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The map label for this gene is dxs

Identifier: 21243297

GI number: 21243297

Start: 3023841

End: 3025757

Strand: Direct

Name: dxs

Synonym: XAC2565

Alternate gene names: 21243297

Gene position: 3023841-3025757 (Clockwise)

Preceding gene: 77748663

Following gene: 21243326

Centisome position: 58.43

GC content: 65.73

Gene sequence:

>1917_bases
ATGATCGACACCACCCGCTATCCGCGCCTGTCCCGCATCCAGACTCCCGACGATCTGCGCCGCTTCGACGAAGCCGAGCT
GACCGCGATCGCCGAAGAACTGCGCTCCTATCTGATCGAATCGGTGGGCAAGAGCGGCGGGCACTTCGCGGCCGGCCTGG
GCGTGATCGAGCTCACCGTCGCCCTGCACTACCTGTATCAGACGCCGGTCGATCAGCTGGTGTGGGACGTCGGGCATCAG
ACCTACCCGCACAAGATCCTCACCGGCCGCCGCGACCAGATCCACACGGTCAAGCAAAAGGACGGCGTGGCGCCGTTTCC
CAAGCGCGAGGAAAGCATCTACGACACCTTTGGCGTTGGCCATTCGTCGACCTCGATTTCGGCCGCGCTCGGCATGGCCA
TCGCCGCGCAGCGCAACGGCGACGACCGCAAGGTGGTGGCGGTGATCGGCGACGGCGCGATGACCGCCGGCATGGTCTAC
GAAGCGCTCAACCACGCCGGCGGCATGGACCCGGAACCGAATCTGCTGGTGATCCTCAACGACAACCGCATGTCGATCTC
CGAAGCAGTGGGCGGGCTGACCAAGATGCTGGGGCGCGCCAGCGGCAGTCGCACGCTCAATGCGATCCGCGAAGGCGGCA
AGAAGATCCTCGGCGACAAGAAGAACAACCCCACCGCGCGTTTCGTGCGGCGTTGGGAAGAACACTGGAAAGGCATGTTC
GTGCCATCCACGCTGTTCGAGGAAATGGGCTTCCATTACACCGGCCCGATCGATGGCCACGACCTGCCCAGCCTGGTCGG
CGCACTGAAGACTCTGCAGACGCTCAAGGGCCCGCAGCTGCTGCACGTCATCACCACCAAGGGCAAGGGCTACGAACTGG
CCGAAGGCGATCAGATCGGCTACCACGCCGTTGGCCCGTTCGATCCAAGCAAGGGCCTGGTCGCCAAGACCGGCGCCAAG
AAGCCGACCTACACCGACGTCTTCAGTGACTGGGTGTGCGACATGGCCGCCGCCGAACCCAAGCTGCTGGTGATCACGCC
GGCGATGCGCGAGGGCTCGGGCCTGGTGCGTTTCAGCAAGCAATATCCGCAGCGCTATTTCGACGTAGCCATTGCCGAGC
AGCACGCGGTCACGCTGGCCGCCGGCATGGCGACCCAGGGCGCCAAGCCGGTGGTCGCGATCTATTCCACGTTCCTGCAG
CGCGGCTACGACCAACTGGTGCACGACGTGGCGGTGCAGCAACTGGATGTGCTGTTCGCGATCGATCGCGGCGGCGTGGT
CGGCCCGGATGGCGCCACCCATGCCGGCAATCTGGATCTGAGCTTTTTGCGCTGCGTGCCGCACATGGTGGTGATGGCGC
CTGCCGATGAGGCCGAATGCCGTCAGATGCTGAGCACCGGCGTGCAATACCAGGGTCCGGCAGCGGTGCGCTACCCGCGT
GGCACCGGTCCCGGCGCAGCACTGGACGCCTCGCTTGCCACGCTGCCGATCGGCAAGGCGCAGCTGCGCCACAGCGGCAC
CCGCATCGCCCTGCTCGGCTTCGGCGCGACGGTGGATGCGGCCGAGGCGGTCGGGCGCGAACTGGGGCTGACGGTGGTGA
ACATGCGCTTCGTCAAGCCGCTCGACAAGGCGCTGCTGCTGGAGCTCGCAAAAACCCACGATGGCTTCGTCACGATCGAA
GACAACGTGGTTGCCGGCGGCGCAGGTTCTGGCGTGTCGGAACTGCTCAACGCCGAAGCCATCACCATGCCGCTGCTGCA
TCTGGGCCTGCCGGACAGCTTCCAGCATCACGCCAGCCGCGAAGACCTGCTTGCGGAAGCCGGCATCGACCAAGCCGGCA
TTCGCGCCGCCTTGCTTAAGCGCTGGCCGCAGCTGATGATCAGCCTGCCGCCTGCGTTGAACGCTGCGACAGGCTGA

Upstream 100 bases:

>100_bases
CGGTGCGCGCGTCCATCACTTCCCGCTGACAGCTGAACCGGTTTGCTTGCCGGGCCTTCGCATGGGGAGGACAATACGGC
TTCAGAAGATTGACACGATG

Downstream 100 bases:

>100_bases
TCGCGCCTGCCAGGCTCCTCGTGGCGCGTGCCGCCTTACATCGGCGGCGCCGCGCCAGTACGCGCAAAACCTTCCACCAG
GTGCACGATGCGCGCCTGCG

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 638; Mature: 638

Protein sequence:

>638_residues
MIDTTRYPRLSRIQTPDDLRRFDEAELTAIAEELRSYLIESVGKSGGHFAAGLGVIELTVALHYLYQTPVDQLVWDVGHQ
TYPHKILTGRRDQIHTVKQKDGVAPFPKREESIYDTFGVGHSSTSISAALGMAIAAQRNGDDRKVVAVIGDGAMTAGMVY
EALNHAGGMDPEPNLLVILNDNRMSISEAVGGLTKMLGRASGSRTLNAIREGGKKILGDKKNNPTARFVRRWEEHWKGMF
VPSTLFEEMGFHYTGPIDGHDLPSLVGALKTLQTLKGPQLLHVITTKGKGYELAEGDQIGYHAVGPFDPSKGLVAKTGAK
KPTYTDVFSDWVCDMAAAEPKLLVITPAMREGSGLVRFSKQYPQRYFDVAIAEQHAVTLAAGMATQGAKPVVAIYSTFLQ
RGYDQLVHDVAVQQLDVLFAIDRGGVVGPDGATHAGNLDLSFLRCVPHMVVMAPADEAECRQMLSTGVQYQGPAAVRYPR
GTGPGAALDASLATLPIGKAQLRHSGTRIALLGFGATVDAAEAVGRELGLTVVNMRFVKPLDKALLLELAKTHDGFVTIE
DNVVAGGAGSGVSELLNAEAITMPLLHLGLPDSFQHHASREDLLAEAGIDQAGIRAALLKRWPQLMISLPPALNAATG

Sequences:

>Translated_638_residues
MIDTTRYPRLSRIQTPDDLRRFDEAELTAIAEELRSYLIESVGKSGGHFAAGLGVIELTVALHYLYQTPVDQLVWDVGHQ
TYPHKILTGRRDQIHTVKQKDGVAPFPKREESIYDTFGVGHSSTSISAALGMAIAAQRNGDDRKVVAVIGDGAMTAGMVY
EALNHAGGMDPEPNLLVILNDNRMSISEAVGGLTKMLGRASGSRTLNAIREGGKKILGDKKNNPTARFVRRWEEHWKGMF
VPSTLFEEMGFHYTGPIDGHDLPSLVGALKTLQTLKGPQLLHVITTKGKGYELAEGDQIGYHAVGPFDPSKGLVAKTGAK
KPTYTDVFSDWVCDMAAAEPKLLVITPAMREGSGLVRFSKQYPQRYFDVAIAEQHAVTLAAGMATQGAKPVVAIYSTFLQ
RGYDQLVHDVAVQQLDVLFAIDRGGVVGPDGATHAGNLDLSFLRCVPHMVVMAPADEAECRQMLSTGVQYQGPAAVRYPR
GTGPGAALDASLATLPIGKAQLRHSGTRIALLGFGATVDAAEAVGRELGLTVVNMRFVKPLDKALLLELAKTHDGFVTIE
DNVVAGGAGSGVSELLNAEAITMPLLHLGLPDSFQHHASREDLLAEAGIDQAGIRAALLKRWPQLMISLPPALNAATG
>Mature_638_residues
MIDTTRYPRLSRIQTPDDLRRFDEAELTAIAEELRSYLIESVGKSGGHFAAGLGVIELTVALHYLYQTPVDQLVWDVGHQ
TYPHKILTGRRDQIHTVKQKDGVAPFPKREESIYDTFGVGHSSTSISAALGMAIAAQRNGDDRKVVAVIGDGAMTAGMVY
EALNHAGGMDPEPNLLVILNDNRMSISEAVGGLTKMLGRASGSRTLNAIREGGKKILGDKKNNPTARFVRRWEEHWKGMF
VPSTLFEEMGFHYTGPIDGHDLPSLVGALKTLQTLKGPQLLHVITTKGKGYELAEGDQIGYHAVGPFDPSKGLVAKTGAK
KPTYTDVFSDWVCDMAAAEPKLLVITPAMREGSGLVRFSKQYPQRYFDVAIAEQHAVTLAAGMATQGAKPVVAIYSTFLQ
RGYDQLVHDVAVQQLDVLFAIDRGGVVGPDGATHAGNLDLSFLRCVPHMVVMAPADEAECRQMLSTGVQYQGPAAVRYPR
GTGPGAALDASLATLPIGKAQLRHSGTRIALLGFGATVDAAEAVGRELGLTVVNMRFVKPLDKALLLELAKTHDGFVTIE
DNVVAGGAGSGVSELLNAEAITMPLLHLGLPDSFQHHASREDLLAEAGIDQAGIRAALLKRWPQLMISLPPALNAATG

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=555, Percent_Identity=23.963963963964, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI4507521, Length=555, Percent_Identity=23.963963963964, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI225637459, Length=275, Percent_Identity=27.6363636363636, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI225637463, Length=295, Percent_Identity=26.7796610169492, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI225637461, Length=275, Percent_Identity=27.6363636363636, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI133778974, Length=520, Percent_Identity=21.5384615384615, Blast_Score=78, Evalue=3e-14,
Organism=Escherichia coli, GI1786622, Length=622, Percent_Identity=56.1093247588424, Blast_Score=732, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=465, Percent_Identity=24.0860215053763, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24666278, Length=471, Percent_Identity=25.0530785562633, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI45551847, Length=237, Percent_Identity=28.2700421940928, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI45550715, Length=237, Percent_Identity=28.2700421940928, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24645119, Length=237, Percent_Identity=28.2700421940928, Blast_Score=83, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_XANAC (Q8PJG7)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_642879.1
- ProteinModelPortal:   Q8PJG7
- SMR:   Q8PJG7
- GeneID:   1156636
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC2565
- NMPDR:   fig|190486.1.peg.2523
- HOGENOM:   HBG571647
- OMA:   QRFPDRY
- ProtClustDB:   PRK05444
- BioCyc:   XAXO190486:XAC2565-MONOMER
- BRENDA:   2.2.1.7
- HAMAP:   MF_00315
- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 68480; Mature: 68480

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDTTRYPRLSRIQTPDDLRRFDEAELTAIAEELRSYLIESVGKSGGHFAAGLGVIELTV
CCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHH
ALHYLYQTPVDQLVWDVGHQTYPHKILTGRRDQIHTVKQKDGVAPFPKREESIYDTFGVG
HHHHHHHCCHHHHHHHHCCCCCCHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHCCC
HSSTSISAALGMAIAAQRNGDDRKVVAVIGDGAMTAGMVYEALNHAGGMDPEPNLLVILN
CCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCEEEEEC
DNRMSISEAVGGLTKMLGRASGSRTLNAIREGGKKILGDKKNNPTARFVRRWEEHWKGMF
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHCCCC
VPSTLFEEMGFHYTGPIDGHDLPSLVGALKTLQTLKGPQLLHVITTKGKGYELAEGDQIG
CHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCC
YHAVGPFDPSKGLVAKTGAKKPTYTDVFSDWVCDMAAAEPKLLVITPAMREGSGLVRFSK
EEEECCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHH
QYPQRYFDVAIAEQHAVTLAAGMATQGAKPVVAIYSTFLQRGYDQLVHDVAVQQLDVLFA
HCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEE
IDRGGVVGPDGATHAGNLDLSFLRCVPHMVVMAPADEAECRQMLSTGVQYQGPAAVRYPR
ECCCCEECCCCCCCCCCCCHHHHHHHHHEEEECCCCHHHHHHHHHCCCCCCCCCEEECCC
GTGPGAALDASLATLPIGKAQLRHSGTRIALLGFGATVDAAEAVGRELGLTVVNMRFVKP
CCCCCCHHCCCHHHCCCCHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCEEEEHHHHHH
LDKALLLELAKTHDGFVTIEDNVVAGGAGSGVSELLNAEAITMPLLHLGLPDSFQHHASR
HHHHHHHHHHHCCCCEEEEECCEEECCCCCCHHHHHCCHHHHHHHHHCCCCCHHHHHCCH
EDLLAEAGIDQAGIRAALLKRWPQLMISLPPALNAATG
HHHHHHCCCCHHHHHHHHHHHHHHHHEECCCCCCCCCC
>Mature Secondary Structure
MIDTTRYPRLSRIQTPDDLRRFDEAELTAIAEELRSYLIESVGKSGGHFAAGLGVIELTV
CCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHH
ALHYLYQTPVDQLVWDVGHQTYPHKILTGRRDQIHTVKQKDGVAPFPKREESIYDTFGVG
HHHHHHHCCHHHHHHHHCCCCCCHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHCCC
HSSTSISAALGMAIAAQRNGDDRKVVAVIGDGAMTAGMVYEALNHAGGMDPEPNLLVILN
CCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCEEEEEC
DNRMSISEAVGGLTKMLGRASGSRTLNAIREGGKKILGDKKNNPTARFVRRWEEHWKGMF
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHCCCC
VPSTLFEEMGFHYTGPIDGHDLPSLVGALKTLQTLKGPQLLHVITTKGKGYELAEGDQIG
CHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCC
YHAVGPFDPSKGLVAKTGAKKPTYTDVFSDWVCDMAAAEPKLLVITPAMREGSGLVRFSK
EEEECCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHH
QYPQRYFDVAIAEQHAVTLAAGMATQGAKPVVAIYSTFLQRGYDQLVHDVAVQQLDVLFA
HCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEE
IDRGGVVGPDGATHAGNLDLSFLRCVPHMVVMAPADEAECRQMLSTGVQYQGPAAVRYPR
ECCCCEECCCCCCCCCCCCHHHHHHHHHEEEECCCCHHHHHHHHHCCCCCCCCCEEECCC
GTGPGAALDASLATLPIGKAQLRHSGTRIALLGFGATVDAAEAVGRELGLTVVNMRFVKP
CCCCCCHHCCCHHHCCCCHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCEEEEHHHHHH
LDKALLLELAKTHDGFVTIEDNVVAGGAGSGVSELLNAEAITMPLLHLGLPDSFQHHASR
HHHHHHHHHHHCCCCEEEEECCEEECCCCCCHHHHHCCHHHHHHHHHCCCCCHHHHHCCH
EDLLAEAGIDQAGIRAALLKRWPQLMISLPPALNAATG
HHHHHHCCCCHHHHHHHHHHHHHHHHEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217