Click here to switch to the map view.

The map label for this gene is ppiD [H]

Identifier: 21241842

GI number: 21241842

Start: 1238644

End: 1240614

Strand: Direct

Name: ppiD [H]

Synonym: XAC1085

Alternate gene names: 21241842

Gene position: 1238644-1240614 (Clockwise)

Preceding gene: 21241841

Following gene: 21241845

Centisome position: 23.93

GC content: 64.49

Gene sequence:

>1971_bases
ATGCTGCAGAAACTTCGCGACAAGACGTCAGGCTGGATCGCTACCGCCATCCTGGGGTTGCTGATGATTCCGTTCCTGTT
CGTCATCGACAACAGCTACCTCGGCGGCATTGGCGCCAACAATGTGGCCAAGGTGCAGGCGCCGCCGGCCTGGTGGAAAT
CGGCGCCGTCGTGGTGGCCGGTCTCTTTGCTGTGGCAACACCATGAAATCAGCACGCAGGATTTCCGCACGCGTTTCGAG
CAGGCGCGTATGCAGGAGCGTCAGCGTCAGGGCGAGAAATTCGATCCGCGCAGCTTCGAATCCCGCGAAAACAAGCTGCA
GGTGCTCGATCAACTGGTCGACGAACAGGTCGTGCGACTGGGTGCGGAAGACGCCGGAATCGTCATCGGCGATGCGACCG
TGCGGGATTACATTGCCAACATTCCCGCATTCCAGGTCGATGGTAAGTTCAGTCCGGACCAGTATCGCGCCGCACTCGCG
CAGGGCACGCCGCCGCGCACGCCAGCGCAGTTCGATGCGTTGGTGCGCGACAGCCTGCAGCAGTCGGTGATCCCGCAGGC
GGTGGCGGAGTCCGGCTTTGCCACCACGTCCGAGTTCGAGCGCCTGCTCAAGCTGATGGGTGAAACGCGCGATGTGGAGT
TGGCGATGCTGCCGCCGCCGGCCGCAGATGCTGCGCCGGTGAGCGATGCGCAGATCAAGCAGTGGTACGACGGGCACACG
CAGGATTTCCGCCAGCCGGAAACCGTGACGATCGAATACGTGGAGCTCAACGCCGCCACGATGCCGCCAGCCACTGCGGC
CGACGAGGCCACGCTGCGCAAGCGCTATGAAGACGAGAAGGCGCGCTTCGTCGAGCCGGAGCAGCGTCTTGCGTCGCACA
TCCTGATCAGTGCCGGCACCGATGCAGCCGCGCAGAAGGCTGCCGAGGCAAAGGCTGCCAAGCTTGCCGCCGAGGCCAAG
CAGACGGGTACCGACTTTGCTGCACTGGCGAAGGCTAATTCGCAAGATCCCGGTTCCAAGGATGCCGGCGGCGACCTGGG
CTGGGTCGAGAAGGGCACGATGGTCAAGCCGTTCGAGGACGCGCTGTTCTCGATGAAGGCTGGCGAGGTGGTGGGCCCGA
TCAAGAGCGAATTCGGCTACCACGTGATCCAGCTGCGTGAGGTCAAGGGCGGCCAGGGCAAGTCGTTCGAGCAGGTGCGC
GACCAGCTGGCTGCCGAGCAGCTCAAGGCCGACGCAGACAAGGCCTTTGCCGATGTCAGCGGCAAGTTGGTGGACCAGGT
TTACAAGAACCCCACCGCACTGGAGCCGGCGGCCAAGCAGGTTGGCCTGCCGGTGCAGACGCTGGGGCCGTTCTCGCGCA
GTGATGCCAGCGGTGTTGCCGCCAACCCGGCTGTGCTGCGCGCGGCGTTCTCCGAAACGCTGGTGCAGGACGGCACGGTG
AGCGACCCCATCACCATCGCGCCGAACCATAGCGTGGTGCTGCGTGTGACCAACCACACCGCCGAACAGGCGTTGCCGTT
GGACAAGGTGCGCGACAAGGTGACGGCGGCAATCCGCGCGGACCGTGCCGAGAAGGCCGCCGCTGCTGCTGCCGATGCCT
TGCTGGCACGCGTGCAGAAAGGCGAAACGCTACAGGCACTGGCCGACAGCGAGAAGCTGCAGGTGCAGCCGATTCCGGGG
CTGCCGCGGACGGCGCCGATCCCGACCCCGGCTGCGAACCGTGCGATCTTCAGCGCGCCGCGACCGACCGAAGGCAAGCC
GTCGGTTGGCAAGGTGGAGTTGGATGGCGGGCGCTTTGCTGTCTTTGTCATCAGCAAGGCGACGCCGGGCGATCTGAAGC
AGATGCCGGCCGAGCAGCAGACGATGCTGCGCGAGCAGTTGAGCCAGATCGACGGAAACAACGCTGCGCAGGCTTACGTC
AAGGAAATGCGCAAGCGCTACAAGATCCAGATCGAAGAAGCCCAGCTGTAA

Upstream 100 bases:

>100_bases
GATTGGATGCGCCACGACGCCGTCGTCACGGGCATTGGGCTGGGTGCCTGGCGCCAAGCGCGTTACACTGCGCGGCTCGC
CCACAGGCCGTGATTTGCCA

Downstream 100 bases:

>100_bases
GGCTGGATCATCGATTGGTGAGAGCAAAGCCCGGGCAACCGGGCTTTTTCTTTGGGCGTTCGTGATGGAAGACGCAGTCC
GGCTGGCGGGCATCCCAGTC

Product: peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase D; Rotamase D [H]

Number of amino acids: Translated: 656; Mature: 656

Protein sequence:

>656_residues
MLQKLRDKTSGWIATAILGLLMIPFLFVIDNSYLGGIGANNVAKVQAPPAWWKSAPSWWPVSLLWQHHEISTQDFRTRFE
QARMQERQRQGEKFDPRSFESRENKLQVLDQLVDEQVVRLGAEDAGIVIGDATVRDYIANIPAFQVDGKFSPDQYRAALA
QGTPPRTPAQFDALVRDSLQQSVIPQAVAESGFATTSEFERLLKLMGETRDVELAMLPPPAADAAPVSDAQIKQWYDGHT
QDFRQPETVTIEYVELNAATMPPATAADEATLRKRYEDEKARFVEPEQRLASHILISAGTDAAAQKAAEAKAAKLAAEAK
QTGTDFAALAKANSQDPGSKDAGGDLGWVEKGTMVKPFEDALFSMKAGEVVGPIKSEFGYHVIQLREVKGGQGKSFEQVR
DQLAAEQLKADADKAFADVSGKLVDQVYKNPTALEPAAKQVGLPVQTLGPFSRSDASGVAANPAVLRAAFSETLVQDGTV
SDPITIAPNHSVVLRVTNHTAEQALPLDKVRDKVTAAIRADRAEKAAAAAADALLARVQKGETLQALADSEKLQVQPIPG
LPRTAPIPTPAANRAIFSAPRPTEGKPSVGKVELDGGRFAVFVISKATPGDLKQMPAEQQTMLREQLSQIDGNNAAQAYV
KEMRKRYKIQIEEAQL

Sequences:

>Translated_656_residues
MLQKLRDKTSGWIATAILGLLMIPFLFVIDNSYLGGIGANNVAKVQAPPAWWKSAPSWWPVSLLWQHHEISTQDFRTRFE
QARMQERQRQGEKFDPRSFESRENKLQVLDQLVDEQVVRLGAEDAGIVIGDATVRDYIANIPAFQVDGKFSPDQYRAALA
QGTPPRTPAQFDALVRDSLQQSVIPQAVAESGFATTSEFERLLKLMGETRDVELAMLPPPAADAAPVSDAQIKQWYDGHT
QDFRQPETVTIEYVELNAATMPPATAADEATLRKRYEDEKARFVEPEQRLASHILISAGTDAAAQKAAEAKAAKLAAEAK
QTGTDFAALAKANSQDPGSKDAGGDLGWVEKGTMVKPFEDALFSMKAGEVVGPIKSEFGYHVIQLREVKGGQGKSFEQVR
DQLAAEQLKADADKAFADVSGKLVDQVYKNPTALEPAAKQVGLPVQTLGPFSRSDASGVAANPAVLRAAFSETLVQDGTV
SDPITIAPNHSVVLRVTNHTAEQALPLDKVRDKVTAAIRADRAEKAAAAAADALLARVQKGETLQALADSEKLQVQPIPG
LPRTAPIPTPAANRAIFSAPRPTEGKPSVGKVELDGGRFAVFVISKATPGDLKQMPAEQQTMLREQLSQIDGNNAAQAYV
KEMRKRYKIQIEEAQL
>Mature_656_residues
MLQKLRDKTSGWIATAILGLLMIPFLFVIDNSYLGGIGANNVAKVQAPPAWWKSAPSWWPVSLLWQHHEISTQDFRTRFE
QARMQERQRQGEKFDPRSFESRENKLQVLDQLVDEQVVRLGAEDAGIVIGDATVRDYIANIPAFQVDGKFSPDQYRAALA
QGTPPRTPAQFDALVRDSLQQSVIPQAVAESGFATTSEFERLLKLMGETRDVELAMLPPPAADAAPVSDAQIKQWYDGHT
QDFRQPETVTIEYVELNAATMPPATAADEATLRKRYEDEKARFVEPEQRLASHILISAGTDAAAQKAAEAKAAKLAAEAK
QTGTDFAALAKANSQDPGSKDAGGDLGWVEKGTMVKPFEDALFSMKAGEVVGPIKSEFGYHVIQLREVKGGQGKSFEQVR
DQLAAEQLKADADKAFADVSGKLVDQVYKNPTALEPAAKQVGLPVQTLGPFSRSDASGVAANPAVLRAAFSETLVQDGTV
SDPITIAPNHSVVLRVTNHTAEQALPLDKVRDKVTAAIRADRAEKAAAAAADALLARVQKGETLQALADSEKLQVQPIPG
LPRTAPIPTPAANRAIFSAPRPTEGKPSVGKVELDGGRFAVFVISKATPGDLKQMPAEQQTMLREQLSQIDGNNAAQAYV
KEMRKRYKIQIEEAQL

Specific function: PPIases accelerate the folding of proteins. Seems to be involved in the folding of outer membrane proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein; Periplasmic side [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Escherichia coli, GI1786645, Length=663, Percent_Identity=27.9034690799397, Blast_Score=212, Evalue=7e-56,
Organism=Escherichia coli, GI1786238, Length=100, Percent_Identity=39, Blast_Score=73, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR015391
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase; PF09312 SurA_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 71195; Mature: 71195

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQKLRDKTSGWIATAILGLLMIPFLFVIDNSYLGGIGANNVAKVQAPPAWWKSAPSWWP
CCHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHCCCCCCCC
VSLLWQHHEISTQDFRTRFEQARMQERQRQGEKFDPRSFESRENKLQVLDQLVDEQVVRL
HHHHEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
GAEDAGIVIGDATVRDYIANIPAFQVDGKFSPDQYRAALAQGTPPRTPAQFDALVRDSLQ
CCCCCCEEEECHHHHHHHHCCCCEEECCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
QSVIPQAVAESGFATTSEFERLLKLMGETRDVELAMLPPPAADAAPVSDAQIKQWYDGHT
HHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHCCCC
QDFRQPETVTIEYVELNAATMPPATAADEATLRKRYEDEKARFVEPEQRLASHILISAGT
HHCCCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHEEEECCC
DAAAQKAAEAKAAKLAAEAKQTGTDFAALAKANSQDPGSKDAGGDLGWVEKGTMVKPFED
CHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHH
ALFSMKAGEVVGPIKSEFGYHVIQLREVKGGQGKSFEQVRDQLAAEQLKADADKAFADVS
HHHHHCCCCHHCCHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GKLVDQVYKNPTALEPAAKQVGLPVQTLGPFSRSDASGVAANPAVLRAAFSETLVQDGTV
HHHHHHHHCCCCCCCHHHHHHCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
SDPITIAPNHSVVLRVTNHTAEQALPLDKVRDKVTAAIRADRAEKAAAAAADALLARVQK
CCCEEECCCCEEEEEECCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GETLQALADSEKLQVQPIPGLPRTAPIPTPAANRAIFSAPRPTEGKPSVGKVELDGGRFA
CCHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCEEEECCCEEE
VFVISKATPGDLKQMPAEQQTMLREQLSQIDGNNAAQAYVKEMRKRYKIQIEEAQL
EEEEECCCCCHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEEEECCCC
>Mature Secondary Structure
MLQKLRDKTSGWIATAILGLLMIPFLFVIDNSYLGGIGANNVAKVQAPPAWWKSAPSWWP
CCHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHCCCCCCCC
VSLLWQHHEISTQDFRTRFEQARMQERQRQGEKFDPRSFESRENKLQVLDQLVDEQVVRL
HHHHEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
GAEDAGIVIGDATVRDYIANIPAFQVDGKFSPDQYRAALAQGTPPRTPAQFDALVRDSLQ
CCCCCCEEEECHHHHHHHHCCCCEEECCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
QSVIPQAVAESGFATTSEFERLLKLMGETRDVELAMLPPPAADAAPVSDAQIKQWYDGHT
HHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHCCCC
QDFRQPETVTIEYVELNAATMPPATAADEATLRKRYEDEKARFVEPEQRLASHILISAGT
HHCCCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHEEEECCC
DAAAQKAAEAKAAKLAAEAKQTGTDFAALAKANSQDPGSKDAGGDLGWVEKGTMVKPFED
CHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHH
ALFSMKAGEVVGPIKSEFGYHVIQLREVKGGQGKSFEQVRDQLAAEQLKADADKAFADVS
HHHHHCCCCHHCCHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GKLVDQVYKNPTALEPAAKQVGLPVQTLGPFSRSDASGVAANPAVLRAAFSETLVQDGTV
HHHHHHHHCCCCCCCHHHHHHCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
SDPITIAPNHSVVLRVTNHTAEQALPLDKVRDKVTAAIRADRAEKAAAAAADALLARVQK
CCCEEECCCCEEEEEECCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GETLQALADSEKLQVQPIPGLPRTAPIPTPAANRAIFSAPRPTEGKPSVGKVELDGGRFA
CCHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCEEEECCCEEE
VFVISKATPGDLKQMPAEQQTMLREQLSQIDGNNAAQAYVKEMRKRYKIQIEEAQL
EEEEECCCCCHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]