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The map label for this gene is apaH

Identifier: 21241631

GI number: 21241631

Start: 1022905

End: 1023849

Strand: Reverse

Name: apaH

Synonym: XAC0861

Alternate gene names: 21241631

Gene position: 1023849-1022905 (Counterclockwise)

Preceding gene: 21241632

Following gene: 21241621

Centisome position: 19.78

GC content: 66.56

Gene sequence:

>945_bases
ATGAGTGTCTGGGCCATCGGCGATCTGCAAGGGTGCTACGACATCACCCAGCGGTTGCTGGAGAAGATCAATTTCGACCC
CGCCCAGGACACGCTGTGGTTCTGCGGCGATCTGGTCAACCGCGGCGGGCAGTCGCTGGAAACCCTGCGCCTGGTGCATT
CCTTGCGCGCGCACAGCGTGGTGGTGCTGGGCAATCACGACCTGTCGCTGCTGGCGATCGGCGCGCGCTCGGAAGAAGAG
CAGCGCAAGGTCAACCCGGATCTGCTGCGCATCGTGATGGCCGAAGATCGCGATGCGCTGCTGGACTGGCTACGCATGCA
GAAGCTGGCGCACGTGGACCGCGAACTGGGCTGGATGATGATCCACGCCGGGCTGGCGCCGAAGTGGACCACGCAGATGG
CCGAAAAGCATGCACGCGAGGTCGAGCAGCAACTGCAGGGCGGCGGCTATCGCAAGCTGCTGCGCAATATGTACGGCGAT
CAGCCCGGCTGGTCGCCGGGCCTGAGCGGCTATGACCGTAGCCGCGCCATCATCAATCTGTTCACCCGCATGCGCTATTG
CACTCCGCGTGGGCGCATCGCCACCGACGACAAGGGAACGCCGGGCACGCAGGCGCAGGGCCTGTATCCATGGTTCGAAG
TGCCGGGACGGGTCGAGCGCGACCTGAAGATCGTCTGCGGGCATTGGTCCGCGCTGGGCCTGACGATCACCCAGGGCGTC
CATGCGATCGATACCGGTGCGGTCTGGGGCGGCAAGCTGACCGCGTTGCAGCTGGATACCGACGAACTACGGGTGGTGCA
GGTGCCGGGAAATCCGATCACGCATCCGCCGAAAACCGCGCAGCGCCCGCGGCAACCGCGTCGCCGGCAGCGGCAGCGTG
GTGGCGACCAAGCGCAGACCGGGCCCGCTCCGACACCGGCATCGACCGGTCCAGCCGGCGGCTGA

Upstream 100 bases:

>100_bases
GCCGACGATGGCACCGAATTTATCGCCCCGATCGCCGCCTTCGTGCTGAGCGTGCCCAGGACGCTGCACTGATGGATGCT
GGAGTGAGGGAGCGCGCGCA

Downstream 100 bases:

>100_bases
TCCGGCGCTCTGGCGAGCGCTATGCCGTCGCGCCGCCTGCCCGGCACGGGAGTGCTGGGCGGCTTGCAGGCGATACCGCC
TATCGGCCGGGTGCGGCCGC

Product: diadenosine tetraphosphatase

Products: NA

Alternate protein names: Ap4A hydrolase; Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase; Diadenosine tetraphosphatase

Number of amino acids: Translated: 314; Mature: 313

Protein sequence:

>314_residues
MSVWAIGDLQGCYDITQRLLEKINFDPAQDTLWFCGDLVNRGGQSLETLRLVHSLRAHSVVVLGNHDLSLLAIGARSEEE
QRKVNPDLLRIVMAEDRDALLDWLRMQKLAHVDRELGWMMIHAGLAPKWTTQMAEKHAREVEQQLQGGGYRKLLRNMYGD
QPGWSPGLSGYDRSRAIINLFTRMRYCTPRGRIATDDKGTPGTQAQGLYPWFEVPGRVERDLKIVCGHWSALGLTITQGV
HAIDTGAVWGGKLTALQLDTDELRVVQVPGNPITHPPKTAQRPRQPRRRQRQRGGDQAQTGPAPTPASTGPAGG

Sequences:

>Translated_314_residues
MSVWAIGDLQGCYDITQRLLEKINFDPAQDTLWFCGDLVNRGGQSLETLRLVHSLRAHSVVVLGNHDLSLLAIGARSEEE
QRKVNPDLLRIVMAEDRDALLDWLRMQKLAHVDRELGWMMIHAGLAPKWTTQMAEKHAREVEQQLQGGGYRKLLRNMYGD
QPGWSPGLSGYDRSRAIINLFTRMRYCTPRGRIATDDKGTPGTQAQGLYPWFEVPGRVERDLKIVCGHWSALGLTITQGV
HAIDTGAVWGGKLTALQLDTDELRVVQVPGNPITHPPKTAQRPRQPRRRQRQRGGDQAQTGPAPTPASTGPAGG
>Mature_313_residues
SVWAIGDLQGCYDITQRLLEKINFDPAQDTLWFCGDLVNRGGQSLETLRLVHSLRAHSVVVLGNHDLSLLAIGARSEEEQ
RKVNPDLLRIVMAEDRDALLDWLRMQKLAHVDRELGWMMIHAGLAPKWTTQMAEKHAREVEQQLQGGGYRKLLRNMYGDQ
PGWSPGLSGYDRSRAIINLFTRMRYCTPRGRIATDDKGTPGTQAQGLYPWFEVPGRVERDLKIVCGHWSALGLTITQGVH
AIDTGAVWGGKLTALQLDTDELRVVQVPGNPITHPPKTAQRPRQPRRRQRQRGGDQAQTGPAPTPASTGPAGG

Specific function: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP

COG id: COG0639

COG function: function code T; Diadenosine tetraphosphatase and related serine/threonine protein phosphatases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Ap4A hydrolase family

Homologues:

Organism=Escherichia coli, GI1786234, Length=273, Percent_Identity=45.0549450549451, Blast_Score=219, Evalue=2e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APAH_XANAC (Q8PP27)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_641213.1
- ProteinModelPortal:   Q8PP27
- SMR:   Q8PP27
- GeneID:   1154932
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC0861
- NMPDR:   fig|190486.1.peg.857
- HOGENOM:   HBG724457
- OMA:   LVFGHWA
- ProtClustDB:   PRK00166
- BioCyc:   XAXO190486:XAC0861-MONOMER
- BRENDA:   3.6.1.41
- HAMAP:   MF_00199
- InterPro:   IPR004617
- InterPro:   IPR004843
- InterPro:   IPR006186
- PIRSF:   PIRSF000903
- PRINTS:   PR00114
- TIGRFAMs:   TIGR00668

Pfam domain/function: PF00149 Metallophos

EC number: =3.6.1.41

Molecular weight: Translated: 34941; Mature: 34810

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVWAIGDLQGCYDITQRLLEKINFDPAQDTLWFCGDLVNRGGQSLETLRLVHSLRAHSV
CCEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCEE
VVLGNHDLSLLAIGARSEEEQRKVNPDLLRIVMAEDRDALLDWLRMQKLAHVDRELGWMM
EEECCCCEEEEEECCCCCHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCEEE
IHAGLAPKWTTQMAEKHAREVEQQLQGGGYRKLLRNMYGDQPGWSPGLSGYDRSRAIINL
EECCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHH
FTRMRYCTPRGRIATDDKGTPGTQAQGLYPWFEVPGRVERDLKIVCGHWSALGLTITQGV
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCEEEEECCCHHHHHHHHCCC
HAIDTGAVWGGKLTALQLDTDELRVVQVPGNPITHPPKTAQRPRQPRRRQRQRGGDQAQT
CEECCCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCCHHCCCCCHHHHHHHCCCCCCCC
GPAPTPASTGPAGG
CCCCCCCCCCCCCC
>Mature Secondary Structure 
SVWAIGDLQGCYDITQRLLEKINFDPAQDTLWFCGDLVNRGGQSLETLRLVHSLRAHSV
CEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCEE
VVLGNHDLSLLAIGARSEEEQRKVNPDLLRIVMAEDRDALLDWLRMQKLAHVDRELGWMM
EEECCCCEEEEEECCCCCHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCEEE
IHAGLAPKWTTQMAEKHAREVEQQLQGGGYRKLLRNMYGDQPGWSPGLSGYDRSRAIINL
EECCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHH
FTRMRYCTPRGRIATDDKGTPGTQAQGLYPWFEVPGRVERDLKIVCGHWSALGLTITQGV
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCEEEEECCCHHHHHHHHCCC
HAIDTGAVWGGKLTALQLDTDELRVVQVPGNPITHPPKTAQRPRQPRRRQRQRGGDQAQT
CEECCCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCCHHCCCCCHHHHHHHCCCCCCCC
GPAPTPASTGPAGG
CCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217