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The map label for this gene is ggt [H]

Identifier: 21243256

GI number: 21243256

Start: 2956404

End: 2958182

Strand: Reverse

Name: ggt [H]

Synonym: XAC2523

Alternate gene names: 21243256

Gene position: 2958182-2956404 (Counterclockwise)

Preceding gene: 21243257

Following gene: 21243255

Centisome position: 57.16

GC content: 67.28

Gene sequence:

>1779_bases
GTGAGCACTTTTTCCCGACGTTTTTCTTCGCGCGGCGTGTTGCTGCTGGCCTTTGTGCTGGCGCCAGCGGCCTGGTGCGC
CGATGCCGCCAAGCCGGCGACGGCCACCACCGCAACGGTTGCCGCGCATCCGCCCGGCGCGGCGATCGCCAGCGGCCATG
CGCTGGCCACCGATGCCGGCCTGCAGATCCTGCGCGAAGGCGGGAATGCATTCGATGCCGCGGTGGCGGTGTCGTCCACG
CTGGCGGTGGTCGAGCCGATCAGCTCGGGGCTGGGCGGCGGCGGTTTCTTCCTGTTGCACGACGCCAAGACCGGTAAGGA
CGTGATGCTGGACGCGCGCGAAACCGCGCCCGCGTCGGCCACAGAAGCGCAATTTCTCGACAAGAAGGGCGAGCTGGACC
GCGACCGCTCGGTCAACGGCCCGTGGTCGGCGGGCATCCCGGGCCTGCCCGCAGCGCTGGTGGAGTTGGCTGCCAAGCAC
GGCCGCCTGCCGCTCAAGCAGTCGCTGGCCCCATCGATTCGCATCGCCACGGAAGGTTTCCCGGTCTACGCGCGCATGGC
CAAGGGCTATGCCTCGCGACGCGAGGTGATGGAGCGTTACCCCGGTACGCGCGCGGTGTATCTGCGCGGCGGCAAGCCCA
TTGCCGAAGGCGAGATCTTCAAGCAGCCGGAGCTGGCGCATACGCTGCAGCTGCTCGGCGACAAGGGGTTCGACGGCTTC
TACAAGGGCGAAACGGCCAAGAAGCTGCTGGCCGGCGTGAAGCAGGCCGGCGGCCAGTGGAGCGCGGCCGAGCTGGCCGG
CTATCGTGTCAAGGAGCGCGCGCCGATCCAGTTCGACTACCGCGGCTGGAAGATCACCACTGCGCCGCCGCCGTCGTCCG
GTGGTATTGCGCTGGCGGCGATGCTGCAGATTCTGGAAGGCTGGGATTTGAACATGCTCGATGACGTGCATCGCACCCAT
CTGGTGGTGGAGTCGATGCGTCGCGCCTATCGGGATCGCACCTTCTTCCTGGGCGACCCGGACTTTGTGGACGTGCCGCA
GCGTGTGCTGACCAGCAAGGATTACGCGCAAGGCCTGCGGGCCACCATCAACCCGGACAAGGCCACCCCCAGCGATCTGC
TGTCGGGTAACCCCACGCCGCTGGAAGACGACGAGACCACGCACTTTTCCATCATCGATGGCGAAGGCAACCGCGTTGGC
GCCACCCAGACCGTGAACCTGCTGTACGGCTCGGGCCTGATTCCCAAGGGCACCGGCGTGCTGCTCAACAACGAGATGGA
CGACTTCGCGCTCAAGCCCGGCACCCCGAACGCCTTCGGCGTGATGGGCTACGCCGCCAACGCGCCCAAGCCGGGCAAGC
GCATGCTCAGCTCGATGACGCCCACCTTCATGGAATCGGCCGACAAGGCGATCGTGCTCGGCACCCCGGGCGGCAGCCGC
ATCATCACCATGGTGCTGCTGGGGATCCTGGGCTATGACGCCGGCCTGGATGCACAGGCGGTCAGCGCCTTGCCGCGTTA
TCACCACCAGTGGCTGCCGGACGTGATCGATGCCGAGACCGACGCGTTTTCGGCGCAGACCGCCAAGGGCCTGCAAGCGA
TGGGGCATGCGCTGGAATTGCCAGGCGACACCGCCGAAGGCGGCCGCGGCTCCAGCCATGTGTGGGGCAACCTGCAAACG
GTGGAGTGGGACAAGCGCAGCAACGTGCTCAGCGGCGGCAGCGACCCGCGCAACCCGGTGGGCAAGGCGCAAGTGCAGTT
GGACACTGCGGCACACTAA

Upstream 100 bases:

>100_bases
CGGATCCGGCCATTCCGGAAACCCATGATCAGTTGCTGGCCAAGCTGATGCAGTTGCAGCGCGATCACCCCGAATTGTAC
GAACAGGAGCCCCCCGCCCC

Downstream 100 bases:

>100_bases
GGTGTGAAGCCCATTGCGTTGACGCCCGGTAGCCGGCAACGCGGCCGGGCGTTGTCCGTTGTTTCGATCGATCGCCGCAG
ATGCAATGCGACCGTGGTTG

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 592; Mature: 591

Protein sequence:

>592_residues
MSTFSRRFSSRGVLLLAFVLAPAAWCADAAKPATATTATVAAHPPGAAIASGHALATDAGLQILREGGNAFDAAVAVSST
LAVVEPISSGLGGGGFFLLHDAKTGKDVMLDARETAPASATEAQFLDKKGELDRDRSVNGPWSAGIPGLPAALVELAAKH
GRLPLKQSLAPSIRIATEGFPVYARMAKGYASRREVMERYPGTRAVYLRGGKPIAEGEIFKQPELAHTLQLLGDKGFDGF
YKGETAKKLLAGVKQAGGQWSAAELAGYRVKERAPIQFDYRGWKITTAPPPSSGGIALAAMLQILEGWDLNMLDDVHRTH
LVVESMRRAYRDRTFFLGDPDFVDVPQRVLTSKDYAQGLRATINPDKATPSDLLSGNPTPLEDDETTHFSIIDGEGNRVG
ATQTVNLLYGSGLIPKGTGVLLNNEMDDFALKPGTPNAFGVMGYAANAPKPGKRMLSSMTPTFMESADKAIVLGTPGGSR
IITMVLLGILGYDAGLDAQAVSALPRYHHQWLPDVIDAETDAFSAQTAKGLQAMGHALELPGDTAEGGRGSSHVWGNLQT
VEWDKRSNVLSGGSDPRNPVGKAQVQLDTAAH

Sequences:

>Translated_592_residues
MSTFSRRFSSRGVLLLAFVLAPAAWCADAAKPATATTATVAAHPPGAAIASGHALATDAGLQILREGGNAFDAAVAVSST
LAVVEPISSGLGGGGFFLLHDAKTGKDVMLDARETAPASATEAQFLDKKGELDRDRSVNGPWSAGIPGLPAALVELAAKH
GRLPLKQSLAPSIRIATEGFPVYARMAKGYASRREVMERYPGTRAVYLRGGKPIAEGEIFKQPELAHTLQLLGDKGFDGF
YKGETAKKLLAGVKQAGGQWSAAELAGYRVKERAPIQFDYRGWKITTAPPPSSGGIALAAMLQILEGWDLNMLDDVHRTH
LVVESMRRAYRDRTFFLGDPDFVDVPQRVLTSKDYAQGLRATINPDKATPSDLLSGNPTPLEDDETTHFSIIDGEGNRVG
ATQTVNLLYGSGLIPKGTGVLLNNEMDDFALKPGTPNAFGVMGYAANAPKPGKRMLSSMTPTFMESADKAIVLGTPGGSR
IITMVLLGILGYDAGLDAQAVSALPRYHHQWLPDVIDAETDAFSAQTAKGLQAMGHALELPGDTAEGGRGSSHVWGNLQT
VEWDKRSNVLSGGSDPRNPVGKAQVQLDTAAH
>Mature_591_residues
STFSRRFSSRGVLLLAFVLAPAAWCADAAKPATATTATVAAHPPGAAIASGHALATDAGLQILREGGNAFDAAVAVSSTL
AVVEPISSGLGGGGFFLLHDAKTGKDVMLDARETAPASATEAQFLDKKGELDRDRSVNGPWSAGIPGLPAALVELAAKHG
RLPLKQSLAPSIRIATEGFPVYARMAKGYASRREVMERYPGTRAVYLRGGKPIAEGEIFKQPELAHTLQLLGDKGFDGFY
KGETAKKLLAGVKQAGGQWSAAELAGYRVKERAPIQFDYRGWKITTAPPPSSGGIALAAMLQILEGWDLNMLDDVHRTHL
VVESMRRAYRDRTFFLGDPDFVDVPQRVLTSKDYAQGLRATINPDKATPSDLLSGNPTPLEDDETTHFSIIDGEGNRVGA
TQTVNLLYGSGLIPKGTGVLLNNEMDDFALKPGTPNAFGVMGYAANAPKPGKRMLSSMTPTFMESADKAIVLGTPGGSRI
ITMVLLGILGYDAGLDAQAVSALPRYHHQWLPDVIDAETDAFSAQTAKGLQAMGHALELPGDTAEGGRGSSHVWGNLQTV
EWDKRSNVLSGGSDPRNPVGKAQVQLDTAAH

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=508, Percent_Identity=34.251968503937, Blast_Score=246, Evalue=4e-65,
Organism=Homo sapiens, GI73915090, Length=508, Percent_Identity=34.251968503937, Blast_Score=246, Evalue=4e-65,
Organism=Homo sapiens, GI73915096, Length=508, Percent_Identity=34.251968503937, Blast_Score=246, Evalue=4e-65,
Organism=Homo sapiens, GI73915094, Length=508, Percent_Identity=34.251968503937, Blast_Score=246, Evalue=4e-65,
Organism=Homo sapiens, GI113429324, Length=508, Percent_Identity=32.6771653543307, Blast_Score=222, Evalue=8e-58,
Organism=Homo sapiens, GI113429326, Length=513, Percent_Identity=31.9688109161793, Blast_Score=213, Evalue=4e-55,
Organism=Homo sapiens, GI109148539, Length=511, Percent_Identity=30.5283757338552, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI153266901, Length=508, Percent_Identity=27.755905511811, Blast_Score=152, Evalue=1e-36,
Organism=Homo sapiens, GI153266885, Length=507, Percent_Identity=27.4161735700197, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI153266907, Length=507, Percent_Identity=25.6410256410256, Blast_Score=129, Evalue=9e-30,
Organism=Homo sapiens, GI30581157, Length=195, Percent_Identity=36.4102564102564, Blast_Score=102, Evalue=2e-21,
Organism=Homo sapiens, GI30581155, Length=195, Percent_Identity=36.4102564102564, Blast_Score=102, Evalue=2e-21,
Organism=Homo sapiens, GI218505805, Length=191, Percent_Identity=34.0314136125654, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI310124095, Length=193, Percent_Identity=31.6062176165803, Blast_Score=73, Evalue=7e-13,
Organism=Escherichia coli, GI1789856, Length=538, Percent_Identity=40.1486988847584, Blast_Score=383, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI212646519, Length=490, Percent_Identity=34.4897959183673, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI72000294, Length=490, Percent_Identity=34.4897959183673, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI193208245, Length=511, Percent_Identity=32.8767123287671, Blast_Score=211, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI193208247, Length=511, Percent_Identity=32.8767123287671, Blast_Score=210, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17506189, Length=514, Percent_Identity=31.9066147859922, Blast_Score=205, Evalue=7e-53,
Organism=Caenorhabditis elegans, GI17542894, Length=503, Percent_Identity=29.8210735586481, Blast_Score=186, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17564448, Length=395, Percent_Identity=26.3291139240506, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323330, Length=538, Percent_Identity=27.6951672862454, Blast_Score=132, Evalue=1e-31,
Organism=Drosophila melanogaster, GI161077880, Length=535, Percent_Identity=30.8411214953271, Blast_Score=200, Evalue=3e-51,
Organism=Drosophila melanogaster, GI161077878, Length=535, Percent_Identity=30.8411214953271, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI45551474, Length=535, Percent_Identity=30.8411214953271, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24642670, Length=535, Percent_Identity=30.8411214953271, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24642666, Length=535, Percent_Identity=30.8411214953271, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI18859893, Length=511, Percent_Identity=31.3111545988258, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI161077496, Length=510, Percent_Identity=30.5882352941176, Blast_Score=190, Evalue=3e-48,
Organism=Drosophila melanogaster, GI18859741, Length=510, Percent_Identity=26.8627450980392, Blast_Score=142, Evalue=7e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 62644; Mature: 62512

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTFSRRFSSRGVLLLAFVLAPAAWCADAAKPATATTATVAAHPPGAAIASGHALATDAG
CCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHCCCCHHHHHH
LQILREGGNAFDAAVAVSSTLAVVEPISSGLGGGGFFLLHDAKTGKDVMLDARETAPASA
HHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEECCCCCCCCH
TEAQFLDKKGELDRDRSVNGPWSAGIPGLPAALVELAAKHGRLPLKQSLAPSIRIATEGF
HHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHCCCCEEEEECCC
PVYARMAKGYASRREVMERYPGTRAVYLRGGKPIAEGEIFKQPELAHTLQLLGDKGFDGF
CHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCC
YKGETAKKLLAGVKQAGGQWSAAELAGYRVKERAPIQFDYRGWKITTAPPPSSGGIALAA
CCCHHHHHHHHHHHHCCCCCCHHHHHCCEECCCCCEEEECCCEEEEECCCCCCCCHHHHH
MLQILEGWDLNMLDDVHRTHLVVESMRRAYRDRTFFLGDPDFVDVPQRVLTSKDYAQGLR
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHCCCHHHHCCC
ATINPDKATPSDLLSGNPTPLEDDETTHFSIIDGEGNRVGATQTVNLLYGSGLIPKGTGV
EECCCCCCCHHHHHCCCCCCCCCCCCCEEEEECCCCCEECCCEEEEEEECCCCCCCCCCE
LLNNEMDDFALKPGTPNAFGVMGYAANAPKPGKRMLSSMTPTFMESADKAIVLGTPGGSR
EECCCCCCCEECCCCCCCEEEEEECCCCCCHHHHHHHHCCHHHHHCCCCEEEEECCCCHH
IITMVLLGILGYDAGLDAQAVSALPRYHHQWLPDVIDAETDAFSAQTAKGLQAMGHALEL
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHCHHEEC
PGDTAEGGRGSSHVWGNLQTVEWDKRSNVLSGGSDPRNPVGKAQVQLDTAAH
CCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCC
>Mature Secondary Structure 
STFSRRFSSRGVLLLAFVLAPAAWCADAAKPATATTATVAAHPPGAAIASGHALATDAG
CHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHCCCCHHHHHH
LQILREGGNAFDAAVAVSSTLAVVEPISSGLGGGGFFLLHDAKTGKDVMLDARETAPASA
HHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEECCCCCCCCH
TEAQFLDKKGELDRDRSVNGPWSAGIPGLPAALVELAAKHGRLPLKQSLAPSIRIATEGF
HHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHCCCCEEEEECCC
PVYARMAKGYASRREVMERYPGTRAVYLRGGKPIAEGEIFKQPELAHTLQLLGDKGFDGF
CHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCC
YKGETAKKLLAGVKQAGGQWSAAELAGYRVKERAPIQFDYRGWKITTAPPPSSGGIALAA
CCCHHHHHHHHHHHHCCCCCCHHHHHCCEECCCCCEEEECCCEEEEECCCCCCCCHHHHH
MLQILEGWDLNMLDDVHRTHLVVESMRRAYRDRTFFLGDPDFVDVPQRVLTSKDYAQGLR
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHCCCHHHHCCC
ATINPDKATPSDLLSGNPTPLEDDETTHFSIIDGEGNRVGATQTVNLLYGSGLIPKGTGV
EECCCCCCCHHHHHCCCCCCCCCCCCCEEEEECCCCCEECCCEEEEEEECCCCCCCCCCE
LLNNEMDDFALKPGTPNAFGVMGYAANAPKPGKRMLSSMTPTFMESADKAIVLGTPGGSR
EECCCCCCCEECCCCCCCEEEEEECCCCCCHHHHHHHHCCHHHHHCCCCEEEEECCCCHH
IITMVLLGILGYDAGLDAQAVSALPRYHHQWLPDVIDAETDAFSAQTAKGLQAMGHALEL
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHCHHEEC
PGDTAEGGRGSSHVWGNLQTVEWDKRSNVLSGGSDPRNPVGKAQVQLDTAAH
CCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2570061; 9278503; 8041620; 1360205 [H]