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The map label for this gene is cysS

Identifier: 21243088

GI number: 21243088

Start: 2749400

End: 2750830

Strand: Direct

Name: cysS

Synonym: XAC2354

Alternate gene names: 21243088

Gene position: 2749400-2750830 (Clockwise)

Preceding gene: 21243074

Following gene: 21243089

Centisome position: 53.12

GC content: 65.13

Gene sequence:

>1431_bases
ATGCCGATGAGCCTGCGCCTGCACAACAACCTGACGCGGCGGGTCGAGCCGTTCGCGCCGCTCGATCCGTCCAGCCCCAC
CCTGTATGTCTGCGGTCCCACCGTCTACAACTACGCGCATATCGGCAACGCCCGCGGCCCGGTGGTCTTCGATGTGCTTG
CCGCATTGCTGCGGCGACGCTACGGCGCGCTGCGCTACGCGCGCAACATCACCGACGTGGACGACAAGATCAACGCCGCC
GCGCAGGCGCAGGGTGTGCCGATTTCGACGATCACCGACCGCTTCGCGGCGATCTACCGGCAGGACATGGCGGCGCTTGG
CGTGGTTCCACCGGACATCGAACCGGAGGCCACCGCGCATATCCCGCAGATCGTGGCGATGATCGAGCAGCTGATCGCCA
ATGGGCATGCCTACGCCGCAGAAGGCCACGTGCTGTTTTCGGTTTCCAGCTTCGATGGCTACGGCAAGCTCTCGCGGCGC
GACCCGGACGAAATGCTGGCCGGCGCGCGCGTGGACGTGGCGCCGTACAAGCGCGACCCCGGCGACTTCGTGCTGTGGAA
ACCCTCCAGCGCCGACCTGCCCGGCTGGGAATCGCCCTGGGGCCGCGGCCGCCCGGGTTGGCATATCGAATGCTCGGCGA
TGGCTGCGGCGCATCTGGGCCCCACCATCGACATTCATGCCGGCGGCGTGGACCTGCAGTTTCCGCATCACGAAAACGAG
ATTGCGCAGAGCGAGTGCGCGCATGGCGGCGCCACCTTTGCGCGGTTCTGGCTGCACAACGGCATGCTCAATTTCAGCGG
CGCGAAGATGAGCAAGTCGCTGGGCAATATCGAAACCGTGCACGAGCTCATCGCCAGGCATCCGCCCGAAGCGCTGCGCT
ATGCGCTGTTGAGCGCGCATTACCGTCAGCCGCTGGATTGGTCGGATGGGCTGATCGAGCAGGCGAAAAACACGCTGGAC
CGGTTGTATGGCACGTTGCGGGATCTGGCTGCGCTGCAAGCCGATAGCGGCAACGATGTCGCGCCATCGAGGACGATTCC
CGTCGAGGTGGAGTCCGCGCTCGAAGACGATCTCAACACGCCGCTGGCCTTGTCGGTTATCGCCAGCATCGCCTCGGAAG
CGCGCGCGCTGCGCAATGAGTTGGTTCATGGCGGCGAACCCTCGACGCGTATGAGCGACCTTCATGCGGTGCACGCGAAG
TTGCTGGGCGCCGGCTTGGCCTTGGGACTGCTGCAGCAAGATCCGGCCGCCTGGTTCTCGCGCGGCACTGATGCCGGCGA
CGATGCACGCATCACCGCCTTGGTCGAAGAACGCAGCACGGCAAAAAAAGCCAAGGATTTTGCCCGCGCCGATGCCATCC
GCAAGCAACTGGCAGAAGAAGGCATCGTGCTCGAAGACACCCCGCAAGGCGTGCGCTGGAAACGCGCTTGA

Upstream 100 bases:

>100_bases
GCCGCGTGGGCTGAACGCAACCCATCCGGTCGCCATTGTCAGGCTGGCGATTCGCCATCGCGCCACAACGGGCTAGAATC
GCGCGATTGCCCTTTTTCGG

Downstream 100 bases:

>100_bases
CCTCCTCCCTTCTCCCGCCGGGAGAAGGTGCCCCGCAGGGGCGGATGAGGGTACGGGCGAAGCCACATGGGAGAAGTTAA
TGCACGTGGCTCCGCCCGTA

Product: cysteinyl-tRNA synthetase

Products: NA

Alternate protein names: Cysteine--tRNA ligase; CysRS

Number of amino acids: Translated: 476; Mature: 475

Protein sequence:

>476_residues
MPMSLRLHNNLTRRVEPFAPLDPSSPTLYVCGPTVYNYAHIGNARGPVVFDVLAALLRRRYGALRYARNITDVDDKINAA
AQAQGVPISTITDRFAAIYRQDMAALGVVPPDIEPEATAHIPQIVAMIEQLIANGHAYAAEGHVLFSVSSFDGYGKLSRR
DPDEMLAGARVDVAPYKRDPGDFVLWKPSSADLPGWESPWGRGRPGWHIECSAMAAAHLGPTIDIHAGGVDLQFPHHENE
IAQSECAHGGATFARFWLHNGMLNFSGAKMSKSLGNIETVHELIARHPPEALRYALLSAHYRQPLDWSDGLIEQAKNTLD
RLYGTLRDLAALQADSGNDVAPSRTIPVEVESALEDDLNTPLALSVIASIASEARALRNELVHGGEPSTRMSDLHAVHAK
LLGAGLALGLLQQDPAAWFSRGTDAGDDARITALVEERSTAKKAKDFARADAIRKQLAEEGIVLEDTPQGVRWKRA

Sequences:

>Translated_476_residues
MPMSLRLHNNLTRRVEPFAPLDPSSPTLYVCGPTVYNYAHIGNARGPVVFDVLAALLRRRYGALRYARNITDVDDKINAA
AQAQGVPISTITDRFAAIYRQDMAALGVVPPDIEPEATAHIPQIVAMIEQLIANGHAYAAEGHVLFSVSSFDGYGKLSRR
DPDEMLAGARVDVAPYKRDPGDFVLWKPSSADLPGWESPWGRGRPGWHIECSAMAAAHLGPTIDIHAGGVDLQFPHHENE
IAQSECAHGGATFARFWLHNGMLNFSGAKMSKSLGNIETVHELIARHPPEALRYALLSAHYRQPLDWSDGLIEQAKNTLD
RLYGTLRDLAALQADSGNDVAPSRTIPVEVESALEDDLNTPLALSVIASIASEARALRNELVHGGEPSTRMSDLHAVHAK
LLGAGLALGLLQQDPAAWFSRGTDAGDDARITALVEERSTAKKAKDFARADAIRKQLAEEGIVLEDTPQGVRWKRA
>Mature_475_residues
PMSLRLHNNLTRRVEPFAPLDPSSPTLYVCGPTVYNYAHIGNARGPVVFDVLAALLRRRYGALRYARNITDVDDKINAAA
QAQGVPISTITDRFAAIYRQDMAALGVVPPDIEPEATAHIPQIVAMIEQLIANGHAYAAEGHVLFSVSSFDGYGKLSRRD
PDEMLAGARVDVAPYKRDPGDFVLWKPSSADLPGWESPWGRGRPGWHIECSAMAAAHLGPTIDIHAGGVDLQFPHHENEI
AQSECAHGGATFARFWLHNGMLNFSGAKMSKSLGNIETVHELIARHPPEALRYALLSAHYRQPLDWSDGLIEQAKNTLDR
LYGTLRDLAALQADSGNDVAPSRTIPVEVESALEDDLNTPLALSVIASIASEARALRNELVHGGEPSTRMSDLHAVHAKL
LGAGLALGLLQQDPAAWFSRGTDAGDDARITALVEERSTAKKAKDFARADAIRKQLAEEGIVLEDTPQGVRWKRA

Specific function: Unknown

COG id: COG0215

COG function: function code J; Cysteinyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI13375695, Length=380, Percent_Identity=38.6842105263158, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI10835051, Length=247, Percent_Identity=39.2712550607287, Blast_Score=199, Evalue=5e-51,
Organism=Homo sapiens, GI21269877, Length=247, Percent_Identity=39.2712550607287, Blast_Score=199, Evalue=6e-51,
Organism=Homo sapiens, GI62240992, Length=247, Percent_Identity=39.2712550607287, Blast_Score=199, Evalue=7e-51,
Organism=Homo sapiens, GI303304987, Length=247, Percent_Identity=39.2712550607287, Blast_Score=198, Evalue=8e-51,
Organism=Escherichia coli, GI1786737, Length=474, Percent_Identity=47.2573839662447, Blast_Score=399, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI17509797, Length=249, Percent_Identity=38.5542168674699, Blast_Score=184, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17509795, Length=249, Percent_Identity=38.5542168674699, Blast_Score=184, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6324082, Length=306, Percent_Identity=35.6209150326797, Blast_Score=210, Evalue=3e-55,
Organism=Drosophila melanogaster, GI19922218, Length=499, Percent_Identity=35.0701402805611, Blast_Score=270, Evalue=1e-72,
Organism=Drosophila melanogaster, GI19922364, Length=303, Percent_Identity=38.2838283828383, Blast_Score=217, Evalue=1e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYC_XANAC (Q8PK23)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_642670.1
- ProteinModelPortal:   Q8PK23
- SMR:   Q8PK23
- GeneID:   1156425
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC2354
- NMPDR:   fig|190486.1.peg.2314
- HOGENOM:   HBG327651
- OMA:   PEEMLAG
- ProtClustDB:   PRK00260
- BioCyc:   XAXO190486:XAC2354-MONOMER
- BRENDA:   6.1.1.16
- GO:   GO:0005737
- HAMAP:   MF_00041_B
- InterPro:   IPR015803
- InterPro:   IPR015273
- InterPro:   IPR014729
- InterPro:   IPR009080
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR10890
- PRINTS:   PR00983
- SMART:   SM00840
- TIGRFAMs:   TIGR00435

Pfam domain/function: PF09190 DALR_2; PF01406 tRNA-synt_1e; SSF47323 tRNAsyn_1a_bind

EC number: =6.1.1.16

Molecular weight: Translated: 51741; Mature: 51610

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: BINDING 272-272

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPMSLRLHNNLTRRVEPFAPLDPSSPTLYVCGPTVYNYAHIGNARGPVVFDVLAALLRRR
CCCEEECCCCHHHHCCCCCCCCCCCCEEEEECCCHHHHHHCCCCCCCHHHHHHHHHHHHH
YGALRYARNITDVDDKINAAAQAQGVPISTITDRFAAIYRQDMAALGVVPPDIEPEATAH
HHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
IPQIVAMIEQLIANGHAYAAEGHVLFSVSSFDGYGKLSRRDPDEMLAGARVDVAPYKRDP
HHHHHHHHHHHHHCCCEEEECCEEEEEEECCCCCCCCCCCCHHHHHCCCCEEECCCCCCC
GDFVLWKPSSADLPGWESPWGRGRPGWHIECSAMAAAHLGPTIDIHAGGVDLQFPHHENE
CCEEEECCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHCCCEEEEECCCEEEECCCCCCH
IAQSECAHGGATFARFWLHNGMLNFSGAKMSKSLGNIETVHELIARHPPEALRYALLSAH
HHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHH
YRQPLDWSDGLIEQAKNTLDRLYGTLRDLAALQADSGNDVAPSRTIPVEVESALEDDLNT
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEHHHHHHHHCCC
PLALSVIASIASEARALRNELVHGGEPSTRMSDLHAVHAKLLGAGLALGLLQQDPAAWFS
CHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
RGTDAGDDARITALVEERSTAKKAKDFARADAIRKQLAEEGIVLEDTPQGVRWKRA
CCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCC
>Mature Secondary Structure 
PMSLRLHNNLTRRVEPFAPLDPSSPTLYVCGPTVYNYAHIGNARGPVVFDVLAALLRRR
CCEEECCCCHHHHCCCCCCCCCCCCEEEEECCCHHHHHHCCCCCCCHHHHHHHHHHHHH
YGALRYARNITDVDDKINAAAQAQGVPISTITDRFAAIYRQDMAALGVVPPDIEPEATAH
HHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
IPQIVAMIEQLIANGHAYAAEGHVLFSVSSFDGYGKLSRRDPDEMLAGARVDVAPYKRDP
HHHHHHHHHHHHHCCCEEEECCEEEEEEECCCCCCCCCCCCHHHHHCCCCEEECCCCCCC
GDFVLWKPSSADLPGWESPWGRGRPGWHIECSAMAAAHLGPTIDIHAGGVDLQFPHHENE
CCEEEECCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHCCCEEEEECCCEEEECCCCCCH
IAQSECAHGGATFARFWLHNGMLNFSGAKMSKSLGNIETVHELIARHPPEALRYALLSAH
HHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHH
YRQPLDWSDGLIEQAKNTLDRLYGTLRDLAALQADSGNDVAPSRTIPVEVESALEDDLNT
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEHHHHHHHHCCC
PLALSVIASIASEARALRNELVHGGEPSTRMSDLHAVHAKLLGAGLALGLLQQDPAAWFS
CHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
RGTDAGDDARITALVEERSTAKKAKDFARADAIRKQLAEEGIVLEDTPQGVRWKRA
CCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217