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The map label for this gene is oxyR [H]

Identifier: 21241675

GI number: 21241675

Start: 1065898

End: 1066839

Strand: Reverse

Name: oxyR [H]

Synonym: XAC0905

Alternate gene names: 21241675

Gene position: 1066839-1065898 (Counterclockwise)

Preceding gene: 21241676

Following gene: 21241674

Centisome position: 20.61

GC content: 63.27

Gene sequence:

>942_bases
ATGAATCTGCGTGACCTGAAATATCTGGTAGCCCTGGCCGACCACAAGCATTTCGGCCGCGCGGCGTCCGCCTGCTTTGT
CAGCCAGCCAACGCTGTCCACCCAGATCAAGAAACTCGAAGACGAGCTCGGCGTGTCGCTGGTGGAACGTGCGCCGCGCA
AGGTCATGCTGACCCCGGCCGGCCGCGAAGCCGCCGTGCGTGCACGCAGCATCGTGGCCGAGGTGGAACAGATGAAGGAA
GCCGCACGCCGCAGCCAGGACCCGGAAGCGGGCACGGTGCGTCTGGGCATCTTTCCCACCCTGGCCCCGTATTTGTTGCC
GCATGTGGTACCGCGCATCCGCGAGCGTTTTCCGCGTCTGGAACTGCTGCTGATCGAAGAGAAGAGCGATCAGCTGATGC
ACCAGCTGCGCGAAGGTCGCCTGGATGCCGCCTTGCTTGCATTGCCATTGCAGGACGATCAGCTGCATGCCGAATTCCTG
TTCGAAGAGCCCTTCGTGCTGGCAGTGCCGGAAAGCCACCCGCTGTCGCGCCACGACAGCATGACCCTGGACGACTTGTC
CGAGCAGCGCCTGCTGCTGCTGGAAGATGGCCACTGCCTGCGCGACCAGGCGCTGGATGTCTGCCATCTGGCCGGCGCGC
TGGAAAAATCCGAATTTCAGGCCACAAGTCTGGAAACCCTGCGTCAGATGGTCGCGGCCAATGTCGGGGTGACCTTGCTG
CCGCTGCTGGCGGTCAAGCCTCCTGTTGCGCGCTCGGAAAACATCCGCCTGATCCGCTTCCGTGAAGACAAGCAGCCTAG
CCGCCGCATTGCGATGGCGTGGCGGCGCAGTTCGGCAATGACCGCGTTTTTGGAGCAGCTGTCGCAGCTGTTCAAGGAAT
TGCCCGAGAGCCTGTTCACGCTGGATCAGCCTGCGCCAGGACCGAAGGCGGTGGCGGCTTAG

Upstream 100 bases:

>100_bases
GCCGCATAAGCAAGCGCCCGCTTAGCGCCCGGCCAACCCGGGCGCTAAGCTTGCAACACGCGCCAGTGGTTCCCCGTCAC
CGCAATGAAGGCTGCTGTAT

Downstream 100 bases:

>100_bases
GGAATCGGGAATCGGGAATCGGAAATCGGAAATCGGAAATCGGAAATCGGAAATCGGAAATCGGAAATCGGAAATCGGAA
AAGCGTATCGCGGTTGCGGT

Product: oxidative stress transcriptional regulator

Products: NA

Alternate protein names: Morphology and auto-aggregation control protein [H]

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MNLRDLKYLVALADHKHFGRAASACFVSQPTLSTQIKKLEDELGVSLVERAPRKVMLTPAGREAAVRARSIVAEVEQMKE
AARRSQDPEAGTVRLGIFPTLAPYLLPHVVPRIRERFPRLELLLIEEKSDQLMHQLREGRLDAALLALPLQDDQLHAEFL
FEEPFVLAVPESHPLSRHDSMTLDDLSEQRLLLLEDGHCLRDQALDVCHLAGALEKSEFQATSLETLRQMVAANVGVTLL
PLLAVKPPVARSENIRLIRFREDKQPSRRIAMAWRRSSAMTAFLEQLSQLFKELPESLFTLDQPAPGPKAVAA

Sequences:

>Translated_313_residues
MNLRDLKYLVALADHKHFGRAASACFVSQPTLSTQIKKLEDELGVSLVERAPRKVMLTPAGREAAVRARSIVAEVEQMKE
AARRSQDPEAGTVRLGIFPTLAPYLLPHVVPRIRERFPRLELLLIEEKSDQLMHQLREGRLDAALLALPLQDDQLHAEFL
FEEPFVLAVPESHPLSRHDSMTLDDLSEQRLLLLEDGHCLRDQALDVCHLAGALEKSEFQATSLETLRQMVAANVGVTLL
PLLAVKPPVARSENIRLIRFREDKQPSRRIAMAWRRSSAMTAFLEQLSQLFKELPESLFTLDQPAPGPKAVAA
>Mature_313_residues
MNLRDLKYLVALADHKHFGRAASACFVSQPTLSTQIKKLEDELGVSLVERAPRKVMLTPAGREAAVRARSIVAEVEQMKE
AARRSQDPEAGTVRLGIFPTLAPYLLPHVVPRIRERFPRLELLLIEEKSDQLMHQLREGRLDAALLALPLQDDQLHAEFL
FEEPFVLAVPESHPLSRHDSMTLDDLSEQRLLLLEDGHCLRDQALDVCHLAGALEKSEFQATSLETLRQMVAANVGVTLL
PLLAVKPPVARSENIRLIRFREDKQPSRRIAMAWRRSSAMTAFLEQLSQLFKELPESLFTLDQPAPGPKAVAA

Specific function: Hydrogen peroxide sensor. Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS (a regulatory RNA), dps, fur and grxA. OxyR expression is negatively autoregulated by binding to a 43 bp region upstre

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790399, Length=292, Percent_Identity=47.6027397260274, Blast_Score=269, Evalue=1e-73,
Organism=Escherichia coli, GI157672245, Length=241, Percent_Identity=32.7800829875519, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1787879, Length=248, Percent_Identity=31.8548387096774, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI1787530, Length=295, Percent_Identity=26.7796610169492, Blast_Score=114, Evalue=9e-27,
Organism=Escherichia coli, GI1788887, Length=283, Percent_Identity=30.7420494699647, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI1788748, Length=304, Percent_Identity=25.9868421052632, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI145693105, Length=257, Percent_Identity=28.0155642023346, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI2367136, Length=247, Percent_Identity=29.5546558704453, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1788296, Length=243, Percent_Identity=28.3950617283951, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1789506, Length=280, Percent_Identity=26.7857142857143, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1788297, Length=245, Percent_Identity=28.1632653061224, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786401, Length=302, Percent_Identity=27.4834437086093, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI87082132, Length=263, Percent_Identity=26.615969581749, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790208, Length=245, Percent_Identity=28.9795918367347, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787806, Length=243, Percent_Identity=23.0452674897119, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI87081904, Length=253, Percent_Identity=26.0869565217391, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1787601, Length=176, Percent_Identity=26.1363636363636, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1789639, Length=306, Percent_Identity=23.5294117647059, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1788481, Length=203, Percent_Identity=26.1083743842365, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 35116; Mature: 35116

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLRDLKYLVALADHKHFGRAASACFVSQPTLSTQIKKLEDELGVSLVERAPRKVMLTPA
CCHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCHHHHHCCCCEEEECCC
GREAAVRARSIVAEVEQMKEAARRSQDPEAGTVRLGIFPTLAPYLLPHVVPRIRERFPRL
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCE
ELLLIEEKSDQLMHQLREGRLDAALLALPLQDDQLHAEFLFEEPFVLAVPESHPLSRHDS
EEEEEECHHHHHHHHHHHCCCCEEHEEECCCCCHHHHHHHHCCCEEEECCCCCCCCCCCC
MTLDDLSEQRLLLLEDGHCLRDQALDVCHLAGALEKSEFQATSLETLRQMVAANVGVTLL
CCHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
PLLAVKPPVARSENIRLIRFREDKQPSRRIAMAWRRSSAMTAFLEQLSQLFKELPESLFT
HHHHCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LDQPAPGPKAVAA
CCCCCCCCCCCCC
>Mature Secondary Structure
MNLRDLKYLVALADHKHFGRAASACFVSQPTLSTQIKKLEDELGVSLVERAPRKVMLTPA
CCHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCHHHHHCCCCEEEECCC
GREAAVRARSIVAEVEQMKEAARRSQDPEAGTVRLGIFPTLAPYLLPHVVPRIRERFPRL
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCE
ELLLIEEKSDQLMHQLREGRLDAALLALPLQDDQLHAEFLFEEPFVLAVPESHPLSRHDS
EEEEEECHHHHHHHHHHHCCCCEEHEEECCCCCHHHHHHHHCCCEEEECCCCCCCCCCCC
MTLDDLSEQRLLLLEDGHCLRDQALDVCHLAGALEKSEFQATSLETLRQMVAANVGVTLL
CCHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
PLLAVKPPVARSENIRLIRFREDKQPSRRIAMAWRRSSAMTAFLEQLSQLFKELPESLFT
HHHHCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LDQPAPGPKAVAA
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]