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The map label for this gene is cysG [H]

Identifier: 21242892

GI number: 21242892

Start: 2527505

End: 2529043

Strand: Reverse

Name: cysG [H]

Synonym: XAC2157

Alternate gene names: 21242892

Gene position: 2529043-2527505 (Counterclockwise)

Preceding gene: 21242893

Following gene: 21242891

Centisome position: 48.87

GC content: 67.38

Gene sequence:

>1539_bases
ATGTGGTGGATGGTCTGGCGCCCGCGCGGTTGCGCCCATCGTGCAGGTGGCGCTGGCCCGTTTTGCGCAGGAAAGCAGCA
GGCGCTGCAGGACCGCAAGCAGATCGACCGCGCGAAGGGCTTGCTGATGGAAAAACGTGGCCTGAGCGAGGCCGATGCTT
ATGCGGCATTACGCCAGCAGGCGATGAAGCAGGGCGTCAAACTGACCGAAGTGGCGCGCCGTATCGTGGCCATGGCCGAA
TACAGCCGGGGTTGGGTCGTGCTGCATGCCGCCTGCGAACGCGCGCCCGATGCCATGTGGATGGATCGCCTGGTCGCCGC
GTTGCATCTGCCGGCCGGCGCGGATGTGCTGGAGTACTGCGACCTGCGCCGCGGGCCGATGCGCCGCGTTGGCTGGCGCA
TGCACGACGGGCATCGCCATATCGACGGCGTGCTGCTGACGGCCGCGCAACCCAGCGACGCCAATCGATCGTTGCTTGCG
ACCGCATTGGCTGGCAAGCCGTGGCGTGGTGCGCGGCTGTCGGTCTTCACGCATACCCACAGCGCCTGGCGATCCGATCG
TGTGCACCTGCATGCATGTCTCGGCCGCAGCGATGCACGACGCCATCGACGACGGCGCCACGTTGCACAACTCAAACAAC
GTGGCGGATGCCGTTCGACACCGCAGGAGTTCATCTGCCGGCTGATGCGTCGCTACGCGTTGCAGGGCCGGCGCGTGGTG
CGCGTGAAAGGGGACGATGCGCTGCTGTTCGGCCACGCTGGCGAAGAGATCGCCTTCCTGCGTCGTGCCGGTGTCGGTGT
GCAGGTGATCGACGGCGTGAGTGCGGCATTCGCTGCGGTGGCCGCACTGGACGTCTCGCTGACCCATCGCAGCCACTGCC
ACGGCATCACCTTCGTCACCGCGCACACGCACGACCACGGCGAGCCGAACTGGGGCGCGCTTGCGGCCAGCGGCACGACG
CTGGGTATCTACATGGGCCTGCGCCGCGCAGATGCGCTGGCCGCTGCATTGCTGGCCGGCACACCCGCCGCCATCGTGCA
GGCCGCCACGCGGCCGGAGCAGCAACGTCGCCTCACCGCCCTGGGCGACCTTGGGACGACAGCCGCCGCGCTGCCACCGG
GTCTGCCCACCTTGTTGCTGGTGGGCGATGCTTTGTCCGAAGCTGCTGCAGCGTGCGACGACCGCGATGGGCCGATGGCG
GTGCAGGCAGTGGGGTGGGGACAGCACACCACCGATGACGCGGCTGCAGGGCAGGGCCACTCGGGCTCACGGTTTCCGTG
TGACATGATGCGTGCGCATCCCGAAGACTCCTTGCCGAGCCTCTGGGCCAGCCGCATCCGCGCGTGGACGGCATGCATGC
GTAATGGTTACGGCCTAGTGTCGACGTCGGCCGGTGGTACCGGCCTGCACACAACCGCAAAGTCTTTCGCAGGGTGTATC
GACGTGGCGACTGAAGGCGCGTCAGTGCGCGTCCAGATCCGTGCGCAGTTATGTGTGCGTGCATTGCCTGTTTCGACCTG
TGGCTGCGCCGCTGTCTGA

Upstream 100 bases:

>100_bases
TCGATGTTGCATGCGCACGCGCCGCGGCCGGTGGTGATGTTCTTTGGGGATGGCGACGATGCGTTGATTCATGCAGCGGT
CGGCGCGGGGGTGACGGCGT

Downstream 100 bases:

>100_bases
GCTGCCCGTAGCGAATCGGCCGAGCGATCTGCGGTATCGACAGCACGCGCCTTGCGAGGCGCGGCGCACGCCGTCACCGA
GGCGATGGCCTCATGCAGGC

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM [H]

Number of amino acids: Translated: 512; Mature: 512

Protein sequence:

>512_residues
MWWMVWRPRGCAHRAGGAGPFCAGKQQALQDRKQIDRAKGLLMEKRGLSEADAYAALRQQAMKQGVKLTEVARRIVAMAE
YSRGWVVLHAACERAPDAMWMDRLVAALHLPAGADVLEYCDLRRGPMRRVGWRMHDGHRHIDGVLLTAAQPSDANRSLLA
TALAGKPWRGARLSVFTHTHSAWRSDRVHLHACLGRSDARRHRRRRHVAQLKQRGGCRSTPQEFICRLMRRYALQGRRVV
RVKGDDALLFGHAGEEIAFLRRAGVGVQVIDGVSAAFAAVAALDVSLTHRSHCHGITFVTAHTHDHGEPNWGALAASGTT
LGIYMGLRRADALAAALLAGTPAAIVQAATRPEQQRRLTALGDLGTTAAALPPGLPTLLLVGDALSEAAAACDDRDGPMA
VQAVGWGQHTTDDAAAGQGHSGSRFPCDMMRAHPEDSLPSLWASRIRAWTACMRNGYGLVSTSAGGTGLHTTAKSFAGCI
DVATEGASVRVQIRAQLCVRALPVSTCGCAAV

Sequences:

>Translated_512_residues
MWWMVWRPRGCAHRAGGAGPFCAGKQQALQDRKQIDRAKGLLMEKRGLSEADAYAALRQQAMKQGVKLTEVARRIVAMAE
YSRGWVVLHAACERAPDAMWMDRLVAALHLPAGADVLEYCDLRRGPMRRVGWRMHDGHRHIDGVLLTAAQPSDANRSLLA
TALAGKPWRGARLSVFTHTHSAWRSDRVHLHACLGRSDARRHRRRRHVAQLKQRGGCRSTPQEFICRLMRRYALQGRRVV
RVKGDDALLFGHAGEEIAFLRRAGVGVQVIDGVSAAFAAVAALDVSLTHRSHCHGITFVTAHTHDHGEPNWGALAASGTT
LGIYMGLRRADALAAALLAGTPAAIVQAATRPEQQRRLTALGDLGTTAAALPPGLPTLLLVGDALSEAAAACDDRDGPMA
VQAVGWGQHTTDDAAAGQGHSGSRFPCDMMRAHPEDSLPSLWASRIRAWTACMRNGYGLVSTSAGGTGLHTTAKSFAGCI
DVATEGASVRVQIRAQLCVRALPVSTCGCAAV
>Mature_512_residues
MWWMVWRPRGCAHRAGGAGPFCAGKQQALQDRKQIDRAKGLLMEKRGLSEADAYAALRQQAMKQGVKLTEVARRIVAMAE
YSRGWVVLHAACERAPDAMWMDRLVAALHLPAGADVLEYCDLRRGPMRRVGWRMHDGHRHIDGVLLTAAQPSDANRSLLA
TALAGKPWRGARLSVFTHTHSAWRSDRVHLHACLGRSDARRHRRRRHVAQLKQRGGCRSTPQEFICRLMRRYALQGRRVV
RVKGDDALLFGHAGEEIAFLRRAGVGVQVIDGVSAAFAAVAALDVSLTHRSHCHGITFVTAHTHDHGEPNWGALAASGTT
LGIYMGLRRADALAAALLAGTPAAIVQAATRPEQQRRLTALGDLGTTAAALPPGLPTLLLVGDALSEAAAACDDRDGPMA
VQAVGWGQHTTDDAAAGQGHSGSRFPCDMMRAHPEDSLPSLWASRIRAWTACMRNGYGLVSTSAGGTGLHTTAKSFAGCI
DVATEGASVRVQIRAQLCVRALPVSTCGCAAV

Specific function: Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin [H]

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=178, Percent_Identity=35.3932584269663, Blast_Score=103, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR003043 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.107 [H]

Molecular weight: Translated: 55051; Mature: 55051

Theoretical pI: Translated: 10.39; Mature: 10.39

Prosite motif: PS50921 ANTAR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWWMVWRPRGCAHRAGGAGPFCAGKQQALQDRKQIDRAKGLLMEKRGLSEADAYAALRQQ
CCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
AMKQGVKLTEVARRIVAMAEYSRGWVVLHAACERAPDAMWMDRLVAALHLPAGADVLEYC
HHHCCCCHHHHHHHHHHHHHCCCCEEEEEEHHHCCCCHHHHHHHHHHHCCCCCCHHHHHH
DLRRGPMRRVGWRMHDGHRHIDGVLLTAAQPSDANRSLLATALAGKPWRGARLSVFTHTH
HCCCCCHHHHCCEECCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCCCCEEEEEEECH
SAWRSDRVHLHACLGRSDARRHRRRRHVAQLKQRGGCRSTPQEFICRLMRRYALQGRRVV
HHHCCCCEEEEEHHCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEE
RVKGDDALLFGHAGEEIAFLRRAGVGVQVIDGVSAAFAAVAALDVSLTHRSHCHGITFVT
EEECCCEEEECCCCCHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
AHTHDHGEPNWGALAASGTTLGIYMGLRRADALAAALLAGTPAAIVQAATRPEQQRRLTA
EECCCCCCCCCCEEEECCCEEEEHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHH
LGDLGTTAAALPPGLPTLLLVGDALSEAAAACDDRDGPMAVQAVGWGQHTTDDAAAGQGH
HHCCCCHHHHCCCCCCCHHEEHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCC
SGSRFPCDMMRAHPEDSLPSLWASRIRAWTACMRNGYGLVSTSAGGTGLHTTAKSFAGCI
CCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHH
DVATEGASVRVQIRAQLCVRALPVSTCGCAAV
HHHCCCCEEEEEEEHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MWWMVWRPRGCAHRAGGAGPFCAGKQQALQDRKQIDRAKGLLMEKRGLSEADAYAALRQQ
CCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
AMKQGVKLTEVARRIVAMAEYSRGWVVLHAACERAPDAMWMDRLVAALHLPAGADVLEYC
HHHCCCCHHHHHHHHHHHHHCCCCEEEEEEHHHCCCCHHHHHHHHHHHCCCCCCHHHHHH
DLRRGPMRRVGWRMHDGHRHIDGVLLTAAQPSDANRSLLATALAGKPWRGARLSVFTHTH
HCCCCCHHHHCCEECCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCCCCEEEEEEECH
SAWRSDRVHLHACLGRSDARRHRRRRHVAQLKQRGGCRSTPQEFICRLMRRYALQGRRVV
HHHCCCCEEEEEHHCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEE
RVKGDDALLFGHAGEEIAFLRRAGVGVQVIDGVSAAFAAVAALDVSLTHRSHCHGITFVT
EEECCCEEEECCCCCHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
AHTHDHGEPNWGALAASGTTLGIYMGLRRADALAAALLAGTPAAIVQAATRPEQQRRLTA
EECCCCCCCCCCEEEECCCEEEEHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHH
LGDLGTTAAALPPGLPTLLLVGDALSEAAAACDDRDGPMAVQAVGWGQHTTDDAAAGQGH
HHCCCCHHHHCCCCCCCHHEEHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCC
SGSRFPCDMMRAHPEDSLPSLWASRIRAWTACMRNGYGLVSTSAGGTGLHTTAKSFAGCI
CCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHH
DVATEGASVRVQIRAQLCVRALPVSTCGCAAV
HHHCCCCEEEEEEEHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]