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The map label for this gene is intS [H]

Identifier: 21242918

GI number: 21242918

Start: 2553541

End: 2554800

Strand: Reverse

Name: intS [H]

Synonym: XAC2183

Alternate gene names: 21242918

Gene position: 2554800-2553541 (Counterclockwise)

Preceding gene: 21242922

Following gene: 21242917

Centisome position: 49.36

GC content: 64.68

Gene sequence:

>1260_bases
ATGCTCACCGACACAGCACTGCGCAATCTCAAGCCTAAGTCCAAGATTTATAAGGTTTTTGACCGCGATGGCATGTACGT
GGCGGTATCGACCGCCGGTACCATCACCTTCCGCTACGACTACCGTCTCAACGGGCGCCGCGAGACGCTCACGCTCGGAC
GGTACGGGCCGGCCGGCATGTCGCTGGCCATGGCGCGAGAGCGACTGCTCGATGCCAAGCGGTCCGTCGTTCAGGGCCTT
TCCCCTGCGCTGGAGAAGCAGCGGGCCAAGCGGCGACTGACGGCCGCCAGGACCTTCGGCGAGATGATGGAACGCTGGCT
GGCCGATGCCCGCATGGCCGACAGCACCCGGGCGATGCGCAAGCACATCATCGACCGCGACATCCTGCCGGTCTTCCAGA
ACCGGAAGCTGAAGGAAGTCACCCCTGACGACCTGCGGGCGCTGTGCAATAAGGTGAAGGCGCGCGGCGCACCGGCCACG
GCCATCCACGTCCGCGACATCGTGAAGCAGGTCTATGCCTTCGCCATCCTGCATGGCGAACGGCTCGCCAACCCGGCCGA
CGATGTGAAGGCGGCCTCGATTGCGACCTTCGTTCCCAAGGACCGGGCGCTCTCGCCGGCGGAGATCCGGCTGGCCTTCC
ACCAACTGGAGACCATCGCGTCCTATCCGACCATCCGGCTGGCCTTGCGCCTGATCCTGCTGACGATGGTGCGCAAGAGC
GAACTCGTCGAAGCGACGTGGAACGAGGTGGATTTCGAAAATGCCACCTGGACGATCCCCAAGGTGCGGATGAAAGGGCG
TAAGCCGCACGTGGTCTACCTGTCGCGGCAGGCGATGGACATCTTCGTGGCCTTGCACACTTGCGCTGCGGGATCGCGGT
TCGTGCTGCCGTCGCGCTATGACCCCGATCGATGCATGTCGCATGCAACGCTTAACCGGGTGACGCAGCTCATTGGGTCG
CGCGCGAAGGAAGCCGGGTTGCCGCTGGATCCTTTCACGGTGCACGACCTGCGGCGCACCGCGTCCACGCTGCTTAACGA
GGTGGGCTTCAACGGCGACTGGATCGAGAAGTGCTTGGCGCACGAAGAAGGCAGCCGGACGTCGCGGTCGGTCTACAACA
AGGCCGAGTACGCCGGGCCTCGGCGGCACATGCTCCAGGAGTGGGCCGACATGGTGGAGGCGTGGCTCGATGGGCGCACG
CATGTGCCGAAGCTGGTGCCGGAGGACGTGTCGGTCCCGGTGCTCAGTCCGGCTTTGTGA

Upstream 100 bases:

>100_bases
AAACTCCTGAGGAAAGCTTGTTTCATGCGGCTTTCCGAGCATCAACGGGTCTCCAAGTCCCTGACGGTAAAAGCCGTCAC
GAACAGGAGGAACACCCTCA

Downstream 100 bases:

>100_bases
GGGAGGAGCGCATGATGACCTTGGCTGGGAACGCTTTTGGTGGGTCGCCCGGGGTTTTTGTTTATCAAAAAAAGATCACT
CTGGATGATCTTTTTCCTGC

Product: phage-related integrase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MLTDTALRNLKPKSKIYKVFDRDGMYVAVSTAGTITFRYDYRLNGRRETLTLGRYGPAGMSLAMARERLLDAKRSVVQGL
SPALEKQRAKRRLTAARTFGEMMERWLADARMADSTRAMRKHIIDRDILPVFQNRKLKEVTPDDLRALCNKVKARGAPAT
AIHVRDIVKQVYAFAILHGERLANPADDVKAASIATFVPKDRALSPAEIRLAFHQLETIASYPTIRLALRLILLTMVRKS
ELVEATWNEVDFENATWTIPKVRMKGRKPHVVYLSRQAMDIFVALHTCAAGSRFVLPSRYDPDRCMSHATLNRVTQLIGS
RAKEAGLPLDPFTVHDLRRTASTLLNEVGFNGDWIEKCLAHEEGSRTSRSVYNKAEYAGPRRHMLQEWADMVEAWLDGRT
HVPKLVPEDVSVPVLSPAL

Sequences:

>Translated_419_residues
MLTDTALRNLKPKSKIYKVFDRDGMYVAVSTAGTITFRYDYRLNGRRETLTLGRYGPAGMSLAMARERLLDAKRSVVQGL
SPALEKQRAKRRLTAARTFGEMMERWLADARMADSTRAMRKHIIDRDILPVFQNRKLKEVTPDDLRALCNKVKARGAPAT
AIHVRDIVKQVYAFAILHGERLANPADDVKAASIATFVPKDRALSPAEIRLAFHQLETIASYPTIRLALRLILLTMVRKS
ELVEATWNEVDFENATWTIPKVRMKGRKPHVVYLSRQAMDIFVALHTCAAGSRFVLPSRYDPDRCMSHATLNRVTQLIGS
RAKEAGLPLDPFTVHDLRRTASTLLNEVGFNGDWIEKCLAHEEGSRTSRSVYNKAEYAGPRRHMLQEWADMVEAWLDGRT
HVPKLVPEDVSVPVLSPAL
>Mature_419_residues
MLTDTALRNLKPKSKIYKVFDRDGMYVAVSTAGTITFRYDYRLNGRRETLTLGRYGPAGMSLAMARERLLDAKRSVVQGL
SPALEKQRAKRRLTAARTFGEMMERWLADARMADSTRAMRKHIIDRDILPVFQNRKLKEVTPDDLRALCNKVKARGAPAT
AIHVRDIVKQVYAFAILHGERLANPADDVKAASIATFVPKDRALSPAEIRLAFHQLETIASYPTIRLALRLILLTMVRKS
ELVEATWNEVDFENATWTIPKVRMKGRKPHVVYLSRQAMDIFVALHTCAAGSRFVLPSRYDPDRCMSHATLNRVTQLIGS
RAKEAGLPLDPFTVHDLRRTASTLLNEVGFNGDWIEKCLAHEEGSRTSRSVYNKAEYAGPRRHMLQEWADMVEAWLDGRT
HVPKLVPEDVSVPVLSPAL

Specific function: Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'phage' integrase family [H]

Homologues:

Organism=Escherichia coli, GI1788690, Length=405, Percent_Identity=30.1234567901235, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI145693166, Length=405, Percent_Identity=31.8518518518519, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI1788974, Length=414, Percent_Identity=30.6763285024155, Blast_Score=165, Evalue=5e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011010
- InterPro:   IPR013762
- InterPro:   IPR002104
- InterPro:   IPR023109 [H]

Pfam domain/function: PF00589 Phage_integrase [H]

EC number: NA

Molecular weight: Translated: 47342; Mature: 47342

Theoretical pI: Translated: 10.45; Mature: 10.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTDTALRNLKPKSKIYKVFDRDGMYVAVSTAGTITFRYDYRLNGRRETLTLGRYGPAGM
CCCHHHHHCCCCHHHHHHHHCCCCCEEEEEECCEEEEEEEEEECCCCEEEEECCCCCCHH
SLAMARERLLDAKRSVVQGLSPALEKQRAKRRLTAARTFGEMMERWLADARMADSTRAMR
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KHIIDRDILPVFQNRKLKEVTPDDLRALCNKVKARGAPATAIHVRDIVKQVYAFAILHGE
HHHHCCHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
RLANPADDVKAASIATFVPKDRALSPAEIRLAFHQLETIASYPTIRLALRLILLTMVRKS
HHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
ELVEATWNEVDFENATWTIPKVRMKGRKPHVVYLSRQAMDIFVALHTCAAGSRFVLPSRY
HHHHHHHCCCCCCCCEEECCHHHCCCCCCCEEEEEHHHHHHHHHHHHHCCCCEEECCCCC
DPDRCMSHATLNRVTQLIGSRAKEAGLPLDPFTVHDLRRTASTLLNEVGFNGDWIEKCLA
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHH
HEEGSRTSRSVYNKAEYAGPRRHMLQEWADMVEAWLDGRTHVPKLVPEDVSVPVLSPAL
HCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLTDTALRNLKPKSKIYKVFDRDGMYVAVSTAGTITFRYDYRLNGRRETLTLGRYGPAGM
CCCHHHHHCCCCHHHHHHHHCCCCCEEEEEECCEEEEEEEEEECCCCEEEEECCCCCCHH
SLAMARERLLDAKRSVVQGLSPALEKQRAKRRLTAARTFGEMMERWLADARMADSTRAMR
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KHIIDRDILPVFQNRKLKEVTPDDLRALCNKVKARGAPATAIHVRDIVKQVYAFAILHGE
HHHHCCHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
RLANPADDVKAASIATFVPKDRALSPAEIRLAFHQLETIASYPTIRLALRLILLTMVRKS
HHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
ELVEATWNEVDFENATWTIPKVRMKGRKPHVVYLSRQAMDIFVALHTCAAGSRFVLPSRY
HHHHHHHCCCCCCCCEEECCHHHCCCCCCCEEEEEHHHHHHHHHHHHHCCCCEEECCCCC
DPDRCMSHATLNRVTQLIGSRAKEAGLPLDPFTVHDLRRTASTLLNEVGFNGDWIEKCLA
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHH
HEEGSRTSRSVYNKAEYAGPRRHMLQEWADMVEAWLDGRTHVPKLVPEDVSVPVLSPAL
HCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]