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The map label for this gene is ubiB [C]

Identifier: 21241195

GI number: 21241195

Start: 496358

End: 498076

Strand: Reverse

Name: ubiB [C]

Synonym: XAC0422

Alternate gene names: 21241195

Gene position: 498076-496358 (Counterclockwise)

Preceding gene: 21241197

Following gene: 161485718

Centisome position: 9.62

GC content: 66.84

Gene sequence:

>1719_bases
ATGGCCTTGAGTCAGAACGACCCGCACCGCGCCCCGGCCGCAAGCCCGGCAGATCATGCCGTGGTTGGCGGCATGAGCCG
GCGCACGCAGATCCTGCGCTTGTTGTTGCGCTATCGCGGCTCGGGCGTGTTCGCTGGCATGAACCTGGACCCGGCGGCCA
TCAACGAATACGAGGTGCCCGCAGAAGGCACCCCGGACCAGTTCGTCTCAGACCTGGAATCGCTCGGGCCCACCTTCGTC
AAATTGGGGCAGATGCTGTCGACCCGGCCGGACATCGTGCCGCCGGAATTTGCCACCGCGCTGGAGCGCATGCAGGAGAA
CACCAGCTCGGTGCCGGTGGAGCGCATCCGCCAGATCATCGAAGAAGAGCTCGGGGTCTCGGTCAACAAGGCGTTCTCGT
TCTTCGACCCGGTCCCGTTGGGCTGCGCCTCGCTGGCGCAGGTGCACCGCGCTGCGCTACGCGACGGCACGCCAGTGGCG
ATCAAGGTGCAGAAACCCGAAGTGGCCGCGCAGGTGCGTTCGGATCTGGACGTGCTCAAGAGCTTCGCCACCGCCGCCGA
CCGCCTGACCGGCATCGGCCGGCGTGTGCGCTTTGCCGACTGGCTGGGCGAATTCGGCAAGACCCTGCGCGCCGAGCTCA
ACTACGAAGACGAAGCCGAAACCCTGGCGCGCTTCGGCAAGCACCTCAAGCCGTTCCCCTTGCTGTGGGTGCCGCAGCCG
GTGTGGGACCTGAGCAGCCGCAAGGTGCTGACGATGCAGCTGGCCGAAGGCGTGCGCGTGGACAAGATCTCCGGCCTGCG
TCGCACCGAACAGCCCATGGACGAGCTGGCCGCGGAACTGGTCAAGGGGTATCTGGACCAGATGTTCGTGCATGGCGAAA
TCCATGCCGACCCGCATCCGGGCAATTTGCGCGTGCTGCAGGACGGGCGCCTGGCCATCTTCGACCTGGGCATGGTGGCG
CATGTGCCGCCGCGCCTGCGCGAGCGCCTGCTCAAGTTGCTGTTTGCCGCGGTCGATGGGCGCGGCGAGGAAGTGGCCGA
AGAGACCATTGCGCTGAGCACGCGGCTGGAGGATTACGACGAAGAGCGCTACCAGCGCGAAACCGGGCAGATGATCGCGC
GCTACGCAGCGCACGATGCCACCTCCGAAGGCCGGGTGGTGCTGGATCTGGTGCGCATCGCCACCTCGACCGGCCTGCGG
ACGCCGCCGGAGTTGAGCCTGCTCGGCAAGACCTTGCTGAACCTGGAGGGCGTGTGCCGCGCGTTGTCGCCCACGCTGGA
TACGCGCCGCATCGTCGAGCGCCATCTGCAGCACGTGATGCGCGCGCGCCTGAAGAAGTCCCTGTCCGCCGCCAACCTGG
CCAGCGAGGCGATGGAACTGCAGCATCTGGTGCGCGAAGGACCGCGCCGCATGTCCGAGATCCTGTCGCTGGCTGCGGAA
AACCGCCTGCAGATGCGCGTCACCGGGCTGGAAGAATCGCACCTGATGGAAAGCCTGCAGAAGATCGCCAACCGCGTTGC
GGCGGGCATCGTCACGGCCGCGCTGATCATGGCGTCGGCGCAGATGATGCGCATCGAAACCGGCTTGAAGCTGTGGGGCT
ATCCGGCCATTGCGATGGTGCTGTTCCTGCTCGGGGTGGTACTGGGCCTGGGCATCGTGGTCAGTGCGCTGCTGTTCGAC
CGCCGCGTGCGTGCGCGCGAAGAGCGCGGGCACCGCTAG

Upstream 100 bases:

>100_bases
TCGCCTTGGGCAGGTTTGCCTGCGGTGTGCGGGGGCGCGCGGATTCACTACGCGACGACCCGTCGCTGGCCACACTCGCC
GCCTGCACGACGCCCCGGAG

Downstream 100 bases:

>100_bases
TCGTCAGGACCAGCTGCAGCATGTGGGCGCCTTGGTGCCCCGTAGTCAGGTGTTTGTGATCATCGCGCGCGTTGCATCGT
GCTCGGTGTAACTGATTGCA

Product: ABC transporter substrate-binding protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 572; Mature: 571

Protein sequence:

>572_residues
MALSQNDPHRAPAASPADHAVVGGMSRRTQILRLLLRYRGSGVFAGMNLDPAAINEYEVPAEGTPDQFVSDLESLGPTFV
KLGQMLSTRPDIVPPEFATALERMQENTSSVPVERIRQIIEEELGVSVNKAFSFFDPVPLGCASLAQVHRAALRDGTPVA
IKVQKPEVAAQVRSDLDVLKSFATAADRLTGIGRRVRFADWLGEFGKTLRAELNYEDEAETLARFGKHLKPFPLLWVPQP
VWDLSSRKVLTMQLAEGVRVDKISGLRRTEQPMDELAAELVKGYLDQMFVHGEIHADPHPGNLRVLQDGRLAIFDLGMVA
HVPPRLRERLLKLLFAAVDGRGEEVAEETIALSTRLEDYDEERYQRETGQMIARYAAHDATSEGRVVLDLVRIATSTGLR
TPPELSLLGKTLLNLEGVCRALSPTLDTRRIVERHLQHVMRARLKKSLSAANLASEAMELQHLVREGPRRMSEILSLAAE
NRLQMRVTGLEESHLMESLQKIANRVAAGIVTAALIMASAQMMRIETGLKLWGYPAIAMVLFLLGVVLGLGIVVSALLFD
RRVRAREERGHR

Sequences:

>Translated_572_residues
MALSQNDPHRAPAASPADHAVVGGMSRRTQILRLLLRYRGSGVFAGMNLDPAAINEYEVPAEGTPDQFVSDLESLGPTFV
KLGQMLSTRPDIVPPEFATALERMQENTSSVPVERIRQIIEEELGVSVNKAFSFFDPVPLGCASLAQVHRAALRDGTPVA
IKVQKPEVAAQVRSDLDVLKSFATAADRLTGIGRRVRFADWLGEFGKTLRAELNYEDEAETLARFGKHLKPFPLLWVPQP
VWDLSSRKVLTMQLAEGVRVDKISGLRRTEQPMDELAAELVKGYLDQMFVHGEIHADPHPGNLRVLQDGRLAIFDLGMVA
HVPPRLRERLLKLLFAAVDGRGEEVAEETIALSTRLEDYDEERYQRETGQMIARYAAHDATSEGRVVLDLVRIATSTGLR
TPPELSLLGKTLLNLEGVCRALSPTLDTRRIVERHLQHVMRARLKKSLSAANLASEAMELQHLVREGPRRMSEILSLAAE
NRLQMRVTGLEESHLMESLQKIANRVAAGIVTAALIMASAQMMRIETGLKLWGYPAIAMVLFLLGVVLGLGIVVSALLFD
RRVRAREERGHR
>Mature_571_residues
ALSQNDPHRAPAASPADHAVVGGMSRRTQILRLLLRYRGSGVFAGMNLDPAAINEYEVPAEGTPDQFVSDLESLGPTFVK
LGQMLSTRPDIVPPEFATALERMQENTSSVPVERIRQIIEEELGVSVNKAFSFFDPVPLGCASLAQVHRAALRDGTPVAI
KVQKPEVAAQVRSDLDVLKSFATAADRLTGIGRRVRFADWLGEFGKTLRAELNYEDEAETLARFGKHLKPFPLLWVPQPV
WDLSSRKVLTMQLAEGVRVDKISGLRRTEQPMDELAAELVKGYLDQMFVHGEIHADPHPGNLRVLQDGRLAIFDLGMVAH
VPPRLRERLLKLLFAAVDGRGEEVAEETIALSTRLEDYDEERYQRETGQMIARYAAHDATSEGRVVLDLVRIATSTGLRT
PPELSLLGKTLLNLEGVCRALSPTLDTRRIVERHLQHVMRARLKKSLSAANLASEAMELQHLVREGPRRMSEILSLAAEN
RLQMRVTGLEESHLMESLQKIANRVAAGIVTAALIMASAQMMRIETGLKLWGYPAIAMVLFLLGVVLGLGIVVSALLFDR
RVRAREERGHR

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=228, Percent_Identity=35.9649122807018, Blast_Score=154, Evalue=3e-37,
Organism=Homo sapiens, GI41393593, Length=278, Percent_Identity=31.6546762589928, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI217035081, Length=183, Percent_Identity=36.6120218579235, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI27363457, Length=411, Percent_Identity=24.5742092457421, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI34147522, Length=296, Percent_Identity=26.6891891891892, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI217416386, Length=388, Percent_Identity=24.2268041237113, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI32261307, Length=324, Percent_Identity=25.3086419753086, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI2367309, Length=379, Percent_Identity=30.6068601583113, Blast_Score=158, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI17559152, Length=275, Percent_Identity=29.4545454545455, Blast_Score=138, Evalue=9e-33,
Organism=Caenorhabditis elegans, GI32565180, Length=297, Percent_Identity=28.956228956229, Blast_Score=125, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6321319, Length=291, Percent_Identity=26.4604810996564, Blast_Score=101, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6323282, Length=291, Percent_Identity=27.1477663230241, Blast_Score=100, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6325148, Length=262, Percent_Identity=25.9541984732824, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI22024280, Length=254, Percent_Identity=29.9212598425197, Blast_Score=129, Evalue=6e-30,
Organism=Drosophila melanogaster, GI24662575, Length=268, Percent_Identity=26.865671641791, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI18859849, Length=245, Percent_Identity=32.6530612244898, Blast_Score=117, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 63406; Mature: 63275

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALSQNDPHRAPAASPADHAVVGGMSRRTQILRLLLRYRGSGVFAGMNLDPAAINEYEVP
CCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHCCCCEEECCCCCHHHCCCCCCC
AEGTPDQFVSDLESLGPTFVKLGQMLSTRPDIVPPEFATALERMQENTSSVPVERIRQII
CCCCHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHH
EEELGVSVNKAFSFFDPVPLGCASLAQVHRAALRDGTPVAIKVQKPEVAAQVRSDLDVLK
HHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHH
SFATAADRLTGIGRRVRFADWLGEFGKTLRAELNYEDEAETLARFGKHLKPFPLLWVPQP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEECCCC
VWDLSSRKVLTMQLAEGVRVDKISGLRRTEQPMDELAAELVKGYLDQMFVHGEIHADPHP
CCCCCCCCEEHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCC
GNLRVLQDGRLAIFDLGMVAHVPPRLRERLLKLLFAAVDGRGEEVAEETIALSTRLEDYD
CCEEEEECCCEEEEECCHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
EERYQRETGQMIARYAAHDATSEGRVVLDLVRIATSTGLRTPPELSLLGKTLLNLEGVCR
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
ALSPTLDTRRIVERHLQHVMRARLKKSLSAANLASEAMELQHLVREGPRRMSEILSLAAE
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NRLQMRVTGLEESHLMESLQKIANRVAAGIVTAALIMASAQMMRIETGLKLWGYPAIAMV
CCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCHHHHHH
LFLLGVVLGLGIVVSALLFDRRVRAREERGHR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ALSQNDPHRAPAASPADHAVVGGMSRRTQILRLLLRYRGSGVFAGMNLDPAAINEYEVP
CCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHCCCCEEECCCCCHHHCCCCCCC
AEGTPDQFVSDLESLGPTFVKLGQMLSTRPDIVPPEFATALERMQENTSSVPVERIRQII
CCCCHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHH
EEELGVSVNKAFSFFDPVPLGCASLAQVHRAALRDGTPVAIKVQKPEVAAQVRSDLDVLK
HHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHH
SFATAADRLTGIGRRVRFADWLGEFGKTLRAELNYEDEAETLARFGKHLKPFPLLWVPQP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEECCCC
VWDLSSRKVLTMQLAEGVRVDKISGLRRTEQPMDELAAELVKGYLDQMFVHGEIHADPHP
CCCCCCCCEEHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCC
GNLRVLQDGRLAIFDLGMVAHVPPRLRERLLKLLFAAVDGRGEEVAEETIALSTRLEDYD
CCEEEEECCCEEEEECCHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
EERYQRETGQMIARYAAHDATSEGRVVLDLVRIATSTGLRTPPELSLLGKTLLNLEGVCR
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
ALSPTLDTRRIVERHLQHVMRARLKKSLSAANLASEAMELQHLVREGPRRMSEILSLAAE
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NRLQMRVTGLEESHLMESLQKIANRVAAGIVTAALIMASAQMMRIETGLKLWGYPAIAMV
CCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCHHHHHH
LFLLGVVLGLGIVVSALLFDRRVRAREERGHR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]