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The map label for this gene is htpX

Identifier: 21243133

GI number: 21243133

Start: 2795409

End: 2796287

Strand: Reverse

Name: htpX

Synonym: XAC2399

Alternate gene names: 21243133

Gene position: 2796287-2795409 (Counterclockwise)

Preceding gene: 21243137

Following gene: 21243129

Centisome position: 54.03

GC content: 63.82

Gene sequence:

>879_bases
ATGTTCAACCGCATTTTCCTGTTCCTGCTGACCAATCTTGCGGTGCTGATGCTCGCCGGCATCGTCATGTCGTTGCTTGG
CGTCAATCCCGCGCAGATGAGTGGCCTGTTGGTGATGGCCGCCATCTTCGGTTTCGGCGGCTCGTTCATTTCCTTGCTGC
TGTCCAAGTTCATGGCCAAGCGCAGCACCGGTGCGCAGGTCATCACCGAGCCGCGCACGCCGACCGAACGCTGGTTGCTG
GAGACCGTGCGCCGTCAGGCCCAGGCTGCCGGTATCGGCATGCCGGAAGTAGCGGTCTACGAGGGACCGGAAATCAACGC
GTTCGCCACCGGCGCCAACCGCAACAACGCCCTTGTGGCGGTGTCCACCGGCCTGCTGCAGAACATGGACCAGGATGAAG
CCGAAGCGGTGCTTGGCCACGAGATCGCCCACGTTGCCAATGGCGACATGGTCACCATGGCACTGCTGCAGGGCGTACTC
AATACCTTCGTGATCGTGCTCGCCCGCGTGGTCGGCGGCATCATCGACAGCACCTTGTCGGGCAACCGCGAAGGCGGTCG
TGGCTTTGCGTACTACATCATCGTGTTTGCGTTGGAGATGGTGTTCGGCCTGTTCGCGACCATGATTGCGATGTGGTTCT
CGCGACGCCGCGAATTCCGCGCCGATGCCGGTGGCGCGCAGCTGGCCGGCCGCAGCAAGATGATCGCTGCACTGGAGCGG
CTGTCGCTCAACCATGGCCAGAACACCTTGCCCTCGCAAGTGCAGGCGTTCGGCATCTCCGGCGGGGTGGGCGAGGGCTT
GCGCCGCCTGTTCCTGAGCCATCCGCCGCTCACAGAACGCATCGCTGCGCTGCGCGCGGCCAGCGGTAGCGCCAGGTAA

Upstream 100 bases:

>100_bases
CATGGGCAGCTGAATCGTCGGTCAGGTGCTTGCTTGATTTCAAGCCGCAACACCCGCAGATCCGCAACAGTTCACCCCGC
ATCCGTGGAGCCATCGCGCC

Downstream 100 bases:

>100_bases
GTTGCCGAGTGTATGGCTGCCTGGCAGGCAACAAAAAACCCGCGCAATGCGGGTTTTTTGTTGCCCAGCGATGGTGCGAA
CGAGCGGGCGCTGCAGGCTT

Product: heat shock protein HtpX

Products: NA

Alternate protein names: Heat shock protein HtpX

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MFNRIFLFLLTNLAVLMLAGIVMSLLGVNPAQMSGLLVMAAIFGFGGSFISLLLSKFMAKRSTGAQVITEPRTPTERWLL
ETVRRQAQAAGIGMPEVAVYEGPEINAFATGANRNNALVAVSTGLLQNMDQDEAEAVLGHEIAHVANGDMVTMALLQGVL
NTFVIVLARVVGGIIDSTLSGNREGGRGFAYYIIVFALEMVFGLFATMIAMWFSRRREFRADAGGAQLAGRSKMIAALER
LSLNHGQNTLPSQVQAFGISGGVGEGLRRLFLSHPPLTERIAALRAASGSAR

Sequences:

>Translated_292_residues
MFNRIFLFLLTNLAVLMLAGIVMSLLGVNPAQMSGLLVMAAIFGFGGSFISLLLSKFMAKRSTGAQVITEPRTPTERWLL
ETVRRQAQAAGIGMPEVAVYEGPEINAFATGANRNNALVAVSTGLLQNMDQDEAEAVLGHEIAHVANGDMVTMALLQGVL
NTFVIVLARVVGGIIDSTLSGNREGGRGFAYYIIVFALEMVFGLFATMIAMWFSRRREFRADAGGAQLAGRSKMIAALER
LSLNHGQNTLPSQVQAFGISGGVGEGLRRLFLSHPPLTERIAALRAASGSAR
>Mature_292_residues
MFNRIFLFLLTNLAVLMLAGIVMSLLGVNPAQMSGLLVMAAIFGFGGSFISLLLSKFMAKRSTGAQVITEPRTPTERWLL
ETVRRQAQAAGIGMPEVAVYEGPEINAFATGANRNNALVAVSTGLLQNMDQDEAEAVLGHEIAHVANGDMVTMALLQGVL
NTFVIVLARVVGGIIDSTLSGNREGGRGFAYYIIVFALEMVFGLFATMIAMWFSRRREFRADAGGAQLAGRSKMIAALER
LSLNHGQNTLPSQVQAFGISGGVGEGLRRLFLSHPPLTERIAALRAASGSAR

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family

Homologues:

Organism=Escherichia coli, GI1788133, Length=287, Percent_Identity=55.4006968641115, Blast_Score=318, Evalue=2e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HTPX_XANAC (Q8PJX8)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_642715.1
- ProteinModelPortal:   Q8PJX8
- SMR:   Q8PJX8
- GeneID:   1156470
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC2399
- NMPDR:   fig|190486.1.peg.2359
- HOGENOM:   HBG739460
- OMA:   KMISALE
- ProtClustDB:   PRK05457
- BioCyc:   XAXO190486:XAC2399-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_00188
- InterPro:   IPR022919
- InterPro:   IPR001915

Pfam domain/function: PF01435 Peptidase_M48

EC number: 3.4.24.-

Molecular weight: Translated: 31215; Mature: 31215

Theoretical pI: Translated: 10.40; Mature: 10.40

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: ACT_SITE 141-141

Signals:

None

Transmembrane regions:

HASH(0x10452998)-; HASH(0x10475d14)-; HASH(0x10b70a38)-; HASH(0xf4c93a0)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNRIFLFLLTNLAVLMLAGIVMSLLGVNPAQMSGLLVMAAIFGFGGSFISLLLSKFMAK
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
RSTGAQVITEPRTPTERWLLETVRRQAQAAGIGMPEVAVYEGPEINAFATGANRNNALVA
CCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCEEEECCCCCCEEEE
VSTGLLQNMDQDEAEAVLGHEIAHVANGDMVTMALLQGVLNTFVIVLARVVGGIIDSTLS
EEHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GNREGGRGFAYYIIVFALEMVFGLFATMIAMWFSRRREFRADAGGAQLAGRSKMIAALER
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHH
LSLNHGQNTLPSQVQAFGISGGVGEGLRRLFLSHPPLTERIAALRAASGSAR
HHHCCCCCCCHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCH
>Mature Secondary Structure
MFNRIFLFLLTNLAVLMLAGIVMSLLGVNPAQMSGLLVMAAIFGFGGSFISLLLSKFMAK
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
RSTGAQVITEPRTPTERWLLETVRRQAQAAGIGMPEVAVYEGPEINAFATGANRNNALVA
CCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCEEEECCCCCCEEEE
VSTGLLQNMDQDEAEAVLGHEIAHVANGDMVTMALLQGVLNTFVIVLARVVGGIIDSTLS
EEHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GNREGGRGFAYYIIVFALEMVFGLFATMIAMWFSRRREFRADAGGAQLAGRSKMIAALER
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHH
LSLNHGQNTLPSQVQAFGISGGVGEGLRRLFLSHPPLTERIAALRAASGSAR
HHHCCCCCCCHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12024217