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The map label for this gene is gor [H]

Identifier: 21243477

GI number: 21243477

Start: 3221604

End: 3222974

Strand: Reverse

Name: gor [H]

Synonym: XAC2750

Alternate gene names: 21243477

Gene position: 3222974-3221604 (Counterclockwise)

Preceding gene: 21243478

Following gene: 21243476

Centisome position: 62.27

GC content: 64.55

Gene sequence:

>1371_bases
ATGAGTGCGCGTTACGACTACGATGTGGTGATTCTGGGCGGCGGGTCCGGCGGCCTCGCGGCGGGATTTCGCGCGGCAAA
ACATGGCGCGCGCGTGGCGATCATGGAGCCCGACGAATTGGGCGGCACCTGCGTCAATCTCGGTTGCGTGCCGAAGAAGG
CGATGTGGCTGGCCGCCGATCTGGCCGGCAAGATCGAGTTGGCCAGCGCCTTGGGATTCGATGTGCCGCGCCCGACGTTG
GTCTGGCAGGAGCTGGTCACGCATCGGCAGGGGTACATCGCCAACATCCACGCCAGCTATCGACGCCGCCTCAACGAAGA
TGGCGTGGTCTTGATCCCGCAGCGCGGCGTATTGCAGGACCGCCATACCGTCATGGGCAGCGACGGCGTGCCGGTCACCG
CCGGGCACATCGTGATCGCCACTGGCGCGCACGCGTTACGCCCGGACGTGGAGGGCGCAGAGCATGGCGAGGTCTCCGAC
GATTTCTTCAATCTCTGCCATGCGCCCGAGCAGGTCGCGATTATCGGCGGCGGCTATATCGCGGTGGAAATCGCCGGGCT
GCTGCAGGCCTTAGGGAGCCGCGTGCATCTATTCGTGCAGGGCGAGCGCTTGCTGGAACGCTTCGATGCGGAACTGACCT
TGCAGTTGGCCGACAACCTGCGCCATCTGGGCGTGCGGCTGCACTTCGGTTTCACCACCACCGCATTGGAGCGCGATATG
CACGGTGCGCTGCGCGTGCATGGGCATTCCGTACATCCGCGCGAGCAGGGCAACGACGTCTTCGACAAGGTGTTTTTCGC
GGTGGGCCGCCGCGCCAATACCGCAGGGCTGGGTCTGGACACCGTGGGTGTTGCGCTTGGCGACAAGGGCGAAGTGGTGG
TGGACGACAGGCAGACCACCAACGTGCCGAATATTCACGCAATCGGCGATGTGGGCGGCAAGGTCGGACTGACGCCGGTG
GCGATTGCGGCGGGGCGCAAGCTGATGGACCGCCTGTTCGGTCACCAACCGGATGCGCGCATGGATTACGAAAACGTGCC
CAGCGTGGTGTTTTCGCACCCGCCGCTTGGCAACGTCGGGCTCACCGAAGAACAGGCACGTGCGCGCTACAACGGGGCGG
TGCGCGTGTACCGCAGCAATTTCCGCCCGATGCTGCACGCACTGGCGGACGCGCCGCAGCGCAGCCTGTTCAAGCTGGTG
TGCGTGGGCGAAGAAGAACGTGTGGTCGGCGTGCATCTGCTGGGTGAGAGCGCCGACGAAATGCTGCAAGGCTTTGCGGT
GGCGGTGAAGATGGGCGCGACCAAGCGCGACTTCGACGAAACCGTGGCGATTCATCCCACCTCGTCTGAAGAGATTGTGT
TGATGCACTGA

Upstream 100 bases:

>100_bases
GCATCAGCATGAGCACTGCAAGCGGACAATTGATGGCCGACCTGATCACGGGCCGCGCACCTGCGCTGGACCCGCATCCT
TACCGGGCGGAGCGTTTCGC

Downstream 100 bases:

>100_bases
GGCCGAGGTGGCCGGAGGTGGCAGGTTAGCGGGCTGGTGACGCTCTGATCGGTGCACCATCGCAGGTCGCAAAAAATGGC
AGCAGCAGCGGACCCTGCCG

Product: reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MSARYDYDVVILGGGSGGLAAGFRAAKHGARVAIMEPDELGGTCVNLGCVPKKAMWLAADLAGKIELASALGFDVPRPTL
VWQELVTHRQGYIANIHASYRRRLNEDGVVLIPQRGVLQDRHTVMGSDGVPVTAGHIVIATGAHALRPDVEGAEHGEVSD
DFFNLCHAPEQVAIIGGGYIAVEIAGLLQALGSRVHLFVQGERLLERFDAELTLQLADNLRHLGVRLHFGFTTTALERDM
HGALRVHGHSVHPREQGNDVFDKVFFAVGRRANTAGLGLDTVGVALGDKGEVVVDDRQTTNVPNIHAIGDVGGKVGLTPV
AIAAGRKLMDRLFGHQPDARMDYENVPSVVFSHPPLGNVGLTEEQARARYNGAVRVYRSNFRPMLHALADAPQRSLFKLV
CVGEEERVVGVHLLGESADEMLQGFAVAVKMGATKRDFDETVAIHPTSSEEIVLMH

Sequences:

>Translated_456_residues
MSARYDYDVVILGGGSGGLAAGFRAAKHGARVAIMEPDELGGTCVNLGCVPKKAMWLAADLAGKIELASALGFDVPRPTL
VWQELVTHRQGYIANIHASYRRRLNEDGVVLIPQRGVLQDRHTVMGSDGVPVTAGHIVIATGAHALRPDVEGAEHGEVSD
DFFNLCHAPEQVAIIGGGYIAVEIAGLLQALGSRVHLFVQGERLLERFDAELTLQLADNLRHLGVRLHFGFTTTALERDM
HGALRVHGHSVHPREQGNDVFDKVFFAVGRRANTAGLGLDTVGVALGDKGEVVVDDRQTTNVPNIHAIGDVGGKVGLTPV
AIAAGRKLMDRLFGHQPDARMDYENVPSVVFSHPPLGNVGLTEEQARARYNGAVRVYRSNFRPMLHALADAPQRSLFKLV
CVGEEERVVGVHLLGESADEMLQGFAVAVKMGATKRDFDETVAIHPTSSEEIVLMH
>Mature_455_residues
SARYDYDVVILGGGSGGLAAGFRAAKHGARVAIMEPDELGGTCVNLGCVPKKAMWLAADLAGKIELASALGFDVPRPTLV
WQELVTHRQGYIANIHASYRRRLNEDGVVLIPQRGVLQDRHTVMGSDGVPVTAGHIVIATGAHALRPDVEGAEHGEVSDD
FFNLCHAPEQVAIIGGGYIAVEIAGLLQALGSRVHLFVQGERLLERFDAELTLQLADNLRHLGVRLHFGFTTTALERDMH
GALRVHGHSVHPREQGNDVFDKVFFAVGRRANTAGLGLDTVGVALGDKGEVVVDDRQTTNVPNIHAIGDVGGKVGLTPVA
IAAGRKLMDRLFGHQPDARMDYENVPSVVFSHPPLGNVGLTEEQARARYNGAVRVYRSNFRPMLHALADAPQRSLFKLVC
VGEEERVVGVHLLGESADEMLQGFAVAVKMGATKRDFDETVAIHPTSSEEIVLMH

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=466, Percent_Identity=44.4206008583691, Blast_Score=355, Evalue=4e-98,
Organism=Homo sapiens, GI22035672, Length=472, Percent_Identity=37.9237288135593, Blast_Score=255, Evalue=6e-68,
Organism=Homo sapiens, GI148277065, Length=473, Percent_Identity=35.7293868921776, Blast_Score=236, Evalue=5e-62,
Organism=Homo sapiens, GI33519430, Length=473, Percent_Identity=35.7293868921776, Blast_Score=236, Evalue=5e-62,
Organism=Homo sapiens, GI33519428, Length=473, Percent_Identity=35.7293868921776, Blast_Score=236, Evalue=5e-62,
Organism=Homo sapiens, GI33519426, Length=473, Percent_Identity=35.7293868921776, Blast_Score=236, Evalue=5e-62,
Organism=Homo sapiens, GI148277071, Length=473, Percent_Identity=35.7293868921776, Blast_Score=235, Evalue=5e-62,
Organism=Homo sapiens, GI291045266, Length=469, Percent_Identity=34.5415778251599, Blast_Score=232, Evalue=6e-61,
Organism=Homo sapiens, GI291045268, Length=468, Percent_Identity=31.6239316239316, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI91199540, Length=456, Percent_Identity=28.0701754385965, Blast_Score=152, Evalue=7e-37,
Organism=Escherichia coli, GI1789915, Length=434, Percent_Identity=45.3917050691244, Blast_Score=375, Evalue=1e-105,
Organism=Escherichia coli, GI1786307, Length=471, Percent_Identity=28.0254777070064, Blast_Score=144, Evalue=2e-35,
Organism=Escherichia coli, GI87081717, Length=461, Percent_Identity=28.1995661605206, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI87082354, Length=463, Percent_Identity=27.645788336933, Blast_Score=132, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI71983419, Length=461, Percent_Identity=42.2993492407809, Blast_Score=307, Evalue=6e-84,
Organism=Caenorhabditis elegans, GI71983429, Length=461, Percent_Identity=42.2993492407809, Blast_Score=307, Evalue=7e-84,
Organism=Caenorhabditis elegans, GI17557007, Length=477, Percent_Identity=31.6561844863732, Blast_Score=221, Evalue=9e-58,
Organism=Caenorhabditis elegans, GI71982272, Length=479, Percent_Identity=32.3590814196242, Blast_Score=218, Evalue=7e-57,
Organism=Caenorhabditis elegans, GI32565766, Length=471, Percent_Identity=28.2377919320594, Blast_Score=144, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6325166, Length=474, Percent_Identity=40.7172995780591, Blast_Score=350, Evalue=2e-97,
Organism=Saccharomyces cerevisiae, GI6321091, Length=469, Percent_Identity=27.2921108742004, Blast_Score=135, Evalue=9e-33,
Organism=Saccharomyces cerevisiae, GI6325240, Length=463, Percent_Identity=25.4859611231102, Blast_Score=123, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24640553, Length=472, Percent_Identity=36.228813559322, Blast_Score=252, Evalue=3e-67,
Organism=Drosophila melanogaster, GI24640551, Length=475, Percent_Identity=36, Blast_Score=252, Evalue=5e-67,
Organism=Drosophila melanogaster, GI24640549, Length=472, Percent_Identity=36.228813559322, Blast_Score=251, Evalue=5e-67,
Organism=Drosophila melanogaster, GI17737741, Length=475, Percent_Identity=35.3684210526316, Blast_Score=242, Evalue=5e-64,
Organism=Drosophila melanogaster, GI21358499, Length=468, Percent_Identity=26.9230769230769, Blast_Score=145, Evalue=7e-35,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006322
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 49118; Mature: 48987

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSARYDYDVVILGGGSGGLAAGFRAAKHGARVAIMEPDELGGTCVNLGCVPKKAMWLAAD
CCCCCCEEEEEEECCCCCHHHHHHHHCCCCEEEEECCHHCCCEEEEECCCCCHHHEEEHH
LAGKIELASALGFDVPRPTLVWQELVTHRQGYIANIHASYRRRLNEDGVVLIPQRGVLQD
HCCCEEEHHHHCCCCCCHHHHHHHHHHHCCCEEEEEEHHHHHHCCCCCEEEECCCCCCCC
RHTVMGSDGVPVTAGHIVIATGAHALRPDVEGAEHGEVSDDFFNLCHAPEQVAIIGGGYI
CCEEECCCCCCEEECCEEEEECCHHCCCCCCCCCCCCCCHHHHHHHCCCCEEEEEECCEE
AVEIAGLLQALGSRVHLFVQGERLLERFDAELTLQLADNLRHLGVRLHFGFTTTALERDM
EHHHHHHHHHCCCEEEEEEECHHHHHHHCCCEEEHHHHCHHEEEEEEEECCCHHHHHHHC
HGALRVHGHSVHPREQGNDVFDKVFFAVGRRANTAGLGLDTVGVALGDKGEVVVDDRQTT
CCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHEEEEECCCCCEEECCCCCC
NVPNIHAIGDVGGKVGLTPVAIAAGRKLMDRLFGHQPDARMDYENVPSVVFSHPPLGNVG
CCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCEEECCCCCCCCC
LTEEQARARYNGAVRVYRSNFRPMLHALADAPQRSLFKLVCVGEEERVVGVHLLGESADE
CCHHHHHHHHCCEEEEEECCCHHHHHHHHCCCHHCEEEEEEECCCCCEEEEEEECCCHHH
MLQGFAVAVKMGATKRDFDETVAIHPTSSEEIVLMH
HHHHHEEEEEECCCCCCCCCEEEECCCCCCCEEEEC
>Mature Secondary Structure 
SARYDYDVVILGGGSGGLAAGFRAAKHGARVAIMEPDELGGTCVNLGCVPKKAMWLAAD
CCCCCEEEEEEECCCCCHHHHHHHHCCCCEEEEECCHHCCCEEEEECCCCCHHHEEEHH
LAGKIELASALGFDVPRPTLVWQELVTHRQGYIANIHASYRRRLNEDGVVLIPQRGVLQD
HCCCEEEHHHHCCCCCCHHHHHHHHHHHCCCEEEEEEHHHHHHCCCCCEEEECCCCCCCC
RHTVMGSDGVPVTAGHIVIATGAHALRPDVEGAEHGEVSDDFFNLCHAPEQVAIIGGGYI
CCEEECCCCCCEEECCEEEEECCHHCCCCCCCCCCCCCCHHHHHHHCCCCEEEEEECCEE
AVEIAGLLQALGSRVHLFVQGERLLERFDAELTLQLADNLRHLGVRLHFGFTTTALERDM
EHHHHHHHHHCCCEEEEEEECHHHHHHHCCCEEEHHHHCHHEEEEEEEECCCHHHHHHHC
HGALRVHGHSVHPREQGNDVFDKVFFAVGRRANTAGLGLDTVGVALGDKGEVVVDDRQTT
CCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHEEEEECCCCCEEECCCCCC
NVPNIHAIGDVGGKVGLTPVAIAAGRKLMDRLFGHQPDARMDYENVPSVVFSHPPLGNVG
CCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCEEECCCCCCCCC
LTEEQARARYNGAVRVYRSNFRPMLHALADAPQRSLFKLVCVGEEERVVGVHLLGESADE
CCHHHHHHHHCCEEEEEECCCHHHHHHHHCCCHHCEEEEEEECCCCCEEEEEEECCCHHH
MLQGFAVAVKMGATKRDFDETVAIHPTSSEEIVLMH
HHHHHEEEEEECCCCCCCCCEEEECCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8525054 [H]