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The map label for this gene is pgi

Identifier: 21242533

GI number: 21242533

Start: 2056531

End: 2058045

Strand: Direct

Name: pgi

Synonym: XAC1788

Alternate gene names: 21242533

Gene position: 2056531-2058045 (Clockwise)

Preceding gene: 21242532

Following gene: 21242534

Centisome position: 39.74

GC content: 66.2

Gene sequence:

>1515_bases
ATGACACAGACCAACGGATTCGACGCGCTTCACGCCCACGCCCAGCGCCTGCGCGGCGCTGCCATCCCCGCATTGCTTGC
CGCCGAGCCGGAACGGCCGACGCAATACGCCAGGCAAGTCGGTCCGTTGTATTTCAACTTCGCGCGGCAAAAGTACGACC
GCGCCGCGCTCGATGCGCTGTTCGCCATCGCGCGCGAGCGCGATCTTTCCGGCGCGTTCCAGCGCCTGTTCCGTGGCGAG
CAGGTCAATGTCACCGAACAGCGCGCTGCATTGCACACCGCATTGCGTGGCGACCTGACCGATGCGCCGGTGGCCTCCGA
AGCGTATGCCACCGCCGAGGAAGTCCGCCAACGCATGGGCTCGCTGATCCAGCAGCTGGAAGCCACCGACGTCACCGATA
TCGTCAGCGTCGGCATCGGCGGTTCGGACCTGGGGCCGCGGCTGGTGGCCGATGCCTTGCGGGCGCCGTCGGGCGCGCGT
TTCCGCGTGCATTTCGTCTCCAACGTCGATGGCGCGGCGATGCAGCGCACGCTGGCCACGCTGGACCCGGCACGCACCGC
CGGTATCCTGATCTCCAAGACCTTCGGCACCCAGGAAACCCTGCTCAACGGCAGCATCCTGCATGCCTGGCTCGGTGGCA
GCGAGCGGCTGTACGCAGTCAGTGCCAACCCCGAGCGTGCCGCCAAGGCCTTCGATATCGCACCCGGCCGCGTGCTGCCG
ATGTGGGATTGGGTGGGCGGGCGCTACTCGCTGTGGTCGGCAGTGGGTTTCCCGATTGCATTGGCCATTGGTTTCGAGCG
TTTCGAACAACTGCTGGAAGGCGCCGCGCAGTTCGATGCGCATGTGCTCAACACGCCGCTGGAAGAAAACGTTGCGGTGT
TGCATGGCCTGACGGCAGTGTGGAACCGCAACCTGCTCGGTAGCGCCACGCACGCGGTGATGACCTACGACCAGCGCCTG
GCACTGCTGCCGGCTTACCTGCAGCAGCTGGTGATGGAGAGCCTGGGCAAGCGCGTCAAGCTCGATGGCTCGGCGGTGGA
CAGCGACACCGTGTCGGTGTGGTGGGGCGGTGCCGGCACCGATGTGCAGCACAGCTTCTTTCAGGCTCTGCATCAGGGCA
CCAGCGTGGTGCCGGCCGATTTCATCGGCACCGTGCACAACGACGACCCGTACGCGGAAAACCATACTGCGCTGATGGCC
AATGTGCTGGCGCAGACCGAGGCGCTGGCCAACGGCCAGGACAGCAGCGACCCGCACCGCAGCTACCCGGGCGGCCGCCC
GAGCACGGTGATCCTGCTCGATGCGCTCACCCCGCAGGCGCTGGGTGCGCTGATCTCGATGTACGAGCACAGCGTCTACG
TGCAATCGGTGATGTGGGGCATCAATGCGTTCGACCAGTTCGGCGTGGAGCTGGGCAAGCAGCTGGCCAGCCAGTTGCTG
CCGGCGCTGAAAGGCGAATCGGTCGATGTGGCCGACCCGGTGACGCGCGAGCTGCTGAACAAGTTGCGCGGCTGA

Upstream 100 bases:

>100_bases
TGAGCGAAGACGAAGCCAAGACCTTCAAGCCCAATCTGGTATATGTGAACGCGCACAACGCGATCTCCCACACCAACCAC
AGCATCCCCACCCAGGCCGC

Downstream 100 bases:

>100_bases
GCATTTGCGCATCGCGCTTAAAAAAACGGGGCCTGCGGGCCCCGTTTTGTTTTGGACGGCATGGTCGACCGCATTGTTTG
GACAAAATGGACAAATTTCC

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 504; Mature: 503

Protein sequence:

>504_residues
MTQTNGFDALHAHAQRLRGAAIPALLAAEPERPTQYARQVGPLYFNFARQKYDRAALDALFAIARERDLSGAFQRLFRGE
QVNVTEQRAALHTALRGDLTDAPVASEAYATAEEVRQRMGSLIQQLEATDVTDIVSVGIGGSDLGPRLVADALRAPSGAR
FRVHFVSNVDGAAMQRTLATLDPARTAGILISKTFGTQETLLNGSILHAWLGGSERLYAVSANPERAAKAFDIAPGRVLP
MWDWVGGRYSLWSAVGFPIALAIGFERFEQLLEGAAQFDAHVLNTPLEENVAVLHGLTAVWNRNLLGSATHAVMTYDQRL
ALLPAYLQQLVMESLGKRVKLDGSAVDSDTVSVWWGGAGTDVQHSFFQALHQGTSVVPADFIGTVHNDDPYAENHTALMA
NVLAQTEALANGQDSSDPHRSYPGGRPSTVILLDALTPQALGALISMYEHSVYVQSVMWGINAFDQFGVELGKQLASQLL
PALKGESVDVADPVTRELLNKLRG

Sequences:

>Translated_504_residues
MTQTNGFDALHAHAQRLRGAAIPALLAAEPERPTQYARQVGPLYFNFARQKYDRAALDALFAIARERDLSGAFQRLFRGE
QVNVTEQRAALHTALRGDLTDAPVASEAYATAEEVRQRMGSLIQQLEATDVTDIVSVGIGGSDLGPRLVADALRAPSGAR
FRVHFVSNVDGAAMQRTLATLDPARTAGILISKTFGTQETLLNGSILHAWLGGSERLYAVSANPERAAKAFDIAPGRVLP
MWDWVGGRYSLWSAVGFPIALAIGFERFEQLLEGAAQFDAHVLNTPLEENVAVLHGLTAVWNRNLLGSATHAVMTYDQRL
ALLPAYLQQLVMESLGKRVKLDGSAVDSDTVSVWWGGAGTDVQHSFFQALHQGTSVVPADFIGTVHNDDPYAENHTALMA
NVLAQTEALANGQDSSDPHRSYPGGRPSTVILLDALTPQALGALISMYEHSVYVQSVMWGINAFDQFGVELGKQLASQLL
PALKGESVDVADPVTRELLNKLRG
>Mature_503_residues
TQTNGFDALHAHAQRLRGAAIPALLAAEPERPTQYARQVGPLYFNFARQKYDRAALDALFAIARERDLSGAFQRLFRGEQ
VNVTEQRAALHTALRGDLTDAPVASEAYATAEEVRQRMGSLIQQLEATDVTDIVSVGIGGSDLGPRLVADALRAPSGARF
RVHFVSNVDGAAMQRTLATLDPARTAGILISKTFGTQETLLNGSILHAWLGGSERLYAVSANPERAAKAFDIAPGRVLPM
WDWVGGRYSLWSAVGFPIALAIGFERFEQLLEGAAQFDAHVLNTPLEENVAVLHGLTAVWNRNLLGSATHAVMTYDQRLA
LLPAYLQQLVMESLGKRVKLDGSAVDSDTVSVWWGGAGTDVQHSFFQALHQGTSVVPADFIGTVHNDDPYAENHTALMAN
VLAQTEALANGQDSSDPHRSYPGGRPSTVILLDALTPQALGALISMYEHSVYVQSVMWGINAFDQFGVELGKQLASQLLP
ALKGESVDVADPVTRELLNKLRG

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=504, Percent_Identity=39.8809523809524, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI296080693, Length=496, Percent_Identity=38.508064516129, Blast_Score=344, Evalue=1e-94,
Organism=Escherichia coli, GI1790457, Length=542, Percent_Identity=38.0073800738007, Blast_Score=372, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI71996708, Length=545, Percent_Identity=36.1467889908257, Blast_Score=341, Evalue=7e-94,
Organism=Caenorhabditis elegans, GI71996703, Length=545, Percent_Identity=36.1467889908257, Blast_Score=340, Evalue=1e-93,
Organism=Saccharomyces cerevisiae, GI6319673, Length=495, Percent_Identity=38.3838383838384, Blast_Score=339, Evalue=7e-94,
Organism=Drosophila melanogaster, GI24651916, Length=528, Percent_Identity=37.8787878787879, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24651914, Length=528, Percent_Identity=37.8787878787879, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI17737445, Length=528, Percent_Identity=37.8787878787879, Blast_Score=361, Evalue=1e-100,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_XANAC (P0A0T0)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_642115.1
- ProteinModelPortal:   P0A0T0
- SMR:   P0A0T0
- GeneID:   1155859
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC1788
- NMPDR:   fig|190486.1.peg.1759
- HOGENOM:   HBG352954
- OMA:   RTSITSA
- ProtClustDB:   PRK00179
- BioCyc:   XAXO190486:XAC1788-MONOMER
- BRENDA:   5.3.1.9
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189
- Gene3D:   G3DSA:1.10.1390.10
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 54454; Mature: 54323

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 333-333 ACT_SITE 364-364 ACT_SITE 473-473

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQTNGFDALHAHAQRLRGAAIPALLAAEPERPTQYARQVGPLYFNFARQKYDRAALDAL
CCCCCCCHHHHHHHHHHCCHHCHHHHHCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHH
FAIARERDLSGAFQRLFRGEQVNVTEQRAALHTALRGDLTDAPVASEAYATAEEVRQRMG
HHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
SLIQQLEATDVTDIVSVGIGGSDLGPRLVADALRAPSGARFRVHFVSNVDGAAMQRTLAT
HHHHHHHHCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHH
LDPARTAGILISKTFGTQETLLNGSILHAWLGGSERLYAVSANPERAAKAFDIAPGRVLP
CCCHHHCCEEEEECCCCHHHHHCCCCEEEEECCCCEEEEEECCHHHHHHHHCCCCCCEEE
MWDWVGGRYSLWSAVGFPIALAIGFERFEQLLEGAAQFDAHVLNTPLEENVAVLHGLTAV
CHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
WNRNLLGSATHAVMTYDQRLALLPAYLQQLVMESLGKRVKLDGSAVDSDTVSVWWGGAGT
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCEEEEECCCCC
DVQHSFFQALHQGTSVVPADFIGTVHNDDPYAENHTALMANVLAQTEALANGQDSSDPHR
HHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCC
SYPGGRPSTVILLDALTPQALGALISMYEHSVYVQSVMWGINAFDQFGVELGKQLASQLL
CCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PALKGESVDVADPVTRELLNKLRG
HHHCCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
TQTNGFDALHAHAQRLRGAAIPALLAAEPERPTQYARQVGPLYFNFARQKYDRAALDAL
CCCCCCHHHHHHHHHHCCHHCHHHHHCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHH
FAIARERDLSGAFQRLFRGEQVNVTEQRAALHTALRGDLTDAPVASEAYATAEEVRQRMG
HHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
SLIQQLEATDVTDIVSVGIGGSDLGPRLVADALRAPSGARFRVHFVSNVDGAAMQRTLAT
HHHHHHHHCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHH
LDPARTAGILISKTFGTQETLLNGSILHAWLGGSERLYAVSANPERAAKAFDIAPGRVLP
CCCHHHCCEEEEECCCCHHHHHCCCCEEEEECCCCEEEEEECCHHHHHHHHCCCCCCEEE
MWDWVGGRYSLWSAVGFPIALAIGFERFEQLLEGAAQFDAHVLNTPLEENVAVLHGLTAV
CHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
WNRNLLGSATHAVMTYDQRLALLPAYLQQLVMESLGKRVKLDGSAVDSDTVSVWWGGAGT
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCEEEEECCCCC
DVQHSFFQALHQGTSVVPADFIGTVHNDDPYAENHTALMANVLAQTEALANGQDSSDPHR
HHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCC
SYPGGRPSTVILLDALTPQALGALISMYEHSVYVQSVMWGINAFDQFGVELGKQLASQLL
CCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PALKGESVDVADPVTRELLNKLRG
HHHCCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217