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The map label for this gene is fkpA [H]

Identifier: 21242842

GI number: 21242842

Start: 2461616

End: 2462014

Strand: Reverse

Name: fkpA [H]

Synonym: XAC2107

Alternate gene names: 21242842

Gene position: 2462014-2461616 (Counterclockwise)

Preceding gene: 21242846

Following gene: 21242841

Centisome position: 47.57

GC content: 65.91

Gene sequence:

>399_bases
TTGCTCGCAAGCTGCGCACCCACCCTGCCGCCCTCCGGCGGGACCATCGCCAGTTTCGAGCGGATCGACCGCAACCTGGG
GACCGGCGCAGAGGCCACACCAGGGGCCATGGTCACCGTGCACTACACCGGCTGGCTGTACGACGAAAAAGCCGCCGACA
AACATGGCAAGAAGTTCGACAGCTCGCTGGATCGCGCCGAGCCGTTCCAATTCGTATTGGGCGGCCACCAGGTCATCCGC
GGCTGGGACGATGGCGTGGCCGGCATGCGTGTCGGCGGCAAGCGCACCTTGATGATCCCGCCCGATTACGGCTATGGCGA
CAACGGCGCCGGTGGCGTGATACCGCCCGGTGCATCGCTGGTGTTCGATGTGGAATTGCTGGGCGTGCAGCCGCGTTGA

Upstream 100 bases:

>100_bases
TTGGCCATGCCGCGATGATACCGGGAGCCAGGTGCGATAATGGCCGCCTTTCTTCATGGACCCTGCCATGCGCCTTTTGT
TGACGCTCGTCGCCGCCCTG

Downstream 100 bases:

>100_bases
GTGCCTGATGATGACTGATCTGAGCAGGCAGCGGCTGGCCGTGATCGGCGGTGGGCCGGCCGGTTTGATGGCGGCGGAAG
TGGCCTGCGCGGCGGGCCTG

Product: FKBP-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: Peptidyl-prolyl cis-trans isomerase; PPIase; Rotamase [H]

Number of amino acids: Translated: 132; Mature: 132

Protein sequence:

>132_residues
MLASCAPTLPPSGGTIASFERIDRNLGTGAEATPGAMVTVHYTGWLYDEKAADKHGKKFDSSLDRAEPFQFVLGGHQVIR
GWDDGVAGMRVGGKRTLMIPPDYGYGDNGAGGVIPPGASLVFDVELLGVQPR

Sequences:

>Translated_132_residues
MLASCAPTLPPSGGTIASFERIDRNLGTGAEATPGAMVTVHYTGWLYDEKAADKHGKKFDSSLDRAEPFQFVLGGHQVIR
GWDDGVAGMRVGGKRTLMIPPDYGYGDNGAGGVIPPGASLVFDVELLGVQPR
>Mature_132_residues
MLASCAPTLPPSGGTIASFERIDRNLGTGAEATPGAMVTVHYTGWLYDEKAADKHGKKFDSSLDRAEPFQFVLGGHQVIR
GWDDGVAGMRVGGKRTLMIPPDYGYGDNGAGGVIPPGASLVFDVELLGVQPR

Specific function: PPIases accelerate the folding of proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cytoplasm And Periplasmic Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=96, Percent_Identity=56.25, Blast_Score=107, Evalue=3e-24,
Organism=Homo sapiens, GI4503725, Length=96, Percent_Identity=56.25, Blast_Score=107, Evalue=3e-24,
Organism=Homo sapiens, GI4758380, Length=96, Percent_Identity=47.9166666666667, Blast_Score=95, Evalue=2e-20,
Organism=Homo sapiens, GI4503729, Length=131, Percent_Identity=43.5114503816794, Blast_Score=95, Evalue=2e-20,
Organism=Homo sapiens, GI206725530, Length=102, Percent_Identity=49.0196078431373, Blast_Score=94, Evalue=4e-20,
Organism=Homo sapiens, GI17149844, Length=102, Percent_Identity=49.0196078431373, Blast_Score=94, Evalue=4e-20,
Organism=Homo sapiens, GI17149842, Length=102, Percent_Identity=49.0196078431373, Blast_Score=94, Evalue=4e-20,
Organism=Homo sapiens, GI224809329, Length=109, Percent_Identity=47.7064220183486, Blast_Score=87, Evalue=5e-18,
Organism=Homo sapiens, GI224809327, Length=109, Percent_Identity=47.7064220183486, Blast_Score=87, Evalue=5e-18,
Organism=Homo sapiens, GI4758384, Length=109, Percent_Identity=47.7064220183486, Blast_Score=87, Evalue=5e-18,
Organism=Homo sapiens, GI224809331, Length=109, Percent_Identity=47.7064220183486, Blast_Score=87, Evalue=5e-18,
Organism=Homo sapiens, GI192448443, Length=121, Percent_Identity=41.3223140495868, Blast_Score=78, Evalue=3e-15,
Organism=Homo sapiens, GI8923659, Length=98, Percent_Identity=40.8163265306122, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI33469985, Length=95, Percent_Identity=42.1052631578947, Blast_Score=72, Evalue=9e-14,
Organism=Homo sapiens, GI206725547, Length=115, Percent_Identity=37.3913043478261, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI31317231, Length=116, Percent_Identity=37.9310344827586, Blast_Score=69, Evalue=9e-13,
Organism=Homo sapiens, GI150010552, Length=109, Percent_Identity=36.697247706422, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI4503727, Length=96, Percent_Identity=37.5, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI87082390, Length=105, Percent_Identity=45.7142857142857, Blast_Score=79, Evalue=1e-16,
Organism=Escherichia coli, GI1789745, Length=105, Percent_Identity=45.7142857142857, Blast_Score=74, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71993519, Length=96, Percent_Identity=51.0416666666667, Blast_Score=88, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17561782, Length=95, Percent_Identity=49.4736842105263, Blast_Score=86, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17540882, Length=99, Percent_Identity=45.4545454545455, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17506167, Length=121, Percent_Identity=33.8842975206612, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17506169, Length=121, Percent_Identity=33.8842975206612, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17561778, Length=100, Percent_Identity=39, Blast_Score=63, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6320727, Length=100, Percent_Identity=54, Blast_Score=99, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6324194, Length=112, Percent_Identity=50, Blast_Score=95, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6323566, Length=108, Percent_Identity=44.4444444444444, Blast_Score=82, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323482, Length=108, Percent_Identity=43.5185185185185, Blast_Score=79, Evalue=2e-16,
Organism=Drosophila melanogaster, GI281363946, Length=99, Percent_Identity=57.5757575757576, Blast_Score=114, Evalue=2e-26,
Organism=Drosophila melanogaster, GI17352457, Length=99, Percent_Identity=57.5757575757576, Blast_Score=114, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24655568, Length=96, Percent_Identity=55.2083333333333, Blast_Score=103, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24647110, Length=108, Percent_Identity=48.1481481481481, Blast_Score=97, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24583150, Length=104, Percent_Identity=48.0769230769231, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI21356629, Length=103, Percent_Identity=52.4271844660194, Blast_Score=86, Evalue=5e-18,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179 [H]

Pfam domain/function: PF00254 FKBP_C [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 13903; Mature: 13903

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLASCAPTLPPSGGTIASFERIDRNLGTGAEATPGAMVTVHYTGWLYDEKAADKHGKKFD
CCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEECEEECCCCCCCCCCHHC
SSLDRAEPFQFVLGGHQVIRGWDDGVAGMRVGGKRTLMIPPDYGYGDNGAGGVIPPGASL
CCCCCCCCEEEEECCCEEEECCCCCCCCEEECCCEEEEECCCCCCCCCCCCCCCCCCCCE
VFDVELLGVQPR
EEEEEEEECCCC
>Mature Secondary Structure
MLASCAPTLPPSGGTIASFERIDRNLGTGAEATPGAMVTVHYTGWLYDEKAADKHGKKFD
CCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEECEEECCCCCCCCCCHHC
SSLDRAEPFQFVLGGHQVIRGWDDGVAGMRVGGKRTLMIPPDYGYGDNGAGGVIPPGASL
CCCCCCCCEEEEECCCEEEECCCCCCCCEEECCCEEEEECCCCCCCCCCCCCCCCCCCCE
VFDVELLGVQPR
EEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]