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The map label for this gene is nadC [H]

Identifier: 21243410

GI number: 21243410

Start: 3138756

End: 3139619

Strand: Direct

Name: nadC [H]

Synonym: XAC2681

Alternate gene names: 21243410

Gene position: 3138756-3139619 (Clockwise)

Preceding gene: 21243409

Following gene: 21243411

Centisome position: 60.65

GC content: 66.9

Gene sequence:

>864_bases
GTGCCGGACGCGCCACCCGTCGAATCGATCGAGGCGGATGTGGCGCGCGCCCTGGCCGAAGACATGGGCAGCGGCGATGT
CACCGCCGCGCTGCTGCCCGACCAGGCCGACAGTGCCTACCTGCTGTGCAAGCAGGATGCGGTCATCGCCGGCCGTCCCT
GGTTCGATGCCACCCACCGCGCGCTCGACCCGCAGGTACGCATCGACTGGCAGGTGCACGAAGGCCAGCACGTCGGGGCC
GGCACGGTGCTTGCGCTGTTGCAGGGGCGCAGCCGTAGCCTGGTCAGTGCCGAACGCACCTCGCTCAATTTCATGCAGAC
GCTGTCTGCCACGGCGACCACCACCGCGGCGTATGTGGCTGCGGTGGCCGGGACGCAAGCGCGCATTCTGGACACACGCA
AGACGCTGCCGGGCCTGCGCGCCGCGCAGAAATACGCTGTGCGCTGCGGTGGTGGCGACAATCACCGCATCGGCCTGTTC
GACACGGTGATGCTCAAGGAGAACCACATCCGCGCCGCCGGCTCGTTGAGCGCTGCCGTGCATGCCGCACGCGCGCGGCA
ACCGCAGTTGCCGCTGGTGGTGGAAGTGGAAACGCTGGAGCAACTGCATGAAGCACTGCAGATTGGCTGCACGCGCATCC
TGATCGACGACTTCGACCAGCCCATGCGTCGAGAAGCGGTGCGTATCGTTGGCGCATTACCGCCAGAACGGCGCATTCCG
CTGGAAGTTTCCGGCAGCGTGGATCTGGCCGGCATTCGCGCGATTGCCGAAGACGGGGTGGACTGCATTTCGATTGGCGG
GCTCACCAAGCATGTGCAGGCAGTGGATCTGTCGCTCAAACTCGGCCCGCCGCCAGCGCGCTGA

Upstream 100 bases:

>100_bases
GCGTCGACGACGGCATTCCGGTGCTGCTGGCCGAAGAAGCCATCGCCACTGCACAAATCGCCGACTTCCCCGAGAAGTGA
GCCTGCCCGTGCGCACGAAC

Downstream 100 bases:

>100_bases
TTTCACGCGTGCGCGCAGCCGGCTCTGGCAGCCTGCTGCGATGTTTCCATGCAGGACCTGCAATGACCGTCAAACCTTGG
CCGTGGATCTGCTTCTTGCT

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MPDAPPVESIEADVARALAEDMGSGDVTAALLPDQADSAYLLCKQDAVIAGRPWFDATHRALDPQVRIDWQVHEGQHVGA
GTVLALLQGRSRSLVSAERTSLNFMQTLSATATTTAAYVAAVAGTQARILDTRKTLPGLRAAQKYAVRCGGGDNHRIGLF
DTVMLKENHIRAAGSLSAAVHAARARQPQLPLVVEVETLEQLHEALQIGCTRILIDDFDQPMRREAVRIVGALPPERRIP
LEVSGSVDLAGIRAIAEDGVDCISIGGLTKHVQAVDLSLKLGPPPAR

Sequences:

>Translated_287_residues
MPDAPPVESIEADVARALAEDMGSGDVTAALLPDQADSAYLLCKQDAVIAGRPWFDATHRALDPQVRIDWQVHEGQHVGA
GTVLALLQGRSRSLVSAERTSLNFMQTLSATATTTAAYVAAVAGTQARILDTRKTLPGLRAAQKYAVRCGGGDNHRIGLF
DTVMLKENHIRAAGSLSAAVHAARARQPQLPLVVEVETLEQLHEALQIGCTRILIDDFDQPMRREAVRIVGALPPERRIP
LEVSGSVDLAGIRAIAEDGVDCISIGGLTKHVQAVDLSLKLGPPPAR
>Mature_286_residues
PDAPPVESIEADVARALAEDMGSGDVTAALLPDQADSAYLLCKQDAVIAGRPWFDATHRALDPQVRIDWQVHEGQHVGAG
TVLALLQGRSRSLVSAERTSLNFMQTLSATATTTAAYVAAVAGTQARILDTRKTLPGLRAAQKYAVRCGGGDNHRIGLFD
TVMLKENHIRAAGSLSAAVHAARARQPQLPLVVEVETLEQLHEALQIGCTRILIDDFDQPMRREAVRIVGALPPERRIPL
EVSGSVDLAGIRAIAEDGVDCISIGGLTKHVQAVDLSLKLGPPPAR

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=280, Percent_Identity=33.5714285714286, Blast_Score=115, Evalue=7e-26,
Organism=Escherichia coli, GI1786299, Length=275, Percent_Identity=46.5454545454545, Blast_Score=212, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6321162, Length=280, Percent_Identity=32.1428571428571, Blast_Score=130, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 30585; Mature: 30454

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDAPPVESIEADVARALAEDMGSGDVTAALLPDQADSAYLLCKQDAVIAGRPWFDATHR
CCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEECCCEEECCCCCCHHHH
ALDPQVRIDWQVHEGQHVGAGTVLALLQGRSRSLVSAERTSLNFMQTLSATATTTAAYVA
CCCCCEEEEEEEECCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVAGTQARILDTRKTLPGLRAAQKYAVRCGGGDNHRIGLFDTVMLKENHIRAAGSLSAAV
HHCCCHHEEEHHHHHCCCHHHHHHHEEEECCCCCCEEEEEEEEEEECCCCCCCCHHHHHH
HAARARQPQLPLVVEVETLEQLHEALQIGCTRILIDDFDQPMRREAVRIVGALPPERRIP
HHHHCCCCCCCEEEEHHHHHHHHHHHHHCCCEEEEHHCCCHHHHHHHHHHHCCCCCCCCC
LEVSGSVDLAGIRAIAEDGVDCISIGGLTKHVQAVDLSLKLGPPPAR
EEECCCCCHHHHHHHHHCCCCEEEECCHHHEEEEEEEEEECCCCCCC
>Mature Secondary Structure 
PDAPPVESIEADVARALAEDMGSGDVTAALLPDQADSAYLLCKQDAVIAGRPWFDATHR
CCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEECCCEEECCCCCCHHHH
ALDPQVRIDWQVHEGQHVGAGTVLALLQGRSRSLVSAERTSLNFMQTLSATATTTAAYVA
CCCCCEEEEEEEECCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVAGTQARILDTRKTLPGLRAAQKYAVRCGGGDNHRIGLFDTVMLKENHIRAAGSLSAAV
HHCCCHHEEEHHHHHCCCHHHHHHHEEEECCCCCCEEEEEEEEEEECCCCCCCCHHHHHH
HAARARQPQLPLVVEVETLEQLHEALQIGCTRILIDDFDQPMRREAVRIVGALPPERRIP
HHHHCCCCCCCEEEEHHHHHHHHHHHHHCCCEEEEHHCCCHHHHHHHHHHHCCCCCCCCC
LEVSGSVDLAGIRAIAEDGVDCISIGGLTKHVQAVDLSLKLGPPPAR
EEECCCCCHHHHHHHHHCCCCEEEECCHHHEEEEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 2430961; 8419294 [H]