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The map label for this gene is thiL [H]

Identifier: 21241523

GI number: 21241523

Start: 891571

End: 892545

Strand: Direct

Name: thiL [H]

Synonym: XAC0752

Alternate gene names: 21241523

Gene position: 891571-892545 (Clockwise)

Preceding gene: 21241522

Following gene: 21241524

Centisome position: 17.23

GC content: 67.49

Gene sequence:

>975_bases
ATGCCCGAATTCGATCTAATTGCCCGTCTAGGTGCGCGCATTGCAGCGCGTGCCGATGTGCCGTTGGGCATCGGCGACGA
TGCAGCATTGCTGCAGCCGCCGGCCGGCGAGCAGTTGGCGATCACCGCCGATACGCTCAATGCCGGCGTGCATTTTCCGC
ATGAGACGCGCGCTGACGATCTGGGCTGGAAGACGCTGGCTGTCAATCTCTCCGATCTGGCGGCGATGGGCGCGCAACCG
CGTTGGTGCACCTTGTCGTTGTCGTTGCCGCACGACGATGCGGCATGGGTGGATGGGTTTGCTGATGGCTTCTTCGCGCT
GGCTGATGCACACGACATCGTGCTGGTCGGTGGCGACACCACGCGCGGGCCGTTGTCGTGCGCGGTGACTGCGATCGGCA
GCCTGCCGCCTGGCGCAGCATTGCGGCGCGATGGTGCGCGCGTTGGCGATGACGTGTGGGTAACCGGTGCGCCGGGTGAA
GCCGCCGCCGCGTTGGCGTTGTGGCAGGCCGGCCAGCTGGATGTGACCTGCGCGGCTGCCGACCCGTTGCACGAGCGCTG
GCGCGGCCGCCTGCTGCGTCCGCAGCCCCGTGTGCAGGCGGGGCTGCGCCTGCGCGGGCTTGCGCATGCCTGCGTGGACA
TTTCCGACGGTCTGCTGGCCGATCTGGGACATCTATGCGAACGCAGCGGCGTGGGGGCGCGCCTGTTGCTTGCGGCCTTG
CCGGCGATGCCGCGCAGTGCCGGAATCGACGTGGTGCAATGCCTTGGCTGGCAACTCGGCGGTGGCGACGATTACGAGTT
GTGTTTCACCGCCGCGCCGAAGCATCGCGATGCCGTGGCGCAGGCAATGGAATTTGCAAAGGTGGCTGCAACCCGCATCG
GCCAGATTGTCGCCGCGCCCGGTGTGGTGGTGCACGACGCCGAAGGCAACCCCTGGCACCCACCGCAGCGCGGGTACCAG
CATTTCGTCGGCTGA

Upstream 100 bases:

>100_bases
AAATGGGGAGTCGGGAATGGGGAATCGTAAGAGCACCGTTTCCGATACCTGCTGAGGCGCTTTTGCGATTCCCGATTCCC
TTTTCCCGATTCCCGTCGCC

Downstream 100 bases:

>100_bases
GGCGTGGGGTTGGAGCGTGTAGCGGATGTGGGCGGTGTCGGTGCGCTGCGCTGAGACGATGCTGCTGCGCTGATCGCTGA
TCGCTGATCGCTGGGTGCGT

Product: thiamine monophosphate kinase

Products: NA

Alternate protein names: Thiamine-phosphate kinase [H]

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MPEFDLIARLGARIAARADVPLGIGDDAALLQPPAGEQLAITADTLNAGVHFPHETRADDLGWKTLAVNLSDLAAMGAQP
RWCTLSLSLPHDDAAWVDGFADGFFALADAHDIVLVGGDTTRGPLSCAVTAIGSLPPGAALRRDGARVGDDVWVTGAPGE
AAAALALWQAGQLDVTCAAADPLHERWRGRLLRPQPRVQAGLRLRGLAHACVDISDGLLADLGHLCERSGVGARLLLAAL
PAMPRSAGIDVVQCLGWQLGGGDDYELCFTAAPKHRDAVAQAMEFAKVAATRIGQIVAAPGVVVHDAEGNPWHPPQRGYQ
HFVG

Sequences:

>Translated_324_residues
MPEFDLIARLGARIAARADVPLGIGDDAALLQPPAGEQLAITADTLNAGVHFPHETRADDLGWKTLAVNLSDLAAMGAQP
RWCTLSLSLPHDDAAWVDGFADGFFALADAHDIVLVGGDTTRGPLSCAVTAIGSLPPGAALRRDGARVGDDVWVTGAPGE
AAAALALWQAGQLDVTCAAADPLHERWRGRLLRPQPRVQAGLRLRGLAHACVDISDGLLADLGHLCERSGVGARLLLAAL
PAMPRSAGIDVVQCLGWQLGGGDDYELCFTAAPKHRDAVAQAMEFAKVAATRIGQIVAAPGVVVHDAEGNPWHPPQRGYQ
HFVG
>Mature_323_residues
PEFDLIARLGARIAARADVPLGIGDDAALLQPPAGEQLAITADTLNAGVHFPHETRADDLGWKTLAVNLSDLAAMGAQPR
WCTLSLSLPHDDAAWVDGFADGFFALADAHDIVLVGGDTTRGPLSCAVTAIGSLPPGAALRRDGARVGDDVWVTGAPGEA
AAALALWQAGQLDVTCAAADPLHERWRGRLLRPQPRVQAGLRLRGLAHACVDISDGLLADLGHLCERSGVGARLLLAALP
AMPRSAGIDVVQCLGWQLGGGDDYELCFTAAPKHRDAVAQAMEFAKVAATRIGQIVAAPGVVVHDAEGNPWHPPQRGYQH
FVG

Specific function: Thiamine biosynthesis. [C]

COG id: COG0611

COG function: function code H; Thiamine monophosphate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiamine-monophosphate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786619, Length=322, Percent_Identity=47.2049689440994, Blast_Score=253, Evalue=2e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR016188
- InterPro:   IPR006283 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =2.7.4.16 [H]

Molecular weight: Translated: 33860; Mature: 33729

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEFDLIARLGARIAARADVPLGIGDDAALLQPPAGEQLAITADTLNAGVHFPHETRADD
CCCHHHHHHHHHHHEECCCCCCCCCCCCCEECCCCCCEEEEEEEECCCCCCCCCCCCCCC
LGWKTLAVNLSDLAAMGAQPRWCTLSLSLPHDDAAWVDGFADGFFALADAHDIVLVGGDT
CCCEEEEEEHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHCCCEEEECCCEEEEECCCC
TRGPLSCAVTAIGSLPPGAALRRDGARVGDDVWVTGAPGEAAAALALWQAGQLDVTCAAA
CCCCHHHHHHHHCCCCCCHHHHCCCCCCCCCEEEECCCCHHHHHHHHHCCCCEEEEEECC
DPLHERWRGRLLRPQPRVQAGLRLRGLAHACVDISDGLLADLGHLCERSGVGARLLLAAL
CHHHHHHCCCCCCCCCHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHH
PAMPRSAGIDVVQCLGWQLGGGDDYELCFTAAPKHRDAVAQAMEFAKVAATRIGQIVAAP
CCCCCCCCCHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCC
GVVVHDAEGNPWHPPQRGYQHFVG
CEEEECCCCCCCCCCHHHHHHCCC
>Mature Secondary Structure 
PEFDLIARLGARIAARADVPLGIGDDAALLQPPAGEQLAITADTLNAGVHFPHETRADD
CCHHHHHHHHHHHEECCCCCCCCCCCCCEECCCCCCEEEEEEEECCCCCCCCCCCCCCC
LGWKTLAVNLSDLAAMGAQPRWCTLSLSLPHDDAAWVDGFADGFFALADAHDIVLVGGDT
CCCEEEEEEHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHCCCEEEECCCEEEEECCCC
TRGPLSCAVTAIGSLPPGAALRRDGARVGDDVWVTGAPGEAAAALALWQAGQLDVTCAAA
CCCCHHHHHHHHCCCCCCHHHHCCCCCCCCCEEEECCCCHHHHHHHHHCCCCEEEEEECC
DPLHERWRGRLLRPQPRVQAGLRLRGLAHACVDISDGLLADLGHLCERSGVGARLLLAAL
CHHHHHHCCCCCCCCCHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHH
PAMPRSAGIDVVQCLGWQLGGGDDYELCFTAAPKHRDAVAQAMEFAKVAATRIGQIVAAP
CCCCCCCCCHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCC
GVVVHDAEGNPWHPPQRGYQHFVG
CEEEECCCCCCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]