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The map label for this gene is prpR [H]

Identifier: 21241890

GI number: 21241890

Start: 1285128

End: 1286726

Strand: Reverse

Name: prpR [H]

Synonym: XAC1136

Alternate gene names: 21241890

Gene position: 1286726-1285128 (Counterclockwise)

Preceding gene: 21241903

Following gene: 21241880

Centisome position: 24.86

GC content: 66.79

Gene sequence:

>1599_bases
ATGCGCAGCCCTACTCTTCCGGAAACCGCGGACGCTTCCTTGCCCATCATCTGGACCGTCAGCGTCTCGCGCCTGACCGG
CCTGCTGGCCGATGTCATCCCCGAGTTCGACCAGCGCGCACGCATCGAGCAGATCAACCTCGGCTTTGCCGAAGCGGTCG
AGGTCATCGGCCAGCGGCTGCGACGCGAGCGCTGCGACGCGCTGGTGGCGGGCGGATCCAATGCAGCGTACCTGCGCAGC
CGGCTCGCGCTGCCCTTGGCGCCCATCCAGGCCACCGGGTTCGATCTGATGGAAGCGCTGGCGCGGGCGCGCCGCATTGC
GCCGCGCATCGGCGTGGTCACCCATGCCACCGATGTGCCGTCGTTTCACGCCTTCCAGCACAGCTTCGACCTGGAGATCG
AACACCGCCGTTTCGTCACCGCCGAAGACGCACGCGATTGCATCGCCGATCTGCGCGCCAGCGGCATCCAGGTCATTGTC
GGCACCGGCATGGCGATCGACTTCGCCGAGCAGGCCGGGCTGCCTGGCGTGCTGCTGTATTCGGCCGATTCGGTGCGTCA
TGCGCTGGAACAGGCCATCACGCTGGGCACTGCTCCAGGCACGGATCGCGTTGCCGGCCGTACCGCCACGCGCCGCGCAC
GACGGGCCGACGCCCTGCTGGGCGACGACAGCGCAATGCTGCACGTGCGCGAGTTGGTGCAGCTGTACGCACCGCATGCC
GGCACCGTGTTGATCAGCGGCGAAACCGGCACCGGCAAAGAACTGGTCGCGCGTCAACTGCATGCCGGCAGTCGCCGCCG
CGGCCGTTTCGTGGCGATCAATTGTGGCGCCATCAGCGAATCGTTGCTGGAGGCGGAACTGTTCGGCTACAGCGACGGCG
CCTTCACCGGAGCCCGCCGCGGCGGCCACACCGGCCTGATCGAAACCGCGCAGGACGGCACGCTATTCCTCGACGAAATC
GGCGAGTTACCGATGCCGCTGCAAACGCGGCTATTGCGCGTATTGGAAGAGCGCGAAGTGCTGCGTGTCGGCGCAACCAT
ACCCGTTGCGATCGACGTGCGCGTGGTCGCCGCCAGCCTGCAGGAACTGCAGCAGTTGGTCGAACAAGGCCGCTTCCGCC
GCGACCTGTTCTATCGCCTTGCCGCGCTGCGCATTGCACTACCGCCGTTGCGAGACCGCCACCACGACATCGCCCTATTG
CTTGCGCATTATTTCCAGCAACTCGGCAGCATTCCATCGCCGCTATCGCCAGCTGCATTGCAACGCCTCCAGCAACACAC
CTGGCCCGGCAACGTGCGCGAACTGCGCAACCTGGTCGAACGCCTGTGCATTCACTGGAAAGCCCAAGCGCACGACAGCC
TGAGCCTGGAGCAACTCGAACGCTGGGCGCCGGAATTATTCGATACGCCTGCCGACAACCGCGGCGCACCACGTGAGCAT
GCCGATTTAGCGACCTCTCGCCTGCAGCTCACTGCCAGTGCAGTCCGCGTCGCGCTCGACCGCGCCAACGGCAACCGCGC
CCTTGCCGCGCAAGCGCTCGGCGTCTCGCGCACCACGCTGTGGCGCTGGATGCAGGCGCAGGCGGCGGCGCGTGCATAG

Upstream 100 bases:

>100_bases
CAAGCGTAACTCGTTGATTTTCATACCACCCAGGGCATCGATTGTTGCAAAATTGCAACGAATGATTCACGCTGAAACAC
TCTTGAAACGCGACAACGTC

Downstream 100 bases:

>100_bases
GGCAAGCGCGAACTTACACGACTGGTCAGGCGACCCATGCATGCATGACTTCCACACTCAGGCGGTAAGTGAAGGCATGG
TATGGCGCACTCAGCGCATG

Product: propionate catabolism regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 532; Mature: 532

Protein sequence:

>532_residues
MRSPTLPETADASLPIIWTVSVSRLTGLLADVIPEFDQRARIEQINLGFAEAVEVIGQRLRRERCDALVAGGSNAAYLRS
RLALPLAPIQATGFDLMEALARARRIAPRIGVVTHATDVPSFHAFQHSFDLEIEHRRFVTAEDARDCIADLRASGIQVIV
GTGMAIDFAEQAGLPGVLLYSADSVRHALEQAITLGTAPGTDRVAGRTATRRARRADALLGDDSAMLHVRELVQLYAPHA
GTVLISGETGTGKELVARQLHAGSRRRGRFVAINCGAISESLLEAELFGYSDGAFTGARRGGHTGLIETAQDGTLFLDEI
GELPMPLQTRLLRVLEEREVLRVGATIPVAIDVRVVAASLQELQQLVEQGRFRRDLFYRLAALRIALPPLRDRHHDIALL
LAHYFQQLGSIPSPLSPAALQRLQQHTWPGNVRELRNLVERLCIHWKAQAHDSLSLEQLERWAPELFDTPADNRGAPREH
ADLATSRLQLTASAVRVALDRANGNRALAAQALGVSRTTLWRWMQAQAAARA

Sequences:

>Translated_532_residues
MRSPTLPETADASLPIIWTVSVSRLTGLLADVIPEFDQRARIEQINLGFAEAVEVIGQRLRRERCDALVAGGSNAAYLRS
RLALPLAPIQATGFDLMEALARARRIAPRIGVVTHATDVPSFHAFQHSFDLEIEHRRFVTAEDARDCIADLRASGIQVIV
GTGMAIDFAEQAGLPGVLLYSADSVRHALEQAITLGTAPGTDRVAGRTATRRARRADALLGDDSAMLHVRELVQLYAPHA
GTVLISGETGTGKELVARQLHAGSRRRGRFVAINCGAISESLLEAELFGYSDGAFTGARRGGHTGLIETAQDGTLFLDEI
GELPMPLQTRLLRVLEEREVLRVGATIPVAIDVRVVAASLQELQQLVEQGRFRRDLFYRLAALRIALPPLRDRHHDIALL
LAHYFQQLGSIPSPLSPAALQRLQQHTWPGNVRELRNLVERLCIHWKAQAHDSLSLEQLERWAPELFDTPADNRGAPREH
ADLATSRLQLTASAVRVALDRANGNRALAAQALGVSRTTLWRWMQAQAAARA
>Mature_532_residues
MRSPTLPETADASLPIIWTVSVSRLTGLLADVIPEFDQRARIEQINLGFAEAVEVIGQRLRRERCDALVAGGSNAAYLRS
RLALPLAPIQATGFDLMEALARARRIAPRIGVVTHATDVPSFHAFQHSFDLEIEHRRFVTAEDARDCIADLRASGIQVIV
GTGMAIDFAEQAGLPGVLLYSADSVRHALEQAITLGTAPGTDRVAGRTATRRARRADALLGDDSAMLHVRELVQLYAPHA
GTVLISGETGTGKELVARQLHAGSRRRGRFVAINCGAISESLLEAELFGYSDGAFTGARRGGHTGLIETAQDGTLFLDEI
GELPMPLQTRLLRVLEEREVLRVGATIPVAIDVRVVAASLQELQQLVEQGRFRRDLFYRLAALRIALPPLRDRHHDIALL
LAHYFQQLGSIPSPLSPAALQRLQQHTWPGNVRELRNLVERLCIHWKAQAHDSLSLEQLERWAPELFDTPADNRGAPREH
ADLATSRLQLTASAVRVALDRANGNRALAAQALGVSRTTLWRWMQAQAAARA

Specific function: Involved in the transcriptional regulation of the propionate catabolism operon [H]

COG id: COG1221

COG function: function code KT; Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1786524, Length=541, Percent_Identity=46.3955637707948, Blast_Score=454, Evalue=1e-129,
Organism=Escherichia coli, GI1789233, Length=324, Percent_Identity=42.2839506172839, Blast_Score=248, Evalue=9e-67,
Organism=Escherichia coli, GI1788550, Length=316, Percent_Identity=41.1392405063291, Blast_Score=229, Evalue=5e-61,
Organism=Escherichia coli, GI1790437, Length=308, Percent_Identity=40.5844155844156, Blast_Score=212, Evalue=4e-56,
Organism=Escherichia coli, GI87082117, Length=226, Percent_Identity=50.8849557522124, Blast_Score=208, Evalue=6e-55,
Organism=Escherichia coli, GI87081872, Length=313, Percent_Identity=40.5750798722045, Blast_Score=206, Evalue=3e-54,
Organism=Escherichia coli, GI1788905, Length=425, Percent_Identity=34.3529411764706, Blast_Score=202, Evalue=4e-53,
Organism=Escherichia coli, GI1790299, Length=330, Percent_Identity=39.6969696969697, Blast_Score=199, Evalue=4e-52,
Organism=Escherichia coli, GI1789087, Length=312, Percent_Identity=39.7435897435897, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI87082152, Length=313, Percent_Identity=38.0191693290735, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI1787583, Length=222, Percent_Identity=41.4414414414414, Blast_Score=156, Evalue=3e-39,
Organism=Escherichia coli, GI87081858, Length=291, Percent_Identity=34.7079037800687, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1789828, Length=213, Percent_Identity=35.6807511737089, Blast_Score=120, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR012704
- InterPro:   IPR010524 [H]

Pfam domain/function: PF02954 HTH_8; PF06506 PrpR_N; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 58267; Mature: 58267

Theoretical pI: Translated: 8.09; Mature: 8.09

Prosite motif: PS00675 SIGMA54_INTERACT_1 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSPTLPETADASLPIIWTVSVSRLTGLLADVIPEFDQRARIEQINLGFAEAVEVIGQRL
CCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
RRERCDALVAGGSNAAYLRSRLALPLAPIQATGFDLMEALARARRIAPRIGVVTHATDVP
HHHHHCEEEECCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCC
SFHAFQHSFDLEIEHRRFVTAEDARDCIADLRASGIQVIVGTGMAIDFAEQAGLPGVLLY
CHHHHHCCCCCEECCCEEECHHHHHHHHHHHHCCCEEEEEECCCEEEHHHHCCCCEEEEE
SADSVRHALEQAITLGTAPGTDRVAGRTATRRARRADALLGDDSAMLHVRELVQLYAPHA
CCHHHHHHHHHHHHCCCCCCCCHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCC
GTVLISGETGTGKELVARQLHAGSRRRGRFVAINCGAISESLLEAELFGYSDGAFTGARR
CEEEEECCCCCCHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCC
GGHTGLIETAQDGTLFLDEIGELPMPLQTRLLRVLEEREVLRVGATIPVAIDVRVVAASL
CCCCCCEEECCCCEEEHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHH
QELQQLVEQGRFRRDLFYRLAALRIALPPLRDRHHDIALLLAHYFQQLGSIPSPLSPAAL
HHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHH
QRLQQHTWPGNVRELRNLVERLCIHWKAQAHDSLSLEQLERWAPELFDTPADNRGAPREH
HHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCHHHHCCCCCCCCCCHHH
ADLATSRLQLTASAVRVALDRANGNRALAAQALGVSRTTLWRWMQAQAAARA
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRSPTLPETADASLPIIWTVSVSRLTGLLADVIPEFDQRARIEQINLGFAEAVEVIGQRL
CCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
RRERCDALVAGGSNAAYLRSRLALPLAPIQATGFDLMEALARARRIAPRIGVVTHATDVP
HHHHHCEEEECCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCC
SFHAFQHSFDLEIEHRRFVTAEDARDCIADLRASGIQVIVGTGMAIDFAEQAGLPGVLLY
CHHHHHCCCCCEECCCEEECHHHHHHHHHHHHCCCEEEEEECCCEEEHHHHCCCCEEEEE
SADSVRHALEQAITLGTAPGTDRVAGRTATRRARRADALLGDDSAMLHVRELVQLYAPHA
CCHHHHHHHHHHHHCCCCCCCCHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCC
GTVLISGETGTGKELVARQLHAGSRRRGRFVAINCGAISESLLEAELFGYSDGAFTGARR
CEEEEECCCCCCHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCC
GGHTGLIETAQDGTLFLDEIGELPMPLQTRLLRVLEEREVLRVGATIPVAIDVRVVAASL
CCCCCCEEECCCCEEEHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHH
QELQQLVEQGRFRRDLFYRLAALRIALPPLRDRHHDIALLLAHYFQQLGSIPSPLSPAAL
HHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHH
QRLQQHTWPGNVRELRNLVERLCIHWKAQAHDSLSLEQLERWAPELFDTPADNRGAPREH
HHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCHHHHCCCCCCCCCCHHH
ADLATSRLQLTASAVRVALDRANGNRALAAQALGVSRTTLWRWMQAQAAARA
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]