Click here to switch to the map view.

The map label for this gene is uvrA2 [H]

Identifier: 21241940

GI number: 21241940

Start: 1351250

End: 1353778

Strand: Direct

Name: uvrA2 [H]

Synonym: XAC1186

Alternate gene names: 21241940

Gene position: 1351250-1353778 (Clockwise)

Preceding gene: 21241939

Following gene: 21241944

Centisome position: 26.11

GC content: 66.82

Gene sequence:

>2529_bases
ATGTCAAACGCGACGTCTTCCAGTGGCCTGGTGCGCGTACGCGGCGCGCGCGAGCACAACCTCAAGAACGTGGATGTGGA
TGTCCCCCGCGATGCACTGGTGGTGTTCACCGGCGTTTCCGGATCGGGCAAGTCGTCGTTGGCGTTCGGCACCATCTTTG
CAGAGGCGCAGCGGCGCTATCTGGATTCGATCTCGCCGTATGCGCGGCGCCTGATCGACCAGGTAGGCGTGCCGGAGGTG
GATTCCATCGATGGCCTGCCACCGGCGGTGGCCCTGCAGCAGGCCCGCGGCGCGCCTAGCGCACGCTCGTCGGTGGGCAG
CGTCACCACCATCTCCAACTCGTTGCGCATGCTGTATTCGCGTGCCGGCCAGTATCCGCCGGGGCAGGAGATCATCTACG
CCGACGGTTTTTCGCCGAACACGCCCGCGGGGGCATGCCCCACCTGCCACGGCCTGGGGCGCATCTATGACGCCACCGAA
GCGACCATGGTGCTCGACCGCAGCCTGAGCATTCGCGACCGTGCGGTCGCCGCCTGGCCGGGCGCATGGCATGGGCAGAA
CCAGCGCGACATCCTCACCACGCTGGGCCATGACGTGGATGCGCCATGGCACACGCTGCCGAAGAAAACCCGCGACTGGA
TCCTGTTTACCGACGAACAGCCGGTGGTGCCGGTATACGCCGGTTACAACGTGGCCGAGGTCAGGCGCGCCCTCAAGCGC
AAGGAAGAGCCCAGCTACATGGGCACGTTCACCAGTGCGCGGCGTTATGTGCTGCACACCTTCGCCACCACCCAGAGCGC
GCAGATGAAAAAGCGCGTGGCGCAGTATTTGCTCAGCACACAATGCCCGCAGTGCGATGGCAAGCGCCTGCGCCGCGAGG
CCTTGTCGGTCACCTTTGCCGGGCTGGATATCGGGGAGCTGTCGCGGCGCCCCCTGGACGAGGTGGCCGAGCTGCTGCGC
CCCGCCGCCGAAGCCACGCCATCCAAAGGTACGCGCAAGGGTGCGCACCAGCATCCGGAACAGGTGATCGCCGCGCAACG
CATCGCTGCGGATCTGCGCGCGCGAATCGCCGTCGTACAGGCACTGGGTCTGGGCTACCTCAGCCTGGAGCGCAGCACGC
CCACCTTGTCGCCGGGCGAGTTGCAACGGCTGCGGCTGGCCACGCAGATCCGCTCGCAGTTGTTCGGCGTGGTGTACGTG
ATGGACGAACCATCGGCCGGCTTGCATCCCGCCGATGCGCAGGCGCTGCTGGGTGCGTTGGATCAACTCAAGGCGGCGGG
CAATTCGGTCTTCGTGGTCGAACACGAAGTGGACGTGATCCGCCATGCGGACTGGATCGTGGATGTAGGCCCGGCGGCCG
GCGCGCAGGGCGGGCAGGTACTTTATAGCGGGCCGCCCGCAGGCTTGGAGCAGGTGCAGGCCTCGTCCACACGTCGCTAT
CTGTTCGGCACGCCGCCGCAAGTGCATCGCCCGGCGCGCGCGGCAAACGGTTGGTTGCAGCTGCGCGGCATCACCCGCAA
CAACGTACGCGCGCTGGATGTGGATCTGCCGTTGGGCGTATTCACCACTGTTACCGGTGTGTCCGGCTCGGGCAAATCCT
CGTTGGTGAGTCAGGCGCTGGTGGAACTGCTGGCCGCCCATCTGGGGCAAGCGCAGGCAGAGGACGAAGAAGCGCTGGAT
CCACTGGAGCGCGGCACGCAGGTGCCGCTGGAGGGTGCGATTGTGGCCGGGCTGGATCGGGTGCGCCGGCTGGTGCGCGT
GGATCAAAAACCCATCGGCCGCACCCCGCGCTCCAATCTGGCCACATACACCGGCCTGTTCGATCCGGTGCGCAAGCTGT
TTGCGGCCACGCCGGCCGCACGCCGGCGCCGCTACGACCCGGGGCAGTTCTCCTTCAACGTCGCCAAGGGCCGCTGTGCC
ACCTGCGAGGGCGAAGGCTCGGTGTACGTGGAATTGCTGTTCATGCCCAGCGTCTACGCACCGTGCCCGACCTGTCACGG
CGCACGCTATAACGCCAAGACGTTGGAGATCGCGCTACGCGGTCGCAACATCGCGCAGGTGCTGGAGATGACGGTGGATC
AGGCAGCCATCTTCTTTGCCGACGATGCCGGCGTGCTGCGACCGTTGCAGGTGTTGCGCGAAGTGGGGCTGGGCTATCTG
CGTCTCGGCCAGCCGGCCACCGAACTGTCCGGCGGTGAAGCGCAGCGCATCAAGCTGGCGACCGAGCTGCAACGCGCGCA
GCGACGCGACACCGTCTACGTGCTGGACGAACCGACCACCGGCCTGCATCCGTCCGACGTGGATACCTTGATGGCCCAGT
TGCAAGGGCTGGTCGACGCAGGCAATACGGTGATCGTGGTCGAACACGATATGCGCGTGGCCGCCAGCAGCGACTGGGTG
CTGGACATGGGGCCGGGCGCAGGCGGCGTCGGCGGTCACGTGGTGGTGGCAGGACCACCGGATGTCGTGGCACGCCATCG
TGGCAGCCGCACCGCACCGTTCCTGGCGCAGGTGTTGCGCGGGGAATAA

Upstream 100 bases:

>100_bases
GGCAGCTCAGGTGTTGCCTGCGCTCGGTCACCATCGCTGACACCGGCTGCATGTCGCGCGCGCTAGGCTGGCGTCTTGTC
GAATTCTGGTTTCGGTAGTC

Downstream 100 bases:

>100_bases
GTAGCCGACATGTTGGTCAGCCCGCGCCGCGTCGTACGAAATGCCATGTCATGCCTGCGCTCCCGGTCGGCCCAGGCGGG
ACGCACACGGATACACCGGA

Product: excinuclease ABC subunit A

Products: NA

Alternate protein names: UvrA protein; Excinuclease ABC subunit A [H]

Number of amino acids: Translated: 842; Mature: 841

Protein sequence:

>842_residues
MSNATSSSGLVRVRGAREHNLKNVDVDVPRDALVVFTGVSGSGKSSLAFGTIFAEAQRRYLDSISPYARRLIDQVGVPEV
DSIDGLPPAVALQQARGAPSARSSVGSVTTISNSLRMLYSRAGQYPPGQEIIYADGFSPNTPAGACPTCHGLGRIYDATE
ATMVLDRSLSIRDRAVAAWPGAWHGQNQRDILTTLGHDVDAPWHTLPKKTRDWILFTDEQPVVPVYAGYNVAEVRRALKR
KEEPSYMGTFTSARRYVLHTFATTQSAQMKKRVAQYLLSTQCPQCDGKRLRREALSVTFAGLDIGELSRRPLDEVAELLR
PAAEATPSKGTRKGAHQHPEQVIAAQRIAADLRARIAVVQALGLGYLSLERSTPTLSPGELQRLRLATQIRSQLFGVVYV
MDEPSAGLHPADAQALLGALDQLKAAGNSVFVVEHEVDVIRHADWIVDVGPAAGAQGGQVLYSGPPAGLEQVQASSTRRY
LFGTPPQVHRPARAANGWLQLRGITRNNVRALDVDLPLGVFTTVTGVSGSGKSSLVSQALVELLAAHLGQAQAEDEEALD
PLERGTQVPLEGAIVAGLDRVRRLVRVDQKPIGRTPRSNLATYTGLFDPVRKLFAATPAARRRRYDPGQFSFNVAKGRCA
TCEGEGSVYVELLFMPSVYAPCPTCHGARYNAKTLEIALRGRNIAQVLEMTVDQAAIFFADDAGVLRPLQVLREVGLGYL
RLGQPATELSGGEAQRIKLATELQRAQRRDTVYVLDEPTTGLHPSDVDTLMAQLQGLVDAGNTVIVVEHDMRVAASSDWV
LDMGPGAGGVGGHVVVAGPPDVVARHRGSRTAPFLAQVLRGE

Sequences:

>Translated_842_residues
MSNATSSSGLVRVRGAREHNLKNVDVDVPRDALVVFTGVSGSGKSSLAFGTIFAEAQRRYLDSISPYARRLIDQVGVPEV
DSIDGLPPAVALQQARGAPSARSSVGSVTTISNSLRMLYSRAGQYPPGQEIIYADGFSPNTPAGACPTCHGLGRIYDATE
ATMVLDRSLSIRDRAVAAWPGAWHGQNQRDILTTLGHDVDAPWHTLPKKTRDWILFTDEQPVVPVYAGYNVAEVRRALKR
KEEPSYMGTFTSARRYVLHTFATTQSAQMKKRVAQYLLSTQCPQCDGKRLRREALSVTFAGLDIGELSRRPLDEVAELLR
PAAEATPSKGTRKGAHQHPEQVIAAQRIAADLRARIAVVQALGLGYLSLERSTPTLSPGELQRLRLATQIRSQLFGVVYV
MDEPSAGLHPADAQALLGALDQLKAAGNSVFVVEHEVDVIRHADWIVDVGPAAGAQGGQVLYSGPPAGLEQVQASSTRRY
LFGTPPQVHRPARAANGWLQLRGITRNNVRALDVDLPLGVFTTVTGVSGSGKSSLVSQALVELLAAHLGQAQAEDEEALD
PLERGTQVPLEGAIVAGLDRVRRLVRVDQKPIGRTPRSNLATYTGLFDPVRKLFAATPAARRRRYDPGQFSFNVAKGRCA
TCEGEGSVYVELLFMPSVYAPCPTCHGARYNAKTLEIALRGRNIAQVLEMTVDQAAIFFADDAGVLRPLQVLREVGLGYL
RLGQPATELSGGEAQRIKLATELQRAQRRDTVYVLDEPTTGLHPSDVDTLMAQLQGLVDAGNTVIVVEHDMRVAASSDWV
LDMGPGAGGVGGHVVVAGPPDVVARHRGSRTAPFLAQVLRGE
>Mature_841_residues
SNATSSSGLVRVRGAREHNLKNVDVDVPRDALVVFTGVSGSGKSSLAFGTIFAEAQRRYLDSISPYARRLIDQVGVPEVD
SIDGLPPAVALQQARGAPSARSSVGSVTTISNSLRMLYSRAGQYPPGQEIIYADGFSPNTPAGACPTCHGLGRIYDATEA
TMVLDRSLSIRDRAVAAWPGAWHGQNQRDILTTLGHDVDAPWHTLPKKTRDWILFTDEQPVVPVYAGYNVAEVRRALKRK
EEPSYMGTFTSARRYVLHTFATTQSAQMKKRVAQYLLSTQCPQCDGKRLRREALSVTFAGLDIGELSRRPLDEVAELLRP
AAEATPSKGTRKGAHQHPEQVIAAQRIAADLRARIAVVQALGLGYLSLERSTPTLSPGELQRLRLATQIRSQLFGVVYVM
DEPSAGLHPADAQALLGALDQLKAAGNSVFVVEHEVDVIRHADWIVDVGPAAGAQGGQVLYSGPPAGLEQVQASSTRRYL
FGTPPQVHRPARAANGWLQLRGITRNNVRALDVDLPLGVFTTVTGVSGSGKSSLVSQALVELLAAHLGQAQAEDEEALDP
LERGTQVPLEGAIVAGLDRVRRLVRVDQKPIGRTPRSNLATYTGLFDPVRKLFAATPAARRRRYDPGQFSFNVAKGRCAT
CEGEGSVYVELLFMPSVYAPCPTCHGARYNAKTLEIALRGRNIAQVLEMTVDQAAIFFADDAGVLRPLQVLREVGLGYLR
LGQPATELSGGEAQRIKLATELQRAQRRDTVYVLDEPTTGLHPSDVDTLMAQLQGLVDAGNTVIVVEHDMRVAASSDWVL
DMGPGAGGVGGHVVVAGPPDVVARHRGSRTAPFLAQVLRGE

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion h

COG id: COG0178

COG function: function code L; Excinuclease ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Escherichia coli, GI2367343, Length=717, Percent_Identity=39.3305439330544, Blast_Score=486, Evalue=1e-138,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017871 [H]

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 90704; Mature: 90573

Theoretical pI: Translated: 8.79; Mature: 8.79

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNATSSSGLVRVRGAREHNLKNVDVDVPRDALVVFTGVSGSGKSSLAFGTIFAEAQRRY
CCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHH
LDSISPYARRLIDQVGVPEVDSIDGLPPAVALQQARGAPSARSSVGSVTTISNSLRMLYS
HHCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHH
RAGQYPPGQEIIYADGFSPNTPAGACPTCHGLGRIYDATEATMVLDRSLSIRDRAVAAWP
HCCCCCCCCEEEEECCCCCCCCCCCCCCHHHCHHHHCCCHHHEEECCCCCCCCCEEEECC
GAWHGQNQRDILTTLGHDVDAPWHTLPKKTRDWILFTDEQPVVPVYAGYNVAEVRRALKR
CCCCCCCCHHHHHHHCCCCCCCHHHCCCCCCCEEEEECCCCCEEEECCCCHHHHHHHHHC
KEEPSYMGTFTSARRYVLHTFATTQSAQMKKRVAQYLLSTQCPQCDGKRLRREALSVTFA
CCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHEEEE
GLDIGELSRRPLDEVAELLRPAAEATPSKGTRKGAHQHPEQVIAAQRIAADLRARIAVVQ
CCCHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
ALGLGYLSLERSTPTLSPGELQRLRLATQIRSQLFGVVYVMDEPSAGLHPADAQALLGAL
HHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCCCHHHHHHHHH
DQLKAAGNSVFVVEHEVDVIRHADWIVDVGPAAGAQGGQVLYSGPPAGLEQVQASSTRRY
HHHHHCCCEEEEEECCHHHHHHCCEEEECCCCCCCCCCEEEECCCCCCHHHHHHCCCCEE
LFGTPPQVHRPARAANGWLQLRGITRNNVRALDVDLPLGVFTTVTGVSGSGKSSLVSQAL
EECCCCHHCCCHHHCCCEEEEEECCCCCCEEEEECCCCCHHHHCCCCCCCCHHHHHHHHH
VELLAAHLGQAQAEDEEALDPLERGTQVPLEGAIVAGLDRVRRLVRVDQKPIGRTPRSNL
HHHHHHHHCCCCCCCHHHHCHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCH
ATYTGLFDPVRKLFAATPAARRRRYDPGQFSFNVAKGRCATCEGEGSVYVELLFMPSVYA
HHHHHHHHHHHHHHHCCCHHHHCCCCCCCEEEEECCCCEEEECCCCCEEEEEEECCCCCC
PCPTCHGARYNAKTLEIALRGRNIAQVLEMTVDQAAIFFADDAGVLRPLQVLREVGLGYL
CCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHCEEEEEECCCCHHHHHHHHHHCCCCEE
RLGQPATELSGGEAQRIKLATELQRAQRRDTVYVLDEPTTGLHPSDVDTLMAQLQGLVDA
ECCCCHHHCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCC
GNTVIVVEHDMRVAASSDWVLDMGPGAGGVGGHVVVAGPPDVVARHRGSRTAPFLAQVLR
CCEEEEEECCCEEECCCCEEEEECCCCCCCCCEEEEECCHHHHHHCCCCCCHHHHHHHHC
GE
CC
>Mature Secondary Structure 
SNATSSSGLVRVRGAREHNLKNVDVDVPRDALVVFTGVSGSGKSSLAFGTIFAEAQRRY
CCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHH
LDSISPYARRLIDQVGVPEVDSIDGLPPAVALQQARGAPSARSSVGSVTTISNSLRMLYS
HHCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHH
RAGQYPPGQEIIYADGFSPNTPAGACPTCHGLGRIYDATEATMVLDRSLSIRDRAVAAWP
HCCCCCCCCEEEEECCCCCCCCCCCCCCHHHCHHHHCCCHHHEEECCCCCCCCCEEEECC
GAWHGQNQRDILTTLGHDVDAPWHTLPKKTRDWILFTDEQPVVPVYAGYNVAEVRRALKR
CCCCCCCCHHHHHHHCCCCCCCHHHCCCCCCCEEEEECCCCCEEEECCCCHHHHHHHHHC
KEEPSYMGTFTSARRYVLHTFATTQSAQMKKRVAQYLLSTQCPQCDGKRLRREALSVTFA
CCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHEEEE
GLDIGELSRRPLDEVAELLRPAAEATPSKGTRKGAHQHPEQVIAAQRIAADLRARIAVVQ
CCCHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
ALGLGYLSLERSTPTLSPGELQRLRLATQIRSQLFGVVYVMDEPSAGLHPADAQALLGAL
HHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCCCHHHHHHHHH
DQLKAAGNSVFVVEHEVDVIRHADWIVDVGPAAGAQGGQVLYSGPPAGLEQVQASSTRRY
HHHHHCCCEEEEEECCHHHHHHCCEEEECCCCCCCCCCEEEECCCCCCHHHHHHCCCCEE
LFGTPPQVHRPARAANGWLQLRGITRNNVRALDVDLPLGVFTTVTGVSGSGKSSLVSQAL
EECCCCHHCCCHHHCCCEEEEEECCCCCCEEEEECCCCCHHHHCCCCCCCCHHHHHHHHH
VELLAAHLGQAQAEDEEALDPLERGTQVPLEGAIVAGLDRVRRLVRVDQKPIGRTPRSNL
HHHHHHHHCCCCCCCHHHHCHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCH
ATYTGLFDPVRKLFAATPAARRRRYDPGQFSFNVAKGRCATCEGEGSVYVELLFMPSVYA
HHHHHHHHHHHHHHHCCCHHHHCCCCCCCEEEEECCCCEEEECCCCCEEEEEEECCCCCC
PCPTCHGARYNAKTLEIALRGRNIAQVLEMTVDQAAIFFADDAGVLRPLQVLREVGLGYL
CCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHCEEEEEECCCCHHHHHHHHHHCCCCEE
RLGQPATELSGGEAQRIKLATELQRAQRRDTVYVLDEPTTGLHPSDVDTLMAQLQGLVDA
ECCCCHHHCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCC
GNTVIVVEHDMRVAASSDWVLDMGPGAGGVGGHVVVAGPPDVVARHRGSRTAPFLAQVLR
CCEEEEEECCCEEECCCCEEEEECCCCCCCCCEEEEECCHHHHHHCCCCCCHHHHHHHHC
GE
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8269961 [H]