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The map label for this gene is trpC

Identifier: 21241254

GI number: 21241254

Start: 571700

End: 572497

Strand: Direct

Name: trpC

Synonym: XAC0481

Alternate gene names: 21241254

Gene position: 571700-572497 (Clockwise)

Preceding gene: 21241253

Following gene: 21241255

Centisome position: 11.05

GC content: 64.79

Gene sequence:

>798_bases
ATGAGCGACATCCTCAACACCATTCTTGCCCGCAAGGCCGATGAAGTCGCCGAGCGCAGTGCGCGCGTGCCGCTGGCCGA
GTTGATTGCGCGCAGCGCCGACCTGCCGCTCACGCGCGGATTTGCAGCTGCCATGCAGGCCAGCATCGCCGCAGGCGACC
CGGCCGTGATTGCCGAAGTGAAGAAGGCCAGCCCGTCCAAGGGTGTCATCCGGCCGGACTTCCAGCCGGCCGATATCGCG
GTCAGCTACGAATTCGGTGGCGCGACGTGCCTGTCCGTGCTCACCGATGTGGATTTCTTCCAGGGATCCGATGCCTATCT
GCGCCAGGCGCGCGACGCCTGCACGCTGCCGGTGCTGCGCAAGGATTTCACCGTGGACCCGTATCAGGTCTACGAAGCCC
GCGTGCTCGGCGCCGACTGCATCCTGTTGATCGTCTCCGCGCTGGAAGACGCCCAACTGGCCGATCTATCGGGTCTTGCC
ATGCAGCTGGGCCTGGACGTGCTGGTGGAAGTGCACGATATCGACGAGCTCGAGCGTGCGGTGCAGGTGCCGGTGCCGTT
GATCGGCATCAACAACCGCAACCTGCGCACCTTCGAAGTGACGCTGCAGACCACGTTGGACATGCGCTCCGCGGTGCCGC
GCGATCGCGTGCTGGTCACCGAGAGCGGCATCGTCACCCAGGCCGATGTGCAACGGATGCGCAGTCACGATGTGAACGCG
TTTCTGGTCGGCGAGACCTTCATGCGCGCGGCAGAACCCGGCGAGTCGCTGCGTCAGCTATTCTTCGCGCATGACTGA

Upstream 100 bases:

>100_bases
GCATCCTCACAGTCGCGCTGGCATGCTGCGTGCTGGCGCGCAGCCGCTCTCCAGTGCGGCCGTCTTGACCGATAATGCCC
GCCCGCCAGGACCCGATACG

Downstream 100 bases:

>100_bases
GTCGTATCCCGTCCCGCGCGAGGACGCACCGCTGGTGGTCTTCGACTTCGACCACACCTTGTACGACGGCGATTCCGGCA
GTCATCTGTTTGCCTGGCTG

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 265; Mature: 264

Protein sequence:

>265_residues
MSDILNTILARKADEVAERSARVPLAELIARSADLPLTRGFAAAMQASIAAGDPAVIAEVKKASPSKGVIRPDFQPADIA
VSYEFGGATCLSVLTDVDFFQGSDAYLRQARDACTLPVLRKDFTVDPYQVYEARVLGADCILLIVSALEDAQLADLSGLA
MQLGLDVLVEVHDIDELERAVQVPVPLIGINNRNLRTFEVTLQTTLDMRSAVPRDRVLVTESGIVTQADVQRMRSHDVNA
FLVGETFMRAAEPGESLRQLFFAHD

Sequences:

>Translated_265_residues
MSDILNTILARKADEVAERSARVPLAELIARSADLPLTRGFAAAMQASIAAGDPAVIAEVKKASPSKGVIRPDFQPADIA
VSYEFGGATCLSVLTDVDFFQGSDAYLRQARDACTLPVLRKDFTVDPYQVYEARVLGADCILLIVSALEDAQLADLSGLA
MQLGLDVLVEVHDIDELERAVQVPVPLIGINNRNLRTFEVTLQTTLDMRSAVPRDRVLVTESGIVTQADVQRMRSHDVNA
FLVGETFMRAAEPGESLRQLFFAHD
>Mature_264_residues
SDILNTILARKADEVAERSARVPLAELIARSADLPLTRGFAAAMQASIAAGDPAVIAEVKKASPSKGVIRPDFQPADIAV
SYEFGGATCLSVLTDVDFFQGSDAYLRQARDACTLPVLRKDFTVDPYQVYEARVLGADCILLIVSALEDAQLADLSGLAM
QLGLDVLVEVHDIDELERAVQVPVPLIGINNRNLRTFEVTLQTTLDMRSAVPRDRVLVTESGIVTQADVQRMRSHDVNAF
LVGETFMRAAEPGESLRQLFFAHD

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=248, Percent_Identity=41.5322580645161, Blast_Score=167, Evalue=7e-43,
Organism=Saccharomyces cerevisiae, GI6322638, Length=272, Percent_Identity=35.2941176470588, Blast_Score=150, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_XANAC (Q8PQ47)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_640836.1
- ProteinModelPortal:   Q8PQ47
- SMR:   Q8PQ47
- GeneID:   1154552
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC0481
- NMPDR:   fig|190486.1.peg.480
- HOGENOM:   HBG540956
- OMA:   VDLPLLC
- ProtClustDB:   PRK00278
- BioCyc:   XAXO190486:XAC0481-MONOMER
- BRENDA:   4.1.1.48
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 28812; Mature: 28681

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDILNTILARKADEVAERSARVPLAELIARSADLPLTRGFAAAMQASIAAGDPAVIAEV
CHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHH
KKASPSKGVIRPDFQPADIAVSYEFGGATCLSVLTDVDFFQGSDAYLRQARDACTLPVLR
HHCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHH
KDFTVDPYQVYEARVLGADCILLIVSALEDAQLADLSGLAMQLGLDVLVEVHDIDELERA
CCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHCHHHEEEHHCHHHHHHH
VQVPVPLIGINNRNLRTFEVTLQTTLDMRSAVPRDRVLVTESGIVTQADVQRMRSHDVNA
HHCCCEEEECCCCCEEEEEEEEEHHHHHHHCCCCCCEEEECCCCEEHHHHHHHHHCCCCE
FLVGETFMRAAEPGESLRQLFFAHD
EEECHHHHHHCCCCHHHHHHHHCCC
>Mature Secondary Structure 
SDILNTILARKADEVAERSARVPLAELIARSADLPLTRGFAAAMQASIAAGDPAVIAEV
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHH
KKASPSKGVIRPDFQPADIAVSYEFGGATCLSVLTDVDFFQGSDAYLRQARDACTLPVLR
HHCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHH
KDFTVDPYQVYEARVLGADCILLIVSALEDAQLADLSGLAMQLGLDVLVEVHDIDELERA
CCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHCHHHEEEHHCHHHHHHH
VQVPVPLIGINNRNLRTFEVTLQTTLDMRSAVPRDRVLVTESGIVTQADVQRMRSHDVNA
HHCCCEEEECCCCCEEEEEEEEEHHHHHHHCCCCCCEEEECCCCEEHHHHHHHHHCCCCE
FLVGETFMRAAEPGESLRQLFFAHD
EEECHHHHHHCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217