGCGAGCAGGGCAGCCCTGGGCTATGGTGCATGCACTTT
CCCCCGGAAGATTCGACGAC

Downstream 100 bases:

>100_bases
GGCAGCTTGATGCGTGCCGGATCTCCACACCTGCGCGAACGGCTGCAGCAGTTGCCCGAGCTGGAGCGCATGGATGGCGT
GTTGGTGCAGCGCGGCTTGG

Product: glutamate symport protein

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MKLVAAWLRIPFWQRVVAGFVLGALVGWAMGPAADVWFGPLGDLYVTLIKMIAIPLVFFAVINAISSLHGQKSVAALGGR
TFLWFVITAALAVAVGLAVGTIMQPGAGHFSLSVDSGWKPRDVPSPVQVLLDVVPSNPFYALTGIGTKTNAAGETVLAAG
RGSILPVIFFAALLGFAMVKLGERVAEARKLTGQMSDIMIQVTRFVLEMTPLGTFGLIAGLVGSYGFSKLLPFGNFVLAL
YVACAIHIVVVYSSLLLAHGLNPWKFFRGAAPGMQVAFVSSSSFAAMPVAMRSITHNLGVSKDYAAFAVPLGASIKMDGC
GAIFPALCAVFIAQYTGVPLTANQYFVVLIASVLGSFGTAGVPGTAVIMATVVLSAANLPLEVIGYLYAIDRILDMMRTM
TNVTGQMLVPVLVAKQTGLLDKSIYESASTNVGLEEPPADSAKPLR

Sequences:

>Translated_446_residues
MKLVAAWLRIPFWQRVVAGFVLGALVGWAMGPAADVWFGPLGDLYVTLIKMIAIPLVFFAVINAISSLHGQKSVAALGGR
TFLWFVITAALAVAVGLAVGTIMQPGAGHFSLSVDSGWKPRDVPSPVQVLLDVVPSNPFYALTGIGTKTNAAGETVLAAG
RGSILPVIFFAALLGFAMVKLGERVAEARKLTGQMSDIMIQVTRFVLEMTPLGTFGLIAGLVGSYGFSKLLPFGNFVLAL
YVACAIHIVVVYSSLLLAHGLNPWKFFRGAAPGMQVAFVSSSSFAAMPVAMRSITHNLGVSKDYAAFAVPLGASIKMDGC
GAIFPALCAVFIAQYTGVPLTANQYFVVLIASVLGSFGTAGVPGTAVIMATVVLSAANLPLEVIGYLYAIDRILDMMRTM
TNVTGQMLVPVLVAKQTGLLDKSIYESASTNVGLEEPPADSAKPLR
>Mature_446_residues
MKLVAAWLRIPFWQRVVAGFVLGALVGWAMGPAADVWFGPLGDLYVTLIKMIAIPLVFFAVINAISSLHGQKSVAALGGR
TFLWFVITAALAVAVGLAVGTIMQPGAGHFSLSVDSGWKPRDVPSPVQVLLDVVPSNPFYALTGIGTKTNAAGETVLAAG
RGSILPVIFFAALLGFAMVKLGERVAEARKLTGQMSDIMIQVTRFVLEMTPLGTFGLIAGLVGSYGFSKLLPFGNFVLAL
YVACAIHIVVVYSSLLLAHGLNPWKFFRGAAPGMQVAFVSSSSFAAMPVAMRSITHNLGVSKDYAAFAVPLGASIKMDGC
GAIFPALCAVFIAQYTGVPLTANQYFVVLIASVLGSFGTAGVPGTAVIMATVVLSAANLPLEVIGYLYAIDRILDMMRTM
TNVTGQMLVPVLVAKQTGLLDKSIYESASTNVGLEEPPADSAKPLR

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI21314632, Length=393, Percent_Identity=27.9898218829517, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI40254478, Length=411, Percent_Identity=26.7639902676399, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI5032093, Length=443, Percent_Identity=27.9909706546275, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI169790839, Length=434, Percent_Identity=26.036866359447, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI66773030, Length=267, Percent_Identity=31.4606741573034, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI194239697, Length=449, Percent_Identity=24.9443207126949, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI223468564, Length=292, Percent_Identity=28.7671232876712, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI223468566, Length=292, Percent_Identity=28.7671232876712, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI4827012, Length=246, Percent_Identity=29.6747967479675, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI301601644, Length=124, Percent_Identity=40.3225806451613, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI262359914, Length=374, Percent_Identity=24.331550802139, Blast_Score=82, Evalue=7e-16,
Organism=Escherichia coli, GI1789947, Length=432, Percent_Identity=28.7037037037037, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI1790514, Length=421, Percent_Identity=29.4536817102138, Blast_Score=169, Evalue=4e-43,
Organism=Escherichia coli, GI1788024, Length=412, Percent_Identity=30.5825242718447, Blast_Score=164, Evalue=7e-42,
Organism=Escherichia coli, GI1789473, Length=394, Percent_Identity=24.3654822335025, Blast_Score=86, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71983099, Length=451, Percent_Identity=26.8292682926829, Blast_Score=142, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17537407, Length=429, Percent_Identity=28.4382284382284, Blast_Score=142, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI71983106, Length=435, Percent_Identity=27.3563218390805, Blast_Score=141, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI193206505, Length=422, Percent_Identity=27.7251184834123, Blast_Score=127, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI71996953, Length=442, Percent_Identity=24.2081447963801, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI193206654, Length=454, Percent_Identity=24.6696035242291, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17541374, Length=401, Percent_Identity=23.6907730673317, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24583025, Length=429, Percent_Identity=24.4755244755245, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI17137668, Length=429, Percent_Identity=24.4755244755245, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24583023, Length=429, Percent_Identity=24.4755244755245, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI281360483, Length=478, Percent_Identity=25.1046025104602, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17137666, Length=478, Percent_Identity=25.1046025104602, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI281360481, Length=478, Percent_Identity=25.1046025104602, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 46835; Mature: 46835

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLVAAWLRIPFWQRVVAGFVLGALVGWAMGPAADVWFGPLGDLYVTLIKMIAIPLVFFA
CHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHH
VINAISSLHGQKSVAALGGRTFLWFVITAALAVAVGLAVGTIMQPGAGHFSLSVDSGWKP
HHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCC
RDVPSPVQVLLDVVPSNPFYALTGIGTKTNAAGETVLAAGRGSILPVIFFAALLGFAMVK
CCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHH
LGERVAEARKLTGQMSDIMIQVTRFVLEMTPLGTFGLIAGLVGSYGFSKLLPFGNFVLAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHCCCHHHHHHH
YVACAIHIVVVYSSLLLAHGLNPWKFFRGAAPGMQVAFVSSSSFAAMPVAMRSITHNLGV
HHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCC
SKDYAAFAVPLGASIKMDGCGAIFPALCAVFIAQYTGVPLTANQYFVVLIASVLGSFGTA
CCCCHHEEECCCCCEEECCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCC
GVPGTAVIMATVVLSAANLPLEVIGYLYAIDRILDMMRTMTNVTGQMLVPVLVAKQTGLL
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
DKSIYESASTNVGLEEPPADSAKPLR
HHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKLVAAWLRIPFWQRVVAGFVLGALVGWAMGPAADVWFGPLGDLYVTLIKMIAIPLVFFA
CHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHH
VINAISSLHGQKSVAALGGRTFLWFVITAALAVAVGLAVGTIMQPGAGHFSLSVDSGWKP
HHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCC
RDVPSPVQVLLDVVPSNPFYALTGIGTKTNAAGETVLAAGRGSILPVIFFAALLGFAMVK
CCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHH
LGERVAEARKLTGQMSDIMIQVTRFVLEMTPLGTFGLIAGLVGSYGFSKLLPFGNFVLAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHCCCHHHHHHH
YVACAIHIVVVYSSLLLAHGLNPWKFFRGAAPGMQVAFVSSSSFAAMPVAMRSITHNLGV
HHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCC
SKDYAAFAVPLGASIKMDGCGAIFPALCAVFIAQYTGVPLTANQYFVVLIASVLGSFGTA
CCCCHHEEECCCCCEEECCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCC
GVPGTAVIMATVVLSAANLPLEVIGYLYAIDRILDMMRTMTNVTGQMLVPVLVAKQTGLL
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
DKSIYESASTNVGLEEPPADSAKPLR
HHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA