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The map label for this gene is ccmA

Identifier: 21243058

GI number: 21243058

Start: 2717723

End: 2718367

Strand: Direct

Name: ccmA

Synonym: XAC2323

Alternate gene names: 21243058

Gene position: 2717723-2718367 (Clockwise)

Preceding gene: 21243055

Following gene: 21243059

Centisome position: 52.51

GC content: 68.37

Gene sequence:

>645_bases
ATGATCGAACCGCTGCACACCGCACCGCCGCTGCTGGCGGCGCACGACCTGGCCTTCAGCCGCAACGAGGAGCCGGTGTT
TGGCCCGCTGGATTTCCATGTCGATGCCGGCGAGGCGCTGCTGGTGCAAGGCGACAACGGCGCCGGCAAGACCACGTTGC
TGCGCGTGCTGGCTGGCCTGCTGCATGTGGAGCGCGGGCAGATCCAGATCGATGGCAAGAGTGCCAAGCGCGGCGACCGC
AGCCGCTTCATGGCCTACCTCGGCCACCTGCCCGGCCTGAAGGCCGACCTCAGCACGCTGGAAAACCTGCACTTCCTGTG
CGGCCTGCACGGCCGCCGCGCCAAGCAGATGCCCGGCAGCGCGCTGGCGATTGTCGGCCTGGCCGGTTACGAAGACGCGC
TGGTGCGGCAGTTGTCGGCAGGCCAGCGCAAGCGGCTGGCCCTGGCACGGCTATGGCTGTCGCCGGCGCCGCTCTGGTTG
CTGGATGAGCCGTACGCCAACCTGGATCTGGATGGCATCACCCTGGTTAACCGAATGATCTCCGCGCATTTGCGCGGCGG
TGGCGCGGCGCTGGTCACCACGCATGGTGCGTATGCAGCGCCACCGGTGCGCACGCGCATGCTCACGCTGGAGGTTGCGG
CATGA

Upstream 100 bases:

>100_bases
CCCCGGCATGCCACCATCGTCGCTACAATGCGCGCCCGGTCCGGCGCGCCCTGCCCCGGCCCTTCCCCATGCCGTCCTGC
GACCCGAGCCCGCTGCACCG

Downstream 100 bases:

>100_bases
GCACGCATTCGCCGCAACCGTCGCTCTGGCAGGCGGCCCGCGCTCTGCTTGCCCGCGACCTGCAGCTGCTGTGGCGGCGC
CGCAGCGATGCGTTGCAGCC

Product: cytochrome c biogenesis protein CcmA

Products: NA

Alternate protein names: Heme exporter protein A

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MIEPLHTAPPLLAAHDLAFSRNEEPVFGPLDFHVDAGEALLVQGDNGAGKTTLLRVLAGLLHVERGQIQIDGKSAKRGDR
SRFMAYLGHLPGLKADLSTLENLHFLCGLHGRRAKQMPGSALAIVGLAGYEDALVRQLSAGQRKRLALARLWLSPAPLWL
LDEPYANLDLDGITLVNRMISAHLRGGGAALVTTHGAYAAPPVRTRMLTLEVAA

Sequences:

>Translated_214_residues
MIEPLHTAPPLLAAHDLAFSRNEEPVFGPLDFHVDAGEALLVQGDNGAGKTTLLRVLAGLLHVERGQIQIDGKSAKRGDR
SRFMAYLGHLPGLKADLSTLENLHFLCGLHGRRAKQMPGSALAIVGLAGYEDALVRQLSAGQRKRLALARLWLSPAPLWL
LDEPYANLDLDGITLVNRMISAHLRGGGAALVTTHGAYAAPPVRTRMLTLEVAA
>Mature_214_residues
MIEPLHTAPPLLAAHDLAFSRNEEPVFGPLDFHVDAGEALLVQGDNGAGKTTLLRVLAGLLHVERGQIQIDGKSAKRGDR
SRFMAYLGHLPGLKADLSTLENLHFLCGLHGRRAKQMPGSALAIVGLAGYEDALVRQLSAGQRKRLALARLWLSPAPLWL
LDEPYANLDLDGITLVNRMISAHLRGGGAALVTTHGAYAAPPVRTRMLTLEVAA

Specific function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system

COG id: COG4133

COG function: function code O; ABC-type transport system involved in cytochrome c biogenesis, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain

Homologues:

Organism=Homo sapiens, GI105990541, Length=204, Percent_Identity=27.9411764705882, Blast_Score=70, Evalue=9e-13,
Organism=Homo sapiens, GI27881501, Length=180, Percent_Identity=27.2222222222222, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI30795238, Length=180, Percent_Identity=27.2222222222222, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI87082064, Length=202, Percent_Identity=40.5940594059406, Blast_Score=131, Evalue=3e-32,
Organism=Escherichia coli, GI87081709, Length=148, Percent_Identity=35.1351351351351, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI87081782, Length=157, Percent_Identity=34.3949044585987, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI1786563, Length=149, Percent_Identity=33.5570469798658, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI87082267, Length=190, Percent_Identity=30, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1788761, Length=204, Percent_Identity=28.921568627451, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1790467, Length=192, Percent_Identity=31.7708333333333, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1787370, Length=195, Percent_Identity=29.2307692307692, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1787029, Length=211, Percent_Identity=27.4881516587678, Blast_Score=66, Evalue=1e-12,
Organism=Escherichia coli, GI1787182, Length=202, Percent_Identity=27.2277227722772, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1789032, Length=146, Percent_Identity=31.5068493150685, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1790544, Length=210, Percent_Identity=29.0476190476191, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1786872, Length=180, Percent_Identity=31.6666666666667, Blast_Score=65, Evalue=2e-12,
Organism=Escherichia coli, GI1786253, Length=149, Percent_Identity=35.5704697986577, Blast_Score=64, Evalue=5e-12,
Organism=Escherichia coli, GI1787712, Length=146, Percent_Identity=34.9315068493151, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1786698, Length=200, Percent_Identity=27.5, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI87081834, Length=184, Percent_Identity=28.804347826087, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1789873, Length=189, Percent_Identity=29.1005291005291, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI87081791, Length=209, Percent_Identity=30.1435406698565, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1786703, Length=203, Percent_Identity=27.5862068965517, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1787164, Length=192, Percent_Identity=33.8541666666667, Blast_Score=60, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17559834, Length=197, Percent_Identity=28.9340101522843, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI115533608, Length=190, Percent_Identity=28.9473684210526, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71983523, Length=140, Percent_Identity=32.1428571428571, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71983516, Length=140, Percent_Identity=32.1428571428571, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71983510, Length=140, Percent_Identity=32.1428571428571, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17565586, Length=171, Percent_Identity=28.0701754385965, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24641342, Length=195, Percent_Identity=31.2820512820513, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24642252, Length=190, Percent_Identity=32.6315789473684, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI18859989, Length=190, Percent_Identity=32.6315789473684, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI221512771, Length=169, Percent_Identity=30.1775147928994, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI221500365, Length=180, Percent_Identity=30.5555555555556, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI116007184, Length=180, Percent_Identity=30.5555555555556, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI28574744, Length=161, Percent_Identity=32.2981366459627, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CCMA_XANAC (Q8PK53)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_642640.1
- ProteinModelPortal:   Q8PK53
- SMR:   Q8PK53
- GeneID:   1156394
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC2323
- NMPDR:   fig|190486.1.peg.2284
- HOGENOM:   HBG758042
- OMA:   SARRGED
- ProtClustDB:   PRK13543
- BioCyc:   XAXO190486:XAC2323-MONOMER
- BRENDA:   3.6.3.41
- HAMAP:   MF_01707
- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR005895
- InterPro:   IPR003593
- PANTHER:   PTHR19222:SF5
- SMART:   SM00382
- TIGRFAMs:   TIGR01189

Pfam domain/function: PF00005 ABC_tran

EC number: =3.6.3.41

Molecular weight: Translated: 22966; Mature: 22966

Theoretical pI: Translated: 9.09; Mature: 9.09

Prosite motif: PS00211 ABC_TRANSPORTER_1; PS50893 ABC_TRANSPORTER_2; PS51243 CCMA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEPLHTAPPLLAAHDLAFSRNEEPVFGPLDFHVDAGEALLVQGDNGAGKTTLLRVLAGL
CCCCCCCCCCHHHHHHHHHCCCCCCEECCEEEEECCCCEEEEECCCCCCHHHHHHHHHHH
LHVERGQIQIDGKSAKRGDRSRFMAYLGHLPGLKADLSTLENLHFLCGLHGRRAKQMPGS
HHCCCCEEEECCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHCCCCC
ALAIVGLAGYEDALVRQLSAGQRKRLALARLWLSPAPLWLLDEPYANLDLDGITLVNRMI
EEEEEEECCCHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHH
SAHLRGGGAALVTTHGAYAAPPVRTRMLTLEVAA
HHHHCCCCEEEEEECCCCCCCCCCEEEEEEEECC
>Mature Secondary Structure
MIEPLHTAPPLLAAHDLAFSRNEEPVFGPLDFHVDAGEALLVQGDNGAGKTTLLRVLAGL
CCCCCCCCCCHHHHHHHHHCCCCCCEECCEEEEECCCCEEEEECCCCCCHHHHHHHHHHH
LHVERGQIQIDGKSAKRGDRSRFMAYLGHLPGLKADLSTLENLHFLCGLHGRRAKQMPGS
HHCCCCEEEECCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHCCCCC
ALAIVGLAGYEDALVRQLSAGQRKRLALARLWLSPAPLWLLDEPYANLDLDGITLVNRMI
EEEEEEECCCHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHH
SAHLRGGGAALVTTHGAYAAPPVRTRMLTLEVAA
HHHHCCCCEEEEEECCCCCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12024217