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The map label for this gene is envZ [H]

Identifier: 21241500

GI number: 21241500

Start: 869137

End: 870651

Strand: Reverse

Name: envZ [H]

Synonym: XAC0729

Alternate gene names: 21241500

Gene position: 870651-869137 (Counterclockwise)

Preceding gene: 21241501

Following gene: 21241498

Centisome position: 16.82

GC content: 68.51

Gene sequence:

>1515_bases
GTGAGCAAACCGGCACGGCGCGGGCTGTCGATCTTTGCGCGGACCTTTGTATTGTTGGCGGTGGCCCTGCTCACCGCCCA
GGCGGTGGGCATCGCCCTGCTGGTGATGCGTACCCCCGTCTACGAGCCTCCCGTCCATCCGCCGGAAGTGGTGGCGCTGC
TCTCCACCCGCATGCCGGCCGGGACCCAGACCCTGAAAGTGCATGAATCGGCGCAAGCCCCGGTGCCGCCGACAGGCCAG
GTGCGCGACCCCTTCGCCGAAATGCTGCTTGCGCACTGGCTGGATGTGCCCGAACGCCAGGTGCGGTTCTATCGCAACGC
CAATGATCGTGAAGGCCCGCAGCCAGGCATGCTGCCGCCGCAGCGTTGGTCCAACCGGGACCACGCCGGCGACGGCGGTG
GCGGTGGCGGTGGCGGGGCGCACGAACGCCTGGGCACGCAACCTCTGCCGCCGTTTCCGGACGACTGGCCGCGCGACAGC
CACCCCGCTGCGCTGTCCGGCGACGGGCTGCGGCCGGACGAGTTACCCGGCGCATGGGAAAGCGAGCGCCTGACCCCGGG
CGTACCGCTGCTGGACGGGTTCACCGCCGCCCTGCAACAACCCGATGGCCGTTGGCGTACGGTGGAATCGCCGCGTCGAC
GCCTCTCGGGCGAGTTCAAGACCCATGTCGTGCTGCTGTTCCTGGCCGGCCTGCTGGCCAACGTGCCGCTGGCATGGTGG
TTTTCGCGCGCGCTGTCGGCACCGATCAAGCGCTTTGCCGAGGCTGCCGACCGCCTGGGCCGTAATCCCGATGCCGCGGC
CCTGCAACGCAGCGGCCCGCCGGAAATCGTGCGCGCGGCCGATTCGTTCAACGCGATGCAGGCGCGCCTGAACCGCCTAA
TCAACGAACGCACGCACATGGTCGCAGCGATCGCGCACGACTTGCGCACGCCGCTGGCGCGGCTGTCGTTTCGTCTGGAT
GGCCTGCAACCACCGCTGCGCGACAAGGCGCTGGCCGATATCAACGAGATGAAGGCGATGATTTCCGCAGCGCTGGACTT
CATCCAGAACGACCGTCATCGCGGCGAACGCGCGCCGCTGGATCTGCGCTTGCTGGTGGAGAGCGTGGTCGACAACGCCA
CCGATATCGGCGCCGACGCCGAGCTGCTGCCCGGCCCGGAAATTACCCTGGACGGCGACCCGCTGGCATTGCGCCGCGCC
GTCATGAATCTGCTCGAAAACGCGTTGAAATACGGCAAGCGCGCCCGTCTGCAACTGCAGCGCGACGGCGAGGACGGCGT
GTTGTGGATCGACGACGACGGCCCCGGCATCGATCCCACCCAGCGCGAACAATTGTTGCTGCCGTTCGTGCGTGGCGAGT
CCTCGCGCAATCGCGACACCGGCGGCATCGGGCTGGGCCTGTCGGTGGCGCACAGCATCGTGCTGGCGCACGGCGGCGAC
CTACGTCTGGACAATCGGCCGCATGGCGGATTGCGCGTGACCGTACGACTGCCCTGCATGCCGGAGCGACGCTGA

Upstream 100 bases:

>100_bases
TCAGCCGCCTGCGCCGCAAAATCAATGAGCGCGTCCATACCGAATTGATTCGCACCGTACGCAACGAGGGCTACATGCTG
CTGCCGAGCGTCTCGCGCCT

Downstream 100 bases:

>100_bases
CCTGAGATGGAGTGCGGCCTGCCGAGCCGCGCAAGCGGCAGCTGTGCTGATACGACCCGACACAGCTGTTCCGGCACTAG
CCTTGCGCGTGGGGCTACAT

Product: two-component system sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 504; Mature: 503

Protein sequence:

>504_residues
MSKPARRGLSIFARTFVLLAVALLTAQAVGIALLVMRTPVYEPPVHPPEVVALLSTRMPAGTQTLKVHESAQAPVPPTGQ
VRDPFAEMLLAHWLDVPERQVRFYRNANDREGPQPGMLPPQRWSNRDHAGDGGGGGGGGAHERLGTQPLPPFPDDWPRDS
HPAALSGDGLRPDELPGAWESERLTPGVPLLDGFTAALQQPDGRWRTVESPRRRLSGEFKTHVVLLFLAGLLANVPLAWW
FSRALSAPIKRFAEAADRLGRNPDAAALQRSGPPEIVRAADSFNAMQARLNRLINERTHMVAAIAHDLRTPLARLSFRLD
GLQPPLRDKALADINEMKAMISAALDFIQNDRHRGERAPLDLRLLVESVVDNATDIGADAELLPGPEITLDGDPLALRRA
VMNLLENALKYGKRARLQLQRDGEDGVLWIDDDGPGIDPTQREQLLLPFVRGESSRNRDTGGIGLGLSVAHSIVLAHGGD
LRLDNRPHGGLRVTVRLPCMPERR

Sequences:

>Translated_504_residues
MSKPARRGLSIFARTFVLLAVALLTAQAVGIALLVMRTPVYEPPVHPPEVVALLSTRMPAGTQTLKVHESAQAPVPPTGQ
VRDPFAEMLLAHWLDVPERQVRFYRNANDREGPQPGMLPPQRWSNRDHAGDGGGGGGGGAHERLGTQPLPPFPDDWPRDS
HPAALSGDGLRPDELPGAWESERLTPGVPLLDGFTAALQQPDGRWRTVESPRRRLSGEFKTHVVLLFLAGLLANVPLAWW
FSRALSAPIKRFAEAADRLGRNPDAAALQRSGPPEIVRAADSFNAMQARLNRLINERTHMVAAIAHDLRTPLARLSFRLD
GLQPPLRDKALADINEMKAMISAALDFIQNDRHRGERAPLDLRLLVESVVDNATDIGADAELLPGPEITLDGDPLALRRA
VMNLLENALKYGKRARLQLQRDGEDGVLWIDDDGPGIDPTQREQLLLPFVRGESSRNRDTGGIGLGLSVAHSIVLAHGGD
LRLDNRPHGGLRVTVRLPCMPERR
>Mature_503_residues
SKPARRGLSIFARTFVLLAVALLTAQAVGIALLVMRTPVYEPPVHPPEVVALLSTRMPAGTQTLKVHESAQAPVPPTGQV
RDPFAEMLLAHWLDVPERQVRFYRNANDREGPQPGMLPPQRWSNRDHAGDGGGGGGGGAHERLGTQPLPPFPDDWPRDSH
PAALSGDGLRPDELPGAWESERLTPGVPLLDGFTAALQQPDGRWRTVESPRRRLSGEFKTHVVLLFLAGLLANVPLAWWF
SRALSAPIKRFAEAADRLGRNPDAAALQRSGPPEIVRAADSFNAMQARLNRLINERTHMVAAIAHDLRTPLARLSFRLDG
LQPPLRDKALADINEMKAMISAALDFIQNDRHRGERAPLDLRLLVESVVDNATDIGADAELLPGPEITLDGDPLALRRAV
MNLLENALKYGKRARLQLQRDGEDGVLWIDDDGPGIDPTQREQLLLPFVRGESSRNRDTGGIGLGLSVAHSIVLAHGGDL
RLDNRPHGGLRVTVRLPCMPERR

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=282, Percent_Identity=32.2695035460993, Blast_Score=131, Evalue=9e-32,
Organism=Escherichia coli, GI1787894, Length=259, Percent_Identity=33.5907335907336, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1790346, Length=294, Percent_Identity=30.6122448979592, Blast_Score=118, Evalue=8e-28,
Organism=Escherichia coli, GI1788393, Length=273, Percent_Identity=30.03663003663, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1786783, Length=271, Percent_Identity=29.1512915129151, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI145693157, Length=256, Percent_Identity=26.171875, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1790551, Length=243, Percent_Identity=30.8641975308642, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786912, Length=219, Percent_Identity=31.5068493150685, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1789149, Length=395, Percent_Identity=23.7974683544304, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87081816, Length=111, Percent_Identity=36.036036036036, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1786600, Length=233, Percent_Identity=25.7510729613734, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI87082128, Length=304, Percent_Identity=25, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788713, Length=259, Percent_Identity=23.9382239382239, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788549, Length=221, Percent_Identity=25.7918552036199, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 55140; Mature: 55009

Theoretical pI: Translated: 7.96; Mature: 7.96

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKPARRGLSIFARTFVLLAVALLTAQAVGIALLVMRTPVYEPPVHPPEVVALLSTRMPA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCC
GTQTLKVHESAQAPVPPTGQVRDPFAEMLLAHWLDVPERQVRFYRNANDREGPQPGMLPP
CCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCC
QRWSNRDHAGDGGGGGGGGAHERLGTQPLPPFPDDWPRDSHPAALSGDGLRPDELPGAWE
HHCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SERLTPGVPLLDGFTAALQQPDGRWRTVESPRRRLSGEFKTHVVLLFLAGLLANVPLAWW
CCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHH
FSRALSAPIKRFAEAADRLGRNPDAAALQRSGPPEIVRAADSFNAMQARLNRLINERTHM
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAAIAHDLRTPLARLSFRLDGLQPPLRDKALADINEMKAMISAALDFIQNDRHRGERAPL
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
DLRLLVESVVDNATDIGADAELLPGPEITLDGDPLALRRAVMNLLENALKYGKRARLQLQ
HHHHHHHHHHCCHHHCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHCCCEEEEEE
RDGEDGVLWIDDDGPGIDPTQREQLLLPFVRGESSRNRDTGGIGLGLSVAHSIVLAHGGD
ECCCCCEEEECCCCCCCCCCCCHHEEHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCC
LRLDNRPHGGLRVTVRLPCMPERR
EEECCCCCCCEEEEEECCCCCCCC
>Mature Secondary Structure 
SKPARRGLSIFARTFVLLAVALLTAQAVGIALLVMRTPVYEPPVHPPEVVALLSTRMPA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCC
GTQTLKVHESAQAPVPPTGQVRDPFAEMLLAHWLDVPERQVRFYRNANDREGPQPGMLPP
CCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCC
QRWSNRDHAGDGGGGGGGGAHERLGTQPLPPFPDDWPRDSHPAALSGDGLRPDELPGAWE
HHCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SERLTPGVPLLDGFTAALQQPDGRWRTVESPRRRLSGEFKTHVVLLFLAGLLANVPLAWW
CCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHH
FSRALSAPIKRFAEAADRLGRNPDAAALQRSGPPEIVRAADSFNAMQARLNRLINERTHM
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAAIAHDLRTPLARLSFRLDGLQPPLRDKALADINEMKAMISAALDFIQNDRHRGERAPL
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
DLRLLVESVVDNATDIGADAELLPGPEITLDGDPLALRRAVMNLLENALKYGKRARLQLQ
HHHHHHHHHHCCHHHCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHCCCEEEEEE
RDGEDGVLWIDDDGPGIDPTQREQLLLPFVRGESSRNRDTGGIGLGLSVAHSIVLAHGGD
ECCCCCEEEECCCCCCCCCCCCHHEEHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCC
LRLDNRPHGGLRVTVRLPCMPERR
EEECCCCCCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]