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The map label for this gene is folK [H]

Identifier: 21242529

GI number: 21242529

Start: 2053812

End: 2054297

Strand: Direct

Name: folK [H]

Synonym: XAC1784

Alternate gene names: 21242529

Gene position: 2053812-2054297 (Clockwise)

Preceding gene: 21242528

Following gene: 21242530

Centisome position: 39.68

GC content: 71.6

Gene sequence:

>486_bases
ATGCAGACCGCCTTTGTCGGCCTGGGTGCCAACCTGGGCCCGGCCGAGGCCAGCGTGCGCGCGGCCATCGCCGCGCTGGG
CGCCGTGCCGCAAACCACGCTGATCGCCGCATCGCGCTTGTATCGCACGCCGGCCTGGGGCCGCGAAGACCAGCCCGACT
TCATCAATGCCGTGGCCCAGCTGCGTACCGAGCTTGCGCCGCTGCCGCTGCTGGAGGCCTTGCTCGGCATCGAACAGGCG
TTCGGCCGCGAGCGTCGCGCCGGCGAGCGCTGGGGCCCGCGTACGCTCGACCTGGACCTGCTGCTGTACGCCGATCAGGT
GATCGACCTGCCGCAGCTGCAGGTGCCGCATCCGCATCTGCACGCGCGCGCCTTCGCCCTGCTGCCGCTGTCGGAGCTGG
CGCCGGAGGCGATCATTCCGGGGCATGGAACAGTGCGGCGCGCCCTGCACGCCATCGATACCTGCGGGCTGGAGCCGATT
GGGTAG

Upstream 100 bases:

>100_bases
GATCGAATCGGCGCAGGCCGACCACGAGAGCGATGAGGGCGCACCGCGCAAGCGTCGCCGACGCCGCCGTCGGACCGGCG
CACCGGCCGGCGAGTAGGGC

Downstream 100 bases:

>100_bases
ATAATGGCCGGCTTATCACCCCACGTAATGACTTCATGAGCAGCCACGCCGACAGCAAGCCCTGGACCGTGCCCGCCTTG
GCGCAGGCCAAGCGCGAGGG

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 161; Mature: 161

Protein sequence:

>161_residues
MQTAFVGLGANLGPAEASVRAAIAALGAVPQTTLIAASRLYRTPAWGREDQPDFINAVAQLRTELAPLPLLEALLGIEQA
FGRERRAGERWGPRTLDLDLLLYADQVIDLPQLQVPHPHLHARAFALLPLSELAPEAIIPGHGTVRRALHAIDTCGLEPI
G

Sequences:

>Translated_161_residues
MQTAFVGLGANLGPAEASVRAAIAALGAVPQTTLIAASRLYRTPAWGREDQPDFINAVAQLRTELAPLPLLEALLGIEQA
FGRERRAGERWGPRTLDLDLLLYADQVIDLPQLQVPHPHLHARAFALLPLSELAPEAIIPGHGTVRRALHAIDTCGLEPI
G
>Mature_161_residues
MQTAFVGLGANLGPAEASVRAAIAALGAVPQTTLIAASRLYRTPAWGREDQPDFINAVAQLRTELAPLPLLEALLGIEQA
FGRERRAGERWGPRTLDLDLLLYADQVIDLPQLQVPHPHLHARAFALLPLSELAPEAIIPGHGTVRRALHAIDTCGLEPI
G

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=151, Percent_Identity=45.0331125827815, Blast_Score=134, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6324073, Length=138, Percent_Identity=29.7101449275362, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 17280; Mature: 17280

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTAFVGLGANLGPAEASVRAAIAALGAVPQTTLIAASRLYRTPAWGREDQPDFINAVAQ
CCCEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
LRTELAPLPLLEALLGIEQAFGRERRAGERWGPRTLDLDLLLYADQVIDLPQLQVPHPHL
HHHHCCCHHHHHHHHHHHHHHCHHHHCCCCCCCCEECHHHHHHHHHHCCCCCCCCCCCCH
HARAFALLPLSELAPEAIIPGHGTVRRALHAIDTCGLEPIG
HHHHHHCCCHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MQTAFVGLGANLGPAEASVRAAIAALGAVPQTTLIAASRLYRTPAWGREDQPDFINAVAQ
CCCEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
LRTELAPLPLLEALLGIEQAFGRERRAGERWGPRTLDLDLLLYADQVIDLPQLQVPHPHL
HHHHCCCHHHHHHHHHHHHHHCHHHHCCCCCCCCEECHHHHHHHHHHCCCCCCCCCCCCH
HARAFALLPLSELAPEAIIPGHGTVRRALHAIDTCGLEPIG
HHHHHHCCCHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]