Click here to switch to the map view.

The map label for this gene is bcr [H]

Identifier: 21241969

GI number: 21241969

Start: 1392736

End: 1393989

Strand: Direct

Name: bcr [H]

Synonym: XAC1215

Alternate gene names: 21241969

Gene position: 1392736-1393989 (Clockwise)

Preceding gene: 77748569

Following gene: 21241970

Centisome position: 26.91

GC content: 66.83

Gene sequence:

>1254_bases
ATGCCCCCCACCACGCCTTCCACCCGTCGCATGGCGCTGCTGCTGGCCGGGCTGGCGATGTTCGGCCCGTTTTCGATCGA
CACCATCTTCCCGGCGTTCTCGCAGCTTAGCCGCAGCCTGGCGGTGGACCAGGTGGCGATCCAGCAGACCATCAGCGTCT
ATCTGCTGGCGTATGGCCTGATGAGCATCGCGCACGGGCCATTGTCCGACGCCTGGGGCCGCAAGCGGGTGATCCTGGGC
GGGCTGGCCTTGTTTATCGCCGGCTCGATCGGATGTGCACTGTCGCAAGACTTGCCCACGCTGCTGGCATTCCGCGCGCT
GCAGGGCCTGTCGGCCGGCGTGGGCATGATCGTCGGGCGGGCGGTGATCCGCGACCTGTTCCATGGTCCGGACGCGCAGC
GGCTGATGAGCCAGGTATCGATGATCTTCGGGATTGCGCCGGCCATCGCGCCGATCATCGGCGGCTGGATCCTGCTCAGT
GGCGGCGGCTGGCCGTTGATCTTCTGGTTTCTGGTGGTGTTCGGCCTGGTGCTGCTCATCGCAACCCTGACCTGGCTGCC
GGAGACCCATCCGGTGGAGGCGCGTACGCCGCTGCAGTTCAGGCGCCTGTTGCAGGATTACGTGCGCATCGGCTTCAACC
CGCGCTTCCAGCGCCTGGCCGCGGCCGGGTCGTTCAACTTCGCCGGCATCTTCCTGTACATCGCCTCGGCGCCGGTGCTG
ATCATGCAGCACCTGAAGCTGGGCGAAGGCGATTTCGCCTGGCTGTTCATTCCCACCATCGGTGGCATGACGCTGGGCTC
GTTCCTGTCCGGGCGCATGGCCGGGCGCATGCAGCCGGTGCGGCAGATCCGCATCGGCTTCGTTTGCTGCGGGGTGGCGG
CGCTGGTCAATCTGGCCTATACCTTTGCGGTGACGCAGATCGCGCTGCCGTGGGCGGTGCTGCCGATCTTCCTGGCCGGC
GTGGGCATGGCGCTGATCTTCCCGATCCTGGCGCTGGCGGTGCTGGACATGTACCCGCAGCAGCGCGGCCTGGCGTCTTC
TCTGCAGGCCTTCACCCAGTTGATGACCAATACGGTGGTGGCCGGGGTGCTGTCGCCGCTGCTGAGTGAACATCCGCGGC
ATCTGGCGATCGGCATGACCGGTTTTTTCTTGCTGGGCTGGCTATTCTGGCGCTGGGAGCGCCGCAGCGGCCGCCGTCTA
CGGCACCGCCAGGCCACCGAGGCAGTGCCTCTGGAGCCGGCCGACCACCTCTGA

Upstream 100 bases:

>100_bases
CCGGCGCAAGCGCCTATCATCGGCGGCCGTGTGCGCATGCCGGTGCCGCAACAAGCGGACGCCGGCGCGCACTCCATGCA
CTACCGCCGCGGATCCCTGA

Downstream 100 bases:

>100_bases
CCTCACAGGAGCCTGCATGTCCACCGATTCCAAGTTGCGCCGTGATGCCCGCAAGCGCGCCGCCGAGCGCCAGCGCAACC
AGGCCGCCGCCAATCCAGCG

Product: MFS transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Sulfonamide resistance protein [H]

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MPPTTPSTRRMALLLAGLAMFGPFSIDTIFPAFSQLSRSLAVDQVAIQQTISVYLLAYGLMSIAHGPLSDAWGRKRVILG
GLALFIAGSIGCALSQDLPTLLAFRALQGLSAGVGMIVGRAVIRDLFHGPDAQRLMSQVSMIFGIAPAIAPIIGGWILLS
GGGWPLIFWFLVVFGLVLLIATLTWLPETHPVEARTPLQFRRLLQDYVRIGFNPRFQRLAAAGSFNFAGIFLYIASAPVL
IMQHLKLGEGDFAWLFIPTIGGMTLGSFLSGRMAGRMQPVRQIRIGFVCCGVAALVNLAYTFAVTQIALPWAVLPIFLAG
VGMALIFPILALAVLDMYPQQRGLASSLQAFTQLMTNTVVAGVLSPLLSEHPRHLAIGMTGFFLLGWLFWRWERRSGRRL
RHRQATEAVPLEPADHL

Sequences:

>Translated_417_residues
MPPTTPSTRRMALLLAGLAMFGPFSIDTIFPAFSQLSRSLAVDQVAIQQTISVYLLAYGLMSIAHGPLSDAWGRKRVILG
GLALFIAGSIGCALSQDLPTLLAFRALQGLSAGVGMIVGRAVIRDLFHGPDAQRLMSQVSMIFGIAPAIAPIIGGWILLS
GGGWPLIFWFLVVFGLVLLIATLTWLPETHPVEARTPLQFRRLLQDYVRIGFNPRFQRLAAAGSFNFAGIFLYIASAPVL
IMQHLKLGEGDFAWLFIPTIGGMTLGSFLSGRMAGRMQPVRQIRIGFVCCGVAALVNLAYTFAVTQIALPWAVLPIFLAG
VGMALIFPILALAVLDMYPQQRGLASSLQAFTQLMTNTVVAGVLSPLLSEHPRHLAIGMTGFFLLGWLFWRWERRSGRRL
RHRQATEAVPLEPADHL
>Mature_416_residues
PPTTPSTRRMALLLAGLAMFGPFSIDTIFPAFSQLSRSLAVDQVAIQQTISVYLLAYGLMSIAHGPLSDAWGRKRVILGG
LALFIAGSIGCALSQDLPTLLAFRALQGLSAGVGMIVGRAVIRDLFHGPDAQRLMSQVSMIFGIAPAIAPIIGGWILLSG
GGWPLIFWFLVVFGLVLLIATLTWLPETHPVEARTPLQFRRLLQDYVRIGFNPRFQRLAAAGSFNFAGIFLYIASAPVLI
MQHLKLGEGDFAWLFIPTIGGMTLGSFLSGRMAGRMQPVRQIRIGFVCCGVAALVNLAYTFAVTQIALPWAVLPIFLAGV
GMALIFPILALAVLDMYPQQRGLASSLQAFTQLMTNTVVAGVLSPLLSEHPRHLAIGMTGFFLLGWLFWRWERRSGRRLR
HRQATEAVPLEPADHL

Specific function: Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance. Probable membrane translocase [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=367, Percent_Identity=28.8828337874659, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI87082312, Length=351, Percent_Identity=29.9145299145299, Blast_Score=108, Evalue=9e-25,
Organism=Escherichia coli, GI48994889, Length=361, Percent_Identity=25.207756232687, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1790146, Length=263, Percent_Identity=26.9961977186312, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1790794, Length=358, Percent_Identity=25.1396648044693, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1787065, Length=265, Percent_Identity=27.5471698113208, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1790195, Length=163, Percent_Identity=28.2208588957055, Blast_Score=65, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6319517, Length=185, Percent_Identity=29.1891891891892, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324264, Length=162, Percent_Identity=29.0123456790123, Blast_Score=70, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR004734 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 45402; Mature: 45271

Theoretical pI: Translated: 11.33; Mature: 11.33

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
PPTTPSTRRMALLLAGLAMFGPFSIDTIFPAFSQLSRSLAVDQVAIQQTISVYLLAYGL
CCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MSIAHGPLSDAWGRKRVILGGLALFIAGSIGCALSQDLPTLLAFRALQGLSAGVGMIVGR
HHHCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
AVIRDLFHGPDAQRLMSQVSMIFGIAPAIAPIIGGWILLSGGGWPLIFWFLVVFGLVLLI
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHH
ATLTWLPETHPVEARTPLQFRRLLQDYVRIGFNPRFQRLAAAGSFNFAGIFLYIASAPVL
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHH
IMQHLKLGEGDFAWLFIPTIGGMTLGSFLSGRMAGRMQPVRQIRIGFVCCGVAALVNLAY
HHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TFAVTQIALPWAVLPIFLAGVGMALIFPILALAVLDMYPQQRGLASSLQAFTQLMTNTVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHHHH
AGVLSPLLSEHPRHLAIGMTGFFLLGWLFWRWERRSGRRLRHRQATEAVPLEPADHL
HHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8486276; 9278503; 2694948 [H]