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The map label for this gene is fadE9 [H]

Identifier: 21242066

GI number: 21242066

Start: 1516110

End: 1517291

Strand: Direct

Name: fadE9 [H]

Synonym: XAC1313

Alternate gene names: 21242066

Gene position: 1516110-1517291 (Clockwise)

Preceding gene: 21242065

Following gene: 21242067

Centisome position: 29.29

GC content: 64.97

Gene sequence:

>1182_bases
ATGAATGCAGCCATCCAGCTCCATCCCAATACAGCCGATTTGAACGACGAGCAGGAAGCCTTCCGCGCCGCCGCCCGCGA
CTTCGCCGACAAGCAACTCGCCCCGCACGCAGCGCAGTGGGACGCAGAAGGTCACTTCCCGCGCGAGGCCATCGCCAAGG
CCGCCGAACTCGGCTTTTGCGGTCTTTACACCGATGAAGGCGTCGGCGGCCTGGGCATGCGCCGGCTCGATGCGGCAGTG
GTGTTCGAAGAACTCGCCACGGTGGATCCGTCCACCTCCGCCTTCATCAGCATCCACAACATGGCCACCTGGTTGATCGC
CAGCTATGGCACCGACGCGGTGCGCGCGCAGTGGGGCCAGGCGATGACCAGCGGCGCCAAGCTGGGCTCGTACTGCCTGA
CCGAACCGGGCAGCGGCTCGGATGCGGCATCGCTGAAATCGCGCGCGCAGCGCGACGGCGACAGCTATGTGCTCAACGGC
AGCAAGGCCTTCATCTCCGGCGCCGGCGCAACCGACGTGCTGGTGGTGATGGCACGCACCGGCGAAGACGGTGCACGTGG
CATCAGCGCCTTCGTGGTGCCGGCCGATGCGCCTGGCATCAGCTACGGTCGCAAGGAAGAGAAGATGGGCTGGAACAGCC
AGCCCACGCGCGGTGTGAGCTTCGAAAACGTGCGTGTTCCGGCCGAGAACCTGCTGGGCAAGGAAGGCGAAGGCTTCAAG
ATGGCGATGAAGGCGCTGGATGGTGGCCGCATCAATATCGCTGCGTGTTCGTTGGGCGCCGCGCAAGGCGCGCTGGATGC
CGCGCGTCGCTACATGGGCGAGCGTCGCCAGTTCGGCAAGAAACTGGCCGATTTCCAGGCGCTGCAGTTCAAGCTGGCCG
ACATGGCCACGCAGCTGGTGGCTGCGCGGCAGATGGTGCACACCGCCGCGCGCAAGCTCGATGCCGGCAGCCACGATGCC
ACCGTGTGGTGTGCGATGGCCAAGCGCTTCGCCACCGATGCCGGTTTTGCCATCTGCGACGATGCCTTGCAGATCCATGG
CGGCTACGGCTATATCCGCGAATACCCGATCGAGCGTTTGCTGCGCGACAGCCGTGTGCACCGCATTCTGGAAGGCACCA
ACGAGGTGATGCGCATGATCGTGGCGCGTCACTTGCTCAATGGCGAGGAGCAATTGCGATGA

Upstream 100 bases:

>100_bases
TTCTACACCCAGACCAAGACCGTGACCGCGCGCTGGTTCGACGATCAGACGCTGGGCCATGGCGTCAACACCACCATTTC
CCTCAAGTGACCCGATCGCC

Downstream 100 bases:

>100_bases
GCGATTGGGAAGGACGCCTCCATACCGGTCTGCAGGTCGAGCGCGATGGGCACGTCGCCATCGTGACCTTGAGCAACCCG
CCGGCCAACACCTGGACCGT

Product: acyl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MNAAIQLHPNTADLNDEQEAFRAAARDFADKQLAPHAAQWDAEGHFPREAIAKAAELGFCGLYTDEGVGGLGMRRLDAAV
VFEELATVDPSTSAFISIHNMATWLIASYGTDAVRAQWGQAMTSGAKLGSYCLTEPGSGSDAASLKSRAQRDGDSYVLNG
SKAFISGAGATDVLVVMARTGEDGARGISAFVVPADAPGISYGRKEEKMGWNSQPTRGVSFENVRVPAENLLGKEGEGFK
MAMKALDGGRINIAACSLGAAQGALDAARRYMGERRQFGKKLADFQALQFKLADMATQLVAARQMVHTAARKLDAGSHDA
TVWCAMAKRFATDAGFAICDDALQIHGGYGYIREYPIERLLRDSRVHRILEGTNEVMRMIVARHLLNGEEQLR

Sequences:

>Translated_393_residues
MNAAIQLHPNTADLNDEQEAFRAAARDFADKQLAPHAAQWDAEGHFPREAIAKAAELGFCGLYTDEGVGGLGMRRLDAAV
VFEELATVDPSTSAFISIHNMATWLIASYGTDAVRAQWGQAMTSGAKLGSYCLTEPGSGSDAASLKSRAQRDGDSYVLNG
SKAFISGAGATDVLVVMARTGEDGARGISAFVVPADAPGISYGRKEEKMGWNSQPTRGVSFENVRVPAENLLGKEGEGFK
MAMKALDGGRINIAACSLGAAQGALDAARRYMGERRQFGKKLADFQALQFKLADMATQLVAARQMVHTAARKLDAGSHDA
TVWCAMAKRFATDAGFAICDDALQIHGGYGYIREYPIERLLRDSRVHRILEGTNEVMRMIVARHLLNGEEQLR
>Mature_393_residues
MNAAIQLHPNTADLNDEQEAFRAAARDFADKQLAPHAAQWDAEGHFPREAIAKAAELGFCGLYTDEGVGGLGMRRLDAAV
VFEELATVDPSTSAFISIHNMATWLIASYGTDAVRAQWGQAMTSGAKLGSYCLTEPGSGSDAASLKSRAQRDGDSYVLNG
SKAFISGAGATDVLVVMARTGEDGARGISAFVVPADAPGISYGRKEEKMGWNSQPTRGVSFENVRVPAENLLGKEGEGFK
MAMKALDGGRINIAACSLGAAQGALDAARRYMGERRQFGKKLADFQALQFKLADMATQLVAARQMVHTAARKLDAGSHDA
TVWCAMAKRFATDAGFAICDDALQIHGGYGYIREYPIERLLRDSRVHRILEGTNEVMRMIVARHLLNGEEQLR

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7656849, Length=374, Percent_Identity=55.3475935828877, Blast_Score=437, Evalue=1e-122,
Organism=Homo sapiens, GI4557231, Length=379, Percent_Identity=39.3139841688654, Blast_Score=283, Evalue=1e-76,
Organism=Homo sapiens, GI187960098, Length=379, Percent_Identity=39.3139841688654, Blast_Score=283, Evalue=2e-76,
Organism=Homo sapiens, GI4557233, Length=388, Percent_Identity=41.7525773195876, Blast_Score=274, Evalue=8e-74,
Organism=Homo sapiens, GI4501859, Length=386, Percent_Identity=38.60103626943, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI4501857, Length=377, Percent_Identity=36.3395225464191, Blast_Score=252, Evalue=5e-67,
Organism=Homo sapiens, GI21361497, Length=353, Percent_Identity=37.6770538243626, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI226958412, Length=376, Percent_Identity=33.5106382978723, Blast_Score=222, Evalue=5e-58,
Organism=Homo sapiens, GI76496475, Length=391, Percent_Identity=35.2941176470588, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI4557235, Length=391, Percent_Identity=35.2941176470588, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI226958414, Length=340, Percent_Identity=33.5294117647059, Blast_Score=205, Evalue=6e-53,
Organism=Homo sapiens, GI4503943, Length=374, Percent_Identity=30.2139037433155, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI7669494, Length=350, Percent_Identity=30.8571428571429, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI38505218, Length=278, Percent_Identity=32.3741007194245, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI48976061, Length=287, Percent_Identity=31.0104529616725, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI211971008, Length=287, Percent_Identity=31.0104529616725, Blast_Score=120, Evalue=3e-27,
Organism=Escherichia coli, GI1786223, Length=382, Percent_Identity=31.6753926701571, Blast_Score=175, Evalue=5e-45,
Organism=Escherichia coli, GI87081958, Length=380, Percent_Identity=31.0526315789474, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI87082384, Length=268, Percent_Identity=32.089552238806, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87081702, Length=330, Percent_Identity=24.2424242424242, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17533517, Length=376, Percent_Identity=49.2021276595745, Blast_Score=381, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17534899, Length=390, Percent_Identity=37.4358974358974, Blast_Score=272, Evalue=3e-73,
Organism=Caenorhabditis elegans, GI17569725, Length=381, Percent_Identity=37.7952755905512, Blast_Score=269, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI17570075, Length=377, Percent_Identity=37.6657824933687, Blast_Score=267, Evalue=9e-72,
Organism=Caenorhabditis elegans, GI17508101, Length=382, Percent_Identity=35.8638743455497, Blast_Score=242, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI71985184, Length=387, Percent_Identity=35.9173126614987, Blast_Score=241, Evalue=6e-64,
Organism=Caenorhabditis elegans, GI17506239, Length=382, Percent_Identity=35.0785340314136, Blast_Score=232, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI17538396, Length=376, Percent_Identity=35.6382978723404, Blast_Score=221, Evalue=7e-58,
Organism=Caenorhabditis elegans, GI71990804, Length=280, Percent_Identity=39.6428571428571, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI71985192, Length=333, Percent_Identity=33.9339339339339, Blast_Score=177, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI32563615, Length=230, Percent_Identity=39.1304347826087, Blast_Score=174, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17505929, Length=371, Percent_Identity=30.4582210242588, Blast_Score=167, Evalue=8e-42,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=31.3868613138686, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17551932, Length=358, Percent_Identity=29.0502793296089, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17534353, Length=380, Percent_Identity=28.1578947368421, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17562446, Length=288, Percent_Identity=29.5138888888889, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17531909, Length=244, Percent_Identity=29.5081967213115, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI86563383, Length=338, Percent_Identity=26.6272189349112, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI86563381, Length=338, Percent_Identity=26.6272189349112, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17531913, Length=169, Percent_Identity=27.810650887574, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24660351, Length=389, Percent_Identity=35.73264781491, Blast_Score=255, Evalue=4e-68,
Organism=Drosophila melanogaster, GI24666513, Length=385, Percent_Identity=36.3636363636364, Blast_Score=248, Evalue=4e-66,
Organism=Drosophila melanogaster, GI21356377, Length=377, Percent_Identity=37.1352785145889, Blast_Score=244, Evalue=8e-65,
Organism=Drosophila melanogaster, GI24646207, Length=376, Percent_Identity=37.2340425531915, Blast_Score=235, Evalue=3e-62,
Organism=Drosophila melanogaster, GI21355753, Length=378, Percent_Identity=35.978835978836, Blast_Score=231, Evalue=5e-61,
Organism=Drosophila melanogaster, GI281363737, Length=392, Percent_Identity=34.1836734693878, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI19920834, Length=377, Percent_Identity=29.4429708222812, Blast_Score=148, Evalue=5e-36,
Organism=Drosophila melanogaster, GI45550141, Length=318, Percent_Identity=24.2138364779874, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI221473076, Length=318, Percent_Identity=24.2138364779874, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24652780, Length=332, Percent_Identity=22.5903614457831, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 42279; Mature: 42279

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAAIQLHPNTADLNDEQEAFRAAARDFADKQLAPHAAQWDAEGHFPREAIAKAAELGFC
CCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCEE
GLYTDEGVGGLGMRRLDAAVVFEELATVDPSTSAFISIHNMATWLIASYGTDAVRAQWGQ
EEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHCCCHHHHHHHHH
AMTSGAKLGSYCLTEPGSGSDAASLKSRAQRDGDSYVLNGSKAFISGAGATDVLVVMART
HHHCCCHHCCEEECCCCCCCHHHHHHHHHHCCCCCEEECCCCCEEECCCCCEEEEEEEEC
GEDGARGISAFVVPADAPGISYGRKEEKMGWNSQPTRGVSFENVRVPAENLLGKEGEGFK
CCCCCCCCEEEEEECCCCCCCCCCCHHHCCCCCCCCCCCCCCCEECCHHHHCCCCCCCHH
MAMKALDGGRINIAACSLGAAQGALDAARRYMGERRQFGKKLADFQALQFKLADMATQLV
HHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AARQMVHTAARKLDAGSHDATVWCAMAKRFATDAGFAICDDALQIHGGYGYIREYPIERL
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHEECCHHHCCCCCCHHHHHHHHHH
LRDSRVHRILEGTNEVMRMIVARHLLNGEEQLR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCC
>Mature Secondary Structure
MNAAIQLHPNTADLNDEQEAFRAAARDFADKQLAPHAAQWDAEGHFPREAIAKAAELGFC
CCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCEE
GLYTDEGVGGLGMRRLDAAVVFEELATVDPSTSAFISIHNMATWLIASYGTDAVRAQWGQ
EEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHCCCHHHHHHHHH
AMTSGAKLGSYCLTEPGSGSDAASLKSRAQRDGDSYVLNGSKAFISGAGATDVLVVMART
HHHCCCHHCCEEECCCCCCCHHHHHHHHHHCCCCCEEECCCCCEEECCCCCEEEEEEEEC
GEDGARGISAFVVPADAPGISYGRKEEKMGWNSQPTRGVSFENVRVPAENLLGKEGEGFK
CCCCCCCCEEEEEECCCCCCCCCCCHHHCCCCCCCCCCCCCCCEECCHHHHCCCCCCCHH
MAMKALDGGRINIAACSLGAAQGALDAARRYMGERRQFGKKLADFQALQFKLADMATQLV
HHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AARQMVHTAARKLDAGSHDATVWCAMAKRFATDAGFAICDDALQIHGGYGYIREYPIERL
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHEECCHHHCCCCCCHHHHHHHHHH
LRDSRVHRILEGTNEVMRMIVARHLLNGEEQLR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]