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The map label for this gene is fabH

Identifier: 21241878

GI number: 21241878

Start: 1274441

End: 1275418

Strand: Direct

Name: fabH

Synonym: XAC1123

Alternate gene names: 21241878

Gene position: 1274441-1275418 (Clockwise)

Preceding gene: 21241877

Following gene: 21241879

Centisome position: 24.62

GC content: 61.76

Gene sequence:

>978_bases
ATGAGCAAGCGGATCTATTCCAGAATCGCGGGCACGGGTAGTTATTTGCCCGAAAAGGTGTTGACCAACGACGACATGTC
GAAGATTGTCGACACCAGCGATGAATGGATCTTCTCGCGCACTGGCATCCGTGAACGTCACATCGTCGCCGACGACCAGA
CCACCAGCGATCTGGCGTATTTCGCCTCGCTGAGGGCGATGGAAGCGGCCGGTGTGACCGCCGATGAGATCGATCTGATC
GTCATCGGCACCACCACCCCTGACCTGATCTTTCCGTCGACCGCCTGTTTGCTGCAGGCCCGACTGGGTAACATCGGTTG
CGGTGCGATGGACGTCAACGCTGCATGCTCGGGTTTTGTCTACGCGCTCAGCGTGGCCGACAAGTTCGTGCGCAGTGGCG
ACGCCAAGACCGTGCTGGTGGTTGGCGCAGAAACCTTGACCCGCATCGTCGACTGGACCGATCGCACCACCTGCGTGCTG
TTCGGCGATGGCGCCGGCGCGGTGATCCTCAAGGCCGACGAAGAGACCGGCATCCTCAGCACCCATTTGCACGCCGATGG
CAGCAAGAAAGAGCTGCTGTGGGACCCGGTGGGGGTCTCGGTGGGATTCGGCGAAGGCAAGAATGGCGGCGGTGCATTGC
TGATGAAGGGCAACGACGTCTTCAAGTATGCGGTCAAGGCGCTGGACTCGGTGGTCGATGAGACCCTGGCGGCCAGTGGC
TATGACAAGCACGACCTGGATTGGCTGATTCCGCATCAGGCCAACCTGCGCATCATCGAAGCCACTGCCAAGCGGATGGA
GTTGCCGATGGAGCAGGTGGTCGTCACCGTAGATCGCCATGGCAACACGTCGTCTGCCTCGGTGCCGCTGGCGCTGGACG
AAGCGGTGCGCTCCGGTCGCGTGCAGCGCGGCCAGTTGTTGTTGCTGGAAGCCTTCGGTGGCGGGTTTACCTGGGGCTCG
GCGCTGCTGCGCTACTGA

Upstream 100 bases:

>100_bases
AGAAGATTGATCCGTGGCGCCCGCCGCGTTCGGCGCGGCCGGGTGACTCTCGCTTCTTCAGGAGCCGCCGATCACCGCGG
CTCTTGCAATAGGGAACAGT

Downstream 100 bases:

>100_bases
CGGTTCTGCTTCCTGCGCCAGGTAGACGCGCACGTCCACTCAGGCGGATTCGTGCATGGCGGGGACACTCGTCTTCCCTT
GCGGTGGGGGCAGGCTTGCC

Product: 3-oxoacyl-(acyl carrier protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MSKRIYSRIAGTGSYLPEKVLTNDDMSKIVDTSDEWIFSRTGIRERHIVADDQTTSDLAYFASLRAMEAAGVTADEIDLI
VIGTTTPDLIFPSTACLLQARLGNIGCGAMDVNAACSGFVYALSVADKFVRSGDAKTVLVVGAETLTRIVDWTDRTTCVL
FGDGAGAVILKADEETGILSTHLHADGSKKELLWDPVGVSVGFGEGKNGGGALLMKGNDVFKYAVKALDSVVDETLAASG
YDKHDLDWLIPHQANLRIIEATAKRMELPMEQVVVTVDRHGNTSSASVPLALDEAVRSGRVQRGQLLLLEAFGGGFTWGS
ALLRY

Sequences:

>Translated_325_residues
MSKRIYSRIAGTGSYLPEKVLTNDDMSKIVDTSDEWIFSRTGIRERHIVADDQTTSDLAYFASLRAMEAAGVTADEIDLI
VIGTTTPDLIFPSTACLLQARLGNIGCGAMDVNAACSGFVYALSVADKFVRSGDAKTVLVVGAETLTRIVDWTDRTTCVL
FGDGAGAVILKADEETGILSTHLHADGSKKELLWDPVGVSVGFGEGKNGGGALLMKGNDVFKYAVKALDSVVDETLAASG
YDKHDLDWLIPHQANLRIIEATAKRMELPMEQVVVTVDRHGNTSSASVPLALDEAVRSGRVQRGQLLLLEAFGGGFTWGS
ALLRY
>Mature_324_residues
SKRIYSRIAGTGSYLPEKVLTNDDMSKIVDTSDEWIFSRTGIRERHIVADDQTTSDLAYFASLRAMEAAGVTADEIDLIV
IGTTTPDLIFPSTACLLQARLGNIGCGAMDVNAACSGFVYALSVADKFVRSGDAKTVLVVGAETLTRIVDWTDRTTCVLF
GDGAGAVILKADEETGILSTHLHADGSKKELLWDPVGVSVGFGEGKNGGGALLMKGNDVFKYAVKALDSVVDETLAASGY
DKHDLDWLIPHQANLRIIEATAKRMELPMEQVVVTVDRHGNTSSASVPLALDEAVRSGRVQRGQLLLLEAFGGGFTWGSA
LLRY

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=321, Percent_Identity=60.4361370716511, Blast_Score=390, Evalue=1e-110,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_XANAC (Q8PNE8)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_641460.1
- ProteinModelPortal:   Q8PNE8
- SMR:   Q8PNE8
- GeneID:   1155194
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC1123
- NMPDR:   fig|190486.1.peg.1104
- HOGENOM:   HBG649927
- OMA:   ATTTPDM
- ProtClustDB:   PRK09352
- BioCyc:   XAXO190486:XAC1123-MONOMER
- BRENDA:   2.3.1.180
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.180

Molecular weight: Translated: 34818; Mature: 34687

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: ACT_SITE 116-116 ACT_SITE 252-252 ACT_SITE 282-282

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKRIYSRIAGTGSYLPEKVLTNDDMSKIVDTSDEWIFSRTGIRERHIVADDQTTSDLAY
CCHHHHHHHCCCCCCCCHHHCCCCCHHHHHCCCCCEEEECCCCCCCEEEECCCCHHHHHH
FASLRAMEAAGVTADEIDLIVIGTTTPDLIFPSTACLLQARLGNIGCGAMDVNAACSGFV
HHHHHHHHHCCCCHHHEEEEEEECCCCCCCCCCHHHHHHHHCCCCCCCEEECCHHHHHHH
YALSVADKFVRSGDAKTVLVVGAETLTRIVDWTDRTTCVLFGDGAGAVILKADEETGILS
HHHHHHHHHHHCCCCCEEEEECHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCEEE
THLHADGSKKELLWDPVGVSVGFGEGKNGGGALLMKGNDVFKYAVKALDSVVDETLAASG
EEEECCCCCCCEEECCCCEEEECCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCC
YDKHDLDWLIPHQANLRIIEATAKRMELPMEQVVVTVDRHGNTSSASVPLALDEAVRSGR
CCCCCCCEECCCCCCEEEEEEHHHHHHCCHHHEEEEEECCCCCCCCCCCEEHHHHHHCCC
VQRGQLLLLEAFGGGFTWGSALLRY
CCCCCEEEEEECCCCCHHHHHHHCC
>Mature Secondary Structure 
SKRIYSRIAGTGSYLPEKVLTNDDMSKIVDTSDEWIFSRTGIRERHIVADDQTTSDLAY
CHHHHHHHCCCCCCCCHHHCCCCCHHHHHCCCCCEEEECCCCCCCEEEECCCCHHHHHH
FASLRAMEAAGVTADEIDLIVIGTTTPDLIFPSTACLLQARLGNIGCGAMDVNAACSGFV
HHHHHHHHHCCCCHHHEEEEEEECCCCCCCCCCHHHHHHHHCCCCCCCEEECCHHHHHHH
YALSVADKFVRSGDAKTVLVVGAETLTRIVDWTDRTTCVLFGDGAGAVILKADEETGILS
HHHHHHHHHHHCCCCCEEEEECHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCEEE
THLHADGSKKELLWDPVGVSVGFGEGKNGGGALLMKGNDVFKYAVKALDSVVDETLAASG
EEEECCCCCCCEEECCCCEEEECCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCC
YDKHDLDWLIPHQANLRIIEATAKRMELPMEQVVVTVDRHGNTSSASVPLALDEAVRSGR
CCCCCCCEECCCCCCEEEEEEHHHHHHCCHHHEEEEEECCCCCCCCCCCEEHHHHHHCCC
VQRGQLLLLEAFGGGFTWGSALLRY
CCCCCEEEEEECCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217