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The map label for this gene is smeS [H]

Identifier: 21241100

GI number: 21241100

Start: 387021

End: 388400

Strand: Reverse

Name: smeS [H]

Synonym: XAC0326

Alternate gene names: 21241100

Gene position: 388400-387021 (Counterclockwise)

Preceding gene: 21241104

Following gene: 21241099

Centisome position: 7.5

GC content: 69.86

Gene sequence:

>1380_bases
ATGAAATTGGGTATCACCGCCAAGTTGTTTCTCGCCATCCTCGCTGCGTGCGTGGCGGTGCTGCTGATCAACGGCATCGC
CGTGCAGGCCTTCGTCAAACGCCAGTTCCTGGACTATCTCAACGAACAGGGCGTGGAGCGCATGCAAGAGACCTTGCCGC
GGGTCAGGGCCGAATACGCGCGGCACGGCAACTGGGAGTTCGTGCGCGACAACCCCGATGCCTGGTTCGTGCTGATGCGC
CCGGAACGTGGCCCCGGCCCGCCACGCGAGGCGCCGCCGATTTCCGACCAGACCGGTGCGGTGTTTCGCTTCGCGCTGCT
CGACCAGGACTACACGCCGGTGATCGGCAATCCGGAGGTCGGCCGCCACGACATCCTGCGCCCGGTGGTGGTTGGCGGCC
GCACCGTCGGCTGGATGGCGATGCTGCCGTTCCAGAAGGCGCTGGCGGCGGCGGACGCGCGCTTCTACGCCGCGCAGCAA
CGCGCGTGGTGGGCGATCGGCGGCGCCTGCCTGCTGGTCGCCGCGCTGCTCGGCTGGCTGTTGTCGCGCACCTTGCTGCG
GCGCCTGCGTGGCCTGACCCAGGCCACCCACCTGCTCGCTGCGGGCGACTACGCCACCCGCATCGACGCCGCGGCGCGCG
ACGAACTGGGCCAGCTGGCGCGCGATTTCAACCTGCTGGCGCAAGCGCTGGAGCACAACGAACGCGCGCGACGCGACTTC
ATGGCCGACATCTCGCACGAGCTGCGCACGCCGCTGGCGGTCCTGCGCGCCGAACTGGAAGCGCTGCAGGACGGCATCCG
GCCGATGACACCCAACTCGCTGGGGTCGCTGCACCAGCAGGTCGGCCAGCTGGGCAAGCTGATCGAAGACCTGTACGACG
TGTCGCTGACCGATGTCGGTGCGCTGGCGTATCGGCGCGCTCCCGTCGATCTGGCGGTCATCCTGGCGACCGTGCTGGAC
GGCTTGCGCGCGCGCTTTGCCGCCGCGCAGCTGCAGGTGCAGGCGCAGATCGATGCCGGCCCGCTGCAGGTGGACGGCGA
CGAACGCCGTCTGCAGCAACTGCTGGGCAACCTGCTGGAAAACACGCTGCGCTACACCGACGCCGGTGGCACGGTGCAGG
TGCGCTGCGTGCGCCGCGGCGCGGTGCTGGAGATGGTGGTCGAAGACAGCGCGCCAGGCGTGGATGCGGACAAGCGCGCG
CGGCTGTTCGAACGCTTCTACCGCACCGAGGCCTCGCGCAATCGTGCCAGCGGCGGCAGCGGCCTGGGCCTGGCGATCTG
CCGCAACATCGCCGAGGCACATGGCGGCTCGATCCACGCCGAGGCTTCGGCACTGGGCGGGCTGCGCATGGTGCTGCGCC
TGCCGGCGCTGGTCGCATGA

Upstream 100 bases:

>100_bases
TGGAGATTGCCGGCGGCGGCATGAACGCGCTTGATTTCCACTGCCGCGACCCGGCTAATACGCAGCAGCTGCGGTTACCG
CGCTTCGCATCACCTCTTCG

Downstream 100 bases:

>100_bases
GCAGCGCGTCCCCGATCGGGCATGTGCTGATCGTCGAGGACGAACCGCGCCTGGCCGCGGTGTTGGGCGAGTACCTGCAC
GCGGCCGGCTATTCGCACGA

Product: two-component system sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MKLGITAKLFLAILAACVAVLLINGIAVQAFVKRQFLDYLNEQGVERMQETLPRVRAEYARHGNWEFVRDNPDAWFVLMR
PERGPGPPREAPPISDQTGAVFRFALLDQDYTPVIGNPEVGRHDILRPVVVGGRTVGWMAMLPFQKALAAADARFYAAQQ
RAWWAIGGACLLVAALLGWLLSRTLLRRLRGLTQATHLLAAGDYATRIDAAARDELGQLARDFNLLAQALEHNERARRDF
MADISHELRTPLAVLRAELEALQDGIRPMTPNSLGSLHQQVGQLGKLIEDLYDVSLTDVGALAYRRAPVDLAVILATVLD
GLRARFAAAQLQVQAQIDAGPLQVDGDERRLQQLLGNLLENTLRYTDAGGTVQVRCVRRGAVLEMVVEDSAPGVDADKRA
RLFERFYRTEASRNRASGGSGLGLAICRNIAEAHGGSIHAEASALGGLRMVLRLPALVA

Sequences:

>Translated_459_residues
MKLGITAKLFLAILAACVAVLLINGIAVQAFVKRQFLDYLNEQGVERMQETLPRVRAEYARHGNWEFVRDNPDAWFVLMR
PERGPGPPREAPPISDQTGAVFRFALLDQDYTPVIGNPEVGRHDILRPVVVGGRTVGWMAMLPFQKALAAADARFYAAQQ
RAWWAIGGACLLVAALLGWLLSRTLLRRLRGLTQATHLLAAGDYATRIDAAARDELGQLARDFNLLAQALEHNERARRDF
MADISHELRTPLAVLRAELEALQDGIRPMTPNSLGSLHQQVGQLGKLIEDLYDVSLTDVGALAYRRAPVDLAVILATVLD
GLRARFAAAQLQVQAQIDAGPLQVDGDERRLQQLLGNLLENTLRYTDAGGTVQVRCVRRGAVLEMVVEDSAPGVDADKRA
RLFERFYRTEASRNRASGGSGLGLAICRNIAEAHGGSIHAEASALGGLRMVLRLPALVA
>Mature_459_residues
MKLGITAKLFLAILAACVAVLLINGIAVQAFVKRQFLDYLNEQGVERMQETLPRVRAEYARHGNWEFVRDNPDAWFVLMR
PERGPGPPREAPPISDQTGAVFRFALLDQDYTPVIGNPEVGRHDILRPVVVGGRTVGWMAMLPFQKALAAADARFYAAQQ
RAWWAIGGACLLVAALLGWLLSRTLLRRLRGLTQATHLLAAGDYATRIDAAARDELGQLARDFNLLAQALEHNERARRDF
MADISHELRTPLAVLRAELEALQDGIRPMTPNSLGSLHQQVGQLGKLIEDLYDVSLTDVGALAYRRAPVDLAVILATVLD
GLRARFAAAQLQVQAQIDAGPLQVDGDERRLQQLLGNLLENTLRYTDAGGTVQVRCVRRGAVLEMVVEDSAPGVDADKRA
RLFERFYRTEASRNRASGGSGLGLAICRNIAEAHGGSIHAEASALGGLRMVLRLPALVA

Specific function: Member of the two-component regulatory system BaeS/BaeR. May activate BaeR by phosphorylation [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=459, Percent_Identity=45.9694989106754, Blast_Score=368, Evalue=1e-103,
Organism=Escherichia coli, GI1786783, Length=271, Percent_Identity=31.3653136531365, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1786600, Length=253, Percent_Identity=31.2252964426877, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1790346, Length=235, Percent_Identity=33.6170212765957, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1787894, Length=254, Percent_Identity=31.1023622047244, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI1789149, Length=314, Percent_Identity=26.1146496815287, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI145693157, Length=251, Percent_Identity=28.6852589641434, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI48994928, Length=240, Percent_Identity=30.8333333333333, Blast_Score=95, Evalue=9e-21,
Organism=Escherichia coli, GI87081816, Length=241, Percent_Identity=31.9502074688797, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1787374, Length=296, Percent_Identity=27.7027027027027, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1789808, Length=293, Percent_Identity=26.6211604095563, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786912, Length=229, Percent_Identity=28.82096069869, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1788279, Length=271, Percent_Identity=25.0922509225092, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI87082128, Length=274, Percent_Identity=25.9124087591241, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1788713, Length=232, Percent_Identity=27.1551724137931, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1790861, Length=361, Percent_Identity=25.7617728531856, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790551, Length=209, Percent_Identity=33.4928229665072, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1789403, Length=216, Percent_Identity=30.0925925925926, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788549, Length=219, Percent_Identity=24.6575342465753, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790436, Length=244, Percent_Identity=26.2295081967213, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50233; Mature: 50233

Theoretical pI: Translated: 8.60; Mature: 8.60

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLGITAKLFLAILAACVAVLLINGIAVQAFVKRQFLDYLNEQGVERMQETLPRVRAEYA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RHGNWEFVRDNPDAWFVLMRPERGPGPPREAPPISDQTGAVFRFALLDQDYTPVIGNPEV
HCCCCEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCHHEEEHHHCCCCCCCCCCCCC
GRHDILRPVVVGGRTVGWMAMLPFQKALAAADARFYAAQQRAWWAIGGACLLVAALLGWL
CHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSRTLLRRLRGLTQATHLLAAGDYATRIDAAARDELGQLARDFNLLAQALEHNERARRDF
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MADISHELRTPLAVLRAELEALQDGIRPMTPNSLGSLHQQVGQLGKLIEDLYDVSLTDVG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
ALAYRRAPVDLAVILATVLDGLRARFAAAQLQVQAQIDAGPLQVDGDERRLQQLLGNLLE
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCEEECCHHHHHHHHHHHHHH
NTLRYTDAGGTVQVRCVRRGAVLEMVVEDSAPGVDADKRARLFERFYRTEASRNRASGGS
HHHHCCCCCCEEEEEEECCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
GLGLAICRNIAEAHGGSIHAEASALGGLRMVLRLPALVA
CHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKLGITAKLFLAILAACVAVLLINGIAVQAFVKRQFLDYLNEQGVERMQETLPRVRAEYA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RHGNWEFVRDNPDAWFVLMRPERGPGPPREAPPISDQTGAVFRFALLDQDYTPVIGNPEV
HCCCCEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCHHEEEHHHCCCCCCCCCCCCC
GRHDILRPVVVGGRTVGWMAMLPFQKALAAADARFYAAQQRAWWAIGGACLLVAALLGWL
CHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSRTLLRRLRGLTQATHLLAAGDYATRIDAAARDELGQLARDFNLLAQALEHNERARRDF
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MADISHELRTPLAVLRAELEALQDGIRPMTPNSLGSLHQQVGQLGKLIEDLYDVSLTDVG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
ALAYRRAPVDLAVILATVLDGLRARFAAAQLQVQAQIDAGPLQVDGDERRLQQLLGNLLE
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCEEECCHHHHHHHHHHHHHH
NTLRYTDAGGTVQVRCVRRGAVLEMVVEDSAPGVDADKRARLFERFYRTEASRNRASGGS
HHHHCCCCCCEEEEEEECCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
GLGLAICRNIAEAHGGSIHAEASALGGLRMVLRLPALVA
CHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8282725; 9097040; 9278503 [H]