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The map label for this gene is acrA [H]

Identifier: 21243231

GI number: 21243231

Start: 2918018

End: 2919325

Strand: Direct

Name: acrA [H]

Synonym: XAC2498

Alternate gene names: 21243231

Gene position: 2918018-2919325 (Clockwise)

Preceding gene: 21243230

Following gene: 21243232

Centisome position: 56.38

GC content: 70.49

Gene sequence:

>1308_bases
ATGATTGCCCCGCTCCGCACATTCGGCCTGGCCTGTGCCATCACCGTGGCGCTGGCTGCCTGCAGCAAGCCCGACCAACA
GCAGGCACCGCCGCCGCCGGAAGTGTCGGTGCTGGAGATGAAGCCGCAGACGCTGCCGCTGGAACGCGACCTGGTCGGCC
GCCTGTCGGCGTACCGTTCGGCGGACGTGCGCGCGCGCGTGGACGGCGTGGTGCTCAAGCGCCTGTACACCGAAGGCGCC
AACGTCACCGAAGGCCAGCCGCTGTTCCAGATCGACCCGTCGCAGCTGAAGGCCACGCTGCTGCAGGCGCAGGGCCAGCT
GGCCGCCGCCGAAGCGACCTATACCAACGCCAAGATCGCCGCGACGCGTGCGCGCAGCCTGGCGCCGCAGCAGTACGTCT
CGCGCGCCGACATCGACACCGCCGAAGCCAACGAGCGTTCGTCCGGTGCCAACGTGCAACAGGCGCGCGGCGCGGTCGAG
GCCGCGCGCATCCAGCTCGGCTTCGCCACCGTGACCTCGCCGATCACCGGCCGCGCCGGCATTCAGCGCGTGACCGAAGG
CGCACTGGTTGGTGCCGGCGAAGCCACCCTGCTGACCACCGTCGACCAGATCGACCCGCTGTATGTGAACTTCGCCATGA
GCAGCGAAGAACTGGCCGCCCTGCGTCAGGCGCAGAGCAGCGGCAACGTGCAGCTCAGCGGCGACGGCAAGTCCTCCATC
AACGTGGAGCTGGGCAACGGCACGCAGTACCAGCACCCCGGCACGCTGGACGTGTCTGCGGTGACGGTGGACCCGAGCAC
CGGTGCGGTGTCGCTGCGCGCCACCCTGCCCAACCCCGAACAATCGCTGCTGCCGGGCGCGTTCGTGACCTTCAAGGCCA
GCCTGGGCCAGCGCAACAATGCCTACCTGCTGCCGCAGCAGGCGGTGCAGCGCGATGCCACCGGACCCTATGCCCTGGTG
CTGGGCAAGGACGGCAAGGTGGTCCGCAAGAACCTCACCGTCGACGGCCAGCAGAAGGGCCAGTGGATCGTCACCGGCGG
CATGACCCCGGGCGACCAGGTCATCGTCGATGGCGTGCAAAAGGCCAAGGAAGGGCAGCCGGCCAAGGGCGTGCCGTGGG
ATCCGAACAAGCCGGCACAAGGCGGCCAGCCCGGCGCAGCGGGCGCGGCGCCCGCCGCGGCACAGGGCGGCGACGCGCAA
GCTGCACCGTCGGCCGACAAGGCCGATGCAGCGGCGCCGGCCGCCCAGCAACAGCCCAAGCAGGATGCGGCCGCGCAGCC
GGCCGACTCCCAGTCCAAGCAGCAGTGA

Upstream 100 bases:

>100_bases
CCGTGGACACCTTCCTGCGTGCGTTTGCTCCGGCTCCTGCCGCGCCGACGCCGCCACCGCCTTCTCTTCTCACTTCAAGA
CCCTAACGGAGTTCCTCCTG

Downstream 100 bases:

>100_bases
CGGAACCCGGACATGCCTAAGTTTTTTATCGAACACCCGGTCTTTGCGTGGGTGGTGGCGATCCTGATCTCGCTTGCGGG
CGTGATCTCGATCCTGAATC

Product: multidrug resistance protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MIAPLRTFGLACAITVALAACSKPDQQQAPPPPEVSVLEMKPQTLPLERDLVGRLSAYRSADVRARVDGVVLKRLYTEGA
NVTEGQPLFQIDPSQLKATLLQAQGQLAAAEATYTNAKIAATRARSLAPQQYVSRADIDTAEANERSSGANVQQARGAVE
AARIQLGFATVTSPITGRAGIQRVTEGALVGAGEATLLTTVDQIDPLYVNFAMSSEELAALRQAQSSGNVQLSGDGKSSI
NVELGNGTQYQHPGTLDVSAVTVDPSTGAVSLRATLPNPEQSLLPGAFVTFKASLGQRNNAYLLPQQAVQRDATGPYALV
LGKDGKVVRKNLTVDGQQKGQWIVTGGMTPGDQVIVDGVQKAKEGQPAKGVPWDPNKPAQGGQPGAAGAAPAAAQGGDAQ
AAPSADKADAAAPAAQQQPKQDAAAQPADSQSKQQ

Sequences:

>Translated_435_residues
MIAPLRTFGLACAITVALAACSKPDQQQAPPPPEVSVLEMKPQTLPLERDLVGRLSAYRSADVRARVDGVVLKRLYTEGA
NVTEGQPLFQIDPSQLKATLLQAQGQLAAAEATYTNAKIAATRARSLAPQQYVSRADIDTAEANERSSGANVQQARGAVE
AARIQLGFATVTSPITGRAGIQRVTEGALVGAGEATLLTTVDQIDPLYVNFAMSSEELAALRQAQSSGNVQLSGDGKSSI
NVELGNGTQYQHPGTLDVSAVTVDPSTGAVSLRATLPNPEQSLLPGAFVTFKASLGQRNNAYLLPQQAVQRDATGPYALV
LGKDGKVVRKNLTVDGQQKGQWIVTGGMTPGDQVIVDGVQKAKEGQPAKGVPWDPNKPAQGGQPGAAGAAPAAAQGGDAQ
AAPSADKADAAAPAAQQQPKQDAAAQPADSQSKQQ
>Mature_435_residues
MIAPLRTFGLACAITVALAACSKPDQQQAPPPPEVSVLEMKPQTLPLERDLVGRLSAYRSADVRARVDGVVLKRLYTEGA
NVTEGQPLFQIDPSQLKATLLQAQGQLAAAEATYTNAKIAATRARSLAPQQYVSRADIDTAEANERSSGANVQQARGAVE
AARIQLGFATVTSPITGRAGIQRVTEGALVGAGEATLLTTVDQIDPLYVNFAMSSEELAALRQAQSSGNVQLSGDGKSSI
NVELGNGTQYQHPGTLDVSAVTVDPSTGAVSLRATLPNPEQSLLPGAFVTFKASLGQRNNAYLLPQQAVQRDATGPYALV
LGKDGKVVRKNLTVDGQQKGQWIVTGGMTPGDQVIVDGVQKAKEGQPAKGVPWDPNKPAQGGQPGAAGAAPAAAQGGDAQ
AAPSADKADAAAPAAQQQPKQDAAAQPADSQSKQQ

Specific function: Part of a multidrug resistance efflux system that confers resistance to compounds such as rhodamine 6G, erythromycin, doxorubicin, ethidium bromide, TPP, SDS, deoxycholate, crystal violet and benzalkonium [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789929, Length=373, Percent_Identity=39.9463806970509, Blast_Score=249, Evalue=3e-67,
Organism=Escherichia coli, GI1789665, Length=380, Percent_Identity=39.2105263157895, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI1786668, Length=380, Percent_Identity=40.2631578947368, Blast_Score=240, Evalue=1e-64,
Organism=Escherichia coli, GI87082036, Length=315, Percent_Identity=31.1111111111111, Blast_Score=155, Evalue=6e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 44960; Mature: 44960

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAPLRTFGLACAITVALAACSKPDQQQAPPPPEVSVLEMKPQTLPLERDLVGRLSAYRS
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHC
ADVRARVDGVVLKRLYTEGANVTEGQPLFQIDPSQLKATLLQAQGQLAAAEATYTNAKIA
CCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECHHHHHHHHHHHCCCEEEEHEECCCCEEE
ATRARSLAPQQYVSRADIDTAEANERSSGANVQQARGAVEAARIQLGFATVTSPITGRAG
HHHHHHCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHEEHEEEEEHHHHCCCCCCHHH
IQRVTEGALVGAGEATLLTTVDQIDPLYVNFAMSSEELAALRQAQSSGNVQLSGDGKSSI
HHHHHCCCEECCCCCEEEEEHHHCCCEEEEEECCHHHHHHHHHHHCCCCEEEECCCCCEE
NVELGNGTQYQHPGTLDVSAVTVDPSTGAVSLRATLPNPEQSLLPGAFVTFKASLGQRNN
EEEECCCCCCCCCCCEEEEEEEECCCCCEEEEEEECCCCHHHHCCCEEEEEEECCCCCCC
AYLLPQQAVQRDATGPYALVLGKDGKVVRKNLTVDGQQKGQWIVTGGMTPGDQVIVDGVQ
EEECCHHHHHCCCCCCEEEEECCCCCEEEEECCCCCCCCCCEEEECCCCCCCHHHHHHHH
KAKEGQPAKGVPWDPNKPAQGGQPGAAGAAPAAAQGGDAQAAPSADKADAAAPAAQQQPK
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCHHCCCC
QDAAAQPADSQSKQQ
HHHCCCCCCCCCCCC
>Mature Secondary Structure
MIAPLRTFGLACAITVALAACSKPDQQQAPPPPEVSVLEMKPQTLPLERDLVGRLSAYRS
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHC
ADVRARVDGVVLKRLYTEGANVTEGQPLFQIDPSQLKATLLQAQGQLAAAEATYTNAKIA
CCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECHHHHHHHHHHHCCCEEEEHEECCCCEEE
ATRARSLAPQQYVSRADIDTAEANERSSGANVQQARGAVEAARIQLGFATVTSPITGRAG
HHHHHHCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHEEHEEEEEHHHHCCCCCCHHH
IQRVTEGALVGAGEATLLTTVDQIDPLYVNFAMSSEELAALRQAQSSGNVQLSGDGKSSI
HHHHHCCCEECCCCCEEEEEHHHCCCEEEEEECCHHHHHHHHHHHCCCCEEEECCCCCEE
NVELGNGTQYQHPGTLDVSAVTVDPSTGAVSLRATLPNPEQSLLPGAFVTFKASLGQRNN
EEEECCCCCCCCCCCEEEEEEEECCCCCEEEEEEECCCCHHHHCCCEEEEEEECCCCCCC
AYLLPQQAVQRDATGPYALVLGKDGKVVRKNLTVDGQQKGQWIVTGGMTPGDQVIVDGVQ
EEECCHHHHHCCCCCCEEEEECCCCCEEEEECCCCCCCCCCEEEECCCCCCCHHHHHHHH
KAKEGQPAKGVPWDPNKPAQGGQPGAAGAAPAAAQGGDAQAAPSADKADAAAPAAQQQPK
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCHHCCCC
QDAAAQPADSQSKQQ
HHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]