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The map label for this gene is gcvR [H]

Identifier: 21242505

GI number: 21242505

Start: 2016841

End: 2017467

Strand: Reverse

Name: gcvR [H]

Synonym: XAC1759

Alternate gene names: 21242505

Gene position: 2017467-2016841 (Counterclockwise)

Preceding gene: 21242508

Following gene: 21242504

Centisome position: 38.98

GC content: 63.48

Gene sequence:

>627_bases
ATGCTGGTCACCGCCAGGGCGCCTGCCCGGGCGGCCATTCAGCCTGATGCAATGCCGGAAGCCCCTTTGACCGACTCTAC
ACCCCGGCCTTCGCCGACCGAAAATCACCTCCTGATCAACGCCTACACGACGCATCCGGAGTCCCCCCTGTTGCCCGTCA
CTCGCCGCATCGCCGACAGCGGCTGCAATCTCGTGGACGCCCGTCTGGCCACGGTGGGGCGCGACGTCTCGGTCACCGCA
CTGGCAACCGGCTCCTGGGATTCGGTCGCCAAGCTCGAAGCCATGCTGACCCGGCTCGAACGCGAGGAAGGTCTCAAGCT
GGTGTGGTATCGCACCGGCCCCAAGCAGACCCAGTCCAACCTGCTGCCCTACATCGTCGAAGTGATCGCCGCCGACAAGC
CGGGCATCCTGTTCCAGCTCGCCGATTTCTTCGACCGCCAGGGCATCACCATCGAAAACCTGCAAAGCACCCGCTACCGC
GCCATGCAGACCGGCGCGGAGATGTTTTCGGCGCAGGTGACGATCGGCGTGCCGGCCAACATGCACATCGCCGCCTTGCG
CGATGATTTCCTGGAATTCTGTGATCACCTCAATCTCGACGCGATCATGGACCCGATGAAGTTCTAA

Upstream 100 bases:

>100_bases
GGGACAAGATTCTGCTGCTCTTACGTGACAGGAAAAGGCCCGCGCACGCGCGGGTTGCGACCGCCTGCATGTTACTTGCG
GCGCGAAACCACGGGCAAGT

Downstream 100 bases:

>100_bases
GGCACCAACCATGGCCATCGCGATCTCTGCGCTAAAACAGATGTTCGACCACATCCGCTCGGAGACCGATTGGAATCTCG
ACGGTCCGCTGCGCTGGGAG

Product: glycine cleavage system transcriptional repressor

Products: NA

Alternate protein names: Gcv operon repressor [H]

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MLVTARAPARAAIQPDAMPEAPLTDSTPRPSPTENHLLINAYTTHPESPLLPVTRRIADSGCNLVDARLATVGRDVSVTA
LATGSWDSVAKLEAMLTRLEREEGLKLVWYRTGPKQTQSNLLPYIVEVIAADKPGILFQLADFFDRQGITIENLQSTRYR
AMQTGAEMFSAQVTIGVPANMHIAALRDDFLEFCDHLNLDAIMDPMKF

Sequences:

>Translated_208_residues
MLVTARAPARAAIQPDAMPEAPLTDSTPRPSPTENHLLINAYTTHPESPLLPVTRRIADSGCNLVDARLATVGRDVSVTA
LATGSWDSVAKLEAMLTRLEREEGLKLVWYRTGPKQTQSNLLPYIVEVIAADKPGILFQLADFFDRQGITIENLQSTRYR
AMQTGAEMFSAQVTIGVPANMHIAALRDDFLEFCDHLNLDAIMDPMKF
>Mature_208_residues
MLVTARAPARAAIQPDAMPEAPLTDSTPRPSPTENHLLINAYTTHPESPLLPVTRRIADSGCNLVDARLATVGRDVSVTA
LATGSWDSVAKLEAMLTRLEREEGLKLVWYRTGPKQTQSNLLPYIVEVIAADKPGILFQLADFFDRQGITIENLQSTRYR
AMQTGAEMFSAQVTIGVPANMHIAALRDDFLEFCDHLNLDAIMDPMKF

Specific function: Negative transcriptional regulator of the glycine cleavage system operon (GCV). Does not autoregulate its own expression. It is not yet known how gcvR acts as a repressor. It does not seem to bind DNA. It could interact with gcvA and suppress its activato

COG id: COG2716

COG function: function code E; Glycine cleavage system regulatory protein

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI87082113, Length=176, Percent_Identity=25.5681818181818, Blast_Score=68, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR016867 [H]

Pfam domain/function: PF01842 ACT [H]

EC number: NA

Molecular weight: Translated: 22935; Mature: 22935

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVTARAPARAAIQPDAMPEAPLTDSTPRPSPTENHLLINAYTTHPESPLLPVTRRIADS
CEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHC
GCNLVDARLATVGRDVSVTALATGSWDSVAKLEAMLTRLEREEGLKLVWYRTGPKQTQSN
CCCCHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHH
LLPYIVEVIAADKPGILFQLADFFDRQGITIENLQSTRYRAMQTGAEMFSAQVTIGVPAN
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEECCCC
MHIAALRDDFLEFCDHLNLDAIMDPMKF
CCHHHHHHHHHHHHHCCCHHHHHCCCCC
>Mature Secondary Structure
MLVTARAPARAAIQPDAMPEAPLTDSTPRPSPTENHLLINAYTTHPESPLLPVTRRIADS
CEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHC
GCNLVDARLATVGRDVSVTALATGSWDSVAKLEAMLTRLEREEGLKLVWYRTGPKQTQSN
CCCCHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHH
LLPYIVEVIAADKPGILFQLADFFDRQGITIENLQSTRYRAMQTGAEMFSAQVTIGVPAN
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEECCCC
MHIAALRDDFLEFCDHLNLDAIMDPMKF
CCHHHHHHHHHHHHHCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537378; 9205837; 9278503; 2016588 [H]