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The map label for this gene is ilvE [H]

Identifier: 21241697

GI number: 21241697

Start: 1088637

End: 1089722

Strand: Direct

Name: ilvE [H]

Synonym: XAC0927

Alternate gene names: 21241697

Gene position: 1088637-1089722 (Clockwise)

Preceding gene: 21241696

Following gene: 21241698

Centisome position: 21.03

GC content: 67.03

Gene sequence:

>1086_bases
GTGTCCGTGTCCTTCGCTTCCACCCGTTCTCCGTCGCCGCGCAGCGCCGACGAATTGTCCGTGATCCTGGCTGCGCCCGG
TTTCGGGTTGCATTTCACCGACCACATGGTCGCCATCTCCTGGAACAACGAGCAGGGCTGGCACGACGCGCAAGTGCGCG
CGTACGGCCCGCTGCAGCTGGATCCGGCAGCGTCGGTGCTGCATTACGGGCAGGAGATCTTCGAAGGCATCAAGGCCTAC
CGGCACGCCGACGGCTCGATCTGGACCTTCCGTCCGCAAGCCAACGGCGAGCGCCTGCAGCGGTCGGCGCGCCGTCTGGC
GCTGCCGGAATTGCCGGTGGACCTGTTCGTGGAATCGCTGCGCCAGCTGGTGGCCGTGGATGGCGGCTGGGTGCCGTCGG
CGCCGGAGACCAGCCTGTATTTCCGCCCGTTCATGATTGCCGATGAGGCCTTCCTGGGCGTGCGCGCGGCGCACAAGGCC
TCGTATTACGTGATCGCCAGCCCGGCCGGCCCGTACTTCGCCAAGGGCGTGGCGCCGGTGTCGATCTGGCTGTCCACCGA
ATACGCACGTGCGGCCAAGGGCGGGACCGGCGCGGCCAAATGCGGCGGCAATTACGCCGCGTCGCTGCTGCCGCAGCAGA
AGGCCTATGCCCAGGGCTGCTCGCAGGTGTTGTTCCTGGACCCGGTGGAAGGCAAGTACATCGAAGAACTCGGCGGCATG
AACGTGTTCCTGGTCTACAAGGACGGCACGTTGGTGACCCCGGAACTGTCCGGCAGCATCCTGGAAGGCATCACCCGCGA
CAGCATCCTGCAACTGGCCCGCGACCGTGGCATGCAGGTGATCGAGCGCAAGGTCGCGATCGACGAATGGAAGCAGGGCG
TGGCCTCCGGCGAGATCACCGAGGTGTTCGCCTGCGGTACGGCGGCGGTGGTGACCCCCATCGGCGAGCTGAAGGGCGAG
GGGTTCGCGGTGGGCGATCTGTCCGCGCCAGCGGGCCAGGTGACCATGTCGCTGCGCCAGGAACTGACCGATATCCAGTA
CGGCCGCGTGCCGGACCGCCACGGGTGGTTGGTGCGTTTGTCGTAA

Upstream 100 bases:

>100_bases
TCCGAAGCGGCCCGTCTCGAGACCGGCATGCTCTGATCGTCACGCGCCATGTCCACGATGTGGCGCTGCGTCCTTTCGCC
CGCCATACAGGAATCTCCCG

Downstream 100 bases:

>100_bases
GCGGACATATTTCGCCAAACAAGGGCCTCCGTGTGTCAGCACGGGGGCTTTTTTGTTTGCGCAACAGCAAAAAGACCATT
TTTCGACCAAGAACAAGTCG

Product: branched-chain amino acid aminotransferase

Products: NA

Alternate protein names: BCAT [H]

Number of amino acids: Translated: 361; Mature: 360

Protein sequence:

>361_residues
MSVSFASTRSPSPRSADELSVILAAPGFGLHFTDHMVAISWNNEQGWHDAQVRAYGPLQLDPAASVLHYGQEIFEGIKAY
RHADGSIWTFRPQANGERLQRSARRLALPELPVDLFVESLRQLVAVDGGWVPSAPETSLYFRPFMIADEAFLGVRAAHKA
SYYVIASPAGPYFAKGVAPVSIWLSTEYARAAKGGTGAAKCGGNYAASLLPQQKAYAQGCSQVLFLDPVEGKYIEELGGM
NVFLVYKDGTLVTPELSGSILEGITRDSILQLARDRGMQVIERKVAIDEWKQGVASGEITEVFACGTAAVVTPIGELKGE
GFAVGDLSAPAGQVTMSLRQELTDIQYGRVPDRHGWLVRLS

Sequences:

>Translated_361_residues
MSVSFASTRSPSPRSADELSVILAAPGFGLHFTDHMVAISWNNEQGWHDAQVRAYGPLQLDPAASVLHYGQEIFEGIKAY
RHADGSIWTFRPQANGERLQRSARRLALPELPVDLFVESLRQLVAVDGGWVPSAPETSLYFRPFMIADEAFLGVRAAHKA
SYYVIASPAGPYFAKGVAPVSIWLSTEYARAAKGGTGAAKCGGNYAASLLPQQKAYAQGCSQVLFLDPVEGKYIEELGGM
NVFLVYKDGTLVTPELSGSILEGITRDSILQLARDRGMQVIERKVAIDEWKQGVASGEITEVFACGTAAVVTPIGELKGE
GFAVGDLSAPAGQVTMSLRQELTDIQYGRVPDRHGWLVRLS
>Mature_360_residues
SVSFASTRSPSPRSADELSVILAAPGFGLHFTDHMVAISWNNEQGWHDAQVRAYGPLQLDPAASVLHYGQEIFEGIKAYR
HADGSIWTFRPQANGERLQRSARRLALPELPVDLFVESLRQLVAVDGGWVPSAPETSLYFRPFMIADEAFLGVRAAHKAS
YYVIASPAGPYFAKGVAPVSIWLSTEYARAAKGGTGAAKCGGNYAASLLPQQKAYAQGCSQVLFLDPVEGKYIEELGGMN
VFLVYKDGTLVTPELSGSILEGITRDSILQLARDRGMQVIERKVAIDEWKQGVASGEITEVFACGTAAVVTPIGELKGEG
FAVGDLSAPAGQVTMSLRQELTDIQYGRVPDRHGWLVRLS

Specific function: Catalyzes the reversible transfers of an amino group from glutamate to the alpha-ketoacid of the respective amino acid in the final step in the biosynthesis of branchedchain amino acids. The amino acids can be ranked in the following order with respect to

COG id: COG0115

COG function: function code EH; Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI296010904, Length=342, Percent_Identity=41.812865497076, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI296010906, Length=342, Percent_Identity=41.812865497076, Blast_Score=253, Evalue=3e-67,
Organism=Homo sapiens, GI38176287, Length=342, Percent_Identity=41.812865497076, Blast_Score=253, Evalue=3e-67,
Organism=Homo sapiens, GI50658084, Length=329, Percent_Identity=39.209726443769, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI296010902, Length=342, Percent_Identity=36.8421052631579, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI296010900, Length=342, Percent_Identity=36.8421052631579, Blast_Score=202, Evalue=3e-52,
Organism=Homo sapiens, GI258614015, Length=285, Percent_Identity=38.5964912280702, Blast_Score=189, Evalue=3e-48,
Organism=Escherichia coli, GI48994963, Length=320, Percent_Identity=32.1875, Blast_Score=123, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17568601, Length=344, Percent_Identity=38.3720930232558, Blast_Score=243, Evalue=9e-65,
Organism=Caenorhabditis elegans, GI17565728, Length=345, Percent_Identity=35.9420289855072, Blast_Score=194, Evalue=8e-50,
Organism=Saccharomyces cerevisiae, GI6322002, Length=362, Percent_Identity=41.7127071823204, Blast_Score=242, Evalue=8e-65,
Organism=Saccharomyces cerevisiae, GI6322608, Length=341, Percent_Identity=41.0557184750733, Blast_Score=232, Evalue=6e-62,
Organism=Drosophila melanogaster, GI24641779, Length=367, Percent_Identity=40.0544959128065, Blast_Score=229, Evalue=2e-60,

Paralogues:

None

Copy number: 2342 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 11,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001544
- InterPro:   IPR018300
- InterPro:   IPR005786 [H]

Pfam domain/function: PF01063 Aminotran_4 [H]

EC number: =2.6.1.42 [H]

Molecular weight: Translated: 39033; Mature: 38902

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS00770 AA_TRANSFER_CLASS_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVSFASTRSPSPRSADELSVILAAPGFGLHFTDHMVAISWNNEQGWHDAQVRAYGPLQL
CCCCCCCCCCCCCCCCCCEEEEEECCCCCEEECCEEEEEEECCCCCCCCCEEEEECCEEE
DPAASVLHYGQEIFEGIKAYRHADGSIWTFRPQANGERLQRSARRLALPELPVDLFVESL
CHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCHHHHHHHH
RQLVAVDGGWVPSAPETSLYFRPFMIADEAFLGVRAAHKASYYVIASPAGPYFAKGVAPV
HHHHHCCCCCCCCCCCCCEEEEEEEEECHHHHHHHHHCCCCEEEEECCCCCHHHCCCCEE
SIWLSTEYARAAKGGTGAAKCGGNYAASLLPQQKAYAQGCSQVLFLDPVEGKYIEELGGM
EEEEECHHHHHHCCCCCCHHCCCCHHHHHCCHHHHHHHCCCEEEEECCCCCHHHHHHCCC
NVFLVYKDGTLVTPELSGSILEGITRDSILQLARDRGMQVIERKVAIDEWKQGVASGEIT
EEEEEEECCEEECCCCCCHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHH
EVFACGTAAVVTPIGELKGEGFAVGDLSAPAGQVTMSLRQELTDIQYGRVPDRHGWLVRL
EEEECCCHHEECCHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEE
S
C
>Mature Secondary Structure 
SVSFASTRSPSPRSADELSVILAAPGFGLHFTDHMVAISWNNEQGWHDAQVRAYGPLQL
CCCCCCCCCCCCCCCCCEEEEEECCCCCEEECCEEEEEEECCCCCCCCCEEEEECCEEE
DPAASVLHYGQEIFEGIKAYRHADGSIWTFRPQANGERLQRSARRLALPELPVDLFVESL
CHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCHHHHHHHH
RQLVAVDGGWVPSAPETSLYFRPFMIADEAFLGVRAAHKASYYVIASPAGPYFAKGVAPV
HHHHHCCCCCCCCCCCCCEEEEEEEEECHHHHHHHHHCCCCEEEEECCCCCHHHCCCCEE
SIWLSTEYARAAKGGTGAAKCGGNYAASLLPQQKAYAQGCSQVLFLDPVEGKYIEELGGM
EEEEECHHHHHHCCCCCCHHCCCCHHHHHCCHHHHHHHCCCEEEEECCCCCHHHHHHCCC
NVFLVYKDGTLVTPELSGSILEGITRDSILQLARDRGMQVIERKVAIDEWKQGVASGEIT
EEEEEEECCEEECCCCCCHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHH
EVFACGTAAVVTPIGELKGEGFAVGDLSAPAGQVTMSLRQELTDIQYGRVPDRHGWLVRL
EEEECCCHHEECCHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEE
S
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA