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The map label for this gene is nudH

Identifier: 21241262

GI number: 21241262

Start: 578005

End: 578622

Strand: Direct

Name: nudH

Synonym: XAC0491

Alternate gene names: 21241262

Gene position: 578005-578622 (Clockwise)

Preceding gene: 21241261

Following gene: 21241263

Centisome position: 11.17

GC content: 65.21

Gene sequence:

>618_bases
GTGATCGATCCGGACGGTTTCCGGCCAAACGTCGGCATTGTGCTGATGCGGCAGGACGGTCAGGTGTTCTGGGCGCGACG
TGTGCGCAGGGACGGCTGGCAGTTCCCGCAAGGTGGCATGAACACCGATGAGACGCCCGTTGAAGCCATGTACCGCGAGT
TGCGCGAAGAAACCGGGTTGTTGCCCGAGCATGTGGAATTGCTCGGCGCCACGCCTGGCTGGCTACGCTATCGGCTGCCC
AGCCGGGCGGTGCGCCGCAATGAGCGGCAGGTGTGTATCGGGCAGAAGCAGGTCTGGTTCCTGCTGCAGTTCACCGGCGA
CGAATCCCATCTCAAGCTCGACCATACCGACACCCCGGAGTTCGACCACTGGCGCTGGGTGGATTTCTGGTATCCGGTCG
AGCACGTGGTGATGTTCAAGCGCGGCGTCTATGCCCGCGCGCTGCGTCATCTGGCGCCGCTTGCGCAGAGCCTGGCCGGT
CCGGCGGCAGTCGGTGCGATGCCCGAGCGTGCGCTGGAGGCGTGGTTGCCGGGCAGCAGCGCGGCAGGGCACGACAGCCC
ACGCAAGCGGCCACGCAAGCGCAACGGGGCTCGTGCGATGCGGATTAATAATGATTAA

Upstream 100 bases:

>100_bases
CACGATGCGCCGTGCTGTTGTCAAGCATTTCGTTTTCAGCTTGTGAGCCGGGCGTCGCCGTGGCAGAGTCGGTGGCAGTA
GATTTTCAGGAGTCCGCATC

Downstream 100 bases:

>100_bases
CGGATGGAATTGACACCTATTCTCGTTTGCGGTGCAATCAGCGCCGGTCCTTTCCGGATCGCCAACACCCGACCGATACT
GTGTACGTCTGCATCTGTAA

Product: dinucleoside polyphosphate hydrolase

Products: NA

Alternate protein names: (Di)nucleoside polyphosphate hydrolase

Number of amino acids: Translated: 205; Mature: 205

Protein sequence:

>205_residues
MIDPDGFRPNVGIVLMRQDGQVFWARRVRRDGWQFPQGGMNTDETPVEAMYRELREETGLLPEHVELLGATPGWLRYRLP
SRAVRRNERQVCIGQKQVWFLLQFTGDESHLKLDHTDTPEFDHWRWVDFWYPVEHVVMFKRGVYARALRHLAPLAQSLAG
PAAVGAMPERALEAWLPGSSAAGHDSPRKRPRKRNGARAMRINND

Sequences:

>Translated_205_residues
MIDPDGFRPNVGIVLMRQDGQVFWARRVRRDGWQFPQGGMNTDETPVEAMYRELREETGLLPEHVELLGATPGWLRYRLP
SRAVRRNERQVCIGQKQVWFLLQFTGDESHLKLDHTDTPEFDHWRWVDFWYPVEHVVMFKRGVYARALRHLAPLAQSLAG
PAAVGAMPERALEAWLPGSSAAGHDSPRKRPRKRNGARAMRINND
>Mature_205_residues
MIDPDGFRPNVGIVLMRQDGQVFWARRVRRDGWQFPQGGMNTDETPVEAMYRELREETGLLPEHVELLGATPGWLRYRLP
SRAVRRNERQVCIGQKQVWFLLQFTGDESHLKLDHTDTPEFDHWRWVDFWYPVEHVVMFKRGVYARALRHLAPLAQSLAG
PAAVGAMPERALEAWLPGSSAAGHDSPRKRPRKRNGARAMRINND

Specific function: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain

Homologues:

Organism=Escherichia coli, GI1789194, Length=158, Percent_Identity=54.4303797468354, Blast_Score=187, Evalue=4e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RPPH_XANAC (Q8PQ40)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_640844.1
- ProteinModelPortal:   Q8PQ40
- SMR:   Q8PQ40
- GeneID:   1154562
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC0491
- NMPDR:   fig|190486.1.peg.488
- HOGENOM:   HBG302451
- OMA:   GQKQIWY
- ProtClustDB:   PRK00714
- BioCyc:   XAXO190486:XAC0491-MONOMER
- HAMAP:   MF_00298
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR022927
- Gene3D:   G3DSA:3.90.79.10

Pfam domain/function: PF00293 NUDIX; SSF55811 NUDIX_hydrolase

EC number: 3.6.1.- [C]

Molecular weight: Translated: 23675; Mature: 23675

Theoretical pI: Translated: 10.13; Mature: 10.13

Prosite motif: PS51462 NUDIX; PS00893 NUDIX_BOX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDPDGFRPNVGIVLMRQDGQVFWARRVRRDGWQFPQGGMNTDETPVEAMYRELREETGL
CCCCCCCCCCCCEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
LPEHVELLGATPGWLRYRLPSRAVRRNERQVCIGQKQVWFLLQFTGDESHLKLDHTDTPE
CHHHHHHHCCCCCCEEEECCHHHHHCCCCCEEECCCEEEEEEEEECCCCEEEECCCCCCC
FDHWRWVDFWYPVEHVVMFKRGVYARALRHLAPLAQSLAGPAAVGAMPERALEAWLPGSS
CCCEEEEEECCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHCCCCC
AAGHDSPRKRPRKRNGARAMRINND
CCCCCCHHHCCHHCCCCEEEEECCC
>Mature Secondary Structure
MIDPDGFRPNVGIVLMRQDGQVFWARRVRRDGWQFPQGGMNTDETPVEAMYRELREETGL
CCCCCCCCCCCCEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
LPEHVELLGATPGWLRYRLPSRAVRRNERQVCIGQKQVWFLLQFTGDESHLKLDHTDTPE
CHHHHHHHCCCCCCEEEECCHHHHHCCCCCEEECCCEEEEEEEEECCCCEEEECCCCCCC
FDHWRWVDFWYPVEHVVMFKRGVYARALRHLAPLAQSLAGPAAVGAMPERALEAWLPGSS
CCCEEEEEECCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHCCCCC
AAGHDSPRKRPRKRNGARAMRINND
CCCCCCHHHCCHHCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217