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The map label for this gene is mdmC [H]

Identifier: 21242856

GI number: 21242856

Start: 2477938

End: 2478576

Strand: Direct

Name: mdmC [H]

Synonym: XAC2121

Alternate gene names: 21242856

Gene position: 2477938-2478576 (Clockwise)

Preceding gene: 21242855

Following gene: 77748630

Centisome position: 47.88

GC content: 62.91

Gene sequence:

>639_bases
ATGCCAAGGCCATGGCACACACTGCATCAATCAACAGACGGTCAAGGCATGCGCACGTTGCGGGATTTGAAAGAGGAACT
GTCGCGCTTCGGGGCCGACAACGATGCGGTGGAAACCGCGCGTGGCAAACGCATGTTGAATATCACCCCAGAAACCGGCG
AACTGCTCGCCCTGCTCGTGCATGCGACGGGGGCGCGGCAGGTGGTAGAGGTGGGCACTTCGAATGGCTACTCCACGCTA
TGGCTGGCCGAAGCTGTCATCGTCGTCGGTGGACACGTCATCACGCTGGAACATGCCGAGGACAAGGCCGCCCTGGCGGC
TGCGAACTTCGTGCGTGCCGGACTACGGGCACACATCACACAGGTGCTGGGCGATGCAGGCGCATGGTTGGAGACTGTCG
ACGATGGCAGCGTCGACCTGTTGTTCTTGGACGCGGACCGCGGTGCCTATGCGCGGTGGTGGCCGCAGCTGCGCCGTGTG
CTCAAGCGCGGTACTGGCCTGTTGGTGGTGGACAACGCCACCTCGCACGCGACGGAGATGGCAGCTTTCATGCAGGCTGT
CCGTGCCGACATATCCTTCCGATGCAGCGAGCTGCCGGTCGGCAACGGACAGTTCATGGCAGTGCGCGTCGCAGACTGA

Upstream 100 bases:

>100_bases
GAATAGCAAATAGCGAATAGCGAGCACTCTGTATCAGGCAGGCGCGTCGCGCATCCGGTTCGCTCGCATCACGGTGCAGT
GCACTAGGCGTTGAATGGCG

Downstream 100 bases:

>100_bases
ATGGCTAGCGGCGTCCGCACGGCGGCTAAGTGCTCGATGATTCCAACCGGTGCTGTTGCGTGGTTGTTCTGCTGAGGGGC
AGTCCGTCGATTCTTTGCGG

Product: O-methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 212; Mature: 211

Protein sequence:

>212_residues
MPRPWHTLHQSTDGQGMRTLRDLKEELSRFGADNDAVETARGKRMLNITPETGELLALLVHATGARQVVEVGTSNGYSTL
WLAEAVIVVGGHVITLEHAEDKAALAAANFVRAGLRAHITQVLGDAGAWLETVDDGSVDLLFLDADRGAYARWWPQLRRV
LKRGTGLLVVDNATSHATEMAAFMQAVRADISFRCSELPVGNGQFMAVRVAD

Sequences:

>Translated_212_residues
MPRPWHTLHQSTDGQGMRTLRDLKEELSRFGADNDAVETARGKRMLNITPETGELLALLVHATGARQVVEVGTSNGYSTL
WLAEAVIVVGGHVITLEHAEDKAALAAANFVRAGLRAHITQVLGDAGAWLETVDDGSVDLLFLDADRGAYARWWPQLRRV
LKRGTGLLVVDNATSHATEMAAFMQAVRADISFRCSELPVGNGQFMAVRVAD
>Mature_211_residues
PRPWHTLHQSTDGQGMRTLRDLKEELSRFGADNDAVETARGKRMLNITPETGELLALLVHATGARQVVEVGTSNGYSTLW
LAEAVIVVGGHVITLEHAEDKAALAAANFVRAGLRAHITQVLGDAGAWLETVDDGSVDLLFLDADRGAYARWWPQLRRVL
KRGTGLLVVDNATSHATEMAAFMQAVRADISFRCSELPVGNGQFMAVRVAD

Specific function: 4-O-methyltransferase for the lactone ring of midecamycin and other macrolide antibiotics [H]

COG id: COG4122

COG function: function code R; Predicted O-methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Type 3 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002935 [H]

Pfam domain/function: PF01596 Methyltransf_3 [H]

EC number: NA

Molecular weight: Translated: 23027; Mature: 22896

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRPWHTLHQSTDGQGMRTLRDLKEELSRFGADNDAVETARGKRMLNITPETGELLALLV
CCCCCCHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHCCCEEEEECCCHHHHHHHHH
HATGARQVVEVGTSNGYSTLWLAEAVIVVGGHVITLEHAEDKAALAAANFVRAGLRAHIT
HCCCCHHEEEECCCCCCCHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHH
QVLGDAGAWLETVDDGSVDLLFLDADRGAYARWWPQLRRVLKRGTGLLVVDNATSHATEM
HHHCCCCCCEEECCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCHHHHHH
AAFMQAVRADISFRCSELPVGNGQFMAVRVAD
HHHHHHHHHHHCEECCCCCCCCCCEEEEEECC
>Mature Secondary Structure 
PRPWHTLHQSTDGQGMRTLRDLKEELSRFGADNDAVETARGKRMLNITPETGELLALLV
CCCCCHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHCCCEEEEECCCHHHHHHHHH
HATGARQVVEVGTSNGYSTLWLAEAVIVVGGHVITLEHAEDKAALAAANFVRAGLRAHIT
HCCCCHHEEEECCCCCCCHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHH
QVLGDAGAWLETVDDGSVDLLFLDADRGAYARWWPQLRRVLKRGTGLLVVDNATSHATEM
HHHCCCCCCEEECCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCHHHHHH
AAFMQAVRADISFRCSELPVGNGQFMAVRVAD
HHHHHHHHHHHCEECCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629172 [H]