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The map label for this gene is rnhA

Identifier: 21241846

GI number: 21241846

Start: 1243888

End: 1244340

Strand: Direct

Name: rnhA

Synonym: XAC1089

Alternate gene names: 21241846

Gene position: 1243888-1244340 (Clockwise)

Preceding gene: 21241845

Following gene: 21241847

Centisome position: 24.03

GC content: 62.91

Gene sequence:

>453_bases
ATGAAATCCATTGAAGTGCATACCGATGGCTCCTGCCTCGGCAACCCCGGCCCGGGCGGTTGGGCGGCCTTGTTGCGTTA
CAACGGCCGCGAAAAGGAGCTGGCTGGCGGTGAGGCGGTGTCGACGAACAACCGCATGGAATTGATGGCGGCGATCATGG
CGCTGGAAACGCTGACCGAGCCGTGTCAGATCGTGTTGCATACCGATTCGCAGTACGTGCGCCAGGGCATCACCGAATGG
ATGCCAGGATGGGTGCGACGCAACTGGAAAACCGCCGGGTGCGATCCGGTCAAAAATCGCGAGTTGTGGGAGCGGCTGCA
CGCGGCCACGCAGCGCCACCGCATCGATTGGCGTTGGGTGAAAGGCCACAATGGCGACCCGGACAACGAGCGCGTCGACG
TGCTCGCCCGCAATCAGGCCATCGCCCAGCGCGGTGGTCTTGCGACATCGTAA

Upstream 100 bases:

>100_bases
CGCTGCCGCGGCGATCGGGCCGACGCCAATCGCCCTGCCTGCCCGCTGGCCACAACCGGTGGCTACGATCTGACCTGTTT
ACGTTCAACTCTGGAACCTG

Downstream 100 bases:

>100_bases
GAGGACACATGCGTCAGATCATTCTCGATACCGAAACCACCGGCCTGGAATGGCGCAAGGGCAACCGCGTCGTCGAAATC
GGCGCGGTGGAGCTGCTGGA

Product: ribonuclease H

Products: NA

Alternate protein names: RNase H

Number of amino acids: Translated: 150; Mature: 150

Protein sequence:

>150_residues
MKSIEVHTDGSCLGNPGPGGWAALLRYNGREKELAGGEAVSTNNRMELMAAIMALETLTEPCQIVLHTDSQYVRQGITEW
MPGWVRRNWKTAGCDPVKNRELWERLHAATQRHRIDWRWVKGHNGDPDNERVDVLARNQAIAQRGGLATS

Sequences:

>Translated_150_residues
MKSIEVHTDGSCLGNPGPGGWAALLRYNGREKELAGGEAVSTNNRMELMAAIMALETLTEPCQIVLHTDSQYVRQGITEW
MPGWVRRNWKTAGCDPVKNRELWERLHAATQRHRIDWRWVKGHNGDPDNERVDVLARNQAIAQRGGLATS
>Mature_150_residues
MKSIEVHTDGSCLGNPGPGGWAALLRYNGREKELAGGEAVSTNNRMELMAAIMALETLTEPCQIVLHTDSQYVRQGITEW
MPGWVRRNWKTAGCDPVKNRELWERLHAATQRHRIDWRWVKGHNGDPDNERVDVLARNQAIAQRGGLATS

Specific function: Endonuclease that specifically degrades the RNA of RNA- DNA hybrids

COG id: COG0328

COG function: function code L; Ribonuclease HI

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase H domain

Homologues:

Organism=Homo sapiens, GI21359816, Length=142, Percent_Identity=36.6197183098592, Blast_Score=70, Evalue=5e-13,
Organism=Escherichia coli, GI1786408, Length=141, Percent_Identity=62.4113475177305, Blast_Score=191, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI115532542, Length=140, Percent_Identity=32.1428571428571, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45552509, Length=141, Percent_Identity=36.8794326241135, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17137476, Length=139, Percent_Identity=37.410071942446, Blast_Score=85, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNH_XANAC (Q8PNH8)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_641428.1
- ProteinModelPortal:   Q8PNH8
- SMR:   Q8PNH8
- GeneID:   1155160
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC1089
- NMPDR:   fig|190486.1.peg.1072
- HOGENOM:   HBG742437
- OMA:   NGWRTAD
- ProtClustDB:   PRK00203
- BioCyc:   XAXO190486:XAC1089-MONOMER
- BRENDA:   3.1.26.4
- GO:   GO:0005737
- HAMAP:   MF_00042
- InterPro:   IPR022892
- InterPro:   IPR012337
- InterPro:   IPR002156

Pfam domain/function: PF00075 RnaseH; SSF53098 RNaseH_fold

EC number: =3.1.26.4

Molecular weight: Translated: 16856; Mature: 16856

Theoretical pI: Translated: 8.10; Mature: 8.10

Prosite motif: PS50879 RNASE_H

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSIEVHTDGSCLGNPGPGGWAALLRYNGREKELAGGEAVSTNNRMELMAAIMALETLTE
CCCEEECCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHCC
PCQIVLHTDSQYVRQGITEWMPGWVRRNWKTAGCDPVKNRELWERLHAATQRHRIDWRWV
CCEEEEECCHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEE
KGHNGDPDNERVDVLARNQAIAQRGGLATS
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKSIEVHTDGSCLGNPGPGGWAALLRYNGREKELAGGEAVSTNNRMELMAAIMALETLTE
CCCEEECCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHCC
PCQIVLHTDSQYVRQGITEWMPGWVRRNWKTAGCDPVKNRELWERLHAATQRHRIDWRWV
CCEEEEECCHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEE
KGHNGDPDNERVDVLARNQAIAQRGGLATS
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217