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The map label for this gene is barA [H]

Identifier: 21241265

GI number: 21241265

Start: 580031

End: 582340

Strand: Reverse

Name: barA [H]

Synonym: XAC0494

Alternate gene names: 21241265

Gene position: 582340-580031 (Counterclockwise)

Preceding gene: 77748530

Following gene: 21241259

Centisome position: 11.25

GC content: 68.53

Gene sequence:

>2310_bases
GTGAGAGAGCGGGCAGCAGGTCTTCGCGCCTGGAGCATCTTGGCAGTGCTGGCCGCGCTGGCAGCCGCACTCGGCGCAGG
CCTGCAGTGGTCTTCGCTGCAAGGCCCCTGGCGCGCCGTCAGCGCGGTGTCGGCAGCGCTGGCGGTGGTCTGCGGGCTGT
GTGCCGCGTTTGCCGCTCACCGTGCCGCTCATGCGCAGCACGCGTTGGCGCAGCGCCTTGAAGAAGCCGACCTGGCCCGC
GAACGCTTGCAGCAGGAACTGCGGCGCCACGGCGAGCTCGAACAGGAACTGTTGCGCGCCAAGCAGGCCGCCGAGGCCGC
CACTCTGGCCAAGGGCGAATTCCTGGCCACCATGAGCCACGAGATCCGCACCCCGCTCAACGGCATCATTCCGATGCTGG
AGCTGATCTCCAGCGGCCAGCTCAGCCTTGATCAGCGCGACATGCTGCAGACCGCCACCGGCAGCTCGCTGCAACTGCTG
CGCATCGTCGACGACATCCTCGATTACTCCAAGCTCGAGGCCAACAAGCTCGAACTGGAAATCACCACCTTCAATCTGCG
CGAACTGCTCGACGGCGTCATCCAGTTGCTGCAGCGCACCGCCGAAGGCCGCCAGCTGCGCCTGAGCCTGGATATCGAAC
CGTCGGTACGGCTGCTGGTGCGCGGCGACCCGATCCGCCTGCGCCAGGTGCTGGGCAATCTGATCGGCAACGCCATCAAG
TTCACCGAACGCGGCAGCGTCGACATCCAGCTGCGCCGCCTGGGCGAAACGCGCGCCCAGCATCTGCTGCGCTTCCAGGT
GCGCGACACCGGGATCGGCATCGCCCCGGACCAGCAGGCACGCCTGTTCCGCTCCTTCGCACAAGCCGACGCCTCCACCA
CGCGGCTGTACGGCGGCACCGGCTTGGGCCTGGCGATCTGCAAACGCATCATCGACCTGATGGGCGGCCGCATCGGAGTG
GAATCCGAACCCGGGCGCGGCTCCACGTTCTGGTTCGAAATCCCGCTGCTCAAGGTCATCGGCGACCTCCAGCAGGCCAC
CGGCGCCGACGCCGCACGGGTGATGGTGATCAGCTCCGATGCGCGCCTGTCGCAACGCCTCAAGCGCCTGCTCGACAGCT
GGGGCGTGTCGCACGTGCTCATGGAAACCACCCAGGAAGCGCTCGAACGCGTGCGCCGGCACAGCGACGGCGAAGGCTTC
CGCTGCGTCATCGCCGACCACGACACGCTGCGCTACAGCGCGCGCGCAGTGCACCGCGCGCTCGCGCGCCCGGAAAATGC
CAGCAGCGCGCGGCTGATCTGGCTGTACGGCGAAGAACCGGTACCGGCCGAACTGCAGGATCACGCCACCCTGGTGCCAC
GCCTGAGCCCGGACGAAACCCTGCGCGCCCTGGTACTGCCGCCCGAACCCAAGCCCGCCCACGCCACCACGCTGGCCTCG
GCGATGATCCCCGAGCCGTTGCCACCGCCGATGGCCAACGCCCGCGAGGTGCGCATCCTGCTGGTCGAAGACAACCCGGT
GAACCTGCTGGTCGCGCAGAAGCTGCTGGCGGTGCTTGGCTTCGAGGCAGACACCGCCACCGACGGCGAAGCCGCACTGG
CCCGGATGGAATCCACCCGCTACGACATGGTCTTCATGGATTGCCAGATGCCGGTGCTGGATGGCTATGCCGCCACTCGC
CGCTGGCGCGCCATGGAAACCGAAAGCGGCGGCCGCCCGGTGCCGATCGTGGCCATGACCGCCAACGCCATGGCCGGCGA
CCGCGAACGCTGCCTGGCCGCCGGCATGGACGACTATCTGTCCAAGCCGGTCGCACGCGAACAGCTCGACGCCTGTCTGC
AACGCTGGCTGCCGCGTCAGGCGCTGCTGCCCGGCCCAAGCCCTGCCGGGCAGGCCACCCATGACCCCGAAAGCGCCAGC
GCCGCCGCGCAGGCACGCGCCCTGCCGATCCTGGACAACAGCGTCATCGACGAGCTGTACGAGGTGGCGGGCGCGGACAC
AATCACCATCCTGCAATTGTTCCTGGAAGACGCCCCGCTCATCATCGAACAACTGGAAGCGGCCGCCGCCAACCGCGACA
GCATGCAGCTGCGCGATCTGTCCCATACGCTGAAGTCCTCCAGCGCCAACGTCGGCGCGCAGGCCGTGTCCAACGCGGCA
CGGCGGATCGAACTGGCCGCCCGCACCGGCACCATCGAACGCCCCTCGGTCATGGTCGCCCTGGTCATCGCCGAATACGC
CCGCGCCCGCCTCGCCCTGCTGGGCCAGGTCGCCCGCCTGCAAGCCGACGCCAGCACGACAAATCACTAA

Upstream 100 bases:

>100_bases
GGCTGCGATGTGGATGAGCGGCGTGGATTTCATCCAGGGCAACCTGGTGCAGACCGTCGGCAAGGAACTGGACTTCGACT
TCACAAGCGCGGTGCTCTGA

Downstream 100 bases:

>100_bases
TCGCATCAGTGTGTCGAAGCGGCGGCAGACGCCTGGGACCGTCACCTGCATCCGTTAACGCGAGGCTCAAATCGCTCTGA
TGCTCAACGCCTTCTCACCC

Product: two-component system sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 769; Mature: 769

Protein sequence:

>769_residues
MRERAAGLRAWSILAVLAALAAALGAGLQWSSLQGPWRAVSAVSAALAVVCGLCAAFAAHRAAHAQHALAQRLEEADLAR
ERLQQELRRHGELEQELLRAKQAAEAATLAKGEFLATMSHEIRTPLNGIIPMLELISSGQLSLDQRDMLQTATGSSLQLL
RIVDDILDYSKLEANKLELEITTFNLRELLDGVIQLLQRTAEGRQLRLSLDIEPSVRLLVRGDPIRLRQVLGNLIGNAIK
FTERGSVDIQLRRLGETRAQHLLRFQVRDTGIGIAPDQQARLFRSFAQADASTTRLYGGTGLGLAICKRIIDLMGGRIGV
ESEPGRGSTFWFEIPLLKVIGDLQQATGADAARVMVISSDARLSQRLKRLLDSWGVSHVLMETTQEALERVRRHSDGEGF
RCVIADHDTLRYSARAVHRALARPENASSARLIWLYGEEPVPAELQDHATLVPRLSPDETLRALVLPPEPKPAHATTLAS
AMIPEPLPPPMANAREVRILLVEDNPVNLLVAQKLLAVLGFEADTATDGEAALARMESTRYDMVFMDCQMPVLDGYAATR
RWRAMETESGGRPVPIVAMTANAMAGDRERCLAAGMDDYLSKPVAREQLDACLQRWLPRQALLPGPSPAGQATHDPESAS
AAAQARALPILDNSVIDELYEVAGADTITILQLFLEDAPLIIEQLEAAAANRDSMQLRDLSHTLKSSSANVGAQAVSNAA
RRIELAARTGTIERPSVMVALVIAEYARARLALLGQVARLQADASTTNH

Sequences:

>Translated_769_residues
MRERAAGLRAWSILAVLAALAAALGAGLQWSSLQGPWRAVSAVSAALAVVCGLCAAFAAHRAAHAQHALAQRLEEADLAR
ERLQQELRRHGELEQELLRAKQAAEAATLAKGEFLATMSHEIRTPLNGIIPMLELISSGQLSLDQRDMLQTATGSSLQLL
RIVDDILDYSKLEANKLELEITTFNLRELLDGVIQLLQRTAEGRQLRLSLDIEPSVRLLVRGDPIRLRQVLGNLIGNAIK
FTERGSVDIQLRRLGETRAQHLLRFQVRDTGIGIAPDQQARLFRSFAQADASTTRLYGGTGLGLAICKRIIDLMGGRIGV
ESEPGRGSTFWFEIPLLKVIGDLQQATGADAARVMVISSDARLSQRLKRLLDSWGVSHVLMETTQEALERVRRHSDGEGF
RCVIADHDTLRYSARAVHRALARPENASSARLIWLYGEEPVPAELQDHATLVPRLSPDETLRALVLPPEPKPAHATTLAS
AMIPEPLPPPMANAREVRILLVEDNPVNLLVAQKLLAVLGFEADTATDGEAALARMESTRYDMVFMDCQMPVLDGYAATR
RWRAMETESGGRPVPIVAMTANAMAGDRERCLAAGMDDYLSKPVAREQLDACLQRWLPRQALLPGPSPAGQATHDPESAS
AAAQARALPILDNSVIDELYEVAGADTITILQLFLEDAPLIIEQLEAAAANRDSMQLRDLSHTLKSSSANVGAQAVSNAA
RRIELAARTGTIERPSVMVALVIAEYARARLALLGQVARLQADASTTNH
>Mature_769_residues
MRERAAGLRAWSILAVLAALAAALGAGLQWSSLQGPWRAVSAVSAALAVVCGLCAAFAAHRAAHAQHALAQRLEEADLAR
ERLQQELRRHGELEQELLRAKQAAEAATLAKGEFLATMSHEIRTPLNGIIPMLELISSGQLSLDQRDMLQTATGSSLQLL
RIVDDILDYSKLEANKLELEITTFNLRELLDGVIQLLQRTAEGRQLRLSLDIEPSVRLLVRGDPIRLRQVLGNLIGNAIK
FTERGSVDIQLRRLGETRAQHLLRFQVRDTGIGIAPDQQARLFRSFAQADASTTRLYGGTGLGLAICKRIIDLMGGRIGV
ESEPGRGSTFWFEIPLLKVIGDLQQATGADAARVMVISSDARLSQRLKRLLDSWGVSHVLMETTQEALERVRRHSDGEGF
RCVIADHDTLRYSARAVHRALARPENASSARLIWLYGEEPVPAELQDHATLVPRLSPDETLRALVLPPEPKPAHATTLAS
AMIPEPLPPPMANAREVRILLVEDNPVNLLVAQKLLAVLGFEADTATDGEAALARMESTRYDMVFMDCQMPVLDGYAATR
RWRAMETESGGRPVPIVAMTANAMAGDRERCLAAGMDDYLSKPVAREQLDACLQRWLPRQALLPGPSPAGQATHDPESAS
AAAQARALPILDNSVIDELYEVAGADTITILQLFLEDAPLIIEQLEAAAANRDSMQLRDLSHTLKSSSANVGAQAVSNAA
RRIELAARTGTIERPSVMVALVIAEYARARLALLGQVARLQADASTTNH

Specific function: Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY, probably via a four-step phosphorelay [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=682, Percent_Identity=34.6041055718475, Blast_Score=303, Evalue=2e-83,
Organism=Escherichia coli, GI145693157, Length=535, Percent_Identity=33.6448598130841, Blast_Score=259, Evalue=6e-70,
Organism=Escherichia coli, GI87081816, Length=340, Percent_Identity=36.4705882352941, Blast_Score=170, Evalue=4e-43,
Organism=Escherichia coli, GI1788713, Length=256, Percent_Identity=37.5, Blast_Score=153, Evalue=5e-38,
Organism=Escherichia coli, GI48994928, Length=255, Percent_Identity=36.8627450980392, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1786600, Length=248, Percent_Identity=32.258064516129, Blast_Score=99, Evalue=8e-22,
Organism=Escherichia coli, GI1786783, Length=253, Percent_Identity=30.8300395256917, Blast_Score=99, Evalue=9e-22,
Organism=Escherichia coli, GI1788393, Length=258, Percent_Identity=29.8449612403101, Blast_Score=95, Evalue=2e-20,
Organism=Escherichia coli, GI1790436, Length=263, Percent_Identity=28.5171102661597, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1786912, Length=243, Percent_Identity=28.8065843621399, Blast_Score=87, Evalue=5e-18,
Organism=Escherichia coli, GI87082128, Length=229, Percent_Identity=26.2008733624454, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1788549, Length=240, Percent_Identity=28.3333333333333, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1787894, Length=242, Percent_Identity=28.9256198347107, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1789808, Length=251, Percent_Identity=27.4900398406374, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1790346, Length=290, Percent_Identity=28.9655172413793, Blast_Score=72, Evalue=2e-13,
Organism=Escherichia coli, GI1790300, Length=298, Percent_Identity=27.8523489932886, Blast_Score=67, Evalue=6e-12,
Organism=Escherichia coli, GI1788550, Length=125, Percent_Identity=32.8, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=123, Percent_Identity=39.0243902439024, Blast_Score=91, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6322044, Length=130, Percent_Identity=37.6923076923077, Blast_Score=87, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6323034, Length=184, Percent_Identity=27.7173913043478, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR019247
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF09984 DUF2222; PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; PF01627 Hpt; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 83701; Mature: 83701

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS50894 HPT ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRERAAGLRAWSILAVLAALAAALGAGLQWSSLQGPWRAVSAVSAALAVVCGLCAAFAAH
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RAAHAQHALAQRLEEADLARERLQQELRRHGELEQELLRAKQAAEAATLAKGEFLATMSH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
EIRTPLNGIIPMLELISSGQLSLDQRDMLQTATGSSLQLLRIVDDILDYSKLEANKLELE
HHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEEE
ITTFNLRELLDGVIQLLQRTAEGRQLRLSLDIEPSVRLLVRGDPIRLRQVLGNLIGNAIK
EEEHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCHHHHHHHHHHHHHHHEE
FTERGSVDIQLRRLGETRAQHLLRFQVRDTGIGIAPDQQARLFRSFAQADASTTRLYGGT
ECCCCCCEEEHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCC
GLGLAICKRIIDLMGGRIGVESEPGRGSTFWFEIPLLKVIGDLQQATGADAARVMVISSD
CHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHCCCCCEEEEEEECC
ARLSQRLKRLLDSWGVSHVLMETTQEALERVRRHSDGEGFRCVIADHDTLRYSARAVHRA
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHH
LARPENASSARLIWLYGEEPVPAELQDHATLVPRLSPDETLRALVLPPEPKPAHATTLAS
HCCCCCCCCEEEEEEECCCCCCCCHHCCCCCCCCCCCCHHCEEEEECCCCCCCHHHHHHH
AMIPEPLPPPMANAREVRILLVEDNPVNLLVAQKLLAVLGFEADTATDGEAALARMESTR
HHCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCC
YDMVFMDCQMPVLDGYAATRRWRAMETESGGRPVPIVAMTANAMAGDRERCLAAGMDDYL
CCEEEEECCCCHHCCHHHHHHHHHCCCCCCCCCCEEEEEECCHHCCCHHHHHHCCCHHHH
SKPVAREQLDACLQRWLPRQALLPGPSPAGQATHDPESASAAAQARALPILDNSVIDELY
CCCHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHH
EVAGADTITILQLFLEDAPLIIEQLEAAAANRDSMQLRDLSHTLKSSSANVGAQAVSNAA
HHHCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHH
RRIELAARTGTIERPSVMVALVIAEYARARLALLGQVARLQADASTTNH
HHEEHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MRERAAGLRAWSILAVLAALAAALGAGLQWSSLQGPWRAVSAVSAALAVVCGLCAAFAAH
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RAAHAQHALAQRLEEADLARERLQQELRRHGELEQELLRAKQAAEAATLAKGEFLATMSH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
EIRTPLNGIIPMLELISSGQLSLDQRDMLQTATGSSLQLLRIVDDILDYSKLEANKLELE
HHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEEE
ITTFNLRELLDGVIQLLQRTAEGRQLRLSLDIEPSVRLLVRGDPIRLRQVLGNLIGNAIK
EEEHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCHHHHHHHHHHHHHHHEE
FTERGSVDIQLRRLGETRAQHLLRFQVRDTGIGIAPDQQARLFRSFAQADASTTRLYGGT
ECCCCCCEEEHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCC
GLGLAICKRIIDLMGGRIGVESEPGRGSTFWFEIPLLKVIGDLQQATGADAARVMVISSD
CHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHCCCCCEEEEEEECC
ARLSQRLKRLLDSWGVSHVLMETTQEALERVRRHSDGEGFRCVIADHDTLRYSARAVHRA
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHH
LARPENASSARLIWLYGEEPVPAELQDHATLVPRLSPDETLRALVLPPEPKPAHATTLAS
HCCCCCCCCEEEEEEECCCCCCCCHHCCCCCCCCCCCCHHCEEEEECCCCCCCHHHHHHH
AMIPEPLPPPMANAREVRILLVEDNPVNLLVAQKLLAVLGFEADTATDGEAALARMESTR
HHCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCC
YDMVFMDCQMPVLDGYAATRRWRAMETESGGRPVPIVAMTANAMAGDRERCLAAGMDDYL
CCEEEEECCCCHHCCHHHHHHHHHCCCCCCCCCCEEEEEECCHHCCCHHHHHHCCCHHHH
SKPVAREQLDACLQRWLPRQALLPGPSPAGQATHDPESASAAAQARALPILDNSVIDELY
CCCHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHH
EVAGADTITILQLFLEDAPLIIEQLEAAAANRDSMQLRDLSHTLKSSSANVGAQAVSNAA
HHHCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHH
RRIELAARTGTIERPSVMVALVIAEYARARLALLGQVARLQADASTTNH
HHEEHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]