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The map label for this gene is vipA [H]

Identifier: 21242840

GI number: 21242840

Start: 2459067

End: 2460359

Strand: Direct

Name: vipA [H]

Synonym: XAC2105

Alternate gene names: 21242840

Gene position: 2459067-2460359 (Clockwise)

Preceding gene: 21242834

Following gene: 21242843

Centisome position: 47.51

GC content: 63.65

Gene sequence:

>1293_bases
ATGTCCGGCACCACACTTCTCGGCCCCGCACAGGGGCGCATCGCCGTCATCGGCTTAGGTTACGTCGGCCTGCCATTGGC
GGTTGCATTCGGGGAGCAACGCGACACCGTGGGCTTCGACATCGATGCGCAGCGCGTTGCGCAACTGCGCGATGGCCACG
ATGTCACGCTGGAACTGGACGATGCCGAATTGGGTGCCGCAACGCACTTGCGCTACAGCGCAAACGCTGCGGATCTGGCT
GGGTGTCGCATTTTCATCGTGACCGTGCCGACGCCGATCGATAGCTTCGAGCAACCGGATCTGGAGCCGTTGCGTAGCGC
CACGGCCTTGATCGCCGCCGCCCTCAAGCCCGGCGATCTGGTGATCTACGAATCCACGGTCTATCCAGGAACCACTGAAG
AAGTTTGCGTGCCCTTGCTCGAAGCAACCTCCGGGCTGCGTTTCAACCACGACTTCTTTTGCGGCTACAGCCCCGAGCGC
GTCAATCCCGGCGATCGCCAGCGGCGTCTGCGTGATATCCGCAAGATCACCTCGGGCTCGACGGCAGACGCCGCCGATGC
CGTCGATGCGCTATACACCAGCATCATCACTGCCGGCACCTGGCGCGCTCCGTCGATGCGCGTGGCCGAAGCGGCAAAGG
TGGTCGAAAACATCCAGCGCGACGTCAATATCGCGCTGGTCAACGAGTTGGCGTTGATTTTCGACAAGTTGGGAATCGAC
ACCCTCGATGTGCTCGAGGCCGCAGGAACCAAGTGGAATTTCCTGCCATTTCGCCCTGGCCTGGTCGGCGGGCATTGCAT
CGGGGTGGATCCGTACTACCTGATGCACAAATCCGAAAGCGTGGGCTATCACCCGGACCTGATCCACACCGCGCGGCAGG
TCAATAATCGTGTCGGCCGACATGTAGCCGAGCGCGTGTGCGGCATGCTGGCCATGCGTGGCGTCGCGCTTGCGCAGGCG
AGGGTGCTGGTACTGGGCGCGACATTCAAGGAAAACTGCCCGGATCTGCGCAACAGCCGCGCCCTGGAATTGGTGCAGTT
GCTGCAGGCCGCGGGCGTGCAGGTGGACACCTGCGACCCGTGGGCAGACCCGGCTGAAGCGCTGCAGCACGGCGGTGTGC
GCTTAAGCGAGATGCCGGAAGATGGCGCCTACGATGCCGTCGTGCTGGCTGTGGCGCACGCGCAGTATCGCGATTACGAC
GTGGAGCGGATCGCCGCGCTCGGCAAACCGGGCGCGGTGGTGTACGACGTCAAATCGGTGTGGCCGCGTGCGGCGGTCAG
CGATCGCCTGTAG

Upstream 100 bases:

>100_bases
TTTGCAGCGTACTTCCTGCACTGCCTGGCTCATGCGGCCTGCGTTATGCTGCCGCCGCATAGCGCGCCGCCACCGGCTGC
GCACCATTCCAAGGAACCGC

Downstream 100 bases:

>100_bases
CGCGTACGTCGCGCTGCGCTAGCCATTGCACAGCGCCGCGTGCGGCGCGTCGGCCGCTGGCGAAACAGGCGGTGAGCAGA
TAGCCGCCGGTTGGCGCTTC

Product: polysaccharide biosynthetic protein

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MSGTTLLGPAQGRIAVIGLGYVGLPLAVAFGEQRDTVGFDIDAQRVAQLRDGHDVTLELDDAELGAATHLRYSANAADLA
GCRIFIVTVPTPIDSFEQPDLEPLRSATALIAAALKPGDLVIYESTVYPGTTEEVCVPLLEATSGLRFNHDFFCGYSPER
VNPGDRQRRLRDIRKITSGSTADAADAVDALYTSIITAGTWRAPSMRVAEAAKVVENIQRDVNIALVNELALIFDKLGID
TLDVLEAAGTKWNFLPFRPGLVGGHCIGVDPYYLMHKSESVGYHPDLIHTARQVNNRVGRHVAERVCGMLAMRGVALAQA
RVLVLGATFKENCPDLRNSRALELVQLLQAAGVQVDTCDPWADPAEALQHGGVRLSEMPEDGAYDAVVLAVAHAQYRDYD
VERIAALGKPGAVVYDVKSVWPRAAVSDRL

Sequences:

>Translated_430_residues
MSGTTLLGPAQGRIAVIGLGYVGLPLAVAFGEQRDTVGFDIDAQRVAQLRDGHDVTLELDDAELGAATHLRYSANAADLA
GCRIFIVTVPTPIDSFEQPDLEPLRSATALIAAALKPGDLVIYESTVYPGTTEEVCVPLLEATSGLRFNHDFFCGYSPER
VNPGDRQRRLRDIRKITSGSTADAADAVDALYTSIITAGTWRAPSMRVAEAAKVVENIQRDVNIALVNELALIFDKLGID
TLDVLEAAGTKWNFLPFRPGLVGGHCIGVDPYYLMHKSESVGYHPDLIHTARQVNNRVGRHVAERVCGMLAMRGVALAQA
RVLVLGATFKENCPDLRNSRALELVQLLQAAGVQVDTCDPWADPAEALQHGGVRLSEMPEDGAYDAVVLAVAHAQYRDYD
VERIAALGKPGAVVYDVKSVWPRAAVSDRL
>Mature_429_residues
SGTTLLGPAQGRIAVIGLGYVGLPLAVAFGEQRDTVGFDIDAQRVAQLRDGHDVTLELDDAELGAATHLRYSANAADLAG
CRIFIVTVPTPIDSFEQPDLEPLRSATALIAAALKPGDLVIYESTVYPGTTEEVCVPLLEATSGLRFNHDFFCGYSPERV
NPGDRQRRLRDIRKITSGSTADAADAVDALYTSIITAGTWRAPSMRVAEAAKVVENIQRDVNIALVNELALIFDKLGIDT
LDVLEAAGTKWNFLPFRPGLVGGHCIGVDPYYLMHKSESVGYHPDLIHTARQVNNRVGRHVAERVCGMLAMRGVALAQAR
VLVLGATFKENCPDLRNSRALELVQLLQAAGVQVDTCDPWADPAEALQHGGVRLSEMPEDGAYDAVVLAVAHAQYRDYDV
ERIAALGKPGAVVYDVKSVWPRAAVSDRL

Specific function: Catalyzes The Oxidation Of Udp-Mannac To Udp-N- Acetylmannosaminuronic Acid (Udp-Mannaca). [C]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI48994968, Length=427, Percent_Identity=32.3185011709602, Blast_Score=160, Evalue=2e-40,
Organism=Drosophila melanogaster, GI17136908, Length=462, Percent_Identity=23.8095238095238, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 46390; Mature: 46259

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGTTLLGPAQGRIAVIGLGYVGLPLAVAFGEQRDTVGFDIDAQRVAQLRDGHDVTLELD
CCCCEEECCCCCCEEEEEECHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCEEEEEEC
DAELGAATHLRYSANAADLAGCRIFIVTVPTPIDSFEQPDLEPLRSATALIAAALKPGDL
CCCCCCCEEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCE
VIYESTVYPGTTEEVCVPLLEATSGLRFNHDFFCGYSPERVNPGDRQRRLRDIRKITSGS
EEEECCCCCCCHHHHHHHHHHHCCCCEECCCEECCCCCCCCCCCHHHHHHHHHHHHHCCC
TADAADAVDALYTSIITAGTWRAPSMRVAEAAKVVENIQRDVNIALVNELALIFDKLGID
CCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCC
TLDVLEAAGTKWNFLPFRPGLVGGHCIGVDPYYLMHKSESVGYHPDLIHTARQVNNRVGR
HHHHHHHCCCCCCEECCCCCCCCCEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHH
HVAERVCGMLAMRGVALAQARVLVLGATFKENCPDLRNSRALELVQLLQAAGVQVDTCDP
HHHHHHHHHHHHHHHHHHHEEEEEEECCHHHCCCCCCCHHHHHHHHHHHHCCCEEECCCC
WADPAEALQHGGVRLSEMPEDGAYDAVVLAVAHAQYRDYDVERIAALGKPGAVVYDVKSV
CCCHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCEEEEEHHHH
WPRAAVSDRL
CCCCHHCCCC
>Mature Secondary Structure 
SGTTLLGPAQGRIAVIGLGYVGLPLAVAFGEQRDTVGFDIDAQRVAQLRDGHDVTLELD
CCCEEECCCCCCEEEEEECHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCEEEEEEC
DAELGAATHLRYSANAADLAGCRIFIVTVPTPIDSFEQPDLEPLRSATALIAAALKPGDL
CCCCCCCEEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCE
VIYESTVYPGTTEEVCVPLLEATSGLRFNHDFFCGYSPERVNPGDRQRRLRDIRKITSGS
EEEECCCCCCCHHHHHHHHHHHCCCCEECCCEECCCCCCCCCCCHHHHHHHHHHHHHCCC
TADAADAVDALYTSIITAGTWRAPSMRVAEAAKVVENIQRDVNIALVNELALIFDKLGID
CCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCC
TLDVLEAAGTKWNFLPFRPGLVGGHCIGVDPYYLMHKSESVGYHPDLIHTARQVNNRVGR
HHHHHHHCCCCCCEECCCCCCCCCEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHH
HVAERVCGMLAMRGVALAQARVLVLGATFKENCPDLRNSRALELVQLLQAAGVQVDTCDP
HHHHHHHHHHHHHHHHHHHEEEEEEECCHHHCCCCCCCHHHHHHHHHHHHCCCEEECCCC
WADPAEALQHGGVRLSEMPEDGAYDAVVLAVAHAQYRDYDVERIAALGKPGAVVYDVKSV
CCCHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCEEEEEHHHH
WPRAAVSDRL
CCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8248629; 8331073; 11677608; 12644504 [H]