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The map label for this gene is map [H]

Identifier: 21242181

GI number: 21242181

Start: 1644875

End: 1645651

Strand: Direct

Name: map [H]

Synonym: XAC1428

Alternate gene names: 21242181

Gene position: 1644875-1645651 (Clockwise)

Preceding gene: 21242165

Following gene: 21242182

Centisome position: 31.78

GC content: 62.16

Gene sequence:

>777_bases
ATGAGCGTCAATCTGAAAACCAAAGAAGAAATTGAACTGATGCGCGTCGCCGGCCGCTTGGCCGCCGAGGTGCTCGATGT
GGTGGCACCGCACGTGAAGCCGGGCGTGACCACTGCCGAGCTGGACCGCATCTGCCACGACCACATCGTCAACGTGCAGG
GCACCATCCCCGCCAATGTCGGCTATCGCGGCTTCCCCAAGAGCGTGTGCACCTCGGTCAACAACGTGATCTGTCACGGC
ATCCCGAGTGCGGCCAAGGTGTTGAAGGACGGCGACATCGTCAATATCGACGTCACCGTCATCAAGGACGGCTGGCACGG
CGACACCAGCCGCATGTACTACGTCGGCACTCCGTCGGTGATGGCCAAGCGCTTGGTCGAAACGACGCATGAAGCGATGT
GGCGCGGTATCCGGGCGGTCAAGCCGGGTGCCACGCTGGGCGATGTGGGCCATGCGATCCAGAAGTTCGCCGAAGCCGAG
CGCTTCAGCGTGGTACGCGATTACTGTGGCCACGGCATCGGCAAGGTGTATCACGACGAGCCGCAGGTGATGCATTACGG
CCGCCAGGGCGAAGGGTTGGTGCTCAAGCCGGGCATGACCTTCACCATCGAGCCGATGATCAACGAAGGCACCTATCACC
ATAAGACGCTGCCCGACGGCTGGACCGTGGTCACCAAGGACCGCAAGCTGTCTGCGCAGTGGGAACACATGGTTGCGGTC
ACCGAAGACGGCGTGGATGTGTTGACGCTGTCGGCCAATTCGCCCGCGCCGGTATGA

Upstream 100 bases:

>100_bases
TTTTTTGCTGTGCGGTCCGCTTGAGGCGACCCACGGCGTCTCATAAAAAACGCAGGCGCGGGTCGTTCAGATTCAGCCCG
GATCGGCGATAATCGCGGCC

Downstream 100 bases:

>100_bases
CGGACACGCCGGCGGAGCGACCCGACCCGGGCGTCGCCGGCGACGCGGACTGGGCCGCGCAGGCCCGTCCGCTGCTGGTG
CATGTGGACATGCGCCTGTG

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 258; Mature: 257

Protein sequence:

>258_residues
MSVNLKTKEEIELMRVAGRLAAEVLDVVAPHVKPGVTTAELDRICHDHIVNVQGTIPANVGYRGFPKSVCTSVNNVICHG
IPSAAKVLKDGDIVNIDVTVIKDGWHGDTSRMYYVGTPSVMAKRLVETTHEAMWRGIRAVKPGATLGDVGHAIQKFAEAE
RFSVVRDYCGHGIGKVYHDEPQVMHYGRQGEGLVLKPGMTFTIEPMINEGTYHHKTLPDGWTVVTKDRKLSAQWEHMVAV
TEDGVDVLTLSANSPAPV

Sequences:

>Translated_258_residues
MSVNLKTKEEIELMRVAGRLAAEVLDVVAPHVKPGVTTAELDRICHDHIVNVQGTIPANVGYRGFPKSVCTSVNNVICHG
IPSAAKVLKDGDIVNIDVTVIKDGWHGDTSRMYYVGTPSVMAKRLVETTHEAMWRGIRAVKPGATLGDVGHAIQKFAEAE
RFSVVRDYCGHGIGKVYHDEPQVMHYGRQGEGLVLKPGMTFTIEPMINEGTYHHKTLPDGWTVVTKDRKLSAQWEHMVAV
TEDGVDVLTLSANSPAPV
>Mature_257_residues
SVNLKTKEEIELMRVAGRLAAEVLDVVAPHVKPGVTTAELDRICHDHIVNVQGTIPANVGYRGFPKSVCTSVNNVICHGI
PSAAKVLKDGDIVNIDVTVIKDGWHGDTSRMYYVGTPSVMAKRLVETTHEAMWRGIRAVKPGATLGDVGHAIQKFAEAER
FSVVRDYCGHGIGKVYHDEPQVMHYGRQGEGLVLKPGMTFTIEPMINEGTYHHKTLPDGWTVVTKDRKLSAQWEHMVAVT
EDGVDVLTLSANSPAPV

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=256, Percent_Identity=48.828125, Blast_Score=248, Evalue=3e-66,
Organism=Homo sapiens, GI40385867, Length=248, Percent_Identity=41.9354838709677, Blast_Score=201, Evalue=7e-52,
Organism=Escherichia coli, GI1786364, Length=257, Percent_Identity=61.4785992217899, Blast_Score=348, Evalue=2e-97,
Organism=Caenorhabditis elegans, GI71996291, Length=248, Percent_Identity=45.9677419354839, Blast_Score=224, Evalue=4e-59,
Organism=Saccharomyces cerevisiae, GI6323273, Length=257, Percent_Identity=47.8599221789883, Blast_Score=243, Evalue=2e-65,
Organism=Drosophila melanogaster, GI21355531, Length=241, Percent_Identity=49.792531120332, Blast_Score=233, Evalue=1e-61,
Organism=Drosophila melanogaster, GI24583427, Length=248, Percent_Identity=39.1129032258064, Blast_Score=197, Evalue=5e-51,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 28197; Mature: 28065

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVNLKTKEEIELMRVAGRLAAEVLDVVAPHVKPGVTTAELDRICHDHIVNVQGTIPANV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHEECCCCCCCCCC
GYRGFPKSVCTSVNNVICHGIPSAAKVLKDGDIVNIDVTVIKDGWHGDTSRMYYVGTPSV
CCCCCCHHHHHHHHHHEECCCCHHHHHHCCCCEEEEEEEEEECCCCCCCCEEEEEECHHH
MAKRLVETTHEAMWRGIRAVKPGATLGDVGHAIQKFAEAERFSVVRDYCGHGIGKVYHDE
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCC
PQVMHYGRQGEGLVLKPGMTFTIEPMINEGTYHHKTLPDGWTVVTKDRKLSAQWEHMVAV
CHHEECCCCCCCEEECCCCCEEEEEEECCCCCCCCCCCCCCEEEECCCCCCCCHHEEEEE
TEDGVDVLTLSANSPAPV
ECCCCEEEEEECCCCCCC
>Mature Secondary Structure 
SVNLKTKEEIELMRVAGRLAAEVLDVVAPHVKPGVTTAELDRICHDHIVNVQGTIPANV
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHEECCCCCCCCCC
GYRGFPKSVCTSVNNVICHGIPSAAKVLKDGDIVNIDVTVIKDGWHGDTSRMYYVGTPSV
CCCCCCHHHHHHHHHHEECCCCHHHHHHCCCCEEEEEEEEEECCCCCCCCEEEEEECHHH
MAKRLVETTHEAMWRGIRAVKPGATLGDVGHAIQKFAEAERFSVVRDYCGHGIGKVYHDE
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCC
PQVMHYGRQGEGLVLKPGMTFTIEPMINEGTYHHKTLPDGWTVVTKDRKLSAQWEHMVAV
CHHEECCCCCCCEEECCCCCEEEEEEECCCCCCCCCCCCCCEEEECCCCCCCCHHEEEEE
TEDGVDVLTLSANSPAPV
ECCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]